顱內原發性絨毛膜癌的診治進展_West China Medical Journal

Authors：

 劉志勇 ¹ , 郄遠巍 ² ,  徐建國 ¹

1. ;
2. ;

Corresponding?author：

徐建國, Email: jianguo_1229@sina.com

Keywords：

顱內原發性絨毛膜癌; 影像學表現; 人絨毛膜促性腺激素; 聯合治療

DOI：

10.7507/1002-0179.20150111

Video：

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顱內原發性絨毛膜癌是一種惡性程度極高的非生殖細胞性生殖細胞瘤，其臨床罕見，以易發生致命性出血和顱內外播散為主要臨床特征。目前國內外對其治療方法不一，且認識不足，常出現誤診及延誤治療，預后極差。為提高對該病的認識，避免延誤診治，改善預后，現就國內外對于顱內原發性絨毛膜癌的診治進展作一綜述。

Citation： 劉志勇, 郄遠巍, 徐建國. 顱內原發性絨毛膜癌的診治進展. West China Medical Journal, 2015, 30(2): 373-376. doi: 10.7507/1002-0179.20150111 Copy

1.	Askanazy M. Das teratom und chorioepitheliom der zwirbel[J]. Verh Dtsch Ges Pathol, 1906, 10(1):58-76.
2.	Matsutani M, Sano K, Takakura K, et al. Primary intracranial germ cell tumors:a clinical analysis of 153 histologically verified cases[J]. J Neurosurg, 1997, 86(3):446-455.
3.	Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors:natural history and pathogenesis[J]. J Neurosurg, 1985, 63(2):155-167.
4.	The Committee of the Brain Tumor Registry of Japan. Report of the brain tumor registry of Japan (1969-1993) 10th edn[J]. Neurol Med Chir, 2000, 40(Suppl):1-106.
5.	Junko H, Yoichi N. Pathology of pineal region tumors[J]. J Neuro-Oncol, 2001, 54(3):239-249.
6.	Kazuhiro N. Epidemiology of germ cell tumors in Asia of pineal region tumor[J]. J Neuro-Oncol, 2001, 54(3):211-217.
7.	Koyama S, Tsubokawa T, Katayama Y, et al. Choriocarcinoma of the septum pellucidum:case report[J]. Surg Neurol, 1991, 35(6):478-482.
8.	Shinoda J, Sakai N, Yano H, et al. Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG[J]. J Neuro-Oncol, 2004, 66(1/2):225-240.
9.	Page R, Doshi B, Sharr MM. Primary intracranial choriocarcinoma[J]. J Neurol Neurosurg Psychiatry, 1986, 49(1):93-95.
10.	孫學進, 沈進, 戴建平, 等. 顱內原發絨毛膜上皮癌影像學診斷分析[J]. 中國現代影像學雜志, 2006, 3(12):1065-1068.
11.	Teruyoshi K, Shinji N, Kazuhito M et al. Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma:case report[J]. J Neurooncol, 2007, 83(2):199-204.
12.	Nomura K. Special report of brain tumor registry of Japan (1969-1990):Part Ⅱ Results of treatment[J]. Neuro Med Chir, 1999, 39(1):76-106.
13.	Sesterhenn LA,Davis CJ.Pathology of germ cell tumors of the testis[J]. Cancer Control, 2004, 11(6):374-387.
14.	Fine G, Smith RW, Pachter MR. Primary extragenital chiriocarcinoma in the male subject:case report and review of the literature[J]. Am J Med, 1962, 32:776-794.
15.	Ikura Y, Inoue T, Tsukuda H, et al. Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung:are they independent entities?[J]. Histopathology, 2000, 36(1):17-25.
16.	于向榮, 張威江, 李薇. 成年男性鞍區原發性絨毛膜上皮癌一例[J]. 臨床放射學雜志, 2012, 31(10):1485-1486.
17.	陳路佳, 蔡軍, 陳左權, 等. 原發性顱內絨毛膜癌1例[J]. 實用醫學雜志, 2012, 28(15):2051.
18.	Kazuhiko S, Kazunori A, Atsushi T. Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system:histological heterogeneity and surgical meaning[J]. Brain Tumor Pathol, 2001, 18(2):115-122.
