Prospects and developments in the technologies of high frequency oscillatory ventilation_Journal of Biomedical Engineering

Authors：

 YUAN Yueyang ¹ , ZHOU Li ¹ , LIU Wei ³ , DAI Zheng ³ , CHEN Yuqing ²

1. School of Mechanical and Eectrical Engineering, Hunan City University, Yiyang, Hunan 413099, P.R.China;
2. Department of Respiratory Medicine, Shanghai Chest Hospital, Shanghai 200030, P.R.China;
3. Hunan Micomme Medical Development Co., Ltd, Changsha 410000, P.R.China;

Corresponding?author：

YUAN Yueyang, Email: sunmoonanfen@163.com

Keywords：

high frequency oscillation ventilation; ventilation model; mechanisms of high frequency oscillation ventilation; ventilation mode

DOI：

10.7507/1001-5515.202003072

Video：

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Abstract Full text Figures/Tables Video References Cited by

The high frequency oscillatory ventilation (HFOV) is characterized with low tidal volume and low mean airway pressure, and can well support the breathing of the patients with respiratory diseases. Since the HFOV was proposed, it has been widely concerned by medical and scientific researchers. About the HFOV, this paper discussed its current research status and prospected its future development in technologies. The research status of ventilation model, mechanisms and ventilation mode were introduced in detail. In the next years, the technologies in developing HFOV will be focused on: to develop the branched high-order nonlinear or volume-depended resistance-inertance-compliance (RIC) ventilation model, to fully understand the mechanisms of HFOV and to achieve the noninvasive HFOV. The development in technologies of HFOV will be beneficial to the patients with respiratory diseases who failed with conventional mechanical ventilation as one of considerable ventilation methods.

Citation： YUAN Yueyang, ZHOU Li, LIU Wei, DAI Zheng, CHEN Yuqing. Prospects and developments in the technologies of high frequency oscillatory ventilation. Journal of Biomedical Engineering, 2021, 38(1): 185-190, 195. doi: 10.7507/1001-5515.202003072 Copy

