Correlation between Intima-media Thickness of Carotid Artery in Color Ultrasonography and Heart Rate Variability_West China Medical Journal

Authors：

 LIYan-fang ¹ , MAChun-lan ² ,  LUOFeng-ming ¹

1. Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Respiratory Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding?author：

LUOFeng-ming, Email: luofengming@hotmail.com

Keywords：

Carotid color ultrasonography; Intima-media thickness; Dynamic electrocardiogram; Heart rate variability

DOI：

10.7507/1002-0179.20140554

Video：

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Objective To investigate the correlation between intima-media thickness (IMT) of carotid artery in color ultrasonography and the heart rate variability. Methods A retrospective analysis was performed in 64 patients from West China Hospital of Sichuan University between March and May 2013. Carotid intima-media thickness was measured with color ultrasonography and dynamic electrocardiogram, and the heart rate variability was assayed at the same time. Results IMT in the cardiovascular disease group, combination group, coronary heart disease group and hypertension group was significantly thicker than the control group (P<0.05). The differences of SDNN and SDANN were statistically significant (P<0.05) between the combination group and the control group. There were 23 cases with IMT ≥ 1.0 mm in the cardiovascular disease group including 8 cases in the combination group, 10 cases in the coronary heart disease group and 5 cases in the hypertension group. IMT in those groups were all significantly higher than that in the control group with only 2 cases having IMT ≥ 1.0 mm (P<0.05). There were 18 cases with SDNN<100 ms in the cardiovascular disease group including 7 cases in the combination group, 6 cases in the coronary heart disease group and 5 cases in the hypertension group, but there was no statistically significant difference compared with that in the control group with only 11 cases (P>0.05). Negative correlation was found between IMT and SDNN, SDANN in the cardiovascular diseases group (r=-0.574, -0.544; P<0.01) and negative correlation was found between IMT and SDANN in the control group (r=-0.392, P<0.05). Conclusion The carotid artery lesions and autonomic nerve especially sympathetic nerve dysfunction are obvious in patients with cardiovascular diseases and there is a negative correlation between them.

Citation： LIYan-fang, MAChun-lan, LUOFeng-ming. Correlation between Intima-media Thickness of Carotid Artery in Color Ultrasonography and Heart Rate Variability. West China Medical Journal, 2014, 29(10): 1819-1822. doi: 10.7507/1002-0179.20140554 Copy

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5.	中華醫學會心電生理和起搏分會心電圖學學組. 動態心電圖工作指南[J]. 臨床心電學雜志, 1999, 8(2):125-129.
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10.	Magyar MT, Paragh G, Katona E, et al. Serum cholesterols have a more important role than triglycerides in determining intima-media thickness of the common carotid artery in subjects younger than 55 years of age[J]. Ultrasound Med, 2004, 23(9):1161.
11.	Ohara K, Tabara Y, Tachibana R, et al. Micro albuminuria and arterial stiffness in a general population:the Shimanami Health Promoting Program(J-SHIPP)study[J]. J Hypertens Bes, 2004, 27(7):471.
12.	Mizuguchi Y, Oishi Y, Tanaka H, et al. Arterial stiffness is associated with left ventricular diastolic function in patients with cardiovascular risk factors:Early detection with the use of cardio-ankle vascular index and ultrasonic strain imaging[J]. J Card Fail, 2007, 13(9):744-751.
13.	Task Force of the European Society of Cardiology, the North America Society of Pacing, Electrophysiology. Heart rate variability:standards of measurement, physiological interpretation and clinical use[J]. Circulation, 1996, 93(5):1043-1065.
14.	Sullivan Jib, Conroy RM, MacDonald K, et al. Silent ischemia indiabetic men with autonomic neuropathy[J]. Br Heart J, 1999, 66:313-315.
15.	Tsuchiya T, Okumura K, Yasue H, et al. Heart period variability in patients with variant angina[J]. Am J Cardi01, 1996, 77(11):932-936.
16.	陳平安, 劉震, 李韶南. 冠狀動脈病變情況與心率變異性的關系[J]. 實用醫學雜志, 2010, 26(12):2151-2152.
17.	席海林. 55例心功能不全患者心率變異性分析的臨床價值[J]. 四川醫學, 2011, 32(5):715-716.
18.	劉丹, 陳麗江, 陳漢華, 等. 心率變異評價高血壓性心臟病的價值分析[J]. 牡丹江醫學院學報, 2013, 34(4):41-43.
19.	Femia R, Kozakova M, Nannipieri MA, et al. Carotid intima-media thickness in confirmed prehypertensive subjects; predictors and progression[J]. Arterioscler Thromb Vasc Biol, 2007, 27(10):2244-2249.
20.	全國心率變異性分析多中心研究協作組, 尹彥琳, 吳寧, 等. 心率變異性正常值及其重復性的多中心研究[J]. 中華心律失常學雜志, 2000, 4(3):6-11.