19.	張喜安, 漆松濤, 方陸雄, 等. 原發性松果體區絨毛膜癌的綜合治療(附 2 例報告)[J]. 南方醫科大學學報, 2007, 27(8):1193-1195.
20.	李欣欣,汪秀玲. 鞍區絨毛膜癌一例[J]. 臨床放射學雜志, 2011, 30(12):1875.
21.	邱炳輝, 肖罡, 莫益萍, 等. 松果體區腫瘤的MRI表現與其病理學對照研究[J]. 中國臨床神經外科雜志, 2011, 16(8):456-459.
22.	Kohyama S, Uematsu M, Ishihara S, et al. An experience of stereotactic radiation therapy for primary intracranial choriocarcinoma[J]. Tumori, 2001, 87(3):162-165.
23.	Lv XF, Qiu WY, Zhang XL. Primary intracranial choriocarcinoma:MR imaging findings[J]. AJNR Am J Neuroradiol, 2010, 31(10):1994-1998.
24.	徐嬿, 陳燕萍, 王琦, 等. 顱內絨毛膜上皮癌的影像學表現[J]. 臨床放射學雜, 2012, 31(5):746-749.
25.	劉紅艷, 張雪林, 李紹林. 原發性顱內絨毛膜癌的MRI表現[J]. 中華放射學雜志, 2008, 42(10):1108-1109.
26.	Athanassios P, Kyritsis. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
27.	Shin KH, Kim IH, Choe G. Impacts of elevated level of hCG in serum on clinical course and radiotherapy results in the histology conformed intracranial germinomas[J]. Acta Oncologica, 2001, 40(1):98-101.
28.	Ogawa K, Toita T, Nakamura K, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors:a multiinstitutional retrospective analysis of 41 patients[J].Cancer, 2003, 98(2):369-376.
29.	Tomohiro K, Toshihiro K, Masayuki K. Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors[J]. J Neurooncol, 2011, 104(3):779-787.
30.	Utsuki S, Oka H, Tanaka y, et al. Long-term outcome of Intracranial germinoma with hCG elevation in cerebrospinal fluid but not in Serum[J]. Acta Neurochir, 2002, 144(11):1151-1154.
31.	Michel L, Gustavo T, Sabine C. Are stereotactic sample biopsies still of value in the modern management of pineal region tumours? Lessons from a single-department, retrospective series[J]. Acta Neurochir, 2011, 153(5):1111-1122.
32.	柴成奎周俊林. 顱內生殖細胞腫瘤研究進展[J]. 中國CT和MRI雜志, 2012, 10(5):101-105.
33.	Matsutani M, Ushio Y, Abe H, et al. Combined chemotherapy and radiation therapy for central nervous system germ cell tumors:preliminary results of a phase Ⅱ study of the Japanese Pediatric Brain Tumor Study Group(C). Neurosurg Focus, 1998, 5(1):1-7.
34.	Kyritsis AP. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
35.	Kanamori M, Kumabe T, Saito R, et al. Optimal treatment strategy for intracranial germ cell tumors:a single institution analysis[J]. J Neurosurg Pediatr, 2009, 4(6):506-514.
36.	Antonio S, Marica E, Andrea S, et al. Combined chemotherapy and radiotherapy for intracranial germinomas in adult patients: a single-institution study[J]. J Neuro-Oncol, 2005, 71(3):271-276.
37.	Kimura H, Miyashita Y, Inoue K, et al. A case report of successfully treated HCG-secreting primary intracranial choriocarcinoma by high-dose chemotherapy with autologous marrow transplantation[J]. Nippon Naika Gakkai Zasshi, 1995, 84(2):132-134.
38.	Tsuyoshi T, Takeomi T, Fumi N, et al. Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue[J]. J Neuro-Oncol, 1999, 44(1):71-76.

