Cycloxygenase-2 Expression in Patients with Gastric Ulcer and Gastric Cancer and Its Relationship with Helicobacter Pylori_West China Medical Journal

Authors：

XIA Xiaoyan ¹ , WEN Liming ² , ZHOU Ning ² , YANG Ming ¹ , SHI Yong. ¹

1. People’s Hospital of Mianyang, Mianyang, Sichuan 621000, P. R. China; 2. The Second Affiliated Hospital of North Sichuan Medical College, Mianyang, Sichuan 621000, P. R. China;

Corresponding?author：

Keywords：

胃潰瘍; 胃癌; 環氧化酶-2; 幽門螺桿菌; 免疫組織化學

DOI：

10.7507/1002-0179.20130058

Video：

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目的　探討環氧化酶-2（COX-2）在幽門螺桿菌（Hp）感染與非感染性胃潰瘍及胃癌的表達。方法　選擇綿陽市404醫院消化內科2011年2月－2012年2月的門診及住院患者，用免疫組織化學方法檢測196例經胃鏡和組織病理學檢查明確為胃潰瘍（病理分型：腸上皮化生、異型增生）、胃癌及正常胃黏膜者的胃黏膜COX-2蛋白的表達，比較各病理分類之間及Hp感染與非感染之間COX-2蛋白表達的差異。結果　胃潰瘍（腸上皮化生、異型增生）、胃癌組的炎癥細胞、腺上皮細胞、癌細胞及極少量正常黏膜上皮細胞中有COX-2表達。從正常胃黏膜-胃潰瘍（腸上皮化生、異型增生）-胃癌COX-2的陽性表達有逐漸增強的趨勢（P＜0.05）。Hp陽性組COX-2的陽性表達高于Hp陰性組（P＜0.05），胃癌組COX-2的陽性表達高于胃潰瘍組（P＜0．05）。結論　COX-2在胃癌的表達高于胃潰瘍。Hp感染可誘導COX-2過度表達。

Citation： XIA Xiaoyan,WEN Liming,ZHOU Ning,YANG Ming,SHI Yong.. Cycloxygenase-2 Expression in Patients with Gastric Ulcer and Gastric Cancer and Its Relationship with Helicobacter Pylori. West China Medical Journal, 2013, 28(2): 179-183. doi: 10.7507/1002-0179.20130058 Copy

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6.	van Rees BP, Saukkonen K, Ristimaki A, et al. Cyclooxygenase-2 overexpression during carcinogenesis in the human stomach[J]. J Pathol, 2002, 196(2)：171-179.
7.	Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2[J]. Cell, 1995, 83(3): 493-501.
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12.	胡小安, 張潤, 盧靜. 特殊染色與免疫組化染色顯示幽門螺桿菌的效果對比[J]. 臨床與實驗病理學雜志, 2009, 25(2): 222-223.
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1. 　Dannenberg AJ, Altorki NK, Boyle JO, et al. Cyclo-oxygenase 2: a pharmacological target for the prevention of cance[J]. Lancet Oncol, 2001, 2(9): 544-551.
2. 　Howe LR, Dannenberg AJ. A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer[J]. Semin Oncol, 2002, 29 (3 Suppl 11): 111-119.
3. 　Yang XG, Zhang HZ, Wei L, et al. The expression of cyclooxygenase-2 (Cox-2) and p16 in non-Hodgkin’s lymphomas and its climcal significance[J]. Chinese-German Clin Oncol, 2009, 8(2): 104-109．.
4. 　Ferrandina G, Lauriola L, Distefano MG, et al. Increased cycloxygenase-2 expression is associated with chemotherapy resistance and poor surviral in cervical cancer patients[J]. J Clin Oncol, 2002, 20(4)：973-981．.
5. 　Lim HY, Joo HJ, Choi JH, et al. Increased expression of cyclooxygenase-2 protein in human gastric carcinoma[J]. Clin Cancer Res, 2000, 6(2)：519-525．.
6. 　van Rees BP, Saukkonen K, Ristimaki A, et al. Cyclooxygenase-2 overexpression during carcinogenesis in the human stomach[J]. J Pathol, 2002, 196(2)：171-179.
7. 　Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2[J]. Cell, 1995, 83(3): 493-501.
8. 　Jones MK, Wang H, Peskar BM, et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs:insight into mechanisms and implications for cancer growth and ulcer healing[J]. Nat Med, 1999, 5(12): 1418-1423.
9. 　McGinty A, Chang YW, Sorokin A, et al. Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor -differentiated PC12 cells[J]. J Biol Chem, 2000, 275(16): 12095-12101.
10. 　Kishimoto Y, Yashima K, Morisawa T, et al. Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane[J]. J Gastroenterol, 2002, 37(3): 186-193.
11. 　程慧敏, 毛福珍, 王少青, 等．幽門螺桿菌相關性胃炎中的不典型增生[J]. 中華消化內鏡雜志, 1994, 11(2): 85-86.
12. 　胡小安, 張潤, 盧靜. 特殊染色與免疫組化染色顯示幽門螺桿菌的效果對比[J]. 臨床與實驗病理學雜志, 2009, 25(2): 222-223.
13. 　羅玉琴, 吳開春．淺表性胃炎、胃黏膜不典型增生及胃癌組織中COX-1、COX-2、iNOS表達的意義[J]. 中華消化雜志, 2000, 20(4)：223-226．.

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Cycloxygenase-2 Expression in Patients with Gastric Ulcer and Gastric Cancer and Its Relationship with Helicobacter Pylori

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