乳腺癌干細胞的研究進展_West China Medical Journal

Authors：

 王榮 ,  羊曉勤 , 呂青

四川大學華西醫院甲狀腺乳腺外科（成都，610041）;

Corresponding?author：

羊曉勤, Email: laurayang1977@hotmail.com

Keywords：

乳腺癌; 乳腺癌干細胞; 分離; 富集; 腫瘤治療

DOI：

10.7507/1002-0179.20140301

Video：

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Abstract Full text Figures/Tables Video References Cited by

乳腺癌是女性最常見的惡性腫瘤，盡管目前治療手段逐漸多樣化、個體化，乳腺癌患者的預后仍沒有進一步提高。目前普遍認為造成乳腺癌患者復發轉移最后導致死亡的主要原因是腫瘤當中存在一部分具有高致瘤性、對放射化學療法不敏感的乳腺癌干細胞。隨著對乳腺癌干細胞研究的廣泛開展，出現了多種對乳腺癌干細胞進行分離和富集的方法，以及乳腺癌干細胞在腫瘤治療中的應用，現就乳腺癌干細胞的研究進展情況作一綜述。

Citation： 王榮, 羊曉勤, 呂青. 乳腺癌干細胞的研究進展. West China Medical Journal, 2014, 29(5): 988-991. doi: 10.7507/1002-0179.20140301 Copy

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1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013[J]. CA Cancer J Clin, 2013, 63(1):11-30.
2. 石曉君, 張曉佳, 王富生, 等. 1991-2010年中國女性乳腺癌的死亡分布特征[J]. 中華疾病控制雜志, 2012, 16(9):743-747.
3. Reya T, Morrison SJ, Clarke MF, et al. Stem cells, cancer, and cancer stem cells[J]. Nature, 2001, 414(6859):105-111.
4. Kordon EC, Smith GH. An entire functional mammary gland May comprise the progeny from a single cell[J]. Development, 1998, 125(10):1921-1930.
5. Taipale J, Beachy PA. The hedgehog and Wnt signalling pathways in cancer[J]. Nature, 2001, 411(6835):349-354.
6. Reya T, Clevers H. Wnt signalling in stem cells and cancer[J]. Nature, 2005, 434(7035):843-850.
7. Hwang-Verslues WW, Chang KJ, Lee EY, et al. Breast cancer stem cells and tumor suppressor genes[J]. J Formos Med Assoc, 2008, 107(10):751-766.
8. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell[J]. Nat Med, 1997, 3(7):730-737.
9. Phillips TM, Mcbride WH, Pajonk F. The response of CD24(-/low)/CD44⁺ breast cancer-initiating cells to radiation[J]. J Natl Cancer Inst, 2006, 98(24):1777-1785.
10. Li HZ, Yi TB, Wu ZY. Suspension culture combined with anticancer regimens for screening breast cancer stem cells[J]. Med Hypotheses, 2007, 68(5):988-990.
11. Singh SK, Clarke ID, Hide T, et al. Cancer stem cells in nervous system tumors[J]. Oncogene, 2004, 23(43):7267-7273.
12. Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells[J]. Cancer Res, 2005, 65(23):10946-10951.
13. Fang D, Nguyen TK, Leishear K, et al. A tumorigenic subpopulation with stem cell properties in melanomas[J]. Cancer Res, 2005, 65(20):9328-9337.
14. O' brien CA, Pollett A, Gallinger S, et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice[J]. Nature, 2007, 445(7123):106-110.
15. Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells[J]. Nature, 2007, 445(7123):111-115.
16. Matsui W, Huff CA, Wang Q, et al. Characterization of clonogenic multiple myeloma cells[J]. Blood, 2004, 103(6):2332-2336.
17. Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells[J]. Cancer Res, 2007, 67(3):1030-1037.
18. Kim CF, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer[J]. Cell, 2005, 121(6):823-835.
19. Passegué E, Jamieson CH, Ailles LE, et al. Normal and leukemic hematopoiesis:are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?[J]. Proc Natl Acad Sci USA, 2003, 100(Suppl(1):11842-11849.
20. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells[J]. Proc Natl Acad Sci USA, 2003, 100(7):3983-3988.
21. Patrawala L, Calhoun T, Schneider-Broussard R, et al. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2-cancer cells are similarly tumorigenic[J]. Cancer Res, 2005, 65(14):6207-6219.
22. Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties[J]. Cancer Res, 2005, 65(13):5506-5511.
23. Charafe-Jauffret E, Ginestier C, Iovino F, et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature[J]. Cancer Res, 2009, 69(4):1302-1313.
24. Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy[J]. Breast Cancer Res, 2008, 10(2):R25.
25. Ginestier C, Hur MH, Charafe-Jauffret E, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome[J]. Cell Stem Cell, 2007, 1(5):555-567.
26. Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells[J]. Genes Dev, 2003, 17(10):1253-1270.
27. Montanaro F, Liadaki K, Schienda J, et al. Demystifying SP cell purification:viability, yield, and phenotype are defined by isolation parameters[J]. Exp Cell Res, 2004, 298(1):144-154.
28. Ucar D, Cogle CR, Zucali JR, et al. Aldehyde dehydrogenase activity as a functional marker for lung cancer[J]. Chem Biol Interact, 2009, 178(1/3):48-55.
29. Gillet JP, Gottesman MM. Mechanisms of multidrug resistance in cancer[J]. Methods Mol Biol, 2010, 596:47-76.
30. Kenney NJ, Smith GH, Lawrence E, et al. Identification of stem cell units in the terminal end bud and duct of the mouse mammary gland[J]. J Biomed Biotechnol, 2001, 1(3):133-143.
31. Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily[J]. J Lipid Res, 2001, 11(7):1156-1166.
32. Nishio K, Nakamura T, Koh Y, et al. Drug resistance in lung cancer[J]. Curr Opin Oncol, 1999, 11(2):109.
33. Gossage L, Madhusudan S. Current status of excision repair cross complementing-group 1(ERCC1) in cancer[J]. Cancer Treat Rev, 2007, 33(6):565-577.
34. Li GM. Mechanisms and functions of DNA mismatch repair[J]. Cell Res, 2008, 18(1):85-98.
35. Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance[J]. Nat Rev Cancer, 2005, 5(4):275-284.
36. 王文靜. 側群細胞的研究進展[J]. 國際口腔醫學雜志, 2011, 38(6):665-669.
37. Hirsch HA, Iliopoulos D, Tsichlis PN, et al. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission[J]. Cancer Res, 2009, 69(19):7507-7511.
38. Iliopoulos D, Hirsch HA, Struhl K. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types[J]. Cancer Res, 2011, 71(9):3196-3201.

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乳腺癌干細胞的研究進展

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