Experimental study of the response of articular cartilage surface roughness to load_Journal of Biomedical Engineering

Authors：

 MEN Yutao ^1,2 , LIU Kaifeng ^1,2 , LIU Fulong ^1,2 , ZHANG Chunqiu ^1,2

1. Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China;
2. National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology), Tianjin 300384, P. R. China;

Corresponding?author：

MEN Yutao, Email: yutaomen@163.com

Keywords：

Articular cartilage; Surface roughness; Loading; Wear

DOI：

10.7507/1001-5515.202109073

Video：

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Cartilage surface fibrosis is an early sign of osteoarthritis and cartilage surface damage is closely related to load. The purpose of this study was to study the relationship between cartilage surface roughness and load. By applying impact, compression and fatigue loads on fresh porcine articular cartilage, the rough value of cartilage surface was measured at an interval of 10 min each time and the change rule of roughness before and after loading was obtained. It was found that the load increased the roughness of cartilage surface and the increased value was related to the load size. The time of roughness returning to the initial condition was related to the load type and the load size. The impact load had the greatest influence on the roughness of cartilage surface, followed by the severe fatigue load, compression load and mild fatigue load. This article provides reference data for revealing the pathogenesis of early osteoarthritis and preventing and treating articular cartilage diseases.

Citation： MEN Yutao, LIU Kaifeng, LIU Fulong, ZHANG Chunqiu. Experimental study of the response of articular cartilage surface roughness to load. Journal of Biomedical Engineering, 2022, 39(2): 347-352. doi: 10.7507/1001-5515.202109073 Copy

1.	連強強, 遲博婧, 張柳, 等. Wnt信號通路對軟骨和軟骨下骨雙靶向調控及其在骨關節炎進展中的作用. 中國修復重建外科雜志, 2020, 34(6): 797-803.
2.	李鋒, 王成燾. 關節軟骨的微摩擦接觸力學特性. 醫用生物力學, 2016, 31(2): 124-128.
3.	劉志動, 高麗蘭, 張春秋, 等. 關節軟骨不同層區的率相關性能研究. 醫用生物力學, 2014, 29(2): 141-145.
4.	鐘紅剛, 張萬強, 關繼超, 等. 外置式人工關節控制下的家兔膝關節再生與功能恢復. 醫用生物力學, 2014, 29(4): 72-78.
5.	許西凡, 高麗蘭, 門玉濤, 等. 不同壓縮條件下關節軟骨的回彈力學性能. 中國組織工程研究, 2017, 21(20): 3147-3151.
6.	Párraga Quiroga J M, Wilson W, Ito K, et al. The effect of loading rate on the development of early damage in articular cartilage. Biomech Model Mechan, 2017, 16(1): 263-267.
7.	Vazquez K J, Andreae J T, Henak C R. Cartilage-on-cartilage cyclic loading induces mechanical and structural damage. J Mech Behav Biomed, 2019, 98: 262-267.
8.	茅泳濤, 董啟榕. 雙極射頻能量對人膝關節軟骨的急性效應. 中國組織工程研究與臨床康復, 2007(5): 868-871.
9.	Maerz T, Newton M D, Matthew H, et al. Surface roughness and thickness analysis of contrast-enhanced articular cartilage using mesh parameterization. Osteoarthr Cartilage, 2016, 24(2): 290-298.
10.	Newton M D, Jeffrey O, Karissa G, et al. Articular cartilage surface roughness as an imaging-based morphological indicator of osteoarthritis: A preliminary investigation of osteoarthritis initiative subjects. J Orthop Res, 2017, 35(12): 2755-2764.