1. Askanazy M. Das teratom und chorioepitheliom der zwirbel[J]. Verh Dtsch Ges Pathol, 1906, 10(1):58-76.
2. Matsutani M, Sano K, Takakura K, et al. Primary intracranial germ cell tumors:a clinical analysis of 153 histologically verified cases[J]. J Neurosurg, 1997, 86(3):446-455.
3. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors:natural history and pathogenesis[J]. J Neurosurg, 1985, 63(2):155-167.
4. The Committee of the Brain Tumor Registry of Japan. Report of the brain tumor registry of Japan (1969-1993) 10th edn[J]. Neurol Med Chir, 2000, 40(Suppl):1-106.
5. Junko H, Yoichi N. Pathology of pineal region tumors[J]. J Neuro-Oncol, 2001, 54(3):239-249.
6. Kazuhiro N. Epidemiology of germ cell tumors in Asia of pineal region tumor[J]. J Neuro-Oncol, 2001, 54(3):211-217.
7. Koyama S, Tsubokawa T, Katayama Y, et al. Choriocarcinoma of the septum pellucidum:case report[J]. Surg Neurol, 1991, 35(6):478-482.
8. Shinoda J, Sakai N, Yano H, et al. Prognostic factors and therapeutic problems of primary intracranial choriocarcinoma/germ-cell tumors with high levels of HCG[J]. J Neuro-Oncol, 2004, 66(1/2):225-240.
9. Page R, Doshi B, Sharr MM. Primary intracranial choriocarcinoma[J]. J Neurol Neurosurg Psychiatry, 1986, 49(1):93-95.
10. 孫學進, 沈進, 戴建平, 等. 顱內原發絨毛膜上皮癌影像學診斷分析[J]. 中國現代影像學雜志, 2006, 3(12):1065-1068.
11. Teruyoshi K, Shinji N, Kazuhito M et al. Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma:case report[J]. J Neurooncol, 2007, 83(2):199-204.
12. Nomura K. Special report of brain tumor registry of Japan (1969-1990):Part Ⅱ Results of treatment[J]. Neuro Med Chir, 1999, 39(1):76-106.
13. Sesterhenn LA,Davis CJ.Pathology of germ cell tumors of the testis[J]. Cancer Control, 2004, 11(6):374-387.
14. Fine G, Smith RW, Pachter MR. Primary extragenital chiriocarcinoma in the male subject:case report and review of the literature[J]. Am J Med, 1962, 32:776-794.
15. Ikura Y, Inoue T, Tsukuda H, et al. Primary choriocarcinoma and human chorionic gonadotrophin-producing giant cell carcinoma of the lung:are they independent entities?[J]. Histopathology, 2000, 36(1):17-25.
16. 于向榮, 張威江, 李薇. 成年男性鞍區原發性絨毛膜上皮癌一例[J]. 臨床放射學雜志, 2012, 31(10):1485-1486.
17. 陳路佳, 蔡軍, 陳左權, 等. 原發性顱內絨毛膜癌1例[J]. 實用醫學雜志, 2012, 28(15):2051.
18. Kazuhiko S, Kazunori A, Atsushi T. Morphologic features of human chorionic gonadotropin- or alpha-fetoprotein-producing germ cell tumors of the central nervous system:histological heterogeneity and surgical meaning[J]. Brain Tumor Pathol, 2001, 18(2):115-122.
19. 張喜安, 漆松濤, 方陸雄, 等. 原發性松果體區絨毛膜癌的綜合治療(附 2 例報告)[J]. 南方醫科大學學報, 2007, 27(8):1193-1195.
20. 李欣欣,汪秀玲. 鞍區絨毛膜癌一例[J]. 臨床放射學雜志, 2011, 30(12):1875.
21. 邱炳輝, 肖罡, 莫益萍, 等. 松果體區腫瘤的MRI表現與其病理學對照研究[J]. 中國臨床神經外科雜志, 2011, 16(8):456-459.
22. Kohyama S, Uematsu M, Ishihara S, et al. An experience of stereotactic radiation therapy for primary intracranial choriocarcinoma[J]. Tumori, 2001, 87(3):162-165.
