Modified Ultrafiltration Used for Cardiopulmonary Bypass in Children_West China Medical Journal

Authors：

 YANShi-wei , FUChang-jiang , WANGJi-hong , ZHANGJun-biao

Department of Cardiovascular Anesthesiology, the Third People's Hospital of Xingtai, Xingtai, Hebei 054000, P. R. China;

Corresponding?author：

Keywords：

Modified ultrafiltration; Congenital heart disease; Infants; Inflammatory factors

DOI：

10.7507/1002-0179.20150132

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Objective To summarize the clinical usage of modified ultrafiltration in pediatric cardiopulmonary bypass. Methods We selected 40 infants with congenital heart defects as our study subjects between January 2010 and February 2012. They were randomly divided into two groups. One group used modified ultrafiltration, while the other did not, during the operation with cardiopulmonary bypass. The different perioperative changes of pulmonary pressure and the tumor necrosis factor (TNF) and interleukin-8 (IL-8) concentration in plasma were observed in both the two groups. Results No complication relative to modified ultrafiltration was found. After the operations began, TNF and IL-8 concentration in the two groups rose fast; at the end of operations and 2 hours after operation, the pulmonary pressure and TNF and IL-8 concentration in the two groups decreased, and the decrease in the modified ultrafiltration group was faster. Conclusion The use of modified ultrafiltration during operations with cardiopulmonary bypass can reduce residual water within the body in a short period and decrease the concentration of inflammatory factors, which is helpful for postoperative recovery of the cardiac and lung functions.

Citation： YANShi-wei, FUChang-jiang, WANGJi-hong, ZHANGJun-biao. Modified Ultrafiltration Used for Cardiopulmonary Bypass in Children. West China Medical Journal, 2015, 30(3): 464-467. doi: 10.7507/1002-0179.20150132 Copy

1.	Naik SK, Knight A, Elliott MJ. A successful modification of ultrafiltration for cardiopulmonary bypass in children[J]. Perfusion, 1991, 6(5):41-50.
2.	Magilligan DJ, Kam CA, Johnson DC, et al. Hematocrit and blood volume control during cardiopulmonary bypass with the use of hemofiltration[J]. Circulation, 1987, 60(7):478-480.
3.	Tallman RD, Dumond M, Brown D. Inflammatory mediator removal by zero-balance ultrafiltration during cardiopulmonary bypass[J]. Perfusion, 2002, 17(2):111-115.
4.	趙舉, 龍村, 馮正義, 等. 庫血預充液零平衡超濾對嬰幼兒體外循環中炎性反應的影