A Comparative Study between Dynamic Contrast-enhancement MRI and Magnetic Resonance Spectroscopy in Diagnosing Prostate Cancer_West China Medical Journal

Authors：

 PENGTao ¹ , XIAOJian-ming ¹ , YANGJin ²

1. Department of Radiology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;
2. Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;

Corresponding?author：

Keywords：

Magnetic resonance imaging; Dynamic enhancement; Magnetic resonance spectrum; Prostatic neoplasms; Prostate cancer

DOI：

10.7507/1002-0179.20140023

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To compare the effectiveness of magnetic resonance spectroscopy (MRS) and Dynamic Contrast-enhancement (DCE-MRI) with 1.5 T MR scanner in diagnosing prostate cancer. Methods From April 2011 to December 2012, based on the results of biopsy, we measured 216 regions of interest (ROIs) in images of MRS and DCE-MRI, comprised of 131 ROIs from cancer zone and 85 ROIs from non-cancer zone. The data were analyzed with statistical methods, including receiver operating characteristic (ROC) curve. Results There were significant differences between the malignant group and the benign group (P<0.05) in Cit integral, Cho integral, CC/Cit ratio, the type of time-signal intensity curve, initial value, enhancement rate and ratio of enhancement. According to ROC curve, the area under curve (AUC) of CC/Cit and enhancement rate was 0.853 and 0.719, respectively. AUC of time to peak, time difference, enhancement rate and Cit integral was lower than 0.400. The optimal operating point (OOP) of CC/Cit was 0.775, with a specificity of 0.85 and a sensitivity of 0.79, and the AUC was 0.853. The OOP of the ratio of enhancement was 60.89, with a specificity of 0.66 and a sensitivity of 0.71, and the AUC was 0.719. Conclusion MRS is more sensitive and specific than DCE-MRI to diagnose prostate cancer when an 1.5 T MR scanner is used. On the other hand, MRS is susceptible to interference, but DCE-MRI can make up for these deficiencies.

Citation： PENGTao, XIAOJian-ming, YANGJin. A Comparative Study between Dynamic Contrast-enhancement MRI and Magnetic Resonance Spectroscopy in Diagnosing Prostate Cancer. West China Medical Journal, 2014, 29(1): 83-86. doi: 10.7507/1002-0179.20140023 Copy

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1. 徐莉, 譚紹恒, 梁長虹, 等. 靜脈注射釓類對比劑及預飽和帶對腎臟3.0T質子磁共振波譜勻場和抑水的影響[J]. 中國醫學影像技術, 2010, 26(5):940-942.
2. 李春媚, 陳敏, 李颯英, 等. 前列腺癌的MRI診斷:T2WI、DWI、MRS及其綜合應用[J]. 磁共振成像, 2010, 1(4):257-263.
3. Alonzi R, Padhani AR, Allen C. Dynamic contrast enhanced MRI in prostate cancer[J]. Eur J Radiol, 2007, 63(3):335-350.
4. Sciarra A, Panebianco V, Ciccariello M, et al. Magnetic resonance spectroscopic imaging (1H-MRSI) and dynamic contrastenhanced magnetic resonance (DCE-MRI):pattern changes from inflammation to prostate cancer[J]. Cancer Invest, 2010, 28(4):424-432.
5. 張盛箭, 彭衛軍,周良平. 動態增強MRI基本原理及其在前列腺癌中的應用[J]. 中國醫學影像技術, 2010, 26(2):378-380.
6. 周芳, 張同華, 陳建新, 等. 前列腺炎的MRI及MRS初步研究[J]. 臨床放射學雜志, 2011, 30(9):1334-1336.
7. 高志國,肖新蘭,尹建華. MRI、MRS聯合PSA鑒別前列腺癌和前列腺增生的價值[J]. 臨床放射學雜志, 2008, 27(12):1707-1710.
8. 李飛宇, 王霄英, 肖江喜, 等. 中國男性前列腺癌MRS體素診斷標準[J]. 中國醫學影像技術, 2009, 25(5):833-836.
9. Prando A, Billis A. Focal prostatic atrophy:mimicry of prostatic cancer on TRUS and 3D-MRSI studies[J]. Abdom Imaging, 2009, 34(2):271-275.
10. Lee JY, Chang IH, Moon YT, et al. Effect of prostate biopsy hemorrhage on MRDW and MRS imaging[J]. Korean J Urol, 2011, 52(10):674-680.

West China Medical Journal

A Comparative Study between Dynamic Contrast-enhancement MRI and Magnetic Resonance Spectroscopy in Diagnosing Prostate Cancer

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