雙眼乙型肝炎相關性視神經炎1例_Chinese Journal of Ocular Fundus Diseases

Authors：

趙殊藝 , 崔金鵬 , 張會萍 , 張礫文 ,  劉曉晨

云南省滇南中心醫院（紅河州第一人民醫院）眼科, 個舊 661018;

Corresponding?author：

劉曉晨, Email: 1156168563@qq.com

Keywords：

視神經炎; 黃斑水腫; 乙型病毒性肝炎; 病例報告

DOI：

10.3760/cma.j.cn511434-20250723-00318

Video：

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Citation： 趙殊藝, 崔金鵬, 張會萍, 張礫文, 劉曉晨. 雙眼乙型肝炎相關性視神經炎1例. Chinese Journal of Ocular Fundus Diseases, 2026, 42(4): 340-343. doi: 10.3760/cma.j.cn511434-20250723-00318 Copy

1.	中華醫學會眼科學分會神經眼科學組. 視神經炎診斷和治療專家共識(2014年)[J]. 中華眼科雜志, 2014(6): 459-463. DOI: 10.3760/cma.j.issn.0412-4081.2014.06.013.Neuro-ophthalmology Group, Ophthalmology Branch, Chinese Medical Association. Expert consensus on diagnosis and treatment of optic neuritis (2014)[J]. Chin J Ophthalmol, 2014(6): 459-463. DOI: 10.3760/cma.j.issn.0412-4081.2014.06.013.
2.	Shi J, Danesh-Meyer HV, Bhatti MT. Neuroretinitis: a comprehensive review on aetiologies, clinical manifestations, and treatment options[J]. Eye (Lond), 2025, 39(2): 238-250. DOI: 10.1038/s41433-024-03466-7.
3.	Fairbanks AM, Starr MR, Chen JJ, et al. Treatment strategies for neuroretinitis: current options and emerging therapies[J/OL]. Curr Treat Options Neurol, 2019, 21(8): 36[2019-07-05]. https://pubmed.ncbi.nlm.nih.gov/31278547/. DOI: 10.1007/s11940-019-0579-9.
4.	Abdelhakim A, Rasool N. Neuroretinitis: a review[J]. Curr Opin Ophthalmol, 2018, 29(6): 514-519. DOI: 10.1097/ICU.0000000000000527.
5.	Uzawa A, Oertel FC, Mori M, et al. NMOSD and MOGAD: an evolving disease spectrum[J]. Nat Rev Neurol, 2024, 20(10): 602-619. DOI: 10.1038/s41582-024-01014-1.
6.	Chan F, Fraser C, Brilot F, et al. Structural and functional biomarkers of visual dysfunction in MOG antibody-positive optic neuritis: a scoping review[J/OL]. J Neuroimmunol, 2025, 408: 578715[2028-11-15]. https://pubmed.ncbi.nlm.nih.gov/40829360/. DOI: 10.1016/j.jneuroim.2025.578715.
7.	Nowacka B, Lubiński W, Ka?mierczak B. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated optic neuritis-a case report and literature review[J]. Int Med Case Rep J, 2024, 17: 391-399. DOI: 10.2147/IMCRJ.S459799.
8.	Jeyakumar N, Lerch M, Dale RC, et al. MOG antibody-associated optic neuritis[J]. Eye, 2024, 38(12): 2289-2301. DOI: 10.1038/s41433-024-03108-y.
9.	Tajfirouz DA, Bhatti MT, Chen JJ. Clinical characteristics and treatment of MOG-IgG-associated optic neuritis[J/OL]. Curr Neurol Neurosci Rep, 2019, 19(12): 100[2019-11-26]. https://pubmed.ncbi.nlm.nih.gov/31773369/. DOI: 10.1007/s11910-019-1014-z.
10.	Galli M, Morelli R, Casellato A, et al. Retrobulbar optic neuritis in a patient with acute type B hepatitis[J]. J Neurol Sci, 1986, 72(2-3): 195-200. DOI: 10.1016/0022-510X(86)90007-9.
11.	Achiron LR. Postinfectious hepatitis B optic neuritis[J]. Optometry vision sci, 1994, 71(1): 53-56. DOI: 10.1097/00006324-199401000-00011.
12.	Curras-Martin D, Campbell N, Haroon A, et al. Recurrent optic neuritis as the only manifestation of chronic hepatitis b virus flare: a case report[J/OL]. J Med Case Rep, 2018, 12(1): 316[2018-10-16]. https://pubmed.ncbi.nlm.nih.gov/30326966/. DOI: 10.1186/s13256-018-1810-0.
13.	Zhao S, Chen T, Peng C, et al. The putative acceleration of optic neuritis when combined with chronic hepatitis B[J]. J Neurol Sci, 2015, 358(1-2): 207-212. DOI: 10.1016/j.jns.2015.08.1538.
14.	Beck RW, Cleary PA, Anderson MM, et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. the optic neuritis study group[J]. New Engl J Med, 1992, 326(9): 581-588. DOI: 10.1056/NEJM199202273260901.
15.	Cacoub P, Terrier B. Hepatitis B-related autoimmune manifestations[J]. Rheum Dis Clin North Am, 2009, 35(1): 125-137. DOI: 10.1016/j.rdc.2009.03.006.
16.	Hipolito-Fernandes D, Elisa-Luís M, Trigo M, et al. Parainfectious optic neuritis followed by microcystic macular oedema[J/OL]. BMJ Case Rep, 2019, 12(9): e231442[2019-09-24]. https://pubmed.ncbi.nlm.nih.gov/31551321/. DOI: 10.1136/bcr-2019-231442.

