艾拉莫德在類風濕關節炎治療中的研究_West China Medical Journal

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艾拉莫德; 類風濕關節炎; 臨床應用

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10.7507/1002-0179.20130246

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類風濕關節炎是一常見的以關節組織慢性炎癥性病變為主要表現的全身性疾病。艾拉莫德是我國自行研發的、獲得中國食品藥品監督管理局批準，用于治療成人活動性類風濕關節炎的一類新藥。現就艾拉莫德的化學性質、生物活性、作用機制及其在類風濕關節炎臨床治療中的應用進行闡述，并對艾拉莫德未來用途進行展望。

Citation： 郝春芳,劉毅,趙毅. 艾拉莫德在類風濕關節炎治療中的研究. West China Medical Journal, 2013, 28(5): 795-798. doi: 10.7507/1002-0179.20130246 Copy

1.	焦志軍, 王文紅, 李晶, 等. 類風濕關節炎患者外周血單個核細胞Notch及其配體表達[J]. 現代免疫學, 2007, 27(6): 477-480.
2.	宋明俠, 王杏林, 王春龍. 艾拉莫德速釋片的溶出度測定方法研究[J]. 天津藥學, 2006, 18(1): 22-23.
3.	Aikawa Y, Tanuma N, Shin T, et al. A new antirheumatic drug, T-614, effectively suppresses the development of autoimmune encephalomyelitis[J]. J Neuroimm, 1998, 89(1-2): 35-42.
4.	Jiang Y, Yu SQ. The role of nuclear transcription factor-κB pathway in acute lung injury induced by endotoxin[J]. Chin J Crit Care Med, 2004, 24: 902-904.
5.	Sawada T, Hashimoto S, Tohma S, et al. Inhibition of l-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614[J]. Immunopharmacology, 2000, 49(3): 285-294.
6.	張靜, 袁玉, 李健華, 等. 艾拉莫德片在中國健康志愿者體內的藥動學[J]. 中國臨床藥學雜志, 2007, 16(4): 234-237.
7.	陳思曾, 郭永剛. 艾拉莫德、吡咯烷二硫代氨基甲酸鹽單用和聯合治療惡病質[J]. 中華實驗外科雜志, 2011, 28(5): 720-722.
8.	Tanaka K, Urata1 N, Mikami M, et al. Effect of iguratimod and other anti-rheumatic drugs on adenocarcinoma colon 26-induced cachexia in mice[J]. Inflamm Res, 2007, 56 (1) : 17-23.
9.	KeiferJ, Guttridge DC, Ashburner BP, et al. Inhibition of NF-kappa B activity by Thalidomide through Suppression of Ikappa B kinase Activity[J]. Biol Chem, 2001, 276(25): 22382-22387.
10.	高晶, 只德廣, 曾勇, 等. 艾拉莫德(T-614)的臨床前藥代動力學研究[J]. 藥物評價研究, 2009, 32 (1): 19-28.
11.	Du F, Lü LJ , Fu Q , et al. T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis[J]. Arthritis Res Ther, 2008, 10(6):1-11 .
12.	Hara M , Abe T, Sugawara S, et al. Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study[J]. Mod Rheumatol, 2007, 17(1) : 1-9.
