Research Progress in Seeding Cells of Peripheral Nerve_Journal of Biomedical Engineering

Authors：

 SHIGengqiang , HUYi

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;

Corresponding?author：

SHIGengqiang, Email: gengersgq@163.com

Keywords：

seeding cell; Schwann cell; bone marrow mesenchymal stem cell; neural stem cell

DOI：

10.7507/1001-5515.20150085

Video：

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Abstract Full text Figures/Tables Video References Cited by

Seeding cells play an important role in the peripheral nerve damage repair. Seeding cells studied consequently in peripheral nerve are Schwann cells, bone marrow mesenchymal stem cells and neural stem cells. Schwann cells, the first seeding cells, are various unique glial cells in the peripheral nervous system, which can form the myelin sheath for insulation and package of the neuron projecting axons in the peripheral nervous system so that the conduction velocity of the nerve signal was accelerated. It can be proved that Schwann cells played an important role in the maintenance of peripheral nerve function and in the regeneration process after peripheral nerve injury. The second, bone marrow mesenchymal stem cells are the various mesenchymal stem cells mainly exist in the systemic connective tissues and organs. These functional stem cells are often studied at present, and it has been found that they have exuberant proliferation and differentiation potentials. Neural stem cells, mentioned the third in sequence, are the kind of pluripotent cells with multi-directional differentiation, which could conduct the self-renewal function, and generate and differentiate neurons, astrocytes and oligodendrocytes through asymmetric cell division. These three types of seed cells are discussed in this paper.

Citation： SHIGengqiang, HUYi. Research Progress in Seeding Cells of Peripheral Nerve. Journal of Biomedical Engineering, 2015, 32(2): 470-474. doi: 10.7507/1001-5515.20150085 Copy

1.	TORIGOE K, TANAKA H F, TAKAHASHI A, et al. Basic behavior of migratory Schwann cells in peripheral nerve regeneration[J]. Exp Neurol, 1996, 137(2):301-308.
2.	付紅運, 王銳英.雪旺細胞體外培養與純化的研究進展[J].海南醫學, 2012, 23(22):118-121.
3.	TYNER T R, PARKS N, FARIA S, et al. Effects of collagen nerve guide on neuroma formation and neuropathic pain in a rat model[J]. Am J Surg, 2007, 193(1):e1-e6.
4.	NAVARRO X, VIVó M, VALERO-CABRé A. Neural plasticity after peripheral nerve injury and regeneration[J]. Prog Neurobiol, 2007, 82(4):163-201.
5.	成玉澤, 李劍波, 石敏, 等.成人及成年大鼠雪旺細胞的體外培養[J].江蘇醫藥, 2011, 37(17):1985-1987.
6.	陶曉宇, 滕曉華, 劉波, 等.改良新生大鼠雪旺細胞的體外培養和純化[J].湖南師范大學自然科學學報, 2011, 34(3):82-84, 89.
7.	王洪美, 胡琴, 姜曉榮, 等.三種人胚胎許旺細胞培養方法的比較[J].中華臨床醫師雜志(電子版), 2011, 5(19):5599-5603.
8.	陳祥, 趙明, 周華山, 等.新生大鼠雪旺細胞原代培養方法改良[J].四川動物, 2012, 31(3):464-467.
9.	王世清, 范志海, 沈憶新.不同部位取材的雪旺細胞培養與純化研究[J].中國修復重建外科雜志, 2011, 25(2):166-170.
10.	KRAUS A, T?GER J, KOHLER K, et al. Efficacy of various durations of in vitro predegeneration on the cell count and purity of rat Schwann-cell cultures[J]. J Neurotrauma, 2010, 27(1):197-203.
11.	王耀軍, 鄭朝, 張戰鳳, 等.成年大鼠許旺細胞快速擴增的改良方法[J].中華臨床醫師雜志(電子版), 2010, 4(12):2538-2541.
