Expression and Pathological Significance of E-Cadherin and Uridylyl Phosphate Adenosine in Breast Carcinoma_West China Medical Journal

Authors：

ZHOU Li , YU Jiahai , LU Jiafeng.

Department of Pathology, Maternal and Child Health Hospital of Weifang City, Weifang, Shandong 261011, P. R. China;

Corresponding?author：

Keywords：

上皮細胞鈣黏蛋白; 尿激酶型纖溶酶原激活劑; 乳腺癌; 免疫組織化學

DOI：

10.7507/1002-0179.20130065

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目的　探討上皮細胞鈣黏蛋白（E-Cadherin）、尿激酶型纖溶酶原激活劑（uPA）表達與乳腺癌的浸潤、淋巴結轉移的關系。方法　采用免疫組織化學鏈霉菌抗生物素蛋白-過氧化物酶連接法對乳腺纖維腺瘤、乳腺腺病和乳腺癌各40例蠟塊中E-Cadherin、uPA表達進行研究。結果　乳腺纖維腺瘤、腺病和乳腺癌中E-Cadherin陽性率分別為85.0%、82.5%和20.0%，三者差異有統計學意義（P＜0.05）；E-Cadherin表達陰性患者淋巴結轉移率（90.6%）高于E-Cadherin表達陽性者（25.0%），差異有統計學意義（P＜0.01）。uPA在乳腺纖維腺瘤、腺病均呈陰性表達，在乳腺癌中的陽性率為60.0%，三者差異有統計學意義（P＜0.05）；uPA表達陽性患者淋巴結轉移率（88.5%）顯著高于陰性者（50.0%），兩者的表達差異有統計學意義（P＜0.05）。結論　E-Cadherin和uPA的表達與乳腺癌的浸潤轉移密切相關，同步檢測其在乳腺癌組織中的表達并綜合分析二者之間的關系，對評價乳腺癌細胞的侵襲轉移能力及預后判斷具有一定價值。uPA在乳腺癌中表達率較高，而且和乳腺癌的生物學特性有關，它對提示預后和開展靶向治療有指導意義。

Citation： ZHOU Li,YU Jiahai,LU Jiafeng.. Expression and Pathological Significance of E-Cadherin and Uridylyl Phosphate Adenosine in Breast Carcinoma. West China Medical Journal, 2013, 28(2): 204-207. doi: 10.7507/1002-0179.20130065 Copy

1.	金向明, 陳耀平, 王寧菊. 乳腺癌患者血漿uPA、uPAR檢測的臨床意義[J]. 寧夏醫學雜志, 2008, 30(7): 580-581.
2.	Siitonen SM, Kononen JT, Helin HJ, et al. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer[J]. Am J Clin Pathol, 1996, 105(4): 394-402.
3.	Maguire TM, Shering SG, Mcdermott EW, et al. Assay of E-cadherin by ELISA in human breast cancers[J]. Eur J Cancer, 1997, 33(3): 404-408.
4.	丁印魯, 趙榮宇, 由翠珍, 等. E-cadherin和PCNA在肝細胞癌中表達關系的研究[J]. 腫瘤防治雜志, 2002, 9(3): 255-256.
5.	Kamai T, Takagi K, Asami H, et al. Decreasing of p27 (kip1) and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer[J]. Br J Cancer, 2001, 84(9): 1242-1251.
6.	Zbar AP, Simopoulos C, Karayiannakis AJ. Cadherins: an integral role in inflammatory bowel disease and mucosal restitution[J]. J Gastroenterol, 2004, 39(5): 413-421.
7.	Bornman DM, Mathew S, Alsruhe J, et al. Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals[J]. Am J Pathol, 2001, 159(3): 831-835.
8.	Omran OM. CD10 and E-Cad expression in urinary bladder urothelial and squamous cell carcinoma[J]. J Environ Pathol Toxicol Oncol, 2012, 31(3): 203-212.
9.	Sun GY, Wu JX, Wu JS, et al. Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis[J]. Chin J Cancer Res, 2012, 24(1): 23-28.
10.	Wei Y, Lukashev M, Simon DI, et al. Regulation of integrin function by the urokinase receptor[J]. Science, 1996, 273(5281): 1551-1555.
11.	韓艷春, 劉魯英, 楊東霞, 等. 人乳腺癌中p-P38信號分子與UPA表達增強[J]. 基礎醫學與臨床, 2009, 29(2): 170.
12.	Jiang JT, Zhang LF, Zhou B, et al. Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis[J]. Asian Pac J Cancer Prev, 2012, 13(7): 3379-3383.
13.	黃金鳳, 何志明, 李煒霞. 乳腺癌組織UPA和nm23表達及其臨床意義的研究[J]. 中華腫瘤防治雜志, 2008, 6(15): 830-831.
14.	肖繼平, 張莉, 齊云, 等. UPA及VEGF在乳腺癌中的表達及意義[J]. 中國普通外科雜志, 2007, 16(1): 96-98.
15.	高鳳霞. TGF-β1與UPA在乳腺癌中的表達及其相關性的研究[J]. 青島醫藥衛生, 2009, 41(1): 1-4.