13.	Ishiguro N, Yamamoto K, Katayama K, et al. Iguratimod-Clinical Study Group Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double-blind, placebo-controlled trial[J]. Mod Rheumatol, 2012, [Epub ahead of print].
14.	Mitchell JA, Akaraserenont P, Thiemermann C, et al. Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase[J]. Proc Natl Acad Sci USA,1993, 90(24): 11693-11697.
15.	Tanaka K , Yamamoto T , Aikawa Y , et al. Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice[J]. Rheumatol, 2003, 42(11): 1365-1371.
16.	Du F , Lü LJ , Teng JL , et al. T-614 alters the production of matrix metalloproteinases (MMP-1 and MMP-3) and inhibits the migratory expansion of rheumatoid synovial fibroblasts, in vitro[J]. Int Immunopharmacol, 2012, 13(1): 54-60.
17.	Kawakami A, Tsuboi M, Urayama S, et a1. Inhibitory effect of a new anti-rheumatic drug T-614 on costimulatory molecule expression, cytokine production, and antigen presentation by synovial cells[J]. J Lab Clin Med, 1999, 133(6): 566-574.
18.	李秋霞, 古潔若. 艾拉莫德對小鼠成纖維細胞分泌膠原的影響[J]. 醫學研究雜志, 2009, 38(10): 44-47.
19.	舒強, 李興福, 劉花香, 等. 類風濕關節炎滑膜成纖維樣細胞增殖特性的體外研究[J].山東大學學報·醫學版, 2006, 44(11): 1095-1099.
20.	舒強, 李興福, 侯懷水, 等. 艾拉莫德對骨關節炎滑膜成纖維樣細胞特性的影響[J]. 中華風濕病學雜志, 2006, 10(7): 389-392.
21.	Malviya A, Kuiper JH , Makwana N, et al. The effect of newer anti-rheumatic drug on osteogenic cell proliferation an in-vitro study [J]. J Orthop surg Res, 2009, 4(17): 1-7.
22.	Kuriyama K, Higuchi C, Tanaka K, et al . A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein -2-induced bone formation in vivo[J]. Biochem Biophys Res Commun, 2002, 299(5): 903-909.
23.	魏偉, 張玲玲, 肖峰, 等. 艾拉莫德治療類風濕關節炎Ⅱ期臨床試驗[C]. 第十二次全國臨床藥理學學術會議論文集, 武漢, 2010. 北京: 中國藥理學會. 2010.
24.	滕佳臨,呂良敬,鮑春德,等. 艾拉莫德治療類風濕關節炎多中心隨機雙盲安慰劑對照研究[J].中華風濕病雜志, 2007, 11(8): 461-465.
25.	Sullivan S. Iguratimod: novel DMARD promising for rheumatoid artlritis[J]. Inpharma, 2004, 1450(1): 7.
26.	Hara M, Abe T, Sugawara S, et al. Long-term safety study of iguratimod in patients with rheumatoid arthritis[J]. Mod rheumatol, 2007, 17(1): 10-16 .

