Correlation between T/C Polymorphism in 190 Locus ofβ<sub>3</sub>-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis_West China Medical Journal

Authors：

 YOUHang ^1,2 , ZHANGBen-long ^1,2 , SUNYun-peng ³ ,  SHIXiao-ke ^1,2

1. Evidence-based Medicine Center, Chouzhou Hospital of Yiwu City, Yiwu, Zhejiang 322000, P. R. China;
2. Surgical Center, Chouzhou Hospital of Yiwu City, Yiwu, Zhejiang 322000, P. R. China;
3. Department of Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P. R. China;

Corresponding?author：

SHIXiao-ke, Email: sxk158258@163.com

Keywords：

β₃-adrenergic receptor gene; Polymorphism; Type-2 Diabetes Mellitus; Chinese population; Systematic review

DOI：

10.7507/1002-0179.20150003

Video：

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Objective To systematically evaluate the correlation between type-2 diabetes mellitus (T2DM) and T/C polymorphism in 190 locus ofβ3-adrenergic receptor (β₃-AR) gene in Chinese population. Methods The following databases such as CNKI, VIP, CBM, PubMed, EMbase, the Cochrane Library (Issue 8, 2012) and WanFang Data were searched to collect case-control studies on the correlation between T2DM and T/C polymorphism in 190 locus of β₃-AR gene. The retrieval time was from October 1980 to October 2013. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality. Then the meta-analysis was conducted by using RevMan 5.0 and Stata 12.0 software, and the publication bias was analyzed by means of Egger's linear regression. Results A total of 11 studies involving 1 602 T2DM patients and 1 773 healthy volunteers were included. The results of meta-analyses showed that, for Chinese population, TC genotype in case group was more than that in control group[OR=1.19, 95%CI (1.01, 1.40), P=0.04]. CC+TC genotype in case group was more than that in control group[OR=1.23, 95%CI (1.05, 1.45), P=0.01]. Allele C in case group was more than that in control group[OR=1.24, 95%CI (1.08, 1.43), P=0.003]. Conclusions The allele C in 190 locus of β₃-AR gene in Chinese population is significantly associated with T2DM. For the quantity and quality limitation of the included studies, this conclusion has to be further proved by more studies.

Citation： YOUHang, ZHANGBen-long, SUNYun-peng, SHIXiao-ke. Correlation between T/C Polymorphism in 190 Locus ofβ₃-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis. West China Medical Journal, 2015, 30(1): 12-11. doi: 10.7507/1002-0179.20150003 Copy

1.	Walston J, Silver K, Hilfiker H, et al. Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor[J]. J Clin Endocrinol Metab, 2000, 85(11):4019-4022.
2.	Masuo K, Katsuya T, Fu Y, et al. Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals[J]. Am J Hypertens, 2005, 18(7):1009-1014.
3.	Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA):an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1):37-55.
4.	王靜, 莫傳偉, 陳群, 等.應用Stata軟件的Meta分析完成醫學科研定量評價[J].中華中醫藥學刊, 2008, 26(5):947-949.
5.	包愛民, 肖尚喜, 王長江, 等. 2型糖尿病與正常人群中β3腎上腺素能受體基因Trp64Arg多態性表型特征[J].中國糖尿病雜志, 2000, 8(1):13-16.
6.	孫黎明, Iizuka Y, Ishibashi S, 等.中國人與日本人β3腎上腺素能受體基因Trp64Arg突變的比較[J].中華醫學雜志, 2000, 80(2):107-110.
7.	陳玉, 周玲, 徐耀初, 等.β3-腎上腺素能受體基因與2型糖尿病關系的研究[J].中國公共衛生, 2001, 17(7):586-588.
8.	李耀明, 梁劍寧. 2型糖尿病與β3腎上腺素能受體基因Trp64Arg多態性的相關性探討[J].廣州醫學院學報, 2004, 32(2):60-62.
9.	孫玉茹, 楊澤, 紀立農.β3腎上腺素能受體基因Trp64Arg變異與2型糖尿病的關聯研究[J].中華糖尿病雜志, 2004, 12(1):43-44.
10.	修玲玲, 翁建平, 隋昳, 等.解偶聯蛋白2基因和β3-腎上腺素能受體基因聯合變異與2型糖尿病及肥胖癥的關系[J].中華醫學雜志, 2004, 84(5):375-379.
11.	惠宗光, 周學偉, 王曉玲, 等. 2型糖尿病人群胰島素抵抗和β₃-AR基因的相關性[J].濰坊醫學院學報, 2005, 27(3):173-175.
12.	李利, 孫黎明, 王軍, 等.β3腎上腺素能受體基因Trp64Arg突變與胰島素抵抗相關[J].中國醫師雜志, 2006, 8(5):636-638.
13.	姜秀云, 侯新國, 侯為開, 等.腎上腺素能β3受體基因多態性與肥胖和胰島素抵抗的相關性[J].中國糖尿病雜志, 2007, 15(9):526-527.
14.	李慧華, 楊敏, 余敏, 等. β₃-AR Trp64Arg遺傳多態性對T2DM患者羅格列酮療效的影響[J].中國藥理學通報, 2009, 25(3):317-321.
15.	孟曉嶸, 駱杰偉, 鄭姜欽, 等. 2型糖尿病痰濕證的β3腎上腺素能受體基因Trp64Arg多態性分析[J].福建中醫藥, 2011, 42(5):7-8, 13.
16.	Zaagsma J, Nahorski SR. Is the adipocyte beta-adrenoceptor a prototype for the recently cloned atypical "beta 3-adrenoceptor"?[J]. Trends Pharmacol Sci, 1990, 11(1):3-7.
17.	Walston J, Silver K, Bogardus C, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene[J]. N Engl J Med, 1995, 333(6):343-347.
18.	Sakane N, Yoshida T, Umekawa T, et al. Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients[J]. Diabetes Care, 1997, 20(12):1887-1890.
19.	王瑤, 蕭建中, 李光偉.原發性高血壓人群胰島素抵抗與β3-腎上腺素能受體基因多態性的關聯[J].中華內分泌代謝雜志, 2001, 17(3):148-150.
20.	Umekawa T, Yoshida T, Sakane N, et al. Anti-obesity and anti-diabetic effects of CL316, 243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats:induction of uncoupling protein and activation of glucose transporter 4 in white fat[J]. Eur J Endocrinol, 1997, 136(4):429-437.
21.	單志桂, 楊新玲, 姚亞妮.如何運用系統評價結果進行臨床實踐[J].中國循證醫學雜志, 2012, 12(3):357-359.

