Analysis of High-risk Factors for Death in Infants with Severe Pneumonia_West China Medical Journal

Authors：

 LIMao-xia ^1,2 ,  WANChao-min ¹ , LEIMing-yu ²

1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Emergency, Chengdu Women and Children's Central Hospital, Chengdu, Sichuan 610091, P. R. China;

Corresponding?author：

WANChao-min, Email: wcm0220@sina.com

Keywords：

Severe pneumonia; Infants; Death; High-risk factors

DOI：

10.7507/1002-0179.20140516

Video：

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Objective To investigate the high-risk factors for death in infants with severe pneumonia. Methods We analyzed hospitalized infants and young children diagnosed with severe pneumonia from January 2011 to December 2013, and investigated the risk factors for death. Results A total of 1 411 infants with severe pneumonia were included in the analysis. The mortality rate was 3.12%. In single factor analysis, the following factors were significant:age, severe infection, artificial feeding, congenital heart diseases, bad habitation, repeated infection history, surgical history, multi-organ dysfunction, internal environment disorder, multiple drug-resistant strains infection. The results of Logistic multiple regression analysis showed that there were statistical significance in severe infection, repeated infection history, Multiple drug-resistant strains infection, multi-organ dysfunction, and internal environment disorder. Conclusion Infants with severe pneumonia should be intensively monitored and actively treated for reducing the mortality rate if they have one of the following high-risk factors:age, congenital heart diseases, repeated infection history, multiple drug-resistant strains infection, surgical history, multi-organ dysfunction, and internal environment disorder.

Citation： LIMao-xia, WANChao-min, LEIMing-yu. Analysis of High-risk Factors for Death in Infants with Severe Pneumonia. West China Medical Journal, 2014, 29(9): 1693-1696. doi: 10.7507/1002-0179.20140516 Copy

1.	王衛平,毛萌,李廷玉,等.兒科學[M].8版.北京:人民衛生出版社,2013:277.
2.	中華醫學會兒科學分會呼吸學組,中華兒科雜志編輯委員會.兒童社區獲得性肺炎管理指南(試行)(上)[J].中華兒科雜志,2007,45(2):83-90.
3.	British Thoracic Society of standards of care committee.BTS guidelines for the community acquired pneumonia in childhood[J].Thorax,2002,57(Suppl):S1-S24.
4.	Rudan I,Boschi-Pinto C,Biloglav ZA,et al.Epidemiology and etiology of childhood pneumonia[J].Bull World Health Organ,2008,86(5):408-416.
5.	Singh V,Aneja S.Pneumonia-management in the developing world[J].Paediatr Respir Rev,2011,12(1):52-59.
6.	Scott JA,Brooks WA,Peiris JS,et al.Pneumonia research to reduce childhood mortality in the developing world[J].J Clin Invest,2008,118(4):1291-1300.
7.	Tiewsoh K,Lodha R,Pandey RM,et al.Factors determining the outcome of children hospitalized with severe pneumonia[J].BMC Pediatr,2009,9:15.
8.	Chisti MJ,Salam MA,Ashraf H,et al.Clinical risk factors of death from pneumonia in children with severe acute malnutrition in an urban critical care ward of Bangladesh[J].PLoS One,2013,8(9):e73728.
9.	Okiro EA,Ngama M,Bett A,et al.Factors associated with increased risk of progression to respiratory syncytial virus-associated pneumonia in young Kenyan children[J].Trop Med Int Health,2008,13(7):914-926.
10.	Lupisan SP,Ruutu P,Erma Abucejo-Ladesma P,et al.Predictors of death from severe pneumonia among children 2-59 months old hospitalized in Bohol,Philippines:implications for referral criteria at a first-level health facility[J].Trop Med Int Health,2007,12(8):962-971.
11.	Rudan I,Tomaskovic L,Boschi-Pinto C,et al.Global estimate of the incidence of clinical pneumonia among children under five years of age[J].Bull World Health Organ,2004,82(12):895-903.
12.	徐蘋,王強.血清降鈣素原在嬰幼兒重癥肺炎早期診斷中的價值[J].現代實用醫學,2010,22(10):1176-1177.
13.	董宗祈.呼吸系統的防御功能及其保護措施[J].實用兒科臨床雜志,2004,19(2):158-160.
14.	范志忠,趙勇,吳永,等.164例嬰幼兒重癥肺炎高危因素分析[J].中華全科醫學,2009,7(4):370-371.
15.	楊小青,黃英.兒童重癥肺炎的高危因素認識及其對策[J].兒科藥學雜志,2010,16(2):55-57.
16.	陳愛斌.嬰幼兒重癥肺炎死亡高危因素分析[J].實用全科醫學,2005,3(5):437-438.
17.	丁小芳,張兵,鐘禮立,等.兒童重癥社區獲得性肺炎病毒學檢測和危險因素分析[J].中國當代兒科雜志,2012,14(6):449-453.
18.	劉釗鋒.小兒難治性肺炎病因分析及治療觀察[J].臨床醫學,2012,32(3):95-96.
19.	Wunderink RG,Mendelson MH,Somero MS,et al.Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus[J].Chest,2008,134(6):1200-1207.
20.	李玖軍,劉春峰,袁壯,等.嬰幼兒先天性心臟病合并重癥肺炎的治療[J].中國當代兒科雜志,2009,11(8):635-637.
21.	姜大朋.小兒圍手術期低體溫及防治[J].中國實用護理雜志,2005,21(14):62-63.