1. 　金向明, 陳耀平, 王寧菊. 乳腺癌患者血漿uPA、uPAR檢測的臨床意義[J]. 寧夏醫學雜志, 2008, 30(7): 580-581.
2. 　Siitonen SM, Kononen JT, Helin HJ, et al. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer[J]. Am J Clin Pathol, 1996, 105(4): 394-402.
3. 　Maguire TM, Shering SG, Mcdermott EW, et al. Assay of E-cadherin by ELISA in human breast cancers[J]. Eur J Cancer, 1997, 33(3): 404-408.
4. 　丁印魯, 趙榮宇, 由翠珍, 等. E-cadherin和PCNA在肝細胞癌中表達關系的研究[J]. 腫瘤防治雜志, 2002, 9(3): 255-256.
5. 　Kamai T, Takagi K, Asami H, et al. Decreasing of p27 (kip1) and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer[J]. Br J Cancer, 2001, 84(9): 1242-1251.
6. 　Zbar AP, Simopoulos C, Karayiannakis AJ. Cadherins: an integral role in inflammatory bowel disease and mucosal restitution[J]. J Gastroenterol, 2004, 39(5): 413-421.
7. 　Bornman DM, Mathew S, Alsruhe J, et al. Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals[J]. Am J Pathol, 2001, 159(3): 831-835.
8. 　Omran OM. CD10 and E-Cad expression in urinary bladder urothelial and squamous cell carcinoma[J]. J Environ Pathol Toxicol Oncol, 2012, 31(3): 203-212.
9. 　Sun GY, Wu JX, Wu JS, et al. Caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous tissues and chronic non-atrophic gastritis[J]. Chin J Cancer Res, 2012, 24(1): 23-28.
10. 　Wei Y, Lukashev M, Simon DI, et al. Regulation of integrin function by the urokinase receptor[J]. Science, 1996, 273(5281): 1551-1555.
11. 　韓艷春, 劉魯英, 楊東霞, 等. 人乳腺癌中p-P38信號分子與UPA表達增強[J]. 基礎醫學與臨床, 2009, 29(2): 170.
12. 　Jiang JT, Zhang LF, Zhou B, et al. Relationships of uPA and VEGF expression in esophageal cancer and microvascular density with tumorous invasion and metastasis[J]. Asian Pac J Cancer Prev, 2012, 13(7): 3379-3383.
13. 　黃金鳳, 何志明, 李煒霞. 乳腺癌組織UPA和nm23表達及其臨床意義的研究[J]. 中華腫瘤防治雜志, 2008, 6(15): 830-831.
14. 　肖繼平, 張莉, 齊云, 等. UPA及VEGF在乳腺癌中的表達及意義[J]. 中國普通外科雜志, 2007, 16(1): 96-98.
15. 　高鳳霞. TGF-β1與UPA在乳腺癌中的表達及其相關性的研究[J]. 青島醫藥衛生, 2009, 41(1): 1-4.

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West China Medical Journal

Expression and Pathological Significance of E-Cadherin and Uridylyl Phosphate Adenosine in Breast Carcinoma

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