1. 中華醫學會眼科學分會神經眼科學組. 視神經炎診斷和治療專家共識(2014年)[J]. 中華眼科雜志, 2014(6): 459-463. DOI: 10.3760/cma.j.issn.0412-4081.2014.06.013.Neuro-ophthalmology Group, Ophthalmology Branch, Chinese Medical Association. Expert consensus on diagnosis and treatment of optic neuritis (2014)[J]. Chin J Ophthalmol, 2014(6): 459-463. DOI: 10.3760/cma.j.issn.0412-4081.2014.06.013.
2. Shi J, Danesh-Meyer HV, Bhatti MT. Neuroretinitis: a comprehensive review on aetiologies, clinical manifestations, and treatment options[J]. Eye (Lond), 2025, 39(2): 238-250. DOI: 10.1038/s41433-024-03466-7.
3. Fairbanks AM, Starr MR, Chen JJ, et al. Treatment strategies for neuroretinitis: current options and emerging therapies[J/OL]. Curr Treat Options Neurol, 2019, 21(8): 36[2019-07-05]. https://pubmed.ncbi.nlm.nih.gov/31278547/. DOI: 10.1007/s11940-019-0579-9.
4. Abdelhakim A, Rasool N. Neuroretinitis: a review[J]. Curr Opin Ophthalmol, 2018, 29(6): 514-519. DOI: 10.1097/ICU.0000000000000527.
5. Uzawa A, Oertel FC, Mori M, et al. NMOSD and MOGAD: an evolving disease spectrum[J]. Nat Rev Neurol, 2024, 20(10): 602-619. DOI: 10.1038/s41582-024-01014-1.
6. Chan F, Fraser C, Brilot F, et al. Structural and functional biomarkers of visual dysfunction in MOG antibody-positive optic neuritis: a scoping review[J/OL]. J Neuroimmunol, 2025, 408: 578715[2028-11-15]. https://pubmed.ncbi.nlm.nih.gov/40829360/. DOI: 10.1016/j.jneuroim.2025.578715.
7. Nowacka B, Lubiński W, Ka?mierczak B. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated optic neuritis-a case report and literature review[J]. Int Med Case Rep J, 2024, 17: 391-399. DOI: 10.2147/IMCRJ.S459799.
8. Jeyakumar N, Lerch M, Dale RC, et al. MOG antibody-associated optic neuritis[J]. Eye, 2024, 38(12): 2289-2301. DOI: 10.1038/s41433-024-03108-y.
9. Tajfirouz DA, Bhatti MT, Chen JJ. Clinical characteristics and treatment of MOG-IgG-associated optic neuritis[J/OL]. Curr Neurol Neurosci Rep, 2019, 19(12): 100[2019-11-26]. https://pubmed.ncbi.nlm.nih.gov/31773369/. DOI: 10.1007/s11910-019-1014-z.
10. Galli M, Morelli R, Casellato A, et al. Retrobulbar optic neuritis in a patient with acute type B hepatitis[J]. J Neurol Sci, 1986, 72(2-3): 195-200. DOI: 10.1016/0022-510X(86)90007-9.
11. Achiron LR. Postinfectious hepatitis B optic neuritis[J]. Optometry vision sci, 1994, 71(1): 53-56. DOI: 10.1097/00006324-199401000-00011.
12. Curras-Martin D, Campbell N, Haroon A, et al. Recurrent optic neuritis as the only manifestation of chronic hepatitis b virus flare: a case report[J/OL]. J Med Case Rep, 2018, 12(1): 316[2018-10-16]. https://pubmed.ncbi.nlm.nih.gov/30326966/. DOI: 10.1186/s13256-018-1810-0.
13. Zhao S, Chen T, Peng C, et al. The putative acceleration of optic neuritis when combined with chronic hepatitis B[J]. J Neurol Sci, 2015, 358(1-2): 207-212. DOI: 10.1016/j.jns.2015.08.1538.
14. Beck RW, Cleary PA, Anderson MM, et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. the optic neuritis study group[J]. New Engl J Med, 1992, 326(9): 581-588. DOI: 10.1056/NEJM199202273260901.
15. Cacoub P, Terrier B. Hepatitis B-related autoimmune manifestations[J]. Rheum Dis Clin North Am, 2009, 35(1): 125-137. DOI: 10.1016/j.rdc.2009.03.006.
16. Hipolito-Fernandes D, Elisa-Luís M, Trigo M, et al. Parainfectious optic neuritis followed by microcystic macular oedema[J/OL]. BMJ Case Rep, 2019, 12(9): e231442[2019-09-24]. https://pubmed.ncbi.nlm.nih.gov/31551321/. DOI: 10.1136/bcr-2019-231442.

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Chinese Journal of Ocular Fundus Diseases

雙眼乙型肝炎相關性視神經炎1例

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