The Effect of Bacillus Calmette-guerin Polysaccharides Nucleic Acid on Humoral Immunity, Interleukin-8 and Tumor Necrosis Factor-αin Patients with Chronic Obstructive Pulmonary Disease_West China Medical Journal

Authors：

 XULin , ZHANGCheng , YEXian-wei , LIUWei-jia , YUHong ,  ZHANGXiang-yan

Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P. R. China;

Corresponding?author：

ZHANGXiang-yan, Email: zxy35762@126.com

Keywords：

Chronic obstructive pulmonary disease; Bacillus calmette-guerin polysaccharides nucleic acid; Humoral immunity; Tumor necrosis factor-α; Interleukin

DOI：

10.7507/1002-0179.20150001

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Objective To study the effect of bacillus calmette-guerin(BCG) polysaccharides nucleic acid on humoral immunity, interleukin(IL)-8 and tumor necrosis factor(TNF)-αin patients with chronic obstructive pulmonary disease (COPD), and to provide theoretical basis for evaluation of its clinical effectiveness. Methods Thirty hospitalized elderly patients with AECOPD treated from March 2012 to February 2013 and 60 patients with stable COPD treated at the same time were randomly selected as the study subjects. At the same time, 60 healthy people from our physical examination center were also enrolled and divided into two groups:the elderly healthy group (n=30) and nonelderly healthy group (n=30). IL-8, TNF-α, IgA, IgG and IgM levels were determined. The stable COPD group was randomly divided into two groups:group A (n=30) and group B (n=30). Group A received only routine therapy; group B received both routine therapy and intramuscular injection of BCG polysaccharide nucleic acid (0.35 mg/day, three times a week). IL-8, TNF-α, IgA, IgG and IgM levels in peripheral blood were investigated before treatment and one month later. Results There were no statistically significant differences in IL-8 and TNF-αlevels in peripheral blood between elderly healthy group and nonelderly healthy group (P > 0.05), but the IgA, IgG and IgM levels were lower in the nonelderly healthy group than in the elderly healthy group (P < 0.05). Compared with the elderly healthy grouping, IgG and IgM levels were significantly lower in AECOPD group and stable COPD group (P < 0.05), but IL-8 and TNF-αlevels were significantly higher (P > 0.05). There were statistically significant differences in TNF-α, IgA, IgG and IgM levels between group B before and after treatment (P > 0.05). Conclusions Human's humoral immunity decreases with age. Elderly COPD patients are at high risks of abnormal immunologic function, particularly in the acute exacerbation period. The BCG polysaccharides nucleic acid can strength patients' humoral immunity. The levels of inflammatory cytokines can be reduced using BCG polysaccharides nucleic acid.

Citation： XULin, ZHANGCheng, YEXian-wei, LIUWei-jia, YUHong, ZHANGXiang-yan. The Effect of Bacillus Calmette-guerin Polysaccharides Nucleic Acid on Humoral Immunity, Interleukin-8 and Tumor Necrosis Factor-αin Patients with Chronic Obstructive Pulmonary Disease. West China Medical Journal, 2015, 30(1): 1-5. doi: 10.7507/1002-0179.20150001 Copy

1.	冉丕鑫.從我國《慢性阻塞性肺疾病診治規范》的修訂看COPD的定義及診斷研究進展[J].實用醫學雜志, 2002, 18(7):682-683.
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4.	中華醫學會呼吸病學分會慢性阻塞性肺疾病學組.第二屆全國慢性阻塞性肺疾病與第八屆全國肺心病學術會議紀要[J].中華結核與呼吸雜志, 2002, 25(8):504-506.
5.	朱淵紅, 王新華, 王真, 等. 60例慢性阻塞性肺疾病細胞免疫功能的臨床觀察[J].浙江實用醫學, 2005, 10(5):321-322.
6.	劉玉春, 王靜波, 林士軍, 等.慢性阻塞性肺疾病患者IL-2、slL-2R表達的研究[J].中國基層醫藥, 2007, 14(1):25-30.
7.	Cosio MG, Majo J, Cosio MG, et al. Inflammation of the airways and lung parenchy ma in COPD:role of T cells[J]. Chest, 2010, 121(Suppl 5):160S-165S.
8.	黃奕江, 馮夏, 鄭萬川.慢性阻塞性肺病患者免疫功能的研究[J].臨床內科雜志, 1997, 14(1):30-31.
9.	中華人民共和國衛生部.慢性阻塞性肺疾病(COPD)診治規范(草案)[J].中國實用內科雜志, 1998, 20(5):53-57.
10.	張湘燕, 張程, 王娜, 等.卡介菌多糖核酸對慢性阻塞性肺疾病患者免疫功能的影響[J].中國藥房, 2011, 36(36):3394-3395.
11.	Majo J, Ghezzo H, Cosio MG, et al. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema[J]. Eur Respir, 2010, 37(9):946-950.
12.	時宏珍.支氣管哮喘患兒細胞因子的變化[J].中國兒科雜志, 1997, 35(2):84-86.
13.	龔非力.醫學免疫學[M].北京:科學出版社, 2000:126-128.
14.	余傳霖.現代醫學免疫學[M].上海:上海醫科大學出版社, 1998:1112-1124.
15.	Shaughnessy TC, Ansari TW, Bames NG, et al. Inflammation in bronchial biopsies of subjects with chronic bronchitis inverse relationship of CD8+T lymphocytes with FEV1[J]. Am J Respir Crit Care Med, 1997, 155(3):852-853.
16.	中華醫學會呼吸病學分會慢性阻塞性肺疾病學組.全國慢性阻塞性肺疾病與第九屆全國肺心病學術會議紀要[J].中華結核與呼吸雜志, 2004, 5(4):504-510.
17.	吳達會, 丁毅鵬, 林莉, 等.慢性肺心病T淋巴細胞亞群、NK細胞活性及紅細胞免疫功能的初步觀察[J].海南醫學, 2000, 11(2):34.
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19.	Hogg JC, Chu F, Utokaparch S, et al. The Nature of small-airway obstruction in chronic obstructive pulmonary disease[J]. N Engl J Med, 2004, 350(26):2645-2653.
20.	Van DB, Postma DS, Brandsma CA, et al. Cigarette smoke-induced emphysema:a role for the B cell[J]. Am J Respir Crit Care Med, 2006, 173(7):751-758.
21.	Feghali-Bostwick CA, Gadgil AS, Otterbein LE, et al. Autoantibodies in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2008, 177(2):156-163.
22.	于云芝, 漆自立, 劉躍建, 等.卡介菌多糖核酸對慢性阻塞性肺病免疫調節及臨床療效的觀察[J].四川醫學, 2001, 22(6):529-530.
23.	林恩堯, 王世珍, 劉冰潔, 等.卡介菌提取物調節慢性支氣管炎免疫功能效果的觀察[J].中華結核和呼吸雜志, 1987, 10(1):41-43.