11.	Ihnatouski M, Pauk J, Karev D , et al. AFM-based method for measurement of normal and osteoarthritic human articular cartilage surface roughness. Materials, 2020, 13(10): 2302-2314.
12.	Youssef D, El-Azab J, Kandel H, et al. Biospeckle local contrast analysis for surface roughness study of articular cartilage. Optik, 2019, 183: 55-64.
13.	劉愛峰, 魏強, 馬劍雄, 等. 膝關節軟骨摩擦行為研究進展. 中國矯形外科雜志, 2014, 22(11): 996-998.
14.	王泓, 馬信龍, 張園. 新鮮人關節軟骨試件在體外不同環境下退變的組織學觀察. 中國組織工程研究與臨床康復, 2010, 14(15): 2701-2704.
15.	Verteramo A, Seedhom B B. Effect of a single impact loading on the structure and mechanical properties of articular cartilage. J Biomech, 2007, 40(16): 3580-3589.
16.	付彥銘. 自由式滑雪空中技巧運動員落地穩定瞬間人體膝關節軟骨損傷風險的研究. 沈陽體育學院學報, 2018, 37(1): 70-74.
17.	李曉明, 門玉濤, 張春秋. 壓縮載荷下微缺損關節軟骨流體場變化的數值分析. 中國組織工程研究, 2018, 22(32): 5117-5122.
18.	Franz T, Hasler E M, Hagg R, et al. In situ compressive stiffness, biochemical composition, and structural integrity of articular cartilage of the human knee joint. Osteoarthr Cartilage, 2001, 9(6): 582-592.
19.	Yang Xiuping, Sun Fengju, Wang Longtao, et al. Solute transport in articular cartilage under rolling-compression load. J Mech Med Biol, 2019, 19(6): 54-68.
20.	邱璐璐. 步態下膝關節力學性能的數值分析及關節軟骨的傳質實驗研究. 天津: 天津理工大學, 2018.
21.	陳亮宇, 趙婧, 何澤棟, 等. 水含量對骨組織生物摩擦學行為的影響. 生物醫學工程學雜志, 2016, 33(3): 466-472.
22.	劉同眾, 朱林, 程曦, 等. 基于多體動力學和有限元方法的三級跳運動人體膝關節沖擊損傷分析研究. 振動與沖擊, 2015, 34(17): 44-49, 57.
23.	許剛. 缺損關節軟骨棘輪實驗及沖擊響應的數值研究. 天津: 天津理工大學, 2019.
24.	Kaplan J T, Neu C P, Drissi H, et al. Cyclic loading of human articular cartilage: The transition from compaction to fatigue. J Mech Behav Biomed, 2017, 65: 734-742.
25.	Widmyer M R, Utturkar G M, Leddy H A, et al. High body mass index is associated with increased diurnal strains in the articular cartilage of the knee. Arthritis Rheumatol, 2013, 65(10): 2615-2622.
26.	Travascio F, Eltoukhy M, Cami S, et al. Altered mechano-chemical environment in hip articular cartilage: effect of obesity. Biomech Model Mechan, 2014, 13(5): 945-959.
27.	Anandacoomarasamy A, Leibman S, Smith G, et al. Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage. Ann Rheum Dis, 2012, 71(1): 26-32.
28.	楊光露, 郭楊, 涂鵬程, 等. 不同機械刺激調控軟骨細胞代謝的研究進展. 生物醫學工程學雜志, 2020, 37(6): 1101-1108.
29.	謝錦偉, 魯凌云, 余希杰. 細胞衰老在骨關節炎發病機制中的研究進展. 中國修復重建外科雜志, 2021, 35(4): 519-526.
30.	劉波, 戴國鋼, 馬建, 等. 非周期大強度運動訓練對兔關節軟骨壓凹特性的影響. 中國生物醫學工程學報, 2003, 22(4): 373-376.
31.	劉蕾. 靜力性負重對人體身高影響的實驗研究. 濟南: 山東師范大學, 2011.
32.	Milicevic D, Noguchi M, Quadrilatero J, et al. The effect of rest insertions during loading on stifle joint mechanics and cartilage damage in a porcine model. Osteoarthr Cartilage, 2017, 25: S326.
33.	Dreiner M, Willwacher S, Kramer A, et al. Short-term response of serum cartilage oligomeric matrix protein to different types of impact loading under normal and artificial gravity. Front Physiol, 2020, 11: 1032.
34.	蔡振兵. 扭動微動磨損機理研究. 成都: 西南交通大學, 2009.

