Changes of Erythrocyte Sedimentation Rates, C-reactive Protein, and Serum Amyloid A Proteins after Different Types of Hip Replacement and Their Clinical Significances_West China Medical Journal

Authors：

 HUANGRui-liang ¹ ,  LINWei-wen ¹ , RUANYi ² , XIONGHao ¹ , LIUWei ¹ , XIAXiong-chao ¹ , LINGHua-jun ¹

1. Department of Orthopedics;Gaoming Hospital Affiliated to Guangdong Medical College, Foshan, Guangdong 528500, P. R. China;
2. Department of Orthopedics, Genghe Branch of Gaoming Hospital;Gaoming Hospital Affiliated to Guangdong Medical College, Foshan, Guangdong 528500, P. R. China;

Corresponding?author：

LINWei-wen, Email: sixlin666@163.com

Keywords：

Hip replacement surgery; Erythrocyte sedimentation rate; C-reactive protein; Serum amyloid A protein

DOI：

10.7507/1002-0179.20140380

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To observe the changing patterns of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and serum amyloid A protein (SAA) levels before and after hip replacement surgery, and explore their clinical significances. Methods Ninety-seven consecutive patients enrolled in clinical pathway in our hospital for hip replacement from April 2011 to May 2013 were included in the present study. ESR, CRP and SAA levels were investigated preoperatively and post-operatively at day 1, 3, 5, 7, 14, Month 1 and 3. All the cases were followed up, among which there were 14 cases of total hip replacement, 56 cases of cementless hemianthroplasty, and 27 cases of biotype hemianthroplasty. Results All three of ESR, CRP and SAA levels were elevated post-operatively. Levels of CRP and SAA peaked at day 3 after surgery, and then subsided gradually to pre-operative levels after 1 month. ESR level peaked at day 7 postoperatively, and then subsided gradually to pre-operative levels after 3 months. There was a significant correlation between levels of CRP and levels of SAA. Conclusion Compared with ESR and SAA, CRP appears to be a faster and more sensitive parameter. Cementless hemianthroplasty is associated with changes of SAA levels but not with CRP levels. Close monitoring of evolutionary changes in ESR, SAA and CRP levels may help to diagnose and treat early infection after hip replacement surgery.

Citation： HUANGRui-liang, LINWei-wen, RUANYi, XIONGHao, LIUWei, XIAXiong-chao, LINGHua-jun. Changes of Erythrocyte Sedimentation Rates, C-reactive Protein, and Serum Amyloid A Proteins after Different Types of Hip Replacement and Their Clinical Significances. West China Medical Journal, 2014, 29(7): 1234-1237. doi: 10.7507/1002-0179.20140380 Copy

1.	張炅, 馮建民, 王毅, 等. 三相同位素骨掃描診斷髖關節置換后感染的臨床意義[J]. 中國組織工程研究與臨床康復, 2010, 25(4):3041-3045.
2.	MeIler J, Sahlmann CO, Scheel AK. ¹⁸F-FDG PET and PET/CT in fever of unknown origin[J]. J Nucl Med, 2007, 48(1):35-45.
3.	付娜, 鞏路. ¹⁸F-FDG PET/CT對不明原因發熱的診斷價值分析[J]. 臨床薈萃, 2013, 28(5):519-521.
4.	耿紅蓮, 仲人前. 血清淀粉樣物質A研究進展[J]. 現代檢驗醫學雜志, 2010, 25(4):10-12.
5.	儲誠兵, 王繼芳, 王巖, 等. 生化檢查對人工髖關節感染的診斷價值[J]. 中華醫院感染學雜志, 2006, 16(4):403-405.
6.	陳展宇, 梁曉春, 萬智慧. 人工髖關節置換術前后CRP與ESR水平變化研究[J]. 中國醫療前沿, 2010, 5(6):11-12.
7.	陳家富, 孔榮. CRP ESR和WBC計數在髖關節置換手術前后的變化及臨床意義[J]. 安徽醫學, 2012, 33(2):162-164.
8.	宋炎成, 張慧慧, 盧華定, 等. CRP、ESR在關節置換手術前后變化及其臨床意義[J]. 中國矯形外科雜志, 2008, 16(11):823-825.
9.	Shen H, Zhang N, Zhang X, et al. C-reactive protein levels after 4 types of arthroplasty[J]. Acta Orthop, 2009, 80(3):330-333.
10.	White J, Kelly M, Dunsmuir R. C-reactive protein level after total hip and total knee replacement[J]. J Bone Joint Surg Br, 1998, 80(5):909-911.
11.	儲怡星, 張錦鋒, 范基農, 等. C反應蛋白水平對判斷炎癥和創傷轉歸的價值[J]. 上海醫學檢驗雜志, 2000, 15(3):155-156.
12.	林永恩, 胡靜云, 陳棟, 等. 全程CRP、WBC、ANC聯合檢測在血液細菌感染中的應用[J]. 海南醫學, 2011, 22(9):104-105.
13.	Lannerg?rd A, Larsson A, Kragsbjerg P, et al. Correlations between serum amyloid A protein and C-reactive protein in infectious diseases[J]. Scand J Clin Lab Invest, 2003, 63(4):267-272.
14.	Hartmann A, Eide TC, Fauchald P, et al. Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection[J]. Nephrol Dial Transplant, 1997, 12(1):161-166.
15.	Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states[J]. Curr Opin Hematol, 2000, 7(1):64-69.
16.	盛秀芝, 蔡溢, 周杰. 血清淀粉樣蛋白A在腎移植術后排斥反應診斷中的價值[J]. 中國實驗診斷學, 2010, 14(2):242.
17.	陳玉玲, 孫莉, 鄭春京. 術后鎮痛對C-反應蛋白和血清淀粉樣A蛋白的影響[J]. 中國臨床醫生, 2006, 34(3):39-40.