1. 王衛平,毛萌,李廷玉,等.兒科學[M].8版.北京:人民衛生出版社,2013:277.
2. 中華醫學會兒科學分會呼吸學組,中華兒科雜志編輯委員會.兒童社區獲得性肺炎管理指南(試行)(上)[J].中華兒科雜志,2007,45(2):83-90.
3. British Thoracic Society of standards of care committee.BTS guidelines for the community acquired pneumonia in childhood[J].Thorax,2002,57(Suppl):S1-S24.
4. Rudan I,Boschi-Pinto C,Biloglav ZA,et al.Epidemiology and etiology of childhood pneumonia[J].Bull World Health Organ,2008,86(5):408-416.
5. Singh V,Aneja S.Pneumonia-management in the developing world[J].Paediatr Respir Rev,2011,12(1):52-59.
6. Scott JA,Brooks WA,Peiris JS,et al.Pneumonia research to reduce childhood mortality in the developing world[J].J Clin Invest,2008,118(4):1291-1300.
7. Tiewsoh K,Lodha R,Pandey RM,et al.Factors determining the outcome of children hospitalized with severe pneumonia[J].BMC Pediatr,2009,9:15.
8. Chisti MJ,Salam MA,Ashraf H,et al.Clinical risk factors of death from pneumonia in children with severe acute malnutrition in an urban critical care ward of Bangladesh[J].PLoS One,2013,8(9):e73728.
9. Okiro EA,Ngama M,Bett A,et al.Factors associated with increased risk of progression to respiratory syncytial virus-associated pneumonia in young Kenyan children[J].Trop Med Int Health,2008,13(7):914-926.
10. Lupisan SP,Ruutu P,Erma Abucejo-Ladesma P,et al.Predictors of death from severe pneumonia among children 2-59 months old hospitalized in Bohol,Philippines:implications for referral criteria at a first-level health facility[J].Trop Med Int Health,2007,12(8):962-971.
11. Rudan I,Tomaskovic L,Boschi-Pinto C,et al.Global estimate of the incidence of clinical pneumonia among children under five years of age[J].Bull World Health Organ,2004,82(12):895-903.
12. 徐蘋,王強.血清降鈣素原在嬰幼兒重癥肺炎早期診斷中的價值[J].現代實用醫學,2010,22(10):1176-1177.
13. 董宗祈.呼吸系統的防御功能及其保護措施[J].實用兒科臨床雜志,2004,19(2):158-160.
14. 范志忠,趙勇,吳永,等.164例嬰幼兒重癥肺炎高危因素分析[J].中華全科醫學,2009,7(4):370-371.
15. 楊小青,黃英.兒童重癥肺炎的高危因素認識及其對策[J].兒科藥學雜志,2010,16(2):55-57.
16. 陳愛斌.嬰幼兒重癥肺炎死亡高危因素分析[J].實用全科醫學,2005,3(5):437-438.
17. 丁小芳,張兵,鐘禮立,等.兒童重癥社區獲得性肺炎病毒學檢測和危險因素分析[J].中國當代兒科雜志,2012,14(6):449-453.
18. 劉釗鋒.小兒難治性肺炎病因分析及治療觀察[J].臨床醫學,2012,32(3):95-96.
19. Wunderink RG,Mendelson MH,Somero MS,et al.Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus[J].Chest,2008,134(6):1200-1207.
20. 李玖軍,劉春峰,袁壯,等.嬰幼兒先天性心臟病合并重癥肺炎的治療[J].中國當代兒科雜志,2009,11(8):635-637.
21. 姜大朋.小兒圍手術期低體溫及防治[J].中國實用護理雜志,2005,21(14):62-63.

West China Medical Journal

Analysis of High-risk Factors for Death in Infants with Severe Pneumonia

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