12.	張華, 時淑艷, 劉佳, 等.一種簡便的雪旺細胞培養方法[J].四川解剖學雜志, 2012, 20(1):7-9.
13.	KOMIYAMA T, NAKAO Y, TOYAMA Y, et al. A novel technique to isolate adult Schwann cells for an artificial nerve conduit[J]. J Neurosci Methods, 2003, 122(2):195-200.
14.	秦義武, 趙勁民, 蘇偉, 等.單酶消化復合植塊法培養雪旺細胞的實驗研究[J].中國修復重建外科雜志, 2012, 26(9):1107-1111.
15.	劉炎, 張莉, 宮旭, 等.雙向差速法制備高純度雪旺細胞的實驗研究[J].中國矯形外科雜志, 2011, 19(16):1373-1376.
16.	李巖峰.激活態雪旺細胞臨床應用安全性的實驗研究[D].上海:復旦大學, 2010.
17.	YANG Q, MU J, LI Q, et al. A simple and efficient method for deriving neurospheres from bone marrow stromal cells[J]. Biochem Biophys Res Commun, 2008, 372(4):520-524.
18.	曹敏麗, 趙紅斌, 呂志成.超聲評價骨髓間充質干細胞在外周神經缺損修復中的價值[J].臨床誤診誤治, 2011, 24(12):4-5.
19.	MIMURA T, DEZAWA M, KANNO H, et al. Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats[J]. J Neurosurg, 2004, 101(5):806-812.
20.	SHIMIZU S, KITADA M, ISHIKAWA H, et al. Peripheral nerve regeneration by the in vitro differentiated-human bone marrow stromal cells with Schwann cell property[J]. Biochem Biophys Res Commun, 2007, 359(4):915-920.
21.	鄭煜, 周興.神經細胞移植促進大鼠損傷的周圍神經功能的恢復[J].實用醫學雜志, 2012, 28(20):3359-3361.
22.	張杭, 孫天威.骨髓間充質干細胞分化為神經細胞研究進展[J].國際骨科學雜志, 2011, 32(2):104-107.
23.	安秀峰, 黃漢昌, 姜招峰.骨髓間充質干細胞向神經干細胞的分化[J].生命科學, 2013, 25(1):84-90.
24.	HU N, WU H, XUE C B, et al. Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts[J]. Biomaterials, 2013, 34(1):100-111.
25.	ZHENG L, CUI H F. Enhancement of nerve regeneration along a chitosan conduit combined with bone marrow mesenchymal stem cells[J]. J Mater Sci Mater Med, 2012, 23(9):2291-2302.
26.	MIRA H, ANDREU Z, SUH H, et al. Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus[J]. Cell Stem Cell, 2010, 7(1):78-89.
27.	NUMANO F, INOUE A, ENOMOTO M, et al. Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord[J]. Mol Brain, 2009, 2:37.
28.	PASPALA S A, BALAJI A B, NYAMATH P, et al. Neural stem cells & supporting cells--the new therapeutic tools for the treatment of spinal cord injury[J]. Indian J Med Res, 2009, 130(4):379-391.
29.	KEIRSTEAD H S, BEN-HUR T, ROGISTER B, et al. Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation[J]. J Neurosci, 1999, 19(17):7529-7536.
30.	MURAKAMI T, FUJIMOTO Y, YASUNAGA Y, et al. Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair[J]. Brain Res, 2003, 974(1-2):17-24.
31.	CHANG K A, KIM J W, KIM J A, et al. Biphasic electrical currents stimulation promotes both proliferation and differentiation of fetal neural stem cells[J]. PLoS One, 2011, 6(4):e18738.
32.	張民皓, 胡益民, 張紅, 等.坐骨神經損傷大鼠模型鞘內移植神經干細胞后脊髓背角和背根神經節腦源性神經營養因子的表達[J].中國組織工程研究, 2012, 16(10):1851-1855.
33.	CHENG L N, DUAN X H, ZHONG X M, et al. Transplanted neural stem cells promote nerve regeneration in acute peripheral nerve traction injury:assessment using MRI[J]. AJR Am J Roentgenol, 2011, 196(6):1381-1387.
34.	XU L, ZHOU S, FENG G Y, et al. Neural stem cells enhance nerve regeneration after sciatic nerve injury in rats[J]. Mol Neurobiol, 2012, 46(2):265-274.
35.	GU S H, XU W D, XU L, et al. Regenerated host axons form synapses with neurons derived from neural stem cells transplanted into peripheral nerves[J]. J Int Med Res, 2012, 38(5):1721-1729.