1. Walston J, Silver K, Hilfiker H, et al. Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor[J]. J Clin Endocrinol Metab, 2000, 85(11):4019-4022.
2. Masuo K, Katsuya T, Fu Y, et al. Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals[J]. Am J Hypertens, 2005, 18(7):1009-1014.
3. Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA):an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1):37-55.
4. 王靜, 莫傳偉, 陳群, 等.應用Stata軟件的Meta分析完成醫學科研定量評價[J].中華中醫藥學刊, 2008, 26(5):947-949.
5. 包愛民, 肖尚喜, 王長江, 等. 2型糖尿病與正常人群中β3腎上腺素能受體基因Trp64Arg多態性表型特征[J].中國糖尿病雜志, 2000, 8(1):13-16.
6. 孫黎明, Iizuka Y, Ishibashi S, 等.中國人與日本人β3腎上腺素能受體基因Trp64Arg突變的比較[J].中華醫學雜志, 2000, 80(2):107-110.
7. 陳玉, 周玲, 徐耀初, 等.β3-腎上腺素能受體基因與2型糖尿病關系的研究[J].中國公共衛生, 2001, 17(7):586-588.
8. 李耀明, 梁劍寧. 2型糖尿病與β3腎上腺素能受體基因Trp64Arg多態性的相關性探討[J].廣州醫學院學報, 2004, 32(2):60-62.
9. 孫玉茹, 楊澤, 紀立農.β3腎上腺素能受體基因Trp64Arg變異與2型糖尿病的關聯研究[J].中華糖尿病雜志, 2004, 12(1):43-44.
10. 修玲玲, 翁建平, 隋昳, 等.解偶聯蛋白2基因和β3-腎上腺素能受體基因聯合變異與2型糖尿病及肥胖癥的關系[J].中華醫學雜志, 2004, 84(5):375-379.
11. 惠宗光, 周學偉, 王曉玲, 等. 2型糖尿病人群胰島素抵抗和β₃-AR基因的相關性[J].濰坊醫學院學報, 2005, 27(3):173-175.
12. 李利, 孫黎明, 王軍, 等.β3腎上腺素能受體基因Trp64Arg突變與胰島素抵抗相關[J].中國醫師雜志, 2006, 8(5):636-638.
13. 姜秀云, 侯新國, 侯為開, 等.腎上腺素能β3受體基因多態性與肥胖和胰島素抵抗的相關性[J].中國糖尿病雜志, 2007, 15(9):526-527.
14. 李慧華, 楊敏, 余敏, 等. β₃-AR Trp64Arg遺傳多態性對T2DM患者羅格列酮療效的影響[J].中國藥理學通報, 2009, 25(3):317-321.
15. 孟曉嶸, 駱杰偉, 鄭姜欽, 等. 2型糖尿病痰濕證的β3腎上腺素能受體基因Trp64Arg多態性分析[J].福建中醫藥, 2011, 42(5):7-8, 13.
16. Zaagsma J, Nahorski SR. Is the adipocyte beta-adrenoceptor a prototype for the recently cloned atypical "beta 3-adrenoceptor"?[J]. Trends Pharmacol Sci, 1990, 11(1):3-7.
17. Walston J, Silver K, Bogardus C, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene[J]. N Engl J Med, 1995, 333(6):343-347.
18. Sakane N, Yoshida T, Umekawa T, et al. Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients[J]. Diabetes Care, 1997, 20(12):1887-1890.
19. 王瑤, 蕭建中, 李光偉.原發性高血壓人群胰島素抵抗與β3-腎上腺素能受體基因多態性的關聯[J].中華內分泌代謝雜志, 2001, 17(3):148-150.
20. Umekawa T, Yoshida T, Sakane N, et al. Anti-obesity and anti-diabetic effects of CL316, 243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats:induction of uncoupling protein and activation of glucose transporter 4 in white fat[J]. Eur J Endocrinol, 1997, 136(4):429-437.
21. 單志桂, 楊新玲, 姚亞妮.如何運用系統評價結果進行臨床實踐[J].中國循證醫學雜志, 2012, 12(3):357-359.

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West China Medical Journal

Correlation between T/C Polymorphism in 190 Locus ofβ₃-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis

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West China Medical Journal

Correlation between T/C Polymorphism in 190 Locus ofβ3-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis

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Correlation between T/C Polymorphism in 190 Locus ofβ₃-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis