Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis_West China Medical Journal

Authors：

 LINKeng

Department of Clinical Laboratory, Women and Children's Hospital of Huadu District, Guangzhou, Guangdong 510800, P. R. China;

Corresponding?author：

Keywords：

Anti-syphilis; Pregnancy; Pregnancy outcome; Neonatal prognosis

DOI：

10.7507/1002-0179.20140388

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the influence of treatment against syphilis on pregnancy outcome and neonatal prognosis. Methods The data of 5224 cases of pregnant women from January to December 2013 were analyzed. All the pregnant women were screened by toluidine red unheated serum test (TRUST) method. Then, T.pallidum passive partideag glutining assay (TPPA) was used to confirm those positive cases from TRUST. At last, 128 cases of syphilis in those pregnant women were confirmed. According to whether the pregnant women accepted antenatal examination and treatment, they were divided into treatment group and non-treatment group. The pregnancy outcome and neonatal prognosis of these two groups of women were then compared and analyzed. Results The pregnancy outcome of these two groups had comparatively big difference, but without significant difference (χ²=3.34, P>0.05). The neonatal prognosis of the two groups was significantly different (χ²=9.14, P<0.05). Moreover, TPPA showed positive in all newborn infants, and TURST showed 85 positive cases. Conclusion Early finding and treatment of pregnant women with syphilis by screening before pregnancy or during the early period of pregnancy can reduce abortion, stillbirth, fetal abnormalities, and the incidence of neonatal congenital syphilis.

Citation： LINKeng. Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis. West China Medical Journal, 2014, 29(7): 1267-1270. doi: 10.7507/1002-0179.20140388 Copy

1.	王臨虹, 王玲, 王愛玲, 等. 先天梅毒防治指南(一)[J]. 中國婦幼衛生雜志, 2010, l(4):185-188.
2.	王臨虹, 王玲, 王愛玲, 等. 先天梅毒防治指南(二)[J]. 中國婦幼衛生雜志, 2010, 1(5):238-244.
3.	袁柳. 探討三種梅毒血清學檢驗方法的臨床應用[J]. 中國醫藥指南, 2013, 11(2):241-242.
4.	于恩庶, 邵康蔚, 原壽基. 艾滋病與性病學[M]. 廈門:廈門大學出版社, 1993:363-364.
5.	劉冬先, 陳興平, 周禮義. 先天梅毒43例臨床分析及預防探討[J]. 中國麻風皮膚病雜志, 2004, 20(5):461-462.
6.	王千秋, 張國成. 性傳播疾病臨床診療指南[M]. 上海:上海科學技術出版社, 2007:1-2.
7.	馮永芳, 曾志良, 黃萌, 等. 一家三口同患梅毒[J]. 中國皮膚性病學雜志, 2009, 23(6):366-367.
8.	周敏, 陳竹, 曾義嵐, 等. 抗梅毒治療對妊娠結局及新生兒預后的影響[J]. 中華臨床感染病雜志, 2013, 6(4):226-228.
9.	粱嵐. 妊娠期梅毒68例臨床分析[J]. 中國實用醫藥, 2009, 4(8):100-101.
10.	Peeling RW, Ye H. Diagnostic tools for preventing and managing maternal and congenital syphilis:an overview[J]. Bull World Health Organ, 2004, 82(6):439-446.
11.	曹志君, 王偉民, 黃慧娟, 等. 妊娠期梅毒患者圍產結局的臨床分析[J]. 中華婦產科雜志, 2011, 36(3):170-171.
12.	陳涵強, 楊斌, 張爾泉. 52例新生兒梅毒臨床觀察[J]. 中華圍產醫學雜志, 1999, 2(4):255.
13.	王紅兵, 丘瑾, 潘群. 抗梅毒治療對妊娠合并梅毒孕婦及胎兒的影響[J]. 同濟大學學報·醫學版, 2003, 24(5):449-451.
14.	樊尚榮, 董悅. 妊娠合并梅毒[J]. 中華圍產醫學雜志, 1998, 1(3):190-192.
15.	劉小平, 樊尚榮. 妊娠期抗梅毒治療后新生兒先天梅毒[J]. 國外醫學·婦產科學分冊, 2003, 30(2):126-127.
16.	吳瑞萍, 胡亞美, 江載芳, 等. 實用兒科學[M]. 6版. 北京:人民衛生出版社, 1995:980-985.

1. 王臨虹, 王玲, 王愛玲, 等. 先天梅毒防治指南(一)[J]. 中國婦幼衛生雜志, 2010, l(4):185-188.
2. 王臨虹, 王玲, 王愛玲, 等. 先天梅毒防治指南(二)[J]. 中國婦幼衛生雜志, 2010, 1(5):238-244.
3. 袁柳. 探討三種梅毒血清學檢驗方法的臨床應用[J]. 中國醫藥指南, 2013, 11(2):241-242.
4. 于恩庶, 邵康蔚, 原壽基. 艾滋病與性病學[M]. 廈門:廈門大學出版社, 1993:363-364.
5. 劉冬先, 陳興平, 周禮義. 先天梅毒43例臨床分析及預防探討[J]. 中國麻風皮膚病雜志, 2004, 20(5):461-462.
6. 王千秋, 張國成. 性傳播疾病臨床診療指南[M]. 上海:上海科學技術出版社, 2007:1-2.
7. 馮永芳, 曾志良, 黃萌, 等. 一家三口同患梅毒[J]. 中國皮膚性病學雜志, 2009, 23(6):366-367.
8. 周敏, 陳竹, 曾義嵐, 等. 抗梅毒治療對妊娠結局及新生兒預后的影響[J]. 中華臨床感染病雜志, 2013, 6(4):226-228.
9. 粱嵐. 妊娠期梅毒68例臨床分析[J]. 中國實用醫藥, 2009, 4(8):100-101.
10. Peeling RW, Ye H. Diagnostic tools for preventing and managing maternal and congenital syphilis:an overview[J]. Bull World Health Organ, 2004, 82(6):439-446.
11. 曹志君, 王偉民, 黃慧娟, 等. 妊娠期梅毒患者圍產結局的臨床分析[J]. 中華婦產科雜志, 2011, 36(3):170-171.
12. 陳涵強, 楊斌, 張爾泉. 52例新生兒梅毒臨床觀察[J]. 中華圍產醫學雜志, 1999, 2(4):255.
13. 王紅兵, 丘瑾, 潘群. 抗梅毒治療對妊娠合并梅毒孕婦及胎兒的影響[J]. 同濟大學學報·醫學版, 2003, 24(5):449-451.
14. 樊尚榮, 董悅. 妊娠合并梅毒[J]. 中華圍產醫學雜志, 1998, 1(3):190-192.
15. 劉小平, 樊尚榮. 妊娠期抗梅毒治療后新生兒先天梅毒[J]. 國外醫學·婦產科學分冊, 2003, 30(2):126-127.
16. 吳瑞萍, 胡亞美, 江載芳, 等. 實用兒科學[M]. 6版. 北京:人民衛生出版社, 1995:980-985.

West China Medical Journal

Influence of Anti-syphilis Treatment on Pregnancy Outcome and Neonatal Prognosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content