Clinical Feature Analysis of Obstructive Sleep Apnea-hypopnea Syndrome with Pulmonary Embolism_West China Medical Journal

Authors：

 ZHOUZhong-wei , ZOUJun

Department of Respiratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding?author：

Keywords：

Obstructive sleep apnea-hyponea syndrome; Pulmonary thromboembolism; Severity of disease; Treatment

DOI：

10.7507/1002-0179.20140548

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Objective To observe the impact of obstructive sleep apnea-hyponea syndrome (OSAHS) on the severity of pulmonary thromboembolism (PTE) and its treatment strategies. Methods PTE patients hospitalized in our department between January 2006 and December 2012 were screened for this study, including 16 patients with OSAHS and 20 patients without OSAHS, and the difference in clinical characteristics such as arterial blood gas, apnea-hypopnea index, lowest pulse oxygen saturation (LSpO₂) and treatment methods were analyzed and compared between the two groups. Results As compared to PTE patients without OSAHS, the age of patients was lower[(53.4±12.1), (64.5±9.8) years; P=0.005], while body mass index[(29.3±2.2), (26.1±3.3) kg/m², P=0.002] and smoking index (150±24, 101±18; P<0.001) were higher in PTE patients with OSAHS. Additionally, significantly lower LSpO₂[(71.7±8.3), (79.4±7.1) mm Hg (1 mm Hg=0.133 kPa); P=0.005] and more lung segments (8±3, 5±2; P=0.001) were involved in PTE patients with OSAHS. In this cohort, all patients received anticoagulation and/or thrombolysis treatment, but the rate of continuous positive airway pressure (CPAP) ventilation application was significantly higher in PTE patients with OSAHS. Conclusion PTE patients with OSAHS have relatively lower age but serious condition, and both anticoagulation and CPAP should be used in the clinical treatment.

Citation： ZHOUZhong-wei, ZOUJun. Clinical Feature Analysis of Obstructive Sleep Apnea-hypopnea Syndrome with Pulmonary Embolism. West China Medical Journal, 2014, 29(10): 1801-1804. doi: 10.7507/1002-0179.20140548 Copy

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12.	冼樂武, 李濤平, 梁宗安, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者晚期氧化蛋白產物測定的臨床意義[J]. 中國呼吸與危重監護雜志, 2011,10(3):220-223.
13.	Epstein MD, Segal LN, Ibrahim SM, et al. Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism[J]. Sleep, 2010, 33(8):1069-1074.
14.	張立強. 阻塞性睡眠呼吸暫停低通氣綜合征與肺血栓栓塞癥的關系[J]. 中華臨床醫師雜志·電子版, 2013, 7(21):9-10.
15.	陳宇潔, 趙杰, 萬小兵, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者病情程度與臨床特征關系探討[J]. 華西醫學, 2007, 22(3):609.
16.	劉輝國, 徐永健. 慢性阻塞性肺疾病睡眠低氧現狀與診治進展[J]. 中國實用內科雜志, 2010, 30(4):300-303.

1. 洪昭光, 張維君, 房芳. 肺栓塞的流行病學[J]. 中華心血管病雜志, 2001, 29(5):7-8.
2. 徐巧蓮, 萬獻堯. 急性肺栓塞的診斷和治療[J]. 中國呼吸與危重監護雜志, 2011, 10(3):308-312.
3. 謝仕津, 梁灼萍. 阻塞性睡眠呼吸暫停低通氣綜合征的病因與診治研究現狀[J]. 西南軍醫, 2011, 13(3):505-508.
4. 王毓洲, 黃席珍. 阻塞性睡眠呼吸暫停/低通氣綜合征的發病機理[J]. 中國全科醫學, 2002, 5(3):178-179.
5. 馬國強, 代國儀, 王佳烈. 阻塞性睡眠呼吸暫停低通氣綜合征的研究進展[J]. 中國醫藥導報, 2007, 4(31):25-28.
6. 樊利萍, 王蓓, 劉卓拉. 阻塞性睡眠呼吸暫停低通氣綜合征與高血壓的關系[J]. 臨床醫藥實踐雜志, 2008, 17(6):429-431.
7. 張向峰, 丁少芳, 朱光發, 等. 24例合并肺血栓栓塞癥的阻塞性睡眠呼吸暫停低通氣綜合征患者臨床特點及治療分析[J]. 中國呼吸與危重監護雜志, 2011, 10(6):568-571.
8. 吳培英. 肺血栓栓塞癥26例臨床分析[J]. 實用心腦肺血管病雜志, 2008, 16(10):47-48.
9. 劉北林, 黎靜. 肺血栓栓塞癥25例臨床分析[J]. 華西醫學, 2009, 24(10):2617-2618.
10. 孫葵葵, 王辰, 古力夏提, 等. 深靜脈血栓形成的危險因素及臨床分析[J]. 中華結核和呼吸雜志, 2004, 27(11):727-730.
11. 梁民勇, 張田, 何忠. 阻塞性睡眠呼吸暫停低通氣綜合征合并慢性阻塞性肺疾病的治療進展[J]. 中國社區醫師·醫學專業, 2012, 14(36):151, 153.
12. 冼樂武, 李濤平, 梁宗安, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者晚期氧化蛋白產物測定的臨床意義[J]. 中國呼吸與危重監護雜志, 2011,10(3):220-223.
13. Epstein MD, Segal LN, Ibrahim SM, et al. Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism[J]. Sleep, 2010, 33(8):1069-1074.
14. 張立強. 阻塞性睡眠呼吸暫停低通氣綜合征與肺血栓栓塞癥的關系[J]. 中華臨床醫師雜志·電子版, 2013, 7(21):9-10.
15. 陳宇潔, 趙杰, 萬小兵, 等. 阻塞性睡眠呼吸暫停低通氣綜合征患者病情程度與臨床特征關系探討[J]. 華西醫學, 2007, 22(3):609.
16. 劉輝國, 徐永健. 慢性阻塞性肺疾病睡眠低氧現狀與診治進展[J]. 中國實用內科雜志, 2010, 30(4):300-303.

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Clinical Feature Analysis of Obstructive Sleep Apnea-hypopnea Syndrome with Pulmonary Embolism

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