內源性神經干細胞在中樞神經系統創傷修復中的研究進展_West China Medical Journal

Authors：

 梁銳超 ,  方芳

四川大學華西醫院神經外科（成都，610041）;

Corresponding?author：

方芳, Email: merrisn@hotmail.com

Keywords：

內源性神經干細胞; 中樞神經系統; 創傷; 修復

DOI：

10.7507/1002-0179.20140047

Video：

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自上世紀60年代發現神經再生現象以來，神經科學領域專家學者做了大量關于神經再生的研究，包括體外分離培養神經干細胞并探索神經干細胞增殖、分化、遷移的規律和機制，以期最終應用于中樞神經系統疾病的治療，如干細胞移植和神經生長因子誘導治療等。腦脊髓損傷是死殘率高、經濟負擔重的臨床常見疾患，現撰文主要就目前神經科學領域有關調控內源性神經干細胞參與腦脊髓損傷神經再生修復的研究進展作一綜述。

Citation： 梁銳超, 方芳. 內源性神經干細胞在中樞神經系統創傷修復中的研究進展. West China Medical Journal, 2014, 29(1): 150-154. doi: 10.7507/1002-0179.20140047 Copy

1.	Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats[J]. J Comp Neurol, 1965, 124(3):319-335.
2.	Goldman SA, Nottebohm F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain[J]. Proc Natl Acad Sci USA, 1983, 80(8):2390-2394.
3.	Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system[J]. Science, 1992, 255(5052):1707-1710.
4.	Weiss S, Dunne C, Hewson J, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis[J]. J Neurosci, 1996, 16(23):7599-7609.
5.	Zheng W, Zhuge Q, Zhong M, et al. Neurogenesis in adult human brain after traumatic brain injury[J]. J Neurotrauma, 2013, 30(22):1872-1880.
6.	Jordan JD, Ma DK, Ming GL, et al. Cellular niches for endogenous neural stem cells in the adult brain[J]. CNS Neurol Disord Drug Targets, 2007, 6(5):336-341.
7.	Baumann K. Stem cells:holding tight onto the niche[J]. Nat Rev Mol Cell Biol, 2012, 13(5):278-279.
8.	Imura T. Stem cells and cancer stem cells:Vol 4[M]. Dordrecht:Springer, 2012:77-84.
9.	Yuan Q, Liu H, Wu X, et al. Characteristics of acute treatment costs of traumatic brain injury in Eastern China a multi-centre prospective observational study[J]. Injury, 2012, 43(12):2094-2099.
10.	Wislet-Gendebien S, Poulet C, Neirinckx V, et al. In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow[J]. PLoS One, 2012, 7(10):e46425.
11.	Kowalczyk T, Pontious A, Englund C, et al. Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex[J]. Cereb Cortex, 2009, 19(10):2439-2450.
12.	劉靖, 曲靜, 徐曉靜, 等. 神經干細胞遷移的研究進展[J]. 中國細胞生物學學報, 2012, 34(3):201-211.
13.	Rao MS, Carpenter M, Vemuri MC. Neural development and stem cells[M]. 3ed. New York:Springer, 2012:289-328.
14.	顧恩妍, 哈福, 李林鳳, 等. 神經干細胞的鑒定方法[J]. 中國組織工程研究與臨床康復, 2009, 13(10):1947-1950.
15.	Chojnacki A, Cusulin C, Weiss S. Adult periventricular neural stem cells:outstanding progress and outstanding issues[J]. Dev Neurobiol, 2012, 72(7):972-989.
16.	Ma DK, Ma BD, Ming GL, et al. Adult neural stem cells in the mammalian central nervous system[J]. Cell Res, 2009, 19(6):672-682.
17.	Sanai N, Nguyen T, Ihrie RA, et al. Corridors of migrating neurons in the human brain and their decline during infancy[J]. Nature, 2011, 478(7369):382-386.
18.	Chambers RA, Potenza MN, Hoffman RE, et al. Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks[J]. Neuropsychopharmacology, 2004, 29(4):747-758.
19.	Sun W, Kim H, Moon Y. Control of neuronal migration through rostral migration stream in mice[J]. Anat Cell Biol, 2010, 43(4):269-279.
