心房鈉尿肽及其受體在內耳的研究進展_West China Medical Journal

Authors：

 趙超 ,  唐玥玓

四川大學華西醫院耳鼻咽喉頭頸外科（成都，610041）;

Corresponding?author：

唐玥玓, Email: tangyd@hotmail.com

Keywords：

心房鈉尿肽; 受體; 內耳; 綜述

DOI：

10.7507/1002-0179.20140598

Video：

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內耳是重要的聽覺與平衡覺感受器官，由骨迷路和膜迷路構成，含有2套互不相通的內外淋巴系統，內耳中淋巴液的生成、聲信號的傳導以及耳蝸血流量的調節等方面的機制仍不清楚，但多種物質如腎上腺素、血管加壓素、內皮素、醛固酮、一氧化氮、心房鈉尿肽等各自或相互的作用與上述機制有關。現將近年來多肽類信號分子心房鈉尿肽在內耳中的研究狀況綜述如下。

Citation： 趙超, 唐玥玓. 心房鈉尿肽及其受體在內耳的研究進展. West China Medical Journal, 2014, 29(10): 1975-1978. doi: 10.7507/1002-0179.20140598 Copy

1.	De Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats[J]. Life Sci, 1981, 28(1):89-94.
2.	Vink S, Jin AH, Poth KJ, et al. Natriuretic peptide drug leads from snake venom[J]. Toxicon, 2012, 59(4, SI):434-445.
3.	Chen BY, Tie R, Qu P, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes[J]. J Endocrinol Invest, 2011, 34(10):742-746.
4.	Potter LR, Yoder AR, Flora DR, et al. Natriuretic peptides:their structures, receptors, physiologic functions and therapeutic applications[J]. Handb Exp Pharmacol, 2009(191):341-366.
5.	Potter LR, Hunter T. Guanylyl cyclase-linked natriuretic peptide receptors:structure and regulation[J]. J Biol Chem, 2001, 276(9):6057-6060.
6.	Misono KS, Philo JS, Arakawa T, et al. Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase[J]. FEBS Journal, 2011, 278(11):1818-1829.
7.	Suga S, Nakao K, Hosoda K, et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide[J]. Endocrinology, 1992, 130(1):229-239.
8.	Van Den Akker F. Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors[J]. J Mol Biol, 2001, 311(5):923-937.
9.	Misono KS, Ogawa H, Qiu Y, et al. Structural studies of the natriuretic peptide receptor:a novel hormone-induced rotation mechanism for transmembrane signal transduction[J]. Peptides, 2005, 26(6):957-968.
10.	Rubattu S, Sciarretta S, Morriello AA, et al. NPR-C:a component of the natriuretic peptide family with implications in human diseases[J]. J Mol Med, 2010, 88(9):889-897.
11.	Pandey KN. Guanylyl cyclase/atrial natriuretic peptide receptor-A:role in the pathophysiology of cardiovascular regulation[J]. Can J Physiol Pharmacol, 2011, 89(8):557-573.
12.	Lamprecht J. Meyer zum gottesberge AM.the presence and localization of receptors for atrial natriuretic peptide in the inner ear of the Guinea pig[J]. Arch Otorhinolaryngo, 1988, 245(5):300-301.
13.	Yoon YJ, Lee EJ, Kim SH. Synthesis of atrial natriuretic peptide in the rabbit inner ear[J]. Laryngoscope, 2012, 122(7):1605-1608.
14.	陳合新, 史劍波, 邱建華, 等. 心鈉素免疫反應在豚鼠耳蝸中的整體分布[J]. 中國臨床解剖學雜志, 2002, 20(4):290-291.
15.	陳合新, 邱建華. 心鈉素在豚鼠耳蝸螺旋神經節中的分布及定位[J]. 中華醫學雜志, 1996, 76(2):147-148.
16.	陳合新, 王錦玲. 豚鼠耳蝸心鈉素免疫反應陽性顆粒的超微結構觀察[J]. 臨床耳鼻咽喉科雜志, 1998, 12(9):415-417.
17.	張鵬志, 陳俊, 薛濤, 等. 大鼠耳蝸血管紋邊緣細胞原代培養及心鈉素的表達[J]. 中華耳科學雜志, 2008, 6(3):325-330.
18.	Qiao L, Han Y, Zhang PZ, et al. Detection of atrial natriuretic peptide and its receptor in marginal cells and cochlea tissues from the developing rats[J]. Neuro Endocrinol Lett, 2011, 32(2):187-192.