1. 張炅, 馮建民, 王毅, 等. 三相同位素骨掃描診斷髖關節置換后感染的臨床意義[J]. 中國組織工程研究與臨床康復, 2010, 25(4):3041-3045.
2. MeIler J, Sahlmann CO, Scheel AK. ¹⁸F-FDG PET and PET/CT in fever of unknown origin[J]. J Nucl Med, 2007, 48(1):35-45.
3. 付娜, 鞏路. ¹⁸F-FDG PET/CT對不明原因發熱的診斷價值分析[J]. 臨床薈萃, 2013, 28(5):519-521.
4. 耿紅蓮, 仲人前. 血清淀粉樣物質A研究進展[J]. 現代檢驗醫學雜志, 2010, 25(4):10-12.
5. 儲誠兵, 王繼芳, 王巖, 等. 生化檢查對人工髖關節感染的診斷價值[J]. 中華醫院感染學雜志, 2006, 16(4):403-405.
6. 陳展宇, 梁曉春, 萬智慧. 人工髖關節置換術前后CRP與ESR水平變化研究[J]. 中國醫療前沿, 2010, 5(6):11-12.
7. 陳家富, 孔榮. CRP ESR和WBC計數在髖關節置換手術前后的變化及臨床意義[J]. 安徽醫學, 2012, 33(2):162-164.
8. 宋炎成, 張慧慧, 盧華定, 等. CRP、ESR在關節置換手術前后變化及其臨床意義[J]. 中國矯形外科雜志, 2008, 16(11):823-825.
9. Shen H, Zhang N, Zhang X, et al. C-reactive protein levels after 4 types of arthroplasty[J]. Acta Orthop, 2009, 80(3):330-333.
10. White J, Kelly M, Dunsmuir R. C-reactive protein level after total hip and total knee replacement[J]. J Bone Joint Surg Br, 1998, 80(5):909-911.
11. 儲怡星, 張錦鋒, 范基農, 等. C反應蛋白水平對判斷炎癥和創傷轉歸的價值[J]. 上海醫學檢驗雜志, 2000, 15(3):155-156.
12. 林永恩, 胡靜云, 陳棟, 等. 全程CRP、WBC、ANC聯合檢測在血液細菌感染中的應用[J]. 海南醫學, 2011, 22(9):104-105.
13. Lannerg?rd A, Larsson A, Kragsbjerg P, et al. Correlations between serum amyloid A protein and C-reactive protein in infectious diseases[J]. Scand J Clin Lab Invest, 2003, 63(4):267-272.
14. Hartmann A, Eide TC, Fauchald P, et al. Serum amyloid A protein is a clinically useful indicator of acute renal allograft rejection[J]. Nephrol Dial Transplant, 1997, 12(1):161-166.
15. Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states[J]. Curr Opin Hematol, 2000, 7(1):64-69.
16. 盛秀芝, 蔡溢, 周杰. 血清淀粉樣蛋白A在腎移植術后排斥反應診斷中的價值[J]. 中國實驗診斷學, 2010, 14(2):242.
17. 陳玉玲, 孫莉, 鄭春京. 術后鎮痛對C-反應蛋白和血清淀粉樣A蛋白的影響[J]. 中國臨床醫生, 2006, 34(3):39-40.

West China Medical Journal

Changes of Erythrocyte Sedimentation Rates, C-reactive Protein, and Serum Amyloid A Proteins after Different Types of Hip Replacement and Their Clinical Significances

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content