1. TORIGOE K, TANAKA H F, TAKAHASHI A, et al. Basic behavior of migratory Schwann cells in peripheral nerve regeneration[J]. Exp Neurol, 1996, 137(2):301-308.
2. 付紅運, 王銳英.雪旺細胞體外培養與純化的研究進展[J].海南醫學, 2012, 23(22):118-121.
3. TYNER T R, PARKS N, FARIA S, et al. Effects of collagen nerve guide on neuroma formation and neuropathic pain in a rat model[J]. Am J Surg, 2007, 193(1):e1-e6.
4. NAVARRO X, VIVó M, VALERO-CABRé A. Neural plasticity after peripheral nerve injury and regeneration[J]. Prog Neurobiol, 2007, 82(4):163-201.
5. 成玉澤, 李劍波, 石敏, 等.成人及成年大鼠雪旺細胞的體外培養[J].江蘇醫藥, 2011, 37(17):1985-1987.
6. 陶曉宇, 滕曉華, 劉波, 等.改良新生大鼠雪旺細胞的體外培養和純化[J].湖南師范大學自然科學學報, 2011, 34(3):82-84, 89.
7. 王洪美, 胡琴, 姜曉榮, 等.三種人胚胎許旺細胞培養方法的比較[J].中華臨床醫師雜志(電子版), 2011, 5(19):5599-5603.
8. 陳祥, 趙明, 周華山, 等.新生大鼠雪旺細胞原代培養方法改良[J].四川動物, 2012, 31(3):464-467.
9. 王世清, 范志海, 沈憶新.不同部位取材的雪旺細胞培養與純化研究[J].中國修復重建外科雜志, 2011, 25(2):166-170.
10. KRAUS A, T?GER J, KOHLER K, et al. Efficacy of various durations of in vitro predegeneration on the cell count and purity of rat Schwann-cell cultures[J]. J Neurotrauma, 2010, 27(1):197-203.
11. 王耀軍, 鄭朝, 張戰鳳, 等.成年大鼠許旺細胞快速擴增的改良方法[J].中華臨床醫師雜志(電子版), 2010, 4(12):2538-2541.
12. 張華, 時淑艷, 劉佳, 等.一種簡便的雪旺細胞培養方法[J].四川解剖學雜志, 2012, 20(1):7-9.
13. KOMIYAMA T, NAKAO Y, TOYAMA Y, et al. A novel technique to isolate adult Schwann cells for an artificial nerve conduit[J]. J Neurosci Methods, 2003, 122(2):195-200.
14. 秦義武, 趙勁民, 蘇偉, 等.單酶消化復合植塊法培養雪旺細胞的實驗研究[J].中國修復重建外科雜志, 2012, 26(9):1107-1111.
15. 劉炎, 張莉, 宮旭, 等.雙向差速法制備高純度雪旺細胞的實驗研究[J].中國矯形外科雜志, 2011, 19(16):1373-1376.
16. 李巖峰.激活態雪旺細胞臨床應用安全性的實驗研究[D].上海:復旦大學, 2010.
17. YANG Q, MU J, LI Q, et al. A simple and efficient method for deriving neurospheres from bone marrow stromal cells[J]. Biochem Biophys Res Commun, 2008, 372(4):520-524.
18. 曹敏麗, 趙紅斌, 呂志成.超聲評價骨髓間充質干細胞在外周神經缺損修復中的價值[J].臨床誤診誤治, 2011, 24(12):4-5.
19. MIMURA T, DEZAWA M, KANNO H, et al. Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats[J]. J Neurosurg, 2004, 101(5):806-812.
20. SHIMIZU S, KITADA M, ISHIKAWA H, et al. Peripheral nerve regeneration by the in vitro differentiated-human bone marrow stromal cells with Schwann cell property[J]. Biochem Biophys Res Commun, 2007, 359(4):915-920.
21. 鄭煜, 周興.神經細胞移植促進大鼠損傷的周圍神經功能的恢復[J].實用醫學雜志, 2012, 28(20):3359-3361.
22. 張杭, 孫天威.骨髓間充質干細胞分化為神經細胞研究進展[J].國際骨科學雜志, 2011, 32(2):104-107.
23. 安秀峰, 黃漢昌, 姜招峰.骨髓間充質干細胞向神經干細胞的分化[J].生命科學, 2013, 25(1):84-90.
24. HU N, WU H, XUE C B, et al. Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts[J]. Biomaterials, 2013, 34(1):100-111.
25. ZHENG L, CUI H F. Enhancement of nerve regeneration along a chitosan conduit combined with bone marrow mesenchymal stem cells[J]. J Mater Sci Mater Med, 2012, 23(9):2291-2302.
26. MIRA H, ANDREU Z, SUH H, et al. Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus[J]. Cell Stem Cell, 2010, 7(1):78-89.
27. NUMANO F, INOUE A, ENOMOTO M, et al. Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord[J]. Mol Brain, 2009, 2:37.
28. PASPALA S A, BALAJI A B, NYAMATH P, et al. Neural stem cells & supporting cells--the new therapeutic tools for the treatment of spinal cord injury[J]. Indian J Med Res, 2009, 130(4):379-391.
29. KEIRSTEAD H S, BEN-HUR T, ROGISTER B, et al. Polysialylated neural cell adhesion molecule-positive CNS precursors generate both oligodendrocytes and Schwann cells to remyelinate the CNS after transplantation[J]. J Neurosci, 1999, 19(17):7529-7536.
30. MURAKAMI T, FUJIMOTO Y, YASUNAGA Y, et al. Transplanted neuronal progenitor cells in a peripheral nerve gap promote nerve repair[J]. Brain Res, 2003, 974(1-2):17-24.
31. CHANG K A, KIM J W, KIM J A, et al. Biphasic electrical currents stimulation promotes both proliferation and differentiation of fetal neural stem cells[J]. PLoS One, 2011, 6(4):e18738.
32. 張民皓, 胡益民, 張紅, 等.坐骨神經損傷大鼠模型鞘內移植神經干細胞后脊髓背角和背根神經節腦源性神經營養因子的表達[J].中國組織工程研究, 2012, 16(10):1851-1855.
33. CHENG L N, DUAN X H, ZHONG X M, et al. Transplanted neural stem cells promote nerve regeneration in acute peripheral nerve traction injury:assessment using MRI[J]. AJR Am J Roentgenol, 2011, 196(6):1381-1387.
34. XU L, ZHOU S, FENG G Y, et al. Neural stem cells enhance nerve regeneration after sciatic nerve injury in rats[J]. Mol Neurobiol, 2012, 46(2):265-274.
35. GU S H, XU W D, XU L, et al. Regenerated host axons form synapses with neurons derived from neural stem cells transplanted into peripheral nerves[J]. J Int Med Res, 2012, 38(5):1721-1729.

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Research Progress in Seeding Cells of Peripheral Nerve

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