Advances in Research on Reendothelialization after Intervention in Artery_Journal of Biomedical Engineering

Authors：

LITiantian , DINGYangnan , WUJiang ,  LIUXiaoheng

Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China;

Corresponding?author：

LIUXiaoheng, Email: liuxiaohg@scu.edu.cn

Keywords：

reendothelialization; coronary stent; vascular endothelial cells; endothelial progenitor cells; shear stress

DOI：

10.7507/1001-5515.20160032

Video：

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Coronary heart disease is a kind of heart disease that is caused by atherosclerosis.The lipid deposition in the vessel wall results in occlusion of coronary artery and stenosis, which could induce myocardial ischemia and oxygen deficiency. Intervention therapies like percutaneous coronary intervention (PCI) and coronary stent improve myocardial perfusion using catheter angioplasty to reduce stenosis and occlusion of coronary artery lumen. Accordingly, intervention therapies are widely applied in clinic to treat ischemic cardiovascular disease, arterial intima hyperplasia and other heart diseases, which could save the patients′ life rapidly and effectively. However, these interventions also damage the original endothelium, promote acute and subacute thrombosis and intimal hyperplasia, and thus induce in stent restenosis (ISR) eventually. Studies indicated that the rapid reendothelialization of damaged section determined postoperative effects. In this review, reendothelialization of implants after intervention therapy is discussed, including the resource of cells contributed on injured artery, the influences of implanted stents on hemodynamic, and the effects of damaged degree on reendothelialization.

Citation： LITiantian, DINGYangnan, WUJiang, LIUXiaoheng. Advances in Research on Reendothelialization after Intervention in Artery. Journal of Biomedical Engineering, 2016, 33(1): 177-183. doi: 10.7507/1001-5515.20160032 Copy

1.	?CHAABANE C, OTSUKA F, VIRMANI R, et al. Biological responses in stented arteries[J] . Cardiovasc Res, 2013, 99(2): 353-363.
2.	UBIL E, DUAN Jinzhu, PILLAI I C, et al. Mesenchymal endothelial transition contributes to cardiac neovascularization[J] . Nature, 2014, 514(7524): 585-590.
3.	ITOH Y, TORIUMI H, YAMADA S, et al. Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion[J] . Arterioscler Thromb Vasc Biol, 2010, 30(9): 1725-1732.
4.	FISHMAN J A, RYAN G B, KARNOVSKY M J. Endothelial regeneration in the rat carotid artery and the significance of endothelial denudation in the pathogenesis of myointimal thickening[J] . Lab Invest, 1975, 32(3): 339-351.
5.	HAGENSEN M K, RAARUP M K, MORTENSEN M B, et al. Circulating endothelial progenitor cells do not contribute to regeneration of endothelium after murine arterial injury[J] . Cardiovasc Res, 2012, 93(2): 223-231.
6.	ASAHARA T, MUROHARA T, SULLIVAN A, et al. Isolation of putative progenitor endothelial cells for angiogenesis[J] . Science, 1997, 275(532): 964-967.
7.	張會前, 徐善水.內皮祖細胞的研究現狀[J] .科技信息,2013,(7):482-468.
8.	ZAMPETAKI A, KIRTON J P, XU Qingbo. Vascular repair by endothelial progenitor cells[J] . Cardiovasc Res, 2008, 78(3): 413-421.
9.	KAZAKOV A, MLLER P, JAGODA P, et al. Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis[J] . Cardiovasc Res, 2012, 93(3): 397-405.
10.	張煒, 蔡第心,汪虹,等.動員血管內皮祖細胞促進真皮支架移植區的血管新生[J] .中國組織工程研究,2013,17(24):4386-4393.
11.	BAKOGIANNIS C, TOUSOULIS D, ANDROULAKIS E, et al. Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes[J] . Curr Med Chem, 2012, 19(16): 2597-2604.