1.	李歡歡, 朱興旺, 汪萬軍. 無創高頻振蕩通氣在早產兒有創機械通氣撤機后呼吸支持效果的隨機對照研究. 第三軍醫大學學報, 2019, 41(17): 1688-1692.
2.	王陳紅, 施麗萍, 馬曉路, 等. 無創高頻振蕩通氣模式在極低出生體重兒呼吸支持中的應用. 中華兒科雜志, 2017, 55(3): 177-181.
3.	Golfar A, Bhogal J, Kamstra B, et al. Outcome of preterm neonates with a birth weight <1, 500 g with severe hypoxemic respiratory failure rescued by inhaled nitric oxide therapy and high-frequency oscillatory ventilation. Neonatology, 2017, 112(3): 274-280.
4.	Sklar M C, Fan E, Goligher E C. High-frequency oscillatory ventilation in adults with ARDS: past, present, and future. Chest, 2017, 152(6): 1306-1317.
5.	Meyers M, Rodrigues N, Ari A. High-frequency oscillatory ventilation: A narrative review. Can J Respir Ther, 2019, 55: 40-46.
6.	何明嫄, 林新祝. 新生兒高頻振蕩通氣的撤機方式探討. 中國當代兒科雜志, 2019, 21(12): 1234-1239.
7.	Zannin E, Dellaca' R L, Dognini G, et al. Effect of frequency on pressure cost of ventilation and gas exchange in newborns receiving high-frequency oscillatory ventilation. Pediatr Res, 2017, 82(6): 994-999.
8.	Bansal N, Chauhan A S, Menon R P. A learning experience in the use of high-frequency oscillatory ventilation in infants post-cardiac surgery. Indian J Thorac Cardiovasc Surg, 2019, 35(2): 257-258.
9.	向玉萍, 曾玲, 羅天會, 等. 冠狀動脈旁路移植術后低氧血癥危險因素的系統評價與Meta分析. 中國胸心血管外科臨床雜志, 2020, 27(8): 926-932.
10.	González-Pacheco N, Sánchez-Luna M, Chimenti-Camacho P, et al. Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury. J Perinatol, 2019, 39(5): 730-736.
11.	賴娟, 杜立中, 熊國強, 等. 1108 例新生兒呼吸衰竭的臨床流行病學特征. 中國當代兒科雜志, 2016, 18(1): 10-14.
12.	Petrillo F, Gizzi C, Maffei G, et al. Neonatal respiratory support strategies for the management of extremely low gestational age infants: an Italian survey. Ital J Pediatr, 2019, 45(1): 44-48.
13.	Courtney S E, Durand D J, Asselin J M, et al. High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight infants. N Engl J Med, 2002, 347(9): 643-652.
14.	楊旭, 陳善萍, 呂櫻. 高頻振蕩通氣在新生兒嚴重呼吸窘迫綜合征(ARDS)的療效及安全性分析. 臨床醫藥文獻電子雜志, 2020, 7(2): 61.
15.	婁五斌, 張衛星, 員麗, 等. 無創高頻振蕩通氣和雙水平正壓通氣在早產兒呼吸窘迫綜合征中的臨床應用效果比較研究. 中國全科醫學, 2018, 21(16): 1983-1988.
16.	邵桂蓮, 呂艷. 高頻震蕩通氣輔助肺表面活性物質治療重癥胎糞吸入綜合征的應用效果分析. 國際醫藥衛生導報, 2020, 26(8): 1090-1093.
17.	王兆康. 高頻振蕩通氣聯合豬肺磷脂治療新生兒重癥胎糞吸入綜合征合并肺出血的臨床效果. 廣西醫學, 2019, 41(10): 1246-1250.
18.	Ng J, Ferguson N D. High-frequency oscillatory ventilation: still a role?. Curr Opin Crit Care, 2017, 23(2): 175-179.
19.	Medvedev A E, Gafurova P S. Analytical design of the human bronchial tree for healthy patients and patients with obstructive pulmonary diseases. Mathemat Biol Bioinf, 2019, 14(2): 635-648.
20.	Shang Y, Dong J, Tian L, et al. Detailed computational analysis of flow dynamics in an extended respiratory airway model. Clin Biomech (Bristol, Avon), 2019, 61: 105-111.
21.	Avila N, Nazeran H, Meraz E, et al. Characterization of impulse oscillometric measures of respiratory small airway function in children. Adv Electr Electron Eng, 2019, 17(1): 54-63.
22.	Bokov P, Bafunyembaka G, Medjahdi N, et al. Cross-sectional phenotyping of small airway dysfunction in preschool asthma using the impulse oscillometry system[J/OL]. J Asthma, 2020: 1-13 [2020-03-31]. https://doi.org/10.1080/02770903.2020.1719133.
23.	Avanzolini G, Barbini P, Bernardi F, et al. Role of the mechanical properties of tracheobronchial airways in determining the respiratory resistance time course. Ann Biomed Eng, 2001, 29(7): 575-586.
