Clinical Analysis of Plasma Amino Acids and Trace Elements in Breast Cancer Patients_West China Medical Journal

Authors：

 GAOQing-shuang ,  GAOCui-hong , LIUShu-ping

Clinical Laboratory, Tangshan Maternal and Child Health Hospital, Tangshan, Hebei 063000, P. R. China;

Corresponding?author：

GAOCui-hong, Email: tsgaocan@163.com

Keywords：

Breast cancer; Trace elements; Amino acids

DOI：

10.7507/1002-0179.20140672

Video：

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Objective To understand the function of trace element and amino acids detection in early diagnosis of breast cancer, and explore the correlation between plasma amino acid and trace element changes. Methods Fifty-five patients with breast cancer and 50 normal controls were included in our study from May 2012 to June 2013. Trace elements were detected by atomic absorption spectrophotometer, and the level of amino acids was detected by Hitachi L-8900 amino acids analyzer. Then, we analyzed the correlation between the two indexes. Results Compared with the normal controls, breast cancer patients had a higher level of Cu and Fe (P<0.05), and a lower level of Zn (P<0.05). Seven kinds of amino acids had significant changes (P<0.05), including three kinds of increased amino acids, and four reduced. Amino acids and trace element correlation analysis showed that Mg was negatively correlated with Leu, Tyr, Lys, and His; and Ca was negatively correlated with Lys and His. Conclusion There are many kinds of changes of plasma amino acids and trace elements in breast cancer patients. Serum trace element and amino acids detection in patients with breast cancer are helpful in the severity judgment and regimen design.

Citation： GAOQing-shuang, GAOCui-hong, LIUShu-ping. Clinical Analysis of Plasma Amino Acids and Trace Elements in Breast Cancer Patients. West China Medical Journal, 2014, 29(12): 2223-2225. doi: 10.7507/1002-0179.20140672 Copy

1.	曾昭華, 曾雪萍. 中國乳腺癌與土壤環境中化學元素的相關性研究[J]. 江蘇環境科技, 1999, 12(3):1-3.
2.	李桂芝, 郭健, 李萍, 等. 惡性腫瘤患者血清微量元素水平的變化[J]. 濰坊醫學院學報, 2003, 25(1):66-67.
3.	陸東東. 微量元素與肝癌[J]. 湖北預防醫學雜志, 2000, 11(1):11-12.
4.	戴冬梅, 于瑞珍. 乳腺癌患者治療前后微量元素含量的變化[J]. 臨床檢驗雜志, 2005, 23(6):461.
5.	Kuo HW, Chen SF, Wu CC, et al. Serum and tissue trace elements in patients with breast cancer in Taiwan[J]. Biol Trace Elem Res, 2002, 89(1):1-11.
6.	黃家琛. 微量元素銅、鋅與腫瘤[J]. 實用癌癥雜志, 1992, 7(1):55-57.
7.	Wu HD, Chou SY, Chen DR, et al. Differentiation of serum levels of trance elements in normal and malignant breast patients[J].Biol Trance Elem Res, 2006, 113(1):9-18.
8.	武力, 馬宇光. 微量元素與乳腺癌的臨床研究[J]. 現代腫瘤醫學, 2008, 16(5):745-746.
9.	李衛華. 臨汾市正常人血清Cu、Fe、Zn含量分析[J]. 預防醫學情報雜志, 2000, 16(2):161.
10.	王俊雅, 尹頌超. 原發性肝癌患者血清多種微量元素、銅藍蛋白、T淋巴細胞測定與分析[J]. 廣東微量元素科學, 1994, 1(3):32-37.
11.	楊晶, 陸偉, 鄒滿意, 等. 荷肝癌小鼠血漿和腫瘤組織游離氨基酸代謝變化及其與腫瘤體積相關性研究[J]. 實用肝臟病雜志, 2006, 9(1):22-24.
12.	Bozzetti F, Gavazzi C, Cozzaglio L, et al. Total parenteral nutrition and tumor growth in malnourished patients with gastric cancer[J]. Tumori, 1999, 85(3):163-166.
13.	Tsukishiro T, Shimizu Y, Higuchi K, et al. Effect of branched-chain amino acids on the composition and cytolytic activity of liver-associated lymphocytes in rats[J]. J Gastroenterol Hepatol, 2000, 15(8):849-859.
14.	歐敬民, 張一楚, 陳大偉, 等. 蛋氨酸對肝癌細胞生長影響的實驗研究[J]. 中國臨床營養雜志, 2002, 10(3):172-174.
15.	Heys SD, Segar A, Payne S, et al. Dietary supplementation with L-arginine:modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer[J]. Br J Surg, 1997, 84(2):238-241.

1. 曾昭華, 曾雪萍. 中國乳腺癌與土壤環境中化學元素的相關性研究[J]. 江蘇環境科技, 1999, 12(3):1-3.
2. 李桂芝, 郭健, 李萍, 等. 惡性腫瘤患者血清微量元素水平的變化[J]. 濰坊醫學院學報, 2003, 25(1):66-67.
3. 陸東東. 微量元素與肝癌[J]. 湖北預防醫學雜志, 2000, 11(1):11-12.
4. 戴冬梅, 于瑞珍. 乳腺癌患者治療前后微量元素含量的變化[J]. 臨床檢驗雜志, 2005, 23(6):461.
5. Kuo HW, Chen SF, Wu CC, et al. Serum and tissue trace elements in patients with breast cancer in Taiwan[J]. Biol Trace Elem Res, 2002, 89(1):1-11.
6. 黃家琛. 微量元素銅、鋅與腫瘤[J]. 實用癌癥雜志, 1992, 7(1):55-57.
7. Wu HD, Chou SY, Chen DR, et al. Differentiation of serum levels of trance elements in normal and malignant breast patients[J].Biol Trance Elem Res, 2006, 113(1):9-18.
8. 武力, 馬宇光. 微量元素與乳腺癌的臨床研究[J]. 現代腫瘤醫學, 2008, 16(5):745-746.
9. 李衛華. 臨汾市正常人血清Cu、Fe、Zn含量分析[J]. 預防醫學情報雜志, 2000, 16(2):161.
10. 王俊雅, 尹頌超. 原發性肝癌患者血清多種微量元素、銅藍蛋白、T淋巴細胞測定與分析[J]. 廣東微量元素科學, 1994, 1(3):32-37.
11. 楊晶, 陸偉, 鄒滿意, 等. 荷肝癌小鼠血漿和腫瘤組織游離氨基酸代謝變化及其與腫瘤體積相關性研究[J]. 實用肝臟病雜志, 2006, 9(1):22-24.
12. Bozzetti F, Gavazzi C, Cozzaglio L, et al. Total parenteral nutrition and tumor growth in malnourished patients with gastric cancer[J]. Tumori, 1999, 85(3):163-166.
13. Tsukishiro T, Shimizu Y, Higuchi K, et al. Effect of branched-chain amino acids on the composition and cytolytic activity of liver-associated lymphocytes in rats[J]. J Gastroenterol Hepatol, 2000, 15(8):849-859.
14. 歐敬民, 張一楚, 陳大偉, 等. 蛋氨酸對肝癌細胞生長影響的實驗研究[J]. 中國臨床營養雜志, 2002, 10(3):172-174.
15. Heys SD, Segar A, Payne S, et al. Dietary supplementation with L-arginine:modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer[J]. Br J Surg, 1997, 84(2):238-241.

West China Medical Journal

Clinical Analysis of Plasma Amino Acids and Trace Elements in Breast Cancer Patients

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