1. 連強強, 遲博婧, 張柳, 等. Wnt信號通路對軟骨和軟骨下骨雙靶向調控及其在骨關節炎進展中的作用. 中國修復重建外科雜志, 2020, 34(6): 797-803.
2. 李鋒, 王成燾. 關節軟骨的微摩擦接觸力學特性. 醫用生物力學, 2016, 31(2): 124-128.
3. 劉志動, 高麗蘭, 張春秋, 等. 關節軟骨不同層區的率相關性能研究. 醫用生物力學, 2014, 29(2): 141-145.
4. 鐘紅剛, 張萬強, 關繼超, 等. 外置式人工關節控制下的家兔膝關節再生與功能恢復. 醫用生物力學, 2014, 29(4): 72-78.
5. 許西凡, 高麗蘭, 門玉濤, 等. 不同壓縮條件下關節軟骨的回彈力學性能. 中國組織工程研究, 2017, 21(20): 3147-3151.
6. Párraga Quiroga J M, Wilson W, Ito K, et al. The effect of loading rate on the development of early damage in articular cartilage. Biomech Model Mechan, 2017, 16(1): 263-267.
7. Vazquez K J, Andreae J T, Henak C R. Cartilage-on-cartilage cyclic loading induces mechanical and structural damage. J Mech Behav Biomed, 2019, 98: 262-267.
8. 茅泳濤, 董啟榕. 雙極射頻能量對人膝關節軟骨的急性效應. 中國組織工程研究與臨床康復, 2007(5): 868-871.
9. Maerz T, Newton M D, Matthew H, et al. Surface roughness and thickness analysis of contrast-enhanced articular cartilage using mesh parameterization. Osteoarthr Cartilage, 2016, 24(2): 290-298.
10. Newton M D, Jeffrey O, Karissa G, et al. Articular cartilage surface roughness as an imaging-based morphological indicator of osteoarthritis: A preliminary investigation of osteoarthritis initiative subjects. J Orthop Res, 2017, 35(12): 2755-2764.
11. Ihnatouski M, Pauk J, Karev D , et al. AFM-based method for measurement of normal and osteoarthritic human articular cartilage surface roughness. Materials, 2020, 13(10): 2302-2314.
12. Youssef D, El-Azab J, Kandel H, et al. Biospeckle local contrast analysis for surface roughness study of articular cartilage. Optik, 2019, 183: 55-64.
13. 劉愛峰, 魏強, 馬劍雄, 等. 膝關節軟骨摩擦行為研究進展. 中國矯形外科雜志, 2014, 22(11): 996-998.
14. 王泓, 馬信龍, 張園. 新鮮人關節軟骨試件在體外不同環境下退變的組織學觀察. 中國組織工程研究與臨床康復, 2010, 14(15): 2701-2704.
15. Verteramo A, Seedhom B B. Effect of a single impact loading on the structure and mechanical properties of articular cartilage. J Biomech, 2007, 40(16): 3580-3589.
16. 付彥銘. 自由式滑雪空中技巧運動員落地穩定瞬間人體膝關節軟骨損傷風險的研究. 沈陽體育學院學報, 2018, 37(1): 70-74.
17. 李曉明, 門玉濤, 張春秋. 壓縮載荷下微缺損關節軟骨流體場變化的數值分析. 中國組織工程研究, 2018, 22(32): 5117-5122.
18. Franz T, Hasler E M, Hagg R, et al. In situ compressive stiffness, biochemical composition, and structural integrity of articular cartilage of the human knee joint. Osteoarthr Cartilage, 2001, 9(6): 582-592.
19. Yang Xiuping, Sun Fengju, Wang Longtao, et al. Solute transport in articular cartilage under rolling-compression load. J Mech Med Biol, 2019, 19(6): 54-68.
20. 邱璐璐. 步態下膝關節力學性能的數值分析及關節軟骨的傳質實驗研究. 天津: 天津理工大學, 2018.
21. 陳亮宇, 趙婧, 何澤棟, 等. 水含量對骨組織生物摩擦學行為的影響. 生物醫學工程學雜志, 2016, 33(3): 466-472.
22. 劉同眾, 朱林, 程曦, 等. 基于多體動力學和有限元方法的三級跳運動人體膝關節沖擊損傷分析研究. 振動與沖擊, 2015, 34(17): 44-49, 57.
23. 許剛. 缺損關節軟骨棘輪實驗及沖擊響應的數值研究. 天津: 天津理工大學, 2019.
24. Kaplan J T, Neu C P, Drissi H, et al. Cyclic loading of human articular cartilage: The transition from compaction to fatigue. J Mech Behav Biomed, 2017, 65: 734-742.
25. Widmyer M R, Utturkar G M, Leddy H A, et al. High body mass index is associated with increased diurnal strains in the articular cartilage of the knee. Arthritis Rheumatol, 2013, 65(10): 2615-2622.
26. Travascio F, Eltoukhy M, Cami S, et al. Altered mechano-chemical environment in hip articular cartilage: effect of obesity. Biomech Model Mechan, 2014, 13(5): 945-959.
27. Anandacoomarasamy A, Leibman S, Smith G, et al. Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage. Ann Rheum Dis, 2012, 71(1): 26-32.
28. 楊光露, 郭楊, 涂鵬程, 等. 不同機械刺激調控軟骨細胞代謝的研究進展. 生物醫學工程學雜志, 2020, 37(6): 1101-1108.
29. 謝錦偉, 魯凌云, 余希杰. 細胞衰老在骨關節炎發病機制中的研究進展. 中國修復重建外科雜志, 2021, 35(4): 519-526.
30. 劉波, 戴國鋼, 馬建, 等. 非周期大強度運動訓練對兔關節軟骨壓凹特性的影響. 中國生物醫學工程學報, 2003, 22(4): 373-376.
31. 劉蕾. 靜力性負重對人體身高影響的實驗研究. 濟南: 山東師范大學, 2011.
32. Milicevic D, Noguchi M, Quadrilatero J, et al. The effect of rest insertions during loading on stifle joint mechanics and cartilage damage in a porcine model. Osteoarthr Cartilage, 2017, 25: S326.
33. Dreiner M, Willwacher S, Kramer A, et al. Short-term response of serum cartilage oligomeric matrix protein to different types of impact loading under normal and artificial gravity. Front Physiol, 2020, 11: 1032.
34. 蔡振兵. 扭動微動磨損機理研究. 成都: 西南交通大學, 2009.

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