1. 中國醫師協會超聲醫師分會. 血管超聲檢查指南[J]. 中華超聲影像學雜志, 2009, 18(10):911-920.
2. 楊東偉, 劉新葉, 許富英, 等. 頸動脈內-中膜厚度與冠狀動脈病變嚴重程度相關性研究[J]. 臨床和實驗醫學雜志, 2013, 12(10):745-746, 749.
3. Ray A, Tamsma JT, Hovens M, et al. Accuracy of carotid plaque detection and intima-media thickness measurement with ultrasonography in routine clinical practice[J]. Eur J Intern Med, 2010, 21(1):35-39.
4. 茹秀穎. 高血壓病程與頸動脈硬化的關系研究[J]. 現代中西醫結合雜志, 2012, 21(19):2088-2089.
5. 中華醫學會心電生理和起搏分會心電圖學學組. 動態心電圖工作指南[J]. 臨床心電學雜志, 1999, 8(2):125-129.
6. Wahab A, Zaheer MS, Rabbani M, et al. A study of heart rate variability and QT dispersion in patients of acute ST elevation myocardial infarction[J]. Indian Heart J, 2009, 61(3):261-264.
7. 李智, 盧喜烈, 汪劍鋒, 等. 高齡老年住院患者不同性別心率變異性對比分析[J]. 廣東醫學, 2010, 31(2):194-195.
8. 孫順洋, 時陽成, 呂正濤, 等. 頸動脈超聲檢查在高血壓病診治中的意義[J]. 現代中西醫結合雜志, 2012, 21(6):627-628.
9. Zanchetti A, Crepaldi G, Bond MG, et al. Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol)are associated with alterations in carotid intima-media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study. PHYLLIS study group[J]. J Hypertens, 2001, 19(1):79-88.
10. Magyar MT, Paragh G, Katona E, et al. Serum cholesterols have a more important role than triglycerides in determining intima-media thickness of the common carotid artery in subjects younger than 55 years of age[J]. Ultrasound Med, 2004, 23(9):1161.
11. Ohara K, Tabara Y, Tachibana R, et al. Micro albuminuria and arterial stiffness in a general population:the Shimanami Health Promoting Program(J-SHIPP)study[J]. J Hypertens Bes, 2004, 27(7):471.
12. Mizuguchi Y, Oishi Y, Tanaka H, et al. Arterial stiffness is associated with left ventricular diastolic function in patients with cardiovascular risk factors:Early detection with the use of cardio-ankle vascular index and ultrasonic strain imaging[J]. J Card Fail, 2007, 13(9):744-751.
13. Task Force of the European Society of Cardiology, the North America Society of Pacing, Electrophysiology. Heart rate variability:standards of measurement, physiological interpretation and clinical use[J]. Circulation, 1996, 93(5):1043-1065.
14. Sullivan Jib, Conroy RM, MacDonald K, et al. Silent ischemia indiabetic men with autonomic neuropathy[J]. Br Heart J, 1999, 66:313-315.
15. Tsuchiya T, Okumura K, Yasue H, et al. Heart period variability in patients with variant angina[J]. Am J Cardi01, 1996, 77(11):932-936.
16. 陳平安, 劉震, 李韶南. 冠狀動脈病變情況與心率變異性的關系[J]. 實用醫學雜志, 2010, 26(12):2151-2152.
17. 席海林. 55例心功能不全患者心率變異性分析的臨床價值[J]. 四川醫學, 2011, 32(5):715-716.
18. 劉丹, 陳麗江, 陳漢華, 等. 心率變異評價高血壓性心臟病的價值分析[J]. 牡丹江醫學院學報, 2013, 34(4):41-43.
19. Femia R, Kozakova M, Nannipieri MA, et al. Carotid intima-media thickness in confirmed prehypertensive subjects; predictors and progression[J]. Arterioscler Thromb Vasc Biol, 2007, 27(10):2244-2249.
20. 全國心率變異性分析多中心研究協作組, 尹彥琳, 吳寧, 等. 心率變異性正常值及其重復性的多中心研究[J]. 中華心律失常學雜志, 2000, 4(3):6-11.

West China Medical Journal

Correlation between Intima-media Thickness of Carotid Artery in Color Ultrasonography and Heart Rate Variability

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