19.	周柯, 孫菲, 邱建華, 等. 心鈉素在原代培養大鼠耳蝸螺旋神經元細胞中的表達[J]. 中華耳科學雜志, 2010, 8(2):225-230.
20.	Yoon YJ, Hellstrom S. Immunohistochemical localization of alpha-atrial natriuretic polypeptide in the rat cochlea[J]. Acta Otolaryngol, 1992, 112(4):604-610.
21.	李雪梅, 周慶華, 張軍橋. 心房利鈉肽在大鼠蝸管外側壁及螺旋神經節的定位-RNA斑點雜交和免疫組織化學研究[J]. 中國醫藥導刊, 2009, 11(1):90-91.
22.	Long LL, Tang YE, Xia QJ, et al. Detection of atrial natriuretic peptide receptor in the labyrinth of the mouse inner ear[J]. Neuro Endocrinol Lett, 2008, 29(4):577-580.
23.	Long LL, Tang YE, Xia QJ, et al. The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth[J]. Neuro Endocrinol Lett, 2010, 31(1):126-130.
24.	Sun F, Zhou K, Wang SJ, et al. Expression and localization of atrial natriuretic peptide and its receptors in rat spiral ganglion neurons[J]. Brain Res Bull, 2013, 95:28-32.
25.	Koch T, Gloddek B, Gutzke S. Binding sites of atrial natriuretic peptide (ANP) in the mammalian cochlea and stimulation of cyclic GMP synthesis[J]. Hear Res, 1992, 63(1/2):197-202.
26.	Furuta H, Mori N, Luo L, et al. Detection of mRNA encoding guanylate cyclase A atrial natriuretic peptide receptor in the rat cochlea by competitive polymerase chain reaction and in situ hybridization[J]. Hear Res, 1995, 92(1/2):78-84.
27.	Dornhoffer JL, Danner C, Li SL. Natriuretic peptide receptors in the human endolymphatic sac[J]. Arch Otolaryngol Head Neck Surg, 2002, 128(4):379-383.
28.	Cao LH, Yang XL. Natriuretic peptides and their receptors in the central nervous system[J]. Prog Neurobiol, 2008, 84(3):234-248.
29.	陳合新, 邱建華, 王錦玲. 心鈉素免疫反應物質在豚鼠耳蝸Corti器中的分布[J]. 聽力學及言語疾病雜志, 2000, 8(4):213-214.
30.	Yoon YJ, Anniko M. Distribution of alpha-ANP in the cochlea and the vestibular organs[J]. Otorhinolaryngol, 1994, 56(2):73-77.
31.	Nakashima T, Naganawa S, Sone M, et al. Disorders of cochlear blood flow[J]. Brain Res Rev, 2003, 43(1):17-28.
32.	Carlisle L, Aberdeen J, Forge A, et al. Neural basis for regulation of cochlear blood flow:peptidergic and adrenergic innervation of the spiral modiolar artery of the Guinea pig[J]. Hear Res, 1990, 43(2/3):107-113.
33.	熊巍, 邱建華, 林穎, 等. 心鈉素對耳蝸缺血再灌注損傷的影響[J]. 中華耳鼻咽喉頭頸外科雜志, 2006, 41(4):293-296.
34.	林穎, 邱建華, 喬莉, 等. 心鈉素對耳蝸微循環的影響[J]. 聽力學及言語疾病雜志, 2006, 14(5):347-350.
35.	林穎, 邱建華. 心鈉素在豚鼠耳蝸微血管的分布[J]. 第四軍醫大學學報, 2005, 26(7):581-583.
36.	Rachel JD, Dziadziola JK, Quirk WS. Atrial natriuretic peptide participates in the regulation of vestibular blood flow[J]. Hear Res, 1995, 89(1/2):181-186.
37.	Seebacher T, Beitz E, Kumagami H, et al. Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear[J]. Hear Res, 1999, 127(1/2):95-102.
38.	Suzuki M, Kitallo H, Kitanishi T, et al. RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear[J]. Brain Res Mol Brain Res, 1998, 55(1):165-168.
39.	Hibino H, Nin F, Tsuzuki C, et al. How is the highly positive endocochelear potential formed? The specific architecture of the stria vascularis and theroles of the ion-transport apparatus[J]. Pflugers Arch, 2010, 459(4):521-533.