23. Lv XF, Qiu WY, Zhang XL. Primary intracranial choriocarcinoma:MR imaging findings[J]. AJNR Am J Neuroradiol, 2010, 31(10):1994-1998.
24. 徐嬿, 陳燕萍, 王琦, 等. 顱內絨毛膜上皮癌的影像學表現[J]. 臨床放射學雜, 2012, 31(5):746-749.
25. 劉紅艷, 張雪林, 李紹林. 原發性顱內絨毛膜癌的MRI表現[J]. 中華放射學雜志, 2008, 42(10):1108-1109.
26. Athanassios P, Kyritsis. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
27. Shin KH, Kim IH, Choe G. Impacts of elevated level of hCG in serum on clinical course and radiotherapy results in the histology conformed intracranial germinomas[J]. Acta Oncologica, 2001, 40(1):98-101.
28. Ogawa K, Toita T, Nakamura K, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors:a multiinstitutional retrospective analysis of 41 patients[J].Cancer, 2003, 98(2):369-376.
29. Tomohiro K, Toshihiro K, Masayuki K. Logarithmic decrease of serum alpha-fetoprotein or human chorionic gonadotropin in response to chemotherapy can distinguish a subgroup with better prognosis among highly malignant intracranial non-germinomatous germ cell tumors[J]. J Neurooncol, 2011, 104(3):779-787.
30. Utsuki S, Oka H, Tanaka y, et al. Long-term outcome of Intracranial germinoma with hCG elevation in cerebrospinal fluid but not in Serum[J]. Acta Neurochir, 2002, 144(11):1151-1154.
31. Michel L, Gustavo T, Sabine C. Are stereotactic sample biopsies still of value in the modern management of pineal region tumours? Lessons from a single-department, retrospective series[J]. Acta Neurochir, 2011, 153(5):1111-1122.
32. 柴成奎周俊林. 顱內生殖細胞腫瘤研究進展[J]. 中國CT和MRI雜志, 2012, 10(5):101-105.
33. Matsutani M, Ushio Y, Abe H, et al. Combined chemotherapy and radiation therapy for central nervous system germ cell tumors:preliminary results of a phase Ⅱ study of the Japanese Pediatric Brain Tumor Study Group(C). Neurosurg Focus, 1998, 5(1):1-7.
34. Kyritsis AP. Management of primary intracranial germ cell tumors[J]. J Neurooncol, 2010, 96(2):143-149.
35. Kanamori M, Kumabe T, Saito R, et al. Optimal treatment strategy for intracranial germ cell tumors:a single institution analysis[J]. J Neurosurg Pediatr, 2009, 4(6):506-514.
36. Antonio S, Marica E, Andrea S, et al. Combined chemotherapy and radiotherapy for intracranial germinomas in adult patients: a single-institution study[J]. J Neuro-Oncol, 2005, 71(3):271-276.
37. Kimura H, Miyashita Y, Inoue K, et al. A case report of successfully treated HCG-secreting primary intracranial choriocarcinoma by high-dose chemotherapy with autologous marrow transplantation[J]. Nippon Naika Gakkai Zasshi, 1995, 84(2):132-134.
38. Tsuyoshi T, Takeomi T, Fumi N, et al. Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue[J]. J Neuro-Oncol, 1999, 44(1):71-76.

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顱內原發性絨毛膜癌的診治進展

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