24.	Polak A G, Mroczka J. Nonlinear model for mechanical ventilation of human lungs. Comput Biol Med, 2006, 36(1): 41-58.
25.	蔡永銘, 谷凌雁, 陳夫華. 基于非線性多室肺模型優化呼吸氣流模式的研究. 生物醫學工程學雜志, 2015, 32(1): 32-37.
26.	劉天亞, 喬惠婷, 李德玉, 等. 非線性氣道分級呼吸力學模型及健康成人自主呼吸模擬. 生物醫學工程學雜志, 2019, 36(1): 101-106, 115.
27.	Pillow J J. High-frequency oscillatory ventilation: mechanisms of gas exchange and lung mechanics. Crit Care Med, 2005, 33(3 suppl): S135-S141.
28.	Roth C J, F?rster K M, Hilgendorff A, et al. Gas exchange mechanisms in preterm infants on HFOV - a computational approach[J/OL]. Sci Rep, 2018, 8(1): 1-8 [2020-03-31]. https://doi.org/10.1038/s41598-018-30830-x.
29.	Lee W J, Kawahashi M, Hirahara H. Experimental analysis of pendelluft flow generated by HFOV in a human airway model. Physiol Meas, 2006, 27(8): 661-674.
30.	Greenblatt E E, Butler J P, Venegas J G. Pendelluft in the bronchial tree. J Appl Physiol, 2014, 117(9): 979-988.
31.	Yuan Yueyang, Yang Chongchang, Zhe Li, et al. Oscillatory flow of HFV distributed in the left and right lungs: a model-based experiment and investigation. J Mech Med Biol, 2014, 14(6): 1-10.
32.	袁越陽, 陳宇清, 肖輝, 等. 左右肺間相互通氣的高頻通氣機制研究. 生物醫學工程學雜志, 2019, 36(3): 393-400.
33.	Leontini J, Jacob C, Tingay D. Steady streaming and conditional turbulence in high-frequency ventilation// 72nd Annual Meeting of the APS Division of Fluid Dynamics. Seattle: Bulletin of the American Physical Society, 2019, 64(13): 30.
34.	區泳兒, 陳榮昌. 2017-2018 年度無創正壓通氣臨床研究進展. 中華結核和呼吸雜志, 2019, 42(1): 30-32.
35.	侯宇穎, 張彩云, 云榮榮, 等. 頭罩式無創正壓通氣對成人急性呼吸衰竭療效的 Meta 分析. 中國循證醫學雜志, 2017, 17(11): 1283-1290.
36.	岳偉崗, 張志剛, 張彩云, 等. 俯臥位通氣治療急性呼吸窘迫綜合征患者病死率的累積Meta分析. 中國循證醫學雜志, 2017, 17(7): 792-797.
37.	張圳, 薛洋, 李洪華. 有創機械通氣患兒拔管結局預測指標有效性研究進展. 中國當代兒科雜志, 2019, 21(7): 730-735.
38.	Poor H. Basics of mechanical ventilation: basic modes of ventilation. Berlin: Springer International Publishing AG, 2018: 29-38.
39.	Harris C, Thorpe S D, Rushwan S, et al. An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. J Biomech, 2019, 88: 186-189.
40.	陳海山, 王明義, 謝雪嫻. 早產兒應用高頻振蕩通氣和常頻機械通氣并發癥發生率的 Meta 分析. 中華新生兒科雜志, 2018, 33(4): P. 291-P. 297.
41.	De Luca D, Costa R, Visconti F, et al. Oscillation transmission and volume delivery during face mask-delivered HFOV in infants: Bench and in vivo study. Pediatr Pulmonol, 2016, 51(7): 705-712.
42.	Yuan Y Y, Sun J G, Wang B C, et al. A noninvasive high frequency oscillation ventilator: achieved by utilizing a blower and a valve. Rev Sci Instrum, 2016, 87(2): 38-45.
43.	Centorrino R, Dell'orto V, Gitto E, et al. Mechanics of nasal mask-delivered HFOV in neonates: A physiologic study. Pediatr Pulmonol, 2019, 54(8): 1304-1310.
44.	Attar M A, Dechert R E, Donn S M. Rescue high frequency ventilation for congenital diaphragmatic hernia. J Neonatal Perinatal Med, 2019, 12(2): 173-178.
45.	Gien J, Nuxoll C, Kinsella J P. Inhaled nitric oxide in emergency medical transport of the newborn. Neoreviews, 2020, 21(3): e157-e164.
46.	何秋明, 鐘微, 呂俊健, 等. 高頻振蕩通氣下胸腔鏡補片修補巨大先天性膈疝一例并文獻復習. 中華小兒外科雜志, 2019, 40(9): 806-810.
47.	De Luca D, Piastra M, Pietrini D, et al. Effect of amplitude and inspiratory time in a bench model of non-invasive HFOV through nasal prongs. Pediatr Pulmonol, 2012, 47(10): 1012-1018.
48.	Fischer H S, Bohlin K, Buehrer C A, et al. Nasal high-frequency oscillation ventilation in neonates: a survey in five European countries. Eur J Pediatr, 2015, 174(4): 465-471.

