Prognostic Analysis of Chronic Obstructive Pulmonary Disease and Respiratory Failure Patients with Upper Gastrointestinal Bleeding_West China Medical Journal

Authors：

 CHENPei , LIUXiao-jun , YANGXun , GUANHe-li , GAOLing-yun

Department of Respiratory, the Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;

Corresponding?author：

Keywords：

Chronic obstructive pulmonary disease; Respiratory failure; Upper gastrointestinal bleeding; Prevention

DOI：

10.7507/1002-0179.20140272

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Objective To investigate the relationship between chronic obstructive pulmonary disease (COPD) and respiratory failure in patients with upper gastrointestinal bleeding and recent prognosis. Methods We retrospectively analyzed the clinical data of 73 patients with COPD and respiratory failure treated from February 2009 to May 2011. The patients were assigned to the observing group (n=33) and control group (n=40). General characteristics, improvement rates, mortality rates, lengths of hospital stay, endotracheal tube rates and arrhythmia rates were compared between the two groups. Results Age, sex, and medical history of the patients were similar in both groups (P>0.05). Compared with the control group, the improvement rate was lower (P<0.001), the mortality rate (P<0.001), length of hospital stay (P<0.001), endotracheal tube rate (P<0.05) and arrhythmia rate (P<0.05) were all higher in the observing group after treatment. Conclusion Upper gastrointestinal bleeding is a high risk factor for short-term prognosis patients with COPD and respiratory failure.

Citation： CHENPei, LIUXiao-jun, YANGXun, GUANHe-li, GAOLing-yun. Prognostic Analysis of Chronic Obstructive Pulmonary Disease and Respiratory Failure Patients with Upper Gastrointestinal Bleeding. West China Medical Journal, 2014, 29(5): 897-899. doi: 10.7507/1002-0179.20140272 Copy

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2.	楊恂, 劉曉俊, 高凌云, 等. 糖尿病對慢性阻塞性肺疾病患者肺功能及血氣分析影響的研究[J]. 華西醫學, 2010, 25(1):9-11.
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9.	王燕英, 朱蕾, 蔡映云. 無創性通氣治療慢性阻塞性肺疾病呼吸衰竭并發上消化道出血的因素探討[J]. 中國呼吸與危重監護雜志, 2004, 3(3):173-176.
10.	胡品津, 陸再英, 鐘南山. 消化道出血[M]. 7版. 北京:人民衛生出版社, 2007:483-491.
11.	Anthonisen NR, Wright EC, Hodgkin JE. Prognosis in chronic obstructive pulmonary disease[J]. Am Rev Respir Dis, 1986, 133(1):14-20.
12.	唐昊, 修清玉. 慢性阻塞性肺疾病急性加重的研究[J]. 國際呼吸雜志, 2007, 27(3):225-229.
13.	和小文, 韓小年. 奧美拉唑防治腦卒中并發上消化道出血的觀察[J]. 吉林醫學, 2010, 31(16):2414-2415.
14.	李曉康, 陳青, 張海. 全身性皮質激素治療慢性阻塞性肺疾病急性加重期的臨床觀察[J]. 華西醫學, 2006, 21(2):354.
15.	Pirt MJ, Stanley S. Update on stress ulcer prophylaxis in critically ill patients[J]. Crit Care Nurse, 2006, 26(1):18-27.
16.	ASHP Therapeutic Guidelines on Stress Ulcer Prophylaxis. ASHP Commission on Therapeutics and approved by the ASHP Board of Directors on November 14, 1998[J]. Am J Health Syst Pharm, 1999, 56(4):347-379.

1. Han MK, Agusti A, Calverley PM, et al. Chronic obstructive pulmonary disease phenotypes:the future of COPD[J]. Am J Respir Crit Care Med, 2010, 182(5):598-604.
2. 楊恂, 劉曉俊, 高凌云, 等. 糖尿病對慢性阻塞性肺疾病患者肺功能及血氣分析影響的研究[J]. 華西醫學, 2010, 25(1):9-11.
3. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組. 慢性阻塞性肺疾病診治指南(2007年修訂版)[J]. 中華內科雜志, 2007, 30(3):254-261.
4. Liu Y, Croft JB, Anderson LA, et al. The association of chronic obstructive pulmonary disease, disability, engagement in social activities, and mortality among US adults aged 70 years or older, 1994-2006[J]. Int J Chron Obstruct Pulmon Dis, 2014(9):75-83.
5. 周小燕, 王苑蓉, 黃兆晶. 老年慢性阻塞性肺疾病患者家庭功能與應對方式調查[J]. 華西醫學, 2011, 26(4):594-597.
6. 柳濤, 蔡柏薔. 慢性阻塞性肺疾病診斷、處理和預防全球策略(2011年修訂版)介紹[J]. 中國呼吸與危重監護雜志, 2012, 11(1):1-12.
7. Huang KW, Luo JC, Leu HB, et al. Chronic obstructive pulmonary disease:an Independent risk factor for peptic ulcer bleeding:a nationwide population-based study[J]. Aliment Pharmacol Ther, 2012, 35(7):796-802.
8. Button LA, Roberts SE, Evans PA, et al. Hospitalized incidence and case fatality for upper gastrointestinal bleeding from 1999 to 2007:a record linkage study[J]. Aliment Pharmacol Ther, 2011, 33(1):64-76.
9. 王燕英, 朱蕾, 蔡映云. 無創性通氣治療慢性阻塞性肺疾病呼吸衰竭并發上消化道出血的因素探討[J]. 中國呼吸與危重監護雜志, 2004, 3(3):173-176.
10. 胡品津, 陸再英, 鐘南山. 消化道出血[M]. 7版. 北京:人民衛生出版社, 2007:483-491.
11. Anthonisen NR, Wright EC, Hodgkin JE. Prognosis in chronic obstructive pulmonary disease[J]. Am Rev Respir Dis, 1986, 133(1):14-20.
12. 唐昊, 修清玉. 慢性阻塞性肺疾病急性加重的研究[J]. 國際呼吸雜志, 2007, 27(3):225-229.
13. 和小文, 韓小年. 奧美拉唑防治腦卒中并發上消化道出血的觀察[J]. 吉林醫學, 2010, 31(16):2414-2415.
14. 李曉康, 陳青, 張海. 全身性皮質激素治療慢性阻塞性肺疾病急性加重期的臨床觀察[J]. 華西醫學, 2006, 21(2):354.
15. Pirt MJ, Stanley S. Update on stress ulcer prophylaxis in critically ill patients[J]. Crit Care Nurse, 2006, 26(1):18-27.
16. ASHP Therapeutic Guidelines on Stress Ulcer Prophylaxis. ASHP Commission on Therapeutics and approved by the ASHP Board of Directors on November 14, 1998[J]. Am J Health Syst Pharm, 1999, 56(4):347-379.

West China Medical Journal

Prognostic Analysis of Chronic Obstructive Pulmonary Disease and Respiratory Failure Patients with Upper Gastrointestinal Bleeding

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