1. De Bold AJ, Borenstein HB, Veress AT, et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats[J]. Life Sci, 1981, 28(1):89-94.
2. Vink S, Jin AH, Poth KJ, et al. Natriuretic peptide drug leads from snake venom[J]. Toxicon, 2012, 59(4, SI):434-445.
3. Chen BY, Tie R, Qu P, et al. Vasonatrin peptide, a new regulator of adiponectin and interleukin-6 production in adipocytes[J]. J Endocrinol Invest, 2011, 34(10):742-746.
4. Potter LR, Yoder AR, Flora DR, et al. Natriuretic peptides:their structures, receptors, physiologic functions and therapeutic applications[J]. Handb Exp Pharmacol, 2009(191):341-366.
5. Potter LR, Hunter T. Guanylyl cyclase-linked natriuretic peptide receptors:structure and regulation[J]. J Biol Chem, 2001, 276(9):6057-6060.
6. Misono KS, Philo JS, Arakawa T, et al. Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase[J]. FEBS Journal, 2011, 278(11):1818-1829.
7. Suga S, Nakao K, Hosoda K, et al. Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide[J]. Endocrinology, 1992, 130(1):229-239.
8. Van Den Akker F. Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors[J]. J Mol Biol, 2001, 311(5):923-937.
9. Misono KS, Ogawa H, Qiu Y, et al. Structural studies of the natriuretic peptide receptor:a novel hormone-induced rotation mechanism for transmembrane signal transduction[J]. Peptides, 2005, 26(6):957-968.
10. Rubattu S, Sciarretta S, Morriello AA, et al. NPR-C:a component of the natriuretic peptide family with implications in human diseases[J]. J Mol Med, 2010, 88(9):889-897.
11. Pandey KN. Guanylyl cyclase/atrial natriuretic peptide receptor-A:role in the pathophysiology of cardiovascular regulation[J]. Can J Physiol Pharmacol, 2011, 89(8):557-573.
12. Lamprecht J. Meyer zum gottesberge AM.the presence and localization of receptors for atrial natriuretic peptide in the inner ear of the Guinea pig[J]. Arch Otorhinolaryngo, 1988, 245(5):300-301.
13. Yoon YJ, Lee EJ, Kim SH. Synthesis of atrial natriuretic peptide in the rabbit inner ear[J]. Laryngoscope, 2012, 122(7):1605-1608.
14. 陳合新, 史劍波, 邱建華, 等. 心鈉素免疫反應在豚鼠耳蝸中的整體分布[J]. 中國臨床解剖學雜志, 2002, 20(4):290-291.
15. 陳合新, 邱建華. 心鈉素在豚鼠耳蝸螺旋神經節中的分布及定位[J]. 中華醫學雜志, 1996, 76(2):147-148.
16. 陳合新, 王錦玲. 豚鼠耳蝸心鈉素免疫反應陽性顆粒的超微結構觀察[J]. 臨床耳鼻咽喉科雜志, 1998, 12(9):415-417.
17. 張鵬志, 陳俊, 薛濤, 等. 大鼠耳蝸血管紋邊緣細胞原代培養及心鈉素的表達[J]. 中華耳科學雜志, 2008, 6(3):325-330.
18. Qiao L, Han Y, Zhang PZ, et al. Detection of atrial natriuretic peptide and its receptor in marginal cells and cochlea tissues from the developing rats[J]. Neuro Endocrinol Lett, 2011, 32(2):187-192.
19. 周柯, 孫菲, 邱建華, 等. 心鈉素在原代培養大鼠耳蝸螺旋神經元細胞中的表達[J]. 中華耳科學雜志, 2010, 8(2):225-230.
20. Yoon YJ, Hellstrom S. Immunohistochemical localization of alpha-atrial natriuretic polypeptide in the rat cochlea[J]. Acta Otolaryngol, 1992, 112(4):604-610.
21. 李雪梅, 周慶華, 張軍橋. 心房利鈉肽在大鼠蝸管外側壁及螺旋神經節的定位-RNA斑點雜交和免疫組織化學研究[J]. 中國醫藥導刊, 2009, 11(1):90-91.