1. 　焦志軍, 王文紅, 李晶, 等. 類風濕關節炎患者外周血單個核細胞Notch及其配體表達[J]. 現代免疫學, 2007, 27(6): 477-480.
2. 　宋明俠, 王杏林, 王春龍. 艾拉莫德速釋片的溶出度測定方法研究[J]. 天津藥學, 2006, 18(1): 22-23.
3. 　Aikawa Y, Tanuma N, Shin T, et al. A new antirheumatic drug, T-614, effectively suppresses the development of autoimmune encephalomyelitis[J]. J Neuroimm, 1998, 89(1-2): 35-42.
4. 　Jiang Y, Yu SQ. The role of nuclear transcription factor-κB pathway in acute lung injury induced by endotoxin[J]. Chin J Crit Care Med, 2004, 24: 902-904.
5. 　Sawada T, Hashimoto S, Tohma S, et al. Inhibition of l-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614[J]. Immunopharmacology, 2000, 49(3): 285-294.
6. 　張靜, 袁玉, 李健華, 等. 艾拉莫德片在中國健康志愿者體內的藥動學[J]. 中國臨床藥學雜志, 2007, 16(4): 234-237.
7. 　陳思曾, 郭永剛. 艾拉莫德、吡咯烷二硫代氨基甲酸鹽單用和聯合治療惡病質[J]. 中華實驗外科雜志, 2011, 28(5): 720-722.
8. 　Tanaka K, Urata1 N, Mikami M, et al. Effect of iguratimod and other anti-rheumatic drugs on adenocarcinoma colon 26-induced cachexia in mice[J]. Inflamm Res, 2007, 56 (1) : 17-23.
9. 　KeiferJ, Guttridge DC, Ashburner BP, et al. Inhibition of NF-kappa B activity by Thalidomide through Suppression of Ikappa B kinase Activity[J]. Biol Chem, 2001, 276(25): 22382-22387.
10. 　高晶, 只德廣, 曾勇, 等. 艾拉莫德(T-614)的臨床前藥代動力學研究[J]. 藥物評價研究, 2009, 32 (1): 19-28.
11. 　Du F, Lü LJ , Fu Q , et al. T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis[J]. Arthritis Res Ther, 2008, 10(6):1-11 .
12. 　Hara M , Abe T, Sugawara S, et al. Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study[J]. Mod Rheumatol, 2007, 17(1) : 1-9.
13. 　Ishiguro N, Yamamoto K, Katayama K, et al. Iguratimod-Clinical Study Group Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double-blind, placebo-controlled trial[J]. Mod Rheumatol, 2012, [Epub ahead of print].
14. 　Mitchell JA, Akaraserenont P, Thiemermann C, et al. Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase[J]. Proc Natl Acad Sci USA,1993, 90(24): 11693-11697.
15. 　Tanaka K , Yamamoto T , Aikawa Y , et al. Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice[J]. Rheumatol, 2003, 42(11): 1365-1371.
16. 　Du F , Lü LJ , Teng JL , et al. T-614 alters the production of matrix metalloproteinases (MMP-1 and MMP-3) and inhibits the migratory expansion of rheumatoid synovial fibroblasts, in vitro[J]. Int Immunopharmacol, 2012, 13(1): 54-60.
17. 　Kawakami A, Tsuboi M, Urayama S, et a1. Inhibitory effect of a new anti-rheumatic drug T-614 on costimulatory molecule expression, cytokine production, and antigen presentation by synovial cells[J]. J Lab Clin Med, 1999, 133(6): 566-574.
18. 　李秋霞, 古潔若. 艾拉莫德對小鼠成纖維細胞分泌膠原的影響[J]. 醫學研究雜志, 2009, 38(10): 44-47.
19. 　舒強, 李興福, 劉花香, 等. 類風濕關節炎滑膜成纖維樣細胞增殖特性的體外研究[J].山東大學學報·醫學版, 2006, 44(11): 1095-1099.
20. 　舒強, 李興福, 侯懷水, 等. 艾拉莫德對骨關節炎滑膜成纖維樣細胞特性的影響[J]. 中華風濕病學雜志, 2006, 10(7): 389-392.
21. 　Malviya A, Kuiper JH , Makwana N, et al. The effect of newer anti-rheumatic drug on osteogenic cell proliferation an in-vitro study [J]. J Orthop surg Res, 2009, 4(17): 1-7.
22. 　Kuriyama K, Higuchi C, Tanaka K, et al . A novel anti-rheumatic drug, T-614, stimulates osteoblastic differentiation in vitro and bone morphogenetic protein -2-induced bone formation in vivo[J]. Biochem Biophys Res Commun, 2002, 299(5): 903-909.
23. 　魏偉, 張玲玲, 肖峰, 等. 艾拉莫德治療類風濕關節炎Ⅱ期臨床試驗[C]. 第十二次全國臨床藥理學學術會議論文集, 武漢, 2010. 北京: 中國藥理學會. 2010.
24. 　滕佳臨,呂良敬,鮑春德,等. 艾拉莫德治療類風濕關節炎多中心隨機雙盲安慰劑對照研究[J].中華風濕病雜志, 2007, 11(8): 461-465.
25. 　Sullivan S. Iguratimod: novel DMARD promising for rheumatoid artlritis[J]. Inpharma, 2004, 1450(1): 7.
26. 　Hara M, Abe T, Sugawara S, et al. Long-term safety study of iguratimod in patients with rheumatoid arthritis[J]. Mod rheumatol, 2007, 17(1): 10-16 .

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艾拉莫德在類風濕關節炎治療中的研究

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