1. 冉丕鑫.從我國《慢性阻塞性肺疾病診治規范》的修訂看COPD的定義及診斷研究進展[J].實用醫學雜志, 2002, 18(7):682-683.
2. 中華醫學會重癥醫學分會.慢性阻塞性肺疾病急性加重患者的治療指南(2007)[J].中國危重病急救醫學, 2007, 19(9):513-518.
3. 胡瑞成, 戴愛國.慢性阻塞性肺疾病急性加重期的治療[J].內科急危重癥雜志, 2006, 12(2):88-91.
4. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組.第二屆全國慢性阻塞性肺疾病與第八屆全國肺心病學術會議紀要[J].中華結核與呼吸雜志, 2002, 25(8):504-506.
5. 朱淵紅, 王新華, 王真, 等. 60例慢性阻塞性肺疾病細胞免疫功能的臨床觀察[J].浙江實用醫學, 2005, 10(5):321-322.
6. 劉玉春, 王靜波, 林士軍, 等.慢性阻塞性肺疾病患者IL-2、slL-2R表達的研究[J].中國基層醫藥, 2007, 14(1):25-30.
7. Cosio MG, Majo J, Cosio MG, et al. Inflammation of the airways and lung parenchy ma in COPD:role of T cells[J]. Chest, 2010, 121(Suppl 5):160S-165S.
8. 黃奕江, 馮夏, 鄭萬川.慢性阻塞性肺病患者免疫功能的研究[J].臨床內科雜志, 1997, 14(1):30-31.
9. 中華人民共和國衛生部.慢性阻塞性肺疾病(COPD)診治規范(草案)[J].中國實用內科雜志, 1998, 20(5):53-57.
10. 張湘燕, 張程, 王娜, 等.卡介菌多糖核酸對慢性阻塞性肺疾病患者免疫功能的影響[J].中國藥房, 2011, 36(36):3394-3395.
11. Majo J, Ghezzo H, Cosio MG, et al. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema[J]. Eur Respir, 2010, 37(9):946-950.
12. 時宏珍.支氣管哮喘患兒細胞因子的變化[J].中國兒科雜志, 1997, 35(2):84-86.
13. 龔非力.醫學免疫學[M].北京:科學出版社, 2000:126-128.
14. 余傳霖.現代醫學免疫學[M].上海:上海醫科大學出版社, 1998:1112-1124.
15. Shaughnessy TC, Ansari TW, Bames NG, et al. Inflammation in bronchial biopsies of subjects with chronic bronchitis inverse relationship of CD8+T lymphocytes with FEV1[J]. Am J Respir Crit Care Med, 1997, 155(3):852-853.
16. 中華醫學會呼吸病學分會慢性阻塞性肺疾病學組.全國慢性阻塞性肺疾病與第九屆全國肺心病學術會議紀要[J].中華結核與呼吸雜志, 2004, 5(4):504-510.
17. 吳達會, 丁毅鵬, 林莉, 等.慢性肺心病T淋巴細胞亞群、NK細胞活性及紅細胞免疫功能的初步觀察[J].海南醫學, 2000, 11(2):34.
18. Priecto A, Reyes E, Bernstein ED, et al. Defective killer and phagocytic activities in chronic obstructive pulmonary disease are restored by glycophosphopeptical (inmunoferón)[J]. Am J Respir Crit Care Med, 2001, 163(7):1578-1583.
19. Hogg JC, Chu F, Utokaparch S, et al. The Nature of small-airway obstruction in chronic obstructive pulmonary disease[J]. N Engl J Med, 2004, 350(26):2645-2653.
20. Van DB, Postma DS, Brandsma CA, et al. Cigarette smoke-induced emphysema:a role for the B cell[J]. Am J Respir Crit Care Med, 2006, 173(7):751-758.
21. Feghali-Bostwick CA, Gadgil AS, Otterbein LE, et al. Autoantibodies in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2008, 177(2):156-163.
22. 于云芝, 漆自立, 劉躍建, 等.卡介菌多糖核酸對慢性阻塞性肺病免疫調節及臨床療效的觀察[J].四川醫學, 2001, 22(6):529-530.
23. 林恩堯, 王世珍, 劉冰潔, 等.卡介菌提取物調節慢性支氣管炎免疫功能效果的觀察[J].中華結核和呼吸雜志, 1987, 10(1):41-43.

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The Effect of Bacillus Calmette-guerin Polysaccharides Nucleic Acid on Humoral Immunity, Interleukin-8 and Tumor Necrosis Factor-αin Patients with Chronic Obstructive Pulmonary Disease

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