維拉帕米對兔脊髓缺血再灌注神經損傷的影響_《華西醫學》

作者：

屠建琪 , 劉志強

濟寧醫學院人體解剖教研室（山東濟寧，272067）;

關鍵詞：

缺血再灌注損傷兔維拉帕米

DOI：

10.7507/1002-0179.20130323

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目的　觀察維拉帕米對兔脊髓缺血再灌注神經損傷的影響。方法　選用健康兔30只，隨機分為3組，A組為假手術組（只穿線不結扎），B組為缺血再灌注組（腹主動脈缺血30 min后，再灌注48 h），C組為維拉帕米組（0.2 mg/kg維拉帕米靜脈注射后，腹主動脈缺血30 min，再灌注48 h）。對3組動物行神經功能評價并通過病理組織學觀察神經元細胞的變化，以此評價維拉帕米對兔脊髓缺血再灌注神經損傷的保護作用。結果　A組神經功能評價、神經元細胞的病理組織學觀察均正常。B組神經功能出現明顯障礙，神經元細胞形態異常。C組亦出現神經功能障礙，神經元細胞形態異常，但均較B組輕。結論　應用維拉帕米可減輕因脊髓缺血再灌注造成的神經損傷。

引用本文： 屠建琪,劉志強. 維拉帕米對兔脊髓缺血再灌注神經損傷的影響. 華西醫學, 2013, 28(7): 1045-1047. doi: 10.7507/1002-0179.20130323 復制

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13.	孟春陽, 尹飛, 郭麗, 等. 銀杏葉對大鼠脊髓缺血再灌注損傷保護作用的實驗研究[J]. 中國實驗診斷學, 2010, 14(6): 812-814.
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15.	Ucak A, Onan B, Güler A, et al. Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces ischemia/reperfusion-induced spinal cord tissue injury in rats[J]. Ann Vasc Surg, 2011, 25(5): 686-695.

1. 　Mohan IK, Khan M, Wisel S, et al. Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction[J]. Am J Physiol Heart Circ Physiol, 2009, 296(1): 140-151.
2. 　Coetzee A, Conradie S. Calcium antagonist verapamil and reperfusion injury of the heart[J]. J Cardiothorac Vasc Anesth, 2007, 21(3): 337-343.
3. 　Krebs P, Fan W, Chen YH, et al. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet[J]. Proc Natl Acad Sci USA, 2011, 108(49): 19678-19682.
4. 　Turer AT, Hill JA. Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy[J]. Am J Cardiol, 2010, 106(3): 360-368.
5. 　魏育濤, 陳新忠, 董念國, 等. 脂聯素對兔短期缺血再灌注心肌的保護作用[J]. 華中科技大學學報·醫學版, 2010, 39(6): 750-753.
6. 　Giorgi C, Romagnoli A, Pinton P, et al. Ca2+ signaling, mitochondria and cell death[J]. Curr Mol Med, 2008, 8(2): 119-130.
7. 　Wang QD, Pernow J, Sjöquist PO, et al. Pharmacologi-cal possibilities for protection against myocardial reperfu-sion injury[J]. Cardiovasc Res, 2002, 55(1): 25-37.
8. 　Murphy E, Steenbergen C. Ion transport and energetics during cell death and protection[J]. Physiology (Bethesda), 2008, 23(1): 115-123.
9. 　Dong Z, Saikumar P, Weinberg JM, et al. Calcium in cell injury and death[J]. Annu Rev Pathol, 2006, 1(1): 405-434.
10. 　González G, Zaldívar D, Carrillo E, et al. Pharmacological preconditioning by diazoxide downregulates cardiac L-type Ca2+ channels[J]. Br J Pharmacol, 2010, 161(5): 1172-1185.
11. 　胡小琴. 心血管麻醉及體外循環[M]. 北京: 人民衛生出版社, 1997: 249- 249.
12. 　徐成斌, 王思讓, 李文彬. 心臟電生理學與藥理學基礎與臨床[M]. 北京: 軍事醫學科學出版社, 1997: 254-254.
13. 　孟春陽, 尹飛, 郭麗, 等. 銀杏葉對大鼠脊髓缺血再灌注損傷保護作用的實驗研究[J]. 中國實驗診斷學, 2010, 14(6): 812-814.
14. 　Yilmaz ER, Kertmen H, Dolgun H, et al. Effects of darbepoetin-α in spinal cord ischemia-reperfusion injury in the rabbit[J]. Acta Neurochir (Wien), 2012, 154(6): 1037-1043.
15. 　Ucak A, Onan B, Güler A, et al. Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, reduces ischemia/reperfusion-induced spinal cord tissue injury in rats[J]. Ann Vasc Surg, 2011, 25(5): 686-695.

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維拉帕米對兔脊髓缺血再灌注神經損傷的影響

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維拉帕米對兔脊髓缺血再灌注神經損傷的影響

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