Study on Effects of Different Penetration Enhancers on the Transdemal Penetration of Miao Medicine Named Diploclisia Affinis_West China Medical Journal

Authors：

 XUDing-ping

Department of Pharmacy, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei 445000, P. R. China;

Corresponding?author：

Keywords：

Diploclisia affinis; Sinomenines; Penetration enhancers; Percutaneous absorption; High performance liquid chromatography

DOI：

10.7507/1002-0179.20140401

Video：

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Objective To study the effects of different penetration enhancers on the transdermal penetration of Miao medicine named Diploclisia affinis. Methods Improved Franz diffusion cell was adopted as the apparatus for in vitro mouse' skin permeation. The kinetic parameters of percutaneous absorption, such as penetration rate, enhancing rate (ER), and lag time (T_lag) were determined by high performance liquid chromatography. Azone, oleic acid (OA) and borneol were investigated for percutaneous absorption effects. Results The penetration rates of the medicine with 3% azone, OA and borneol added were respectively (214.1872±13.5690), (227.5544±9.8490), and (168.1187±21.5640) μg/(cm²·h), and the ER was 1.61, 1.71, and 1.26 compared with the penetration rate of that with nothing added. The T_lag was 2.1081, 1.8256, and 2.9655 hours. Conclusion All the penetration enhancers can increase significantly the absorption of Miao medicine named Diploclisia affinis, especially 3% OA is the best, but 3% borneol may make the T_lag longer.

Citation： XUDing-ping. Study on Effects of Different Penetration Enhancers on the Transdemal Penetration of Miao Medicine Named Diploclisia Affinis. West China Medical Journal, 2014, 29(7): 1316-1318. doi: 10.7507/1002-0179.20140401 Copy

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1. 方志先, 廖朝林. 湖北恩施藥用植物志-上冊[M]. 武漢:湖北科學技術出版社, 2006:459.
2. 中國科學院華南植物研究所. 廣東植物志(第一卷)[M]. 廣州:廣東科技出版社, 1987:36.
3. 趙國平, 戴慎, 陳仁壽, 等. 中藥大辭典[M]. 2版. 上海:上海科學技術出版社, 2006:516.
4. 徐定平. 苗藥秤鉤風中青藤堿的提取工藝研究[J]. 中國醫藥指南, 2013, 11(8):30-31.
5. 國家藥典委員會. 中華人民共和國藥典[M]. 北京:化學工業出版社, 2009:155-158.
6. 雷海民, 朱蓉, 魏璐雪. 異葉敗醬化學成分的研究[J]. 中國藥學雜志, 1997, 32(5):2712-2731.
7. 何嘉侖, 唐洪梅, 涂星, 等. 吳茱萸提取物的透皮吸收促進劑的篩選[J]. 中成藥, 2013, 35(6):1184-1187.
8. 盧映, 涂星, 吳俊洪, 等. 不同基質和促滲劑對川芎嗪凝膠經皮吸收的影響[J]. 中藥新藥與臨床藥理, 2013, 24(2):166-169.
9. 周莉玲, 李銳, 周華, 等. 青藤堿制劑藥動學相關性研究[J]. 中成藥, 1996, 18(9):1.
10. Naik A, Pechtold L, Potts RO. Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans[J]. J Controlled Release, 1995, 37(3):229.
11. Mangusson BM, Runn P, Karlsson K. Terpenes and ethanol enhance the transdermal permeation of the tripeptide[J]. Int J Pharm, 1997, 157(1):1113.
12. Ferrante M, Andreeta A, Landoni MF. Effect of different penetration enhancers on diclofenac permeation across horse skin[J]. Vet J, 2010, 186(3):312-315.
13. 李莉, 韓國柱. 中草藥揮發油類透皮吸收促進作用研究進展[J]. 中國新藥雜志, 2008, 17(11):914-918, 946.
14. 李熙, 劉玉亭, 吳淑梅, 等. 青藤堿微乳體外透皮特性的研究[J]. 中成藥, 2008, 30(8):1119-1122.
15. 程怡, 高幼衡, 王利勝, 等. 冰片在不同溶劑載體中透皮速率的動力學特征[J]. 中草藥, 2000, 31(8):49-51.

West China Medical Journal

Study on Effects of Different Penetration Enhancers on the Transdemal Penetration of Miao Medicine Named Diploclisia Affinis

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