全身麻醉下超快速脫毒的研究進展_West China Medical Journal

Authors：

 歐夢嬋 ,  李羽

四川大學華西醫院麻醉科（成都，610041）;

Corresponding?author：

李羽, Email: biaojieli@tom.com

Keywords：

阿片類藥物; 成癮; 全身麻醉; 超快速阿片類脫毒; 脫毒

DOI：

10.7507/1002-0179.20140485

Video：

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Abstract Full text Figures/Tables Video References Cited by

全身麻醉（全麻）下超快速阿片類脫毒是一種新的脫毒方法，即在全麻患者無意識時運用大劑量的阿片類藥物拮抗劑激發戒斷癥狀的發生，使患者安全地渡過脫毒期。與傳統的利用美沙酮等脫毒方法相比，它具有近期脫毒成功率高、時間短、患者痛苦少等特點。現就全麻下超快速脫毒的研究進展作一綜述。

Citation： 歐夢嬋, 李羽. 全身麻醉下超快速脫毒的研究進展. West China Medical Journal, 2014, 29(8): 1586-1588. doi: 10.7507/1002-0179.20140485 Copy

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14.	羅俊, 劉進, 劉斌. 全麻下納曲酮快速阿片類脫毒1例分析[J]. 中國誤診學雜志, 2007, 7(18):4429-4430.
15.	Hensel M, Kox WJ. Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia:a prospective study in methadone, heroin, codeine and morphine addicts[J]. Acta Anaesthesiol Scand, 2000, 44(3):326-333.
16.	Nasr D, Omran H, Hakim SM, et al. Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia[J]. J Opioid Manag, 2011, 7(5):337-344.
17.	Roozen HG, De Kan R, Van Den Brink W, et al. Dangers involved in rapid opioid detoxification while using opioid antagonists:dehydration and renal failure[J]. Addiction, 2002, 97(8):1071-1073.
18.	Kaye AD, Gevirtz C, Bosscher HA, et al. Ultrarapid opiate detoxification:a review[J]. Can J Anaesth, 2003, 50(7):663-671.
19.	Safari F, Mottaghi K, Malek S, et al. Effect of ultra-rapid opiate detoxification on withdrawal syndrome[J]. J Addict Dis, 2010, 29(4):449-454.
20.	Nasseri K, Ahsan B, Farhadifar F, et al. Shortening anesthesia duration does not affect severity of withdrawal syndrome in patients undergoing ultra rapid opioid detoxification[J]. Acta Med Iran, 2010, 48(1):27-32.
21.	Streel E, Verbanck P. Ultra-rapid opiate detoxification:from clinical applications to basic science[J]. Addict Biol, 2003, 8(2):141-146.

1. Cami J, Farre M. Drug addiction[J]. N Engl J Med, 2003, 349(10):975-986.
2. 吳寧, 李錦. 藥物成癮的生物學本質[J]. 中國藥物濫用防治雜志, 2013, 19(1):1-6, 19.
3. Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction:the role of reward-related learning and memory[J]. Annu Rev Neurosci, 2006(29):565-598.
4. Mcclung CA, Nestler EJ. Regulation of gene expression and cocaine reward by CREB and DeltaFosB[J]. Nat Neurosci, 2003, 6(11):1208-1215.
5. Zachariou V, Bolanos CA, Selley DE, et al. An essential role for DeltaFosB in the nucleus accumbens in morphine action[J]. Nat Neurosci, 2006, 9(2):205-211.
6. Kalivas PW, O'brien C. Drug addiction as a pathology of staged neuroplasticity[J]. Neuropsychopharmacology, 2008, 33(1):166-180.
7. 徐啟明, 郭曲練, 姚尚龍, 等. 臨床麻醉學[M]. 2版. 北京:人民衛生出版社, 2005:415-418.
8. Bryson EO, Elizabeth AM, Frost. Perioperative addiction:clinical management of the addicted patient[M]. New York:Springer, 2012:10-50.
9. Raisch DW, Fye CL, Boardman KD, et al. Opioid dependence treatment, including buprenorphine/naloxone[J]. Ann Pharmacother, 2002, 36(2):312-321.
10. Singh J, Basu D. Ultra-rapid opioid detoxification:current status and controversies[J]. J Postgrad Med, 2004, 50(3):227-232.
11. Demaria PA, Rodgers C, Braccia G. Propofol for sedation during rapid opiate detoxification[J]. Am J Psychiatry, 1997, 154(2):290-291.
12. Cucchia AT, Monnat M, Spagnoli J, et al. Ultra-rapid opiate detoxification using deep sedation with oral midazolam:short and long-term results[J]. Drug Alcohol Depend, 1998, 52(3):243-250.
13. Gutiérrez REP. Clinical case of rapid opiate detoxification under anesthesia[J]. Anestesia Pediatrica e Neonatale, 2011, 9:1-9.
14. 羅俊, 劉進, 劉斌. 全麻下納曲酮快速阿片類脫毒1例分析[J]. 中國誤診學雜志, 2007, 7(18):4429-4430.
15. Hensel M, Kox WJ. Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia:a prospective study in methadone, heroin, codeine and morphine addicts[J]. Acta Anaesthesiol Scand, 2000, 44(3):326-333.
16. Nasr D, Omran H, Hakim SM, et al. Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia[J]. J Opioid Manag, 2011, 7(5):337-344.
17. Roozen HG, De Kan R, Van Den Brink W, et al. Dangers involved in rapid opioid detoxification while using opioid antagonists:dehydration and renal failure[J]. Addiction, 2002, 97(8):1071-1073.
18. Kaye AD, Gevirtz C, Bosscher HA, et al. Ultrarapid opiate detoxification:a review[J]. Can J Anaesth, 2003, 50(7):663-671.
19. Safari F, Mottaghi K, Malek S, et al. Effect of ultra-rapid opiate detoxification on withdrawal syndrome[J]. J Addict Dis, 2010, 29(4):449-454.
20. Nasseri K, Ahsan B, Farhadifar F, et al. Shortening anesthesia duration does not affect severity of withdrawal syndrome in patients undergoing ultra rapid opioid detoxification[J]. Acta Med Iran, 2010, 48(1):27-32.
21. Streel E, Verbanck P. Ultra-rapid opiate detoxification:from clinical applications to basic science[J]. Addict Biol, 2003, 8(2):141-146.

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