Experimental study on silicone hand disinfection by a touchable non-thermal plasma_Journal of Biomedical Engineering

Authors：

ZHENG Chao ¹ , KOU Yanqin ¹ ,  LIU Zhen ² , JIANG Hongqiang ¹ , HUANG Yifan ² , YAN Keping ²

1. Zhejiang Center for Medical Device Adverse Event Monitoring and Safety Research, Hangzhou 310009, P.R.China;
2. College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P.R.China;

Corresponding?author：

LIU Zhen, Email: zliu@zju.edu.cn

Keywords：

non-thermal plasma; plasma medicine; disinfection and sterilization; hand disinfection

DOI：

10.7507/1001-5515.201605036

Video：

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In this study, silicone hand was disinfected by homemade touchable non-thermal plasma to simulate and evaluate its feasibility of application on human hand. Experimental results showed that there was no significant difference whenEscherichia coli (E. coli),Staphylococcus aureus (S. au),Staphylococcus albus (S. al), andPseudomonas aeruginosa (P. ae) were loaded on the silicone hand surface and treated with plasma. The efficiency of plasma disinfection was higher when the treatment time was prolonged or initial bacterial density was lower. When initial bacterial number was 1.0×10⁶–1.0×10⁷ CFU, the plasma disinfection process mainly occured in the first 5 s and more than 99% of bacteria could be disinfected. This study can provide guidelines for the development of a new plasma device for human hand disinfection.

Citation： ZHENG Chao, KOU Yanqin, LIU Zhen, JIANG Hongqiang, HUANG Yifan, YAN Keping. Experimental study on silicone hand disinfection by a touchable non-thermal plasma. Journal of Biomedical Engineering, 2017, 34(2): 303-307. doi: 10.7507/1001-5515.201605036 Copy

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4.	鄭超, 徐羽貞, 黃逸凡, 等. 低溫等離子體滅菌及生物醫藥技術研究進展. 化工進展, 2013, 32(9): 2185-2193.
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7.	Isbary G, Stolz W, Shimizu T, et al. Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo. Clinical Plasma Medicine, 2013, 1: 25-30.
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9.	Mirpour S, Ghomi H, Piroozmand S A, et al. The selective characterization of nonthermal atmospheric pressure plasma jet on treatment of human breast cancer and normal cells. IEEE Transactions on Plasma Science, 2014, 42(2): 315-322.
10.	Vasilets V N, Shekhter A B, Guller A E, et al. Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations. Clinical Plasma Medicine, 2015, 3: 32-39.
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14.	中華人民共和國衛生部. WS/T 313-2009醫務人員手衛生規范. 北京: 中國標準出版社, 2009.
15.	中華人民共和國衛生部. GB 27950-2011手消毒劑衛生要求. 北京: 中國標準出版社, 2012.
16.	Lademann O, Richter H, Patzelt A, et al. Application of a plasma-jet for skin antisepsis: analysis of the thermal action of the plasma by laser scanning microscopy. Laser Physics Letters, 2010, 7(6): 458-462.
17.	Morfill G E, Shimizu T, Steffes B, et al. Nosocomial infections--a new approach towards preventive medicine using plasmas. New Journal of Physics, 2009, 11: 115019 (10pp).
18.	劉新定, 李嘉豐, 馬致臻, 等. 空氣沿面介質阻擋放電活性粒子成分及其影響因素. 高電壓技術, 2016, 42(2): 421-427.
19.	Boekema B K H L, Vlig M, Guijt D. A new flexible DBD device for treating infected wounds:in vitro andex vivo evaluation and comparison with a RF argon plasma jet. Journal of Physics D: Applied Physics, 2016, 49: 044001.

1. ?于驍, 周再發, 李偉華, 等. 等離子體刻蝕工藝模型研究進展. 微電子學, 2015, 45(1): 94-99.
2. 蘇葆輝, 冉均國, 茍立, 等. 等離子體活化羥基磷灰石(HA)的機理研究. 生物醫學工程學雜志, 2005, 22(4): 711-714.
3. 胡國慶. 我國過氧化氫低溫等離子體滅菌技術應用現狀與管理. 中國消毒學雜志, 2011, 28(3): 353-355.
4. 鄭超, 徐羽貞, 黃逸凡, 等. 低溫等離子體滅菌及生物醫藥技術研究進展. 化工進展, 2013, 32(9): 2185-2193.
5. Fridman G, Friedman G, Gutsol A, et al. Applied plasma medicine. Plasma Processes and Polymers, 2008, 5(6): 503-533.
6. Julak J, Schlotz V. Decontamination of human skin by low-temperature plasma produced by cometary discharge. Clinical Plasma Medicine, 2013, 1: 31-34.
7. Isbary G, Stolz W, Shimizu T, et al. Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo. Clinical Plasma Medicine, 2013, 1: 25-30.
8. Chen C Y, Fan H W, Kuo S P, et al. Blood clotting by low-temperature air plasma. IEEE Transactions on Plasma Science, 2009, 37(6): 993-999.
9. Mirpour S, Ghomi H, Piroozmand S A, et al. The selective characterization of nonthermal atmospheric pressure plasma jet on treatment of human breast cancer and normal cells. IEEE Transactions on Plasma Science, 2014, 42(2): 315-322.
10. Vasilets V N, Shekhter A B, Guller A E, et al. Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations. Clinical Plasma Medicine, 2015, 3: 32-39.
11. 盧新培. 等離子體射流及其醫學應用. 高電壓技術, 2011, 37(6): 1416-1425.
12. Alster T S, Konda S. Plasma skin resurfacing for regeneration of neck, chest, and hands: investigation of a novel device. Dermato-logic Surgery, 2007, 33(11): 1315-1321.
13. 中華人民共和國國家質量監督檢驗檢疫總局. GB 15982-2012醫院消毒衛生標準. 北京: 中國標準出版社, 2012.
14. 中華人民共和國衛生部. WS/T 313-2009醫務人員手衛生規范. 北京: 中國標準出版社, 2009.
15. 中華人民共和國衛生部. GB 27950-2011手消毒劑衛生要求. 北京: 中國標準出版社, 2012.
16. Lademann O, Richter H, Patzelt A, et al. Application of a plasma-jet for skin antisepsis: analysis of the thermal action of the plasma by laser scanning microscopy. Laser Physics Letters, 2010, 7(6): 458-462.
17. Morfill G E, Shimizu T, Steffes B, et al. Nosocomial infections--a new approach towards preventive medicine using plasmas. New Journal of Physics, 2009, 11: 115019 (10pp).
18. 劉新定, 李嘉豐, 馬致臻, 等. 空氣沿面介質阻擋放電活性粒子成分及其影響因素. 高電壓技術, 2016, 42(2): 421-427.
19. Boekema B K H L, Vlig M, Guijt D. A new flexible DBD device for treating infected wounds:in vitro andex vivo evaluation and comparison with a RF argon plasma jet. Journal of Physics D: Applied Physics, 2016, 49: 044001.

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