12.	EISEN A, LESHEM LEV D, YAVIN H, et al. Effect of high dose statin pretreatment on endothelial progenitor cells after percutaneous coronary intervention (HIPOCRATES study)[J] . Cardiovasc Drugs Ther, 2015, 29(2): 129-135.
13.	劉志強. 外周血中內皮祖細胞與椎動脈支架植入后再狹窄相關性的研究[J] .中國實用醫藥,2013,8(18):117-118.
14.	HEO K S, FUJIWARA K, ABE J I. Shear stress and atherosclerosis[J] . Mol Cells, 2014, 37(6): 435-440.
15.	KOSKINAS K C, CHATZIZISIS Y S, ANTONIADIS A P, et al. Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation[J] . J Am Coll Cardiol, 2012, 59(15): 1337-1349.
16.	COSEMANS J M, ANGELILLO SCHERRER A, MATTHEIJ N J, et al. The effects of arterial flow on platelet activation, thrombus growth, and stabilization[J] . Cardiovasc Res, 2013, 99(2): 342-352.
17.	VAN DER HEIDEN K, GIJSEN F J, NARRACOTT A, et al. The effects of stenting on shear stress: relevance to endothelial injury and repair[J] . Cardiovasc Res, 2013, 99(2): 269-275.
18.	ANDO J, YAMAMOTO K. Flow detection and calcium signalling in vascular endothelial cells[J] . Cardiovasc Res, 2013, 99(2): 260-268.
19.	ANWAR M A, SHALHOUB J, LIM C S, et al. The effect of pressure induced mechanical stretch on vascular wall differential gene expression[J] . J Vasc Res, 2012, 49(6): 463-478.
20.	VAN DEN BRANDEN B J, RAHEL B M, LAARMAN G J, et al. Five year clinical outcome after primary stenting of totally occluded native coronary arteries: a randomised comparison of bare metal stent implantation with sirolimus eluting stent implantation for the treatment of total coronary occlusions (PRISON II study)[J] . EuroIntervention, 2012, 7(10): 1189-1196.
21.	PALMERINI T, BIONDI ZOCCAI G, DELLA RIVA D, et al. Stent thrombosis with drug eluting and bare metal stents: evidence from a comprehensive network meta analysis[J] . Lancet, 2012, 379(9824): 1393-1402.
22.	BANGALORE S, KUMAR S, FUSARO M, et al. Short and long term outcomes with drug eluting and bare metal coronary stents: a mixed treatment comparison analysis of 117762 patient years of follow up from randomized trials[J] . Circulation, 2012, 125(23):2873-2891.
23.	GUAGLIUMI G, SIRBU V, MUSUMECI G, et al. Examination of the in vivo mechanisms of late drug eluting stent thrombosis: findings from optical coherence tomography and intravascular ultrasound imaging[J] . JACC Cardiovasc Interv, 2012, 5(1): 12-20.
24.	GUAGLIUMI G, FARB A, MUSUMECI G, et al. Images in cardiovascular medicine. Sirolimus eluting stent implanted in human coronary artery for 16 months: pathological findings[J] . Circulation, 2003, 107(9): 1340-1341.
25.	熊筱偉, 朱勁舟,杜潤,等.聚合物涂層改性對藥物洗脫支架植入后血管內膜修復的作用[J] .介入放射學雜志,2012,21(8):655-659.
26.	KIPSHIDZE N, DANGAS G, TSAPENKO M, et al. Role of the endothelium in modulating neointimal formation: vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions[J] . J Am Coll Cardiol, 2004, 44(4): 733-739.
27.	VAN BEUSEKOM H M, ERTA, SOROP O, et al. The GenousTM endothelial progenitor cell capture stent accelerates stent re endothelialization but does not affect intimal hyperplasia in porcine coronary arteries[J] . Catheter Cardiovasc Interv, 2012, 79(2): 231-242.
28.	朱建兵, 張俊峰.內皮祖細胞捕獲支架的應用研究進展[J] .中華臨床醫師雜志:電子版,2012,6(21):6854-6856.
29.	LEOPOLD J A. Prohealing endothelial progenitor cell capture stents: do the cells captured explain the clinical outcomes?[J] . Circ Cardiovasc Interv, 2013, 6(5): 494-495.
30.	YANG Feng, FENG Shichao, PANG Xiangjun, et al. Combination coating of chitosan and anti CD34 antibody applied on sirolimus eluting stents can promote endothelialization while reducing neointimal formation[J] . BMC Cardiovasc Disord, 2012, 12(18): 96.