20.	Khodosevich K, Monyer H. Signaling in migrating neurons:from molecules to networks[J]. Front Neurosci, 2011, 5:28.
21.	Deng W, Aimone JB, Gage FH. New neurons and new memories:how does adult hippocampal neurogenesis affect learning and memory?[J]. Nat Rev Neurosci, 2010, 11(5):339-350.
22.	Sabelström H, Stenudd M, Frisén J. Neural stem cells in the adult spinal cord[J/OL]. Exp Neurol, (2013-01-30)[2013-04-01]. http://dx.doi.org/10.1016/j.expneuro/.2013.01.026.
23.	Alfaro-Cervello C, Soriano-Navarro M, Mirzadeh Z, et al. Biciliated ependymal cell proliferation contributes to spinal cord growth[J]. J Comp Neurol, 2012, 520(15):3528-3552.
24.	Santos T, Maia J, Agasse F, et al. Nanomedicine boosts neurogenesis:new strategies for brain repair[J]. Integr Biol (Camb), 2012, 4(9):973-981.
25.	Bye N, Carron S, Han X, et al. Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats[J]. J Neurosci Res, 2011, 89(7):986-1000.
26.	Zhao W, Huan L, Zhao Y, et al. Endogenous adult neurogenesis and cognitive function recovery following traumatic brain injury in the rat hippocampus[J]. Neural Regen Res, 2010, 5(9):645-650.
27.	Sorci G, Bianchi R, Riuzzi F, et al. S100B protein, a damage-associated molecular pattern protein in the brain and heart, and beyond[J/OL]. Cardiovasc Psychiatry Neurol, 2010,[2010-08-18]. http://www.ncbi.n/m.nih.gov/pubmeel/20827421.
28.	Gerrard-Morris A, Taylor HG, Yeates KO, et al. Cognitive development after traumatic brain injury in young children[J]. J Int Neuropsychol Soc, 2010, 16(1):157-168.
29.	Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice[J]. Nature, 2000, 405(6789):951-955.
30.	Lledo PM, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits[J]. Nat Rev Neurosci, 2006, 7(3):179-193.
31.	Sonksen P, Hillier S. A patient's journey spinal cord injury[J/OL]. BMJ, 2010(340):b5204[2013-04-16]. http://dx.doi.org/10.1136/bmj.b5204.
32.	Shah SK, Jimenez F, Walker PA. Progenitor cell therapy for neurological injury[M]. Totowa:Humana Press, 2011:69-95.
33.	陳太邦, 趙建華. 內源性NSPCs與脊髓損傷治療的研究進展[J]. 創傷外科雜志, 2012, 14(4):373-376.
34.	Barnabé-Heider F, G?ritz C, Sabelstr?m H, et al. Origin of new glial cells in intact and injured adult spinal cord[J]. Cell Stem Cell, 2010, 7(4):470-482.
35.	Johanson C, Stopa E, Baird A, et al. Traumatic brain injury and recovery mechanisms:peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus[J]. J Neural Transm, 2011, 118(1):115-133.
36.	?berg D. Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis[J]. Endocr Dev, 2010(17):63-76.
37.	Parent JM, Murphy GG. Mechanisms and functional significance of aberrant seizure induced hippocampal neurogenesis[J]. Epilepsia, 2008, 49(s5):19-25.
38.	Zhang L, Yang X, Yang S, et al. The Wnt/β-catenin signaling pathway in the adult neurogenesis[J]. Eur J Neurosci, 2011, 33(1):1-8.
39.	Ables JL, Breunig JJ, Eisch AJ, et al. Not(ch) just development:Notch signalling in the adult brain[J]. Nat Rev Neurosci, 2011, 12(5):269-283.

1. Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats[J]. J Comp Neurol, 1965, 124(3):319-335.
2. Goldman SA, Nottebohm F. Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain[J]. Proc Natl Acad Sci USA, 1983, 80(8):2390-2394.
3. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system[J]. Science, 1992, 255(5052):1707-1710.
4. Weiss S, Dunne C, Hewson J, et al. Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis[J]. J Neurosci, 1996, 16(23):7599-7609.
5. Zheng W, Zhuge Q, Zhong M, et al. Neurogenesis in adult human brain after traumatic brain injury[J]. J Neurotrauma, 2013, 30(22):1872-1880.
6. Jordan JD, Ma DK, Ming GL, et al. Cellular niches for endogenous neural stem cells in the adult brain[J]. CNS Neurol Disord Drug Targets, 2007, 6(5):336-341.
7. Baumann K. Stem cells:holding tight onto the niche[J]. Nat Rev Mol Cell Biol, 2012, 13(5):278-279.
8. Imura T. Stem cells and cancer stem cells:Vol 4[M]. Dordrecht:Springer, 2012:77-84.
9. Yuan Q, Liu H, Wu X, et al. Characteristics of acute treatment costs of traumatic brain injury in Eastern China a multi-centre prospective observational study[J]. Injury, 2012, 43(12):2094-2099.
10. Wislet-Gendebien S, Poulet C, Neirinckx V, et al. In vivo tumorigenesis was observed after injection of in vitro expanded neural crest stem cells isolated from adult bone marrow[J]. PLoS One, 2012, 7(10):e46425.
11. Kowalczyk T, Pontious A, Englund C, et al. Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex[J]. Cereb Cortex, 2009, 19(10):2439-2450.
12. 劉靖, 曲靜, 徐曉靜, 等. 神經干細胞遷移的研究進展[J]. 中國細胞生物學學報, 2012, 34(3):201-211.
13. Rao MS, Carpenter M, Vemuri MC. Neural development and stem cells[M]. 3ed. New York:Springer, 2012:289-328.
14. 顧恩妍, 哈福, 李林鳳, 等. 神經干細胞的鑒定方法[J]. 中國組織工程研究與臨床康復, 2009, 13(10):1947-1950.
15. Chojnacki A, Cusulin C, Weiss S. Adult periventricular neural stem cells:outstanding progress and outstanding issues[J]. Dev Neurobiol, 2012, 72(7):972-989.
16. Ma DK, Ma BD, Ming GL, et al. Adult neural stem cells in the mammalian central nervous system[J]. Cell Res, 2009, 19(6):672-682.
17. Sanai N, Nguyen T, Ihrie RA, et al. Corridors of migrating neurons in the human brain and their decline during infancy[J]. Nature, 2011, 478(7369):382-386.
18. Chambers RA, Potenza MN, Hoffman RE, et al. Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks[J]. Neuropsychopharmacology, 2004, 29(4):747-758.
19. Sun W, Kim H, Moon Y. Control of neuronal migration through rostral migration stream in mice[J]. Anat Cell Biol, 2010, 43(4):269-279.
20. Khodosevich K, Monyer H. Signaling in migrating neurons:from molecules to networks[J]. Front Neurosci, 2011, 5:28.
21. Deng W, Aimone JB, Gage FH. New neurons and new memories:how does adult hippocampal neurogenesis affect learning and memory?[J]. Nat Rev Neurosci, 2010, 11(5):339-350.
22. Sabelström H, Stenudd M, Frisén J. Neural stem cells in the adult spinal cord[J/OL]. Exp Neurol, (2013-01-30)[2013-04-01]. http://dx.doi.org/10.1016/j.expneuro/.2013.01.026.
23. Alfaro-Cervello C, Soriano-Navarro M, Mirzadeh Z, et al. Biciliated ependymal cell proliferation contributes to spinal cord growth[J]. J Comp Neurol, 2012, 520(15):3528-3552.
24. Santos T, Maia J, Agasse F, et al. Nanomedicine boosts neurogenesis:new strategies for brain repair[J]. Integr Biol (Camb), 2012, 4(9):973-981.
25. Bye N, Carron S, Han X, et al. Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats[J]. J Neurosci Res, 2011, 89(7):986-1000.
26. Zhao W, Huan L, Zhao Y, et al. Endogenous adult neurogenesis and cognitive function recovery following traumatic brain injury in the rat hippocampus[J]. Neural Regen Res, 2010, 5(9):645-650.
27. Sorci G, Bianchi R, Riuzzi F, et al. S100B protein, a damage-associated molecular pattern protein in the brain and heart, and beyond[J/OL]. Cardiovasc Psychiatry Neurol, 2010,[2010-08-18]. http://www.ncbi.n/m.nih.gov/pubmeel/20827421.
28. Gerrard-Morris A, Taylor HG, Yeates KO, et al. Cognitive development after traumatic brain injury in young children[J]. J Int Neuropsychol Soc, 2010, 16(1):157-168.
29. Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice[J]. Nature, 2000, 405(6789):951-955.
30. Lledo PM, Alonso M, Grubb MS. Adult neurogenesis and functional plasticity in neuronal circuits[J]. Nat Rev Neurosci, 2006, 7(3):179-193.
31. Sonksen P, Hillier S. A patient's journey spinal cord injury[J/OL]. BMJ, 2010(340):b5204[2013-04-16]. http://dx.doi.org/10.1136/bmj.b5204.
32. Shah SK, Jimenez F, Walker PA. Progenitor cell therapy for neurological injury[M]. Totowa:Humana Press, 2011:69-95.
33. 陳太邦, 趙建華. 內源性NSPCs與脊髓損傷治療的研究進展[J]. 創傷外科雜志, 2012, 14(4):373-376.
34. Barnabé-Heider F, G?ritz C, Sabelstr?m H, et al. Origin of new glial cells in intact and injured adult spinal cord[J]. Cell Stem Cell, 2010, 7(4):470-482.
35. Johanson C, Stopa E, Baird A, et al. Traumatic brain injury and recovery mechanisms:peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus[J]. J Neural Transm, 2011, 118(1):115-133.
36. ?berg D. Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis[J]. Endocr Dev, 2010(17):63-76.
37. Parent JM, Murphy GG. Mechanisms and functional significance of aberrant seizure induced hippocampal neurogenesis[J]. Epilepsia, 2008, 49(s5):19-25.
38. Zhang L, Yang X, Yang S, et al. The Wnt/β-catenin signaling pathway in the adult neurogenesis[J]. Eur J Neurosci, 2011, 33(1):1-8.
39. Ables JL, Breunig JJ, Eisch AJ, et al. Not(ch) just development:Notch signalling in the adult brain[J]. Nat Rev Neurosci, 2011, 12(5):269-283.

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內源性神經干細胞在中樞神經系統創傷修復中的研究進展

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