Study on the Curative Effect of Interventional Chemotherapy for Advanced Gastric Cancer_West China Medical Journal

Authors：

 LIUJia-yun , JIANGChao , XUZhe , CHENChe , YAOXue-quan ,  LIWei-su , LIUFu-kun

Department of Digestive Tumor Surgery, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, P. R. China;

Corresponding?author：

LIWei-su, Email: scidoc@aliyun.com

Keywords：

Advanced gastric cancer; Interventional chemotherapy; Curative effect

DOI：

10.7507/1002-0179.20150024

Video：

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Objective To observe the clinical curative effect of interventional chemotherapy in the treatment of advanced gastric cancer. Methods Thirty advanced gastric cancer patients underwent arterial infusion chemotherapy and embolization treatment between January and December 30, 2013. The treatment was carried out every three weeks. We evaluated the clinical results after the third treatment. The clinical improvement was assessed based on alleviation of such symptoms as epigastric pain, poor appetite, nausea, vomiting and fecal occult blood. The tumor size was evaluated through abdominal CT examination. Results Abdominal pain relieved in 19 out of 28 patients (67.9%); appetite improved in 18 out of 24 patients (75.0%); vomiting relieved in 15 out of 16 cases (93.8%); and fecal 9 out of 12 patients with positive occult blood turned to negative (75.0%). The total effective rate was 83.3%, and 8 patients accepted interventional therapy after operation. The survival rates during the 6, 12 and 24-month follow-up were respectively 85.0%, 65.0%, and 25.0%. Conclusions Interventional chemotherapy and embolization treatment are effective for advanced gastric cancer, which can relieve symptoms and lower tumor stage. Some patients have a second chance of operation, which can be an effective method in the treatment of advanced gastric cancer.

Citation： LIUJia-yun, JIANGChao, XUZhe, CHENChe, YAOXue-quan, LIWei-su, LIUFu-kun. Study on the Curative Effect of Interventional Chemotherapy for Advanced Gastric Cancer. West China Medical Journal, 2015, 30(1): 89-92. doi: 10.7507/1002-0179.20150024 Copy

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12.	劉福坤, 李國立, 陳忠豪, 等.胃癌術前介入治療的臨床和病理觀察(附250例報告)[J].南京大學學報:自然科學版, 1998, 34(2):45-49.
13.	劉福坤, 陳忠豪, 李國立, 等.胃癌術前介入治療后血管變化與癌組織壞死的關系[J].華人消化雜志, 1998, 6(8):686-688.
14.	帥磊淵, 王子衛.介入化療在進展期胃癌新輔助化療中的應用現狀[J].醫學綜述, 2007, 13(13):993-996.
15.	潘彥康.胃癌介入化療與全身化療的療效比較[J].吉林醫學, 2009, 30(15):1561-1562.
16.	劉福坤.介入治療在胃腸道腫瘤中的應用[J].腹部外科, 2004, 17(5):267-269.
17.	吳鵬, 朱正綱, 葉正寶, 等. 5-氟尿嘧啶-2'-脫氧核苷經胃左動脈介入灌注后的藥代動力學實驗研究[J].外科理論與實踐, 2004, 9(2):135-139.
18.	詹文華.胃癌聯合臟器切除術的合理選擇及應用——胰十二指腸切除術在進展期胃癌中的應用[J].中國實用外科雜志, 2001, 21(7):398-400.

1. Krejs GJ. Gastric cancer:epidemiology and risk factors[J]. Dig Dis, 2010, 28(4/5):600-603.
2. Yang D, Hendifar A, Lenz C, et al. Survival of metastatic gastric cancer:significance of age, sex and race/ethnicity[J]. J Gastrointest Oncol, 2011, 2(2):77-84.
3. Jiang Y, Montero AJ, Staveley-O'Carroll KF. Adjuvant and preoperative therapy for localized gastric cancer[J]. Gastrointest Cancer Res, 2007, 1(4):139-145.
4. 彭淑牖.晚期胃癌不要輕易放棄手術切除的機會[J].中國實用外科雜志, 2001, 21(7):400-401.
5. Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial):a phaseⅢtrial[J]. Lancet Oncol, 2008, 9(3):215-221.
6. Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment[J]. Cancer, 1981, 47(1):207-214.
7. 金晟嫻.腫瘤化療藥物新的不良反應評價系統-CTCAE v3.0[J].兒科藥學雜志, 2011, 17(3):53-55.
8. 周際昌.實用腫瘤內科學[M].北京:人民衛生出版社, 1998:47-48.
9. 韓宇.內鏡下介入治療進展期胃癌的療效觀察[J].中國腫瘤臨床與康復, 2007, 14(3):263.
10. 金巨光, 趙忠春, 徐克, 等.進行期胃癌術前經動脈化療栓塞的臨床及病理學研究[J].臨床醫學影像雜志, 1996(2):86-88.
11. 路平, 王舒寶, 袁媛, 等.胃癌術前動脈栓塞化療的臨床及病理學研究[J].中華醫學雜志, 1996(2):67-68.
12. 劉福坤, 李國立, 陳忠豪, 等.胃癌術前介入治療的臨床和病理觀察(附250例報告)[J].南京大學學報:自然科學版, 1998, 34(2):45-49.
13. 劉福坤, 陳忠豪, 李國立, 等.胃癌術前介入治療后血管變化與癌組織壞死的關系[J].華人消化雜志, 1998, 6(8):686-688.
14. 帥磊淵, 王子衛.介入化療在進展期胃癌新輔助化療中的應用現狀[J].醫學綜述, 2007, 13(13):993-996.
15. 潘彥康.胃癌介入化療與全身化療的療效比較[J].吉林醫學, 2009, 30(15):1561-1562.
16. 劉福坤.介入治療在胃腸道腫瘤中的應用[J].腹部外科, 2004, 17(5):267-269.
17. 吳鵬, 朱正綱, 葉正寶, 等. 5-氟尿嘧啶-2'-脫氧核苷經胃左動脈介入灌注后的藥代動力學實驗研究[J].外科理論與實踐, 2004, 9(2):135-139.
18. 詹文華.胃癌聯合臟器切除術的合理選擇及應用——胰十二指腸切除術在進展期胃癌中的應用[J].中國實用外科雜志, 2001, 21(7):398-400.

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