1. 李歡歡, 朱興旺, 汪萬軍. 無創高頻振蕩通氣在早產兒有創機械通氣撤機后呼吸支持效果的隨機對照研究. 第三軍醫大學學報, 2019, 41(17): 1688-1692.
2. 王陳紅, 施麗萍, 馬曉路, 等. 無創高頻振蕩通氣模式在極低出生體重兒呼吸支持中的應用. 中華兒科雜志, 2017, 55(3): 177-181.
3. Golfar A, Bhogal J, Kamstra B, et al. Outcome of preterm neonates with a birth weight <1, 500 g with severe hypoxemic respiratory failure rescued by inhaled nitric oxide therapy and high-frequency oscillatory ventilation. Neonatology, 2017, 112(3): 274-280.
4. Sklar M C, Fan E, Goligher E C. High-frequency oscillatory ventilation in adults with ARDS: past, present, and future. Chest, 2017, 152(6): 1306-1317.
5. Meyers M, Rodrigues N, Ari A. High-frequency oscillatory ventilation: A narrative review. Can J Respir Ther, 2019, 55: 40-46.
6. 何明嫄, 林新祝. 新生兒高頻振蕩通氣的撤機方式探討. 中國當代兒科雜志, 2019, 21(12): 1234-1239.
7. Zannin E, Dellaca' R L, Dognini G, et al. Effect of frequency on pressure cost of ventilation and gas exchange in newborns receiving high-frequency oscillatory ventilation. Pediatr Res, 2017, 82(6): 994-999.
8. Bansal N, Chauhan A S, Menon R P. A learning experience in the use of high-frequency oscillatory ventilation in infants post-cardiac surgery. Indian J Thorac Cardiovasc Surg, 2019, 35(2): 257-258.
9. 向玉萍, 曾玲, 羅天會, 等. 冠狀動脈旁路移植術后低氧血癥危險因素的系統評價與Meta分析. 中國胸心血管外科臨床雜志, 2020, 27(8): 926-932.
10. González-Pacheco N, Sánchez-Luna M, Chimenti-Camacho P, et al. Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury. J Perinatol, 2019, 39(5): 730-736.
11. 賴娟, 杜立中, 熊國強, 等. 1108 例新生兒呼吸衰竭的臨床流行病學特征. 中國當代兒科雜志, 2016, 18(1): 10-14.
12. Petrillo F, Gizzi C, Maffei G, et al. Neonatal respiratory support strategies for the management of extremely low gestational age infants: an Italian survey. Ital J Pediatr, 2019, 45(1): 44-48.
13. Courtney S E, Durand D J, Asselin J M, et al. High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight infants. N Engl J Med, 2002, 347(9): 643-652.
14. 楊旭, 陳善萍, 呂櫻. 高頻振蕩通氣在新生兒嚴重呼吸窘迫綜合征(ARDS)的療效及安全性分析. 臨床醫藥文獻電子雜志, 2020, 7(2): 61.
15. 婁五斌, 張衛星, 員麗, 等. 無創高頻振蕩通氣和雙水平正壓通氣在早產兒呼吸窘迫綜合征中的臨床應用效果比較研究. 中國全科醫學, 2018, 21(16): 1983-1988.
16. 邵桂蓮, 呂艷. 高頻震蕩通氣輔助肺表面活性物質治療重癥胎糞吸入綜合征的應用效果分析. 國際醫藥衛生導報, 2020, 26(8): 1090-1093.
17. 王兆康. 高頻振蕩通氣聯合豬肺磷脂治療新生兒重癥胎糞吸入綜合征合并肺出血的臨床效果. 廣西醫學, 2019, 41(10): 1246-1250.
18. Ng J, Ferguson N D. High-frequency oscillatory ventilation: still a role?. Curr Opin Crit Care, 2017, 23(2): 175-179.
19. Medvedev A E, Gafurova P S. Analytical design of the human bronchial tree for healthy patients and patients with obstructive pulmonary diseases. Mathemat Biol Bioinf, 2019, 14(2): 635-648.
20. Shang Y, Dong J, Tian L, et al. Detailed computational analysis of flow dynamics in an extended respiratory airway model. Clin Biomech (Bristol, Avon), 2019, 61: 105-111.
21. Avila N, Nazeran H, Meraz E, et al. Characterization of impulse oscillometric measures of respiratory small airway function in children. Adv Electr Electron Eng, 2019, 17(1): 54-63.
22. Bokov P, Bafunyembaka G, Medjahdi N, et al. Cross-sectional phenotyping of small airway dysfunction in preschool asthma using the impulse oscillometry system[J/OL]. J Asthma, 2020: 1-13 [2020-03-31]. https://doi.org/10.1080/02770903.2020.1719133.
23. Avanzolini G, Barbini P, Bernardi F, et al. Role of the mechanical properties of tracheobronchial airways in determining the respiratory resistance time course. Ann Biomed Eng, 2001, 29(7): 575-586.
24. Polak A G, Mroczka J. Nonlinear model for mechanical ventilation of human lungs. Comput Biol Med, 2006, 36(1): 41-58.
25. 蔡永銘, 谷凌雁, 陳夫華. 基于非線性多室肺模型優化呼吸氣流模式的研究. 生物醫學工程學雜志, 2015, 32(1): 32-37.
26. 劉天亞, 喬惠婷, 李德玉, 等. 非線性氣道分級呼吸力學模型及健康成人自主呼吸模擬. 生物醫學工程學雜志, 2019, 36(1): 101-106, 115.
27. Pillow J J. High-frequency oscillatory ventilation: mechanisms of gas exchange and lung mechanics. Crit Care Med, 2005, 33(3 suppl): S135-S141.
28. Roth C J, F?rster K M, Hilgendorff A, et al. Gas exchange mechanisms in preterm infants on HFOV - a computational approach[J/OL]. Sci Rep, 2018, 8(1): 1-8 [2020-03-31]. https://doi.org/10.1038/s41598-018-30830-x.
29. Lee W J, Kawahashi M, Hirahara H. Experimental analysis of pendelluft flow generated by HFOV in a human airway model. Physiol Meas, 2006, 27(8): 661-674.
30. Greenblatt E E, Butler J P, Venegas J G. Pendelluft in the bronchial tree. J Appl Physiol, 2014, 117(9): 979-988.
31. Yuan Yueyang, Yang Chongchang, Zhe Li, et al. Oscillatory flow of HFV distributed in the left and right lungs: a model-based experiment and investigation. J Mech Med Biol, 2014, 14(6): 1-10.
32. 袁越陽, 陳宇清, 肖輝, 等. 左右肺間相互通氣的高頻通氣機制研究. 生物醫學工程學雜志, 2019, 36(3): 393-400.
33. Leontini J, Jacob C, Tingay D. Steady streaming and conditional turbulence in high-frequency ventilation// 72nd Annual Meeting of the APS Division of Fluid Dynamics. Seattle: Bulletin of the American Physical Society, 2019, 64(13): 30.
34. 區泳兒, 陳榮昌. 2017-2018 年度無創正壓通氣臨床研究進展. 中華結核和呼吸雜志, 2019, 42(1): 30-32.
35. 侯宇穎, 張彩云, 云榮榮, 等. 頭罩式無創正壓通氣對成人急性呼吸衰竭療效的 Meta 分析. 中國循證醫學雜志, 2017, 17(11): 1283-1290.
36. 岳偉崗, 張志剛, 張彩云, 等. 俯臥位通氣治療急性呼吸窘迫綜合征患者病死率的累積Meta分析. 中國循證醫學雜志, 2017, 17(7): 792-797.
37. 張圳, 薛洋, 李洪華. 有創機械通氣患兒拔管結局預測指標有效性研究進展. 中國當代兒科雜志, 2019, 21(7): 730-735.
38. Poor H. Basics of mechanical ventilation: basic modes of ventilation. Berlin: Springer International Publishing AG, 2018: 29-38.
39. Harris C, Thorpe S D, Rushwan S, et al. An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. J Biomech, 2019, 88: 186-189.
40. 陳海山, 王明義, 謝雪嫻. 早產兒應用高頻振蕩通氣和常頻機械通氣并發癥發生率的 Meta 分析. 中華新生兒科雜志, 2018, 33(4): P. 291-P. 297.
41. De Luca D, Costa R, Visconti F, et al. Oscillation transmission and volume delivery during face mask-delivered HFOV in infants: Bench and in vivo study. Pediatr Pulmonol, 2016, 51(7): 705-712.
42. Yuan Y Y, Sun J G, Wang B C, et al. A noninvasive high frequency oscillation ventilator: achieved by utilizing a blower and a valve. Rev Sci Instrum, 2016, 87(2): 38-45.
43. Centorrino R, Dell'orto V, Gitto E, et al. Mechanics of nasal mask-delivered HFOV in neonates: A physiologic study. Pediatr Pulmonol, 2019, 54(8): 1304-1310.
44. Attar M A, Dechert R E, Donn S M. Rescue high frequency ventilation for congenital diaphragmatic hernia. J Neonatal Perinatal Med, 2019, 12(2): 173-178.
45. Gien J, Nuxoll C, Kinsella J P. Inhaled nitric oxide in emergency medical transport of the newborn. Neoreviews, 2020, 21(3): e157-e164.
46. 何秋明, 鐘微, 呂俊健, 等. 高頻振蕩通氣下胸腔鏡補片修補巨大先天性膈疝一例并文獻復習. 中華小兒外科雜志, 2019, 40(9): 806-810.
47. De Luca D, Piastra M, Pietrini D, et al. Effect of amplitude and inspiratory time in a bench model of non-invasive HFOV through nasal prongs. Pediatr Pulmonol, 2012, 47(10): 1012-1018.
48. Fischer H S, Bohlin K, Buehrer C A, et al. Nasal high-frequency oscillation ventilation in neonates: a survey in five European countries. Eur J Pediatr, 2015, 174(4): 465-471.

Journal of Biomedical Engineering

Prospects and developments in the technologies of high frequency oscillatory ventilation

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