1. ?CHAABANE C, OTSUKA F, VIRMANI R, et al. Biological responses in stented arteries[J] . Cardiovasc Res, 2013, 99(2): 353-363.
2. UBIL E, DUAN Jinzhu, PILLAI I C, et al. Mesenchymal endothelial transition contributes to cardiac neovascularization[J] . Nature, 2014, 514(7524): 585-590.
3. ITOH Y, TORIUMI H, YAMADA S, et al. Resident endothelial cells surrounding damaged arterial endothelium reendothelialize the lesion[J] . Arterioscler Thromb Vasc Biol, 2010, 30(9): 1725-1732.
4. FISHMAN J A, RYAN G B, KARNOVSKY M J. Endothelial regeneration in the rat carotid artery and the significance of endothelial denudation in the pathogenesis of myointimal thickening[J] . Lab Invest, 1975, 32(3): 339-351.
5. HAGENSEN M K, RAARUP M K, MORTENSEN M B, et al. Circulating endothelial progenitor cells do not contribute to regeneration of endothelium after murine arterial injury[J] . Cardiovasc Res, 2012, 93(2): 223-231.
6. ASAHARA T, MUROHARA T, SULLIVAN A, et al. Isolation of putative progenitor endothelial cells for angiogenesis[J] . Science, 1997, 275(532): 964-967.
7. 張會前, 徐善水.內皮祖細胞的研究現狀[J] .科技信息,2013,(7):482-468.
8. ZAMPETAKI A, KIRTON J P, XU Qingbo. Vascular repair by endothelial progenitor cells[J] . Cardiovasc Res, 2008, 78(3): 413-421.
9. KAZAKOV A, MLLER P, JAGODA P, et al. Endothelial nitric oxide synthase of the bone marrow regulates myocardial hypertrophy, fibrosis, and angiogenesis[J] . Cardiovasc Res, 2012, 93(3): 397-405.
10. 張煒, 蔡第心,汪虹,等.動員血管內皮祖細胞促進真皮支架移植區的血管新生[J] .中國組織工程研究,2013,17(24):4386-4393.
11. BAKOGIANNIS C, TOUSOULIS D, ANDROULAKIS E, et al. Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes[J] . Curr Med Chem, 2012, 19(16): 2597-2604.
12. EISEN A, LESHEM LEV D, YAVIN H, et al. Effect of high dose statin pretreatment on endothelial progenitor cells after percutaneous coronary intervention (HIPOCRATES study)[J] . Cardiovasc Drugs Ther, 2015, 29(2): 129-135.
13. 劉志強. 外周血中內皮祖細胞與椎動脈支架植入后再狹窄相關性的研究[J] .中國實用醫藥,2013,8(18):117-118.
14. HEO K S, FUJIWARA K, ABE J I. Shear stress and atherosclerosis[J] . Mol Cells, 2014, 37(6): 435-440.
15. KOSKINAS K C, CHATZIZISIS Y S, ANTONIADIS A P, et al. Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation[J] . J Am Coll Cardiol, 2012, 59(15): 1337-1349.
16. COSEMANS J M, ANGELILLO SCHERRER A, MATTHEIJ N J, et al. The effects of arterial flow on platelet activation, thrombus growth, and stabilization[J] . Cardiovasc Res, 2013, 99(2): 342-352.
17. VAN DER HEIDEN K, GIJSEN F J, NARRACOTT A, et al. The effects of stenting on shear stress: relevance to endothelial injury and repair[J] . Cardiovasc Res, 2013, 99(2): 269-275.
18. ANDO J, YAMAMOTO K. Flow detection and calcium signalling in vascular endothelial cells[J] . Cardiovasc Res, 2013, 99(2): 260-268.
19. ANWAR M A, SHALHOUB J, LIM C S, et al. The effect of pressure induced mechanical stretch on vascular wall differential gene expression[J] . J Vasc Res, 2012, 49(6): 463-478.
20. VAN DEN BRANDEN B J, RAHEL B M, LAARMAN G J, et al. Five year clinical outcome after primary stenting of totally occluded native coronary arteries: a randomised comparison of bare metal stent implantation with sirolimus eluting stent implantation for the treatment of total coronary occlusions (PRISON II study)[J] . EuroIntervention, 2012, 7(10): 1189-1196.
21. PALMERINI T, BIONDI ZOCCAI G, DELLA RIVA D, et al. Stent thrombosis with drug eluting and bare metal stents: evidence from a comprehensive network meta analysis[J] . Lancet, 2012, 379(9824): 1393-1402.
22. BANGALORE S, KUMAR S, FUSARO M, et al. Short and long term outcomes with drug eluting and bare metal coronary stents: a mixed treatment comparison analysis of 117762 patient years of follow up from randomized trials[J] . Circulation, 2012, 125(23):2873-2891.
23. GUAGLIUMI G, SIRBU V, MUSUMECI G, et al. Examination of the in vivo mechanisms of late drug eluting stent thrombosis: findings from optical coherence tomography and intravascular ultrasound imaging[J] . JACC Cardiovasc Interv, 2012, 5(1): 12-20.
24. GUAGLIUMI G, FARB A, MUSUMECI G, et al. Images in cardiovascular medicine. Sirolimus eluting stent implanted in human coronary artery for 16 months: pathological findings[J] . Circulation, 2003, 107(9): 1340-1341.
25. 熊筱偉, 朱勁舟,杜潤,等.聚合物涂層改性對藥物洗脫支架植入后血管內膜修復的作用[J] .介入放射學雜志,2012,21(8):655-659.
26. KIPSHIDZE N, DANGAS G, TSAPENKO M, et al. Role of the endothelium in modulating neointimal formation: vasculoprotective approaches to attenuate restenosis after percutaneous coronary interventions[J] . J Am Coll Cardiol, 2004, 44(4): 733-739.
27. VAN BEUSEKOM H M, ERTA, SOROP O, et al. The GenousTM endothelial progenitor cell capture stent accelerates stent re endothelialization but does not affect intimal hyperplasia in porcine coronary arteries[J] . Catheter Cardiovasc Interv, 2012, 79(2): 231-242.
28. 朱建兵, 張俊峰.內皮祖細胞捕獲支架的應用研究進展[J] .中華臨床醫師雜志:電子版,2012,6(21):6854-6856.
29. LEOPOLD J A. Prohealing endothelial progenitor cell capture stents: do the cells captured explain the clinical outcomes?[J] . Circ Cardiovasc Interv, 2013, 6(5): 494-495.
30. YANG Feng, FENG Shichao, PANG Xiangjun, et al. Combination coating of chitosan and anti CD34 antibody applied on sirolimus eluting stents can promote endothelialization while reducing neointimal formation[J] . BMC Cardiovasc Disord, 2012, 12(18): 96.

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