Mismatch Negativity in Patients with Obsessive-Compulsive Disorder_West China Medical Journal

Authors：

ZHOU Jing , ZHENG Zhong , KUANG Weihong , ZHENG Bo ,  YANG Yanchun.

Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

YANG Yanchun., Email: zhoujing2010jw@126.com

Keywords：

強迫癥; 失匹配負波; 認知功能

DOI：

10.7507/1002-0179.20130278

Video：

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目的　探討強迫癥患者失匹配負波（MMN）的特征以及強迫癥可能存在的認知功能障礙。方法　2010年9月－2012年3月將符合納入標準的21例強迫癥患者（OCD）進行耶魯-布朗強迫癥狀量表（Y-BOCS）評分，使用日本Nihon Kohden腦誘發電位儀，記錄21例OCD患者、21例性別相匹配的正常對照組進行Cz導聯MMN潛伏期以及波幅的測定，并將數據進行t檢驗、相關性分析等處理。結果　強迫癥與正常人組間比較存在MMN潛伏期（t=2.834，P=0.007）延長，波幅增高，但較正常對照組比較無統計學意義，MMN潛伏期與病程以及Y-BOCS評分無相關性。結論　強迫癥患者在大腦處理信息的早期階段存在認知的自動加工功能的損害，與病程長短以及病情的嚴重程度無明顯相關性。MMN是檢測認知功能比較敏感的指標。

Citation： ZHOU Jing,ZHENG Zhong,KUANG Weihong,ZHENG Bo,YANG Yanchun.. Mismatch Negativity in Patients with Obsessive-Compulsive Disorder. West China Medical Journal, 2013, 28(6): 891-893. doi: 10.7507/1002-0179.20130278 Copy

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6.	Lu YZ, Zong WB, Dong HZ, et al. Characterization of event-related potentials in obsessive compulsive disorder patients Comparison with depression and generalized anxiety disorder patients[J]. Neural Regeneration Research,2010, 5(12): 938-941.
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12.	羅躍嘉, 吳宗耀, 魏景漢. 跨通路選擇性注意腦內記憶痕跡的位置[J]. 第三軍醫大學學報, 1998, 20(4): 299-300.
13.	Kohlmetz C, Altenmüller E, Schuppert M, et al. Deficit in automatic sound-change detection may underlie some music perception deficits after acute hemispheric stoke[J]. Neuropsychologia , 2001, 39(11): 1121-1124.
14.	G ö lgeli A, Süer C, Ozesmi C, et al. The effect of sex differences on event-related potentials in young adults[J]. Intern J Neurosci, 1999, 99(1-4): 69-77.
15.	Bodatsch M, Ruhrmann S, Wagner M, et al. Prediction of psychosis by mismatch negativity[J]. Biological Psychiatry , 2011, 69(10): 959-966.

1. 　魏景漢, 羅躍嘉. 事件相關電位原理與技術[M].北京: 科學出版社, 2010: 55-63.
2. 　羅躍嘉. 認知神經科學[M].北京: 北京大學出版社, 2006: 151.
3. 　Weissman MM, Bland RC, Canino GJ, et al. The cross national epidemiology of obsessive-compulsive disorder.The Cross National Collaborative Group[J]. J Clin Psych, 1994, 55(suppl): 5-10.
4. 　林永清, 謝蓓芳, 懂允夫. 氯氮平所致強迫癥狀的臨床探討[J]. 中國行為醫學科學, 2002, 11(1): 52-53.
5. 　Näätänen R, Gaillard AW, Mantysalo S. Early selective-attention effect on evoked potential reinterpreted[J]. Acta Psychologica, 1978, 42(4): 313-329.
6. 　Lu YZ, Zong WB, Dong HZ, et al. Characterization of event-related potentials in obsessive compulsive disorder patients Comparison with depression and generalized anxiety disorder patients[J]. Neural Regeneration Research,2010, 5(12): 938-941.
7. 　Alain C, Woods DL, Knight RT. A distributed cortical network for auditory sensory memory in humans[J]. Brain Research, 1998, 812(1-2): 23-37.
8. 　Näätänen R, Paavilainen P, Rinne T, et al. The mismatch negativity (MMN) in basic research of central auditory processing: a review[J]. Clin Neuroph, 2007, 118(12): 2544-2590.
9. 　Czigler I, Sulykos I .Visual mismatch negativity to irrelevant changes is sensitive to task-relevant changes[J]. Neuropsychologia, 2010, 48(5): 1277-1282.
10. 　Kekoni J, Hämläinen H, Saarinen M, et al. Rate effect and mismatch responses in the somatosensory system: ERP-recordings in humans[J]. Biol Psych, 1997, 46(2): 125-142.
11. 　Pause BM, Krauel K.Chemosensory event-related potentials (CSERP) as a key to the psychology of odors[J]. Psychophysiology, 2000, 36(2): 105-122.
12. 　羅躍嘉, 吳宗耀, 魏景漢. 跨通路選擇性注意腦內記憶痕跡的位置[J]. 第三軍醫大學學報, 1998, 20(4): 299-300.
13. 　Kohlmetz C, Altenmüller E, Schuppert M, et al. Deficit in automatic sound-change detection may underlie some music perception deficits after acute hemispheric stoke[J]. Neuropsychologia , 2001, 39(11): 1121-1124.
14. 　G ö lgeli A, Süer C, Ozesmi C, et al. The effect of sex differences on event-related potentials in young adults[J]. Intern J Neurosci, 1999, 99(1-4): 69-77.
15. 　Bodatsch M, Ruhrmann S, Wagner M, et al. Prediction of psychosis by mismatch negativity[J]. Biological Psychiatry , 2011, 69(10): 959-966.

West China Medical Journal

Mismatch Negativity in Patients with Obsessive-Compulsive Disorder

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