22. Long LL, Tang YE, Xia QJ, et al. Detection of atrial natriuretic peptide receptor in the labyrinth of the mouse inner ear[J]. Neuro Endocrinol Lett, 2008, 29(4):577-580.
23. Long LL, Tang YE, Xia QJ, et al. The expression of atrial natriuretic peptide receptor in the mouse inner ear labyrinth[J]. Neuro Endocrinol Lett, 2010, 31(1):126-130.
24. Sun F, Zhou K, Wang SJ, et al. Expression and localization of atrial natriuretic peptide and its receptors in rat spiral ganglion neurons[J]. Brain Res Bull, 2013, 95:28-32.
25. Koch T, Gloddek B, Gutzke S. Binding sites of atrial natriuretic peptide (ANP) in the mammalian cochlea and stimulation of cyclic GMP synthesis[J]. Hear Res, 1992, 63(1/2):197-202.
26. Furuta H, Mori N, Luo L, et al. Detection of mRNA encoding guanylate cyclase A atrial natriuretic peptide receptor in the rat cochlea by competitive polymerase chain reaction and in situ hybridization[J]. Hear Res, 1995, 92(1/2):78-84.
27. Dornhoffer JL, Danner C, Li SL. Natriuretic peptide receptors in the human endolymphatic sac[J]. Arch Otolaryngol Head Neck Surg, 2002, 128(4):379-383.
28. Cao LH, Yang XL. Natriuretic peptides and their receptors in the central nervous system[J]. Prog Neurobiol, 2008, 84(3):234-248.
29. 陳合新, 邱建華, 王錦玲. 心鈉素免疫反應物質在豚鼠耳蝸Corti器中的分布[J]. 聽力學及言語疾病雜志, 2000, 8(4):213-214.
30. Yoon YJ, Anniko M. Distribution of alpha-ANP in the cochlea and the vestibular organs[J]. Otorhinolaryngol, 1994, 56(2):73-77.
31. Nakashima T, Naganawa S, Sone M, et al. Disorders of cochlear blood flow[J]. Brain Res Rev, 2003, 43(1):17-28.
32. Carlisle L, Aberdeen J, Forge A, et al. Neural basis for regulation of cochlear blood flow:peptidergic and adrenergic innervation of the spiral modiolar artery of the Guinea pig[J]. Hear Res, 1990, 43(2/3):107-113.
33. 熊巍, 邱建華, 林穎, 等. 心鈉素對耳蝸缺血再灌注損傷的影響[J]. 中華耳鼻咽喉頭頸外科雜志, 2006, 41(4):293-296.
34. 林穎, 邱建華, 喬莉, 等. 心鈉素對耳蝸微循環的影響[J]. 聽力學及言語疾病雜志, 2006, 14(5):347-350.
35. 林穎, 邱建華. 心鈉素在豚鼠耳蝸微血管的分布[J]. 第四軍醫大學學報, 2005, 26(7):581-583.
36. Rachel JD, Dziadziola JK, Quirk WS. Atrial natriuretic peptide participates in the regulation of vestibular blood flow[J]. Hear Res, 1995, 89(1/2):181-186.
37. Seebacher T, Beitz E, Kumagami H, et al. Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear[J]. Hear Res, 1999, 127(1/2):95-102.
38. Suzuki M, Kitallo H, Kitanishi T, et al. RT-PCR analysis of mRNA expression of natriuretic peptide family and their receptors in rat inner ear[J]. Brain Res Mol Brain Res, 1998, 55(1):165-168.
39. Hibino H, Nin F, Tsuzuki C, et al. How is the highly positive endocochelear potential formed? The specific architecture of the stria vascularis and theroles of the ion-transport apparatus[J]. Pflugers Arch, 2010, 459(4):521-533.

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心房鈉尿肽及其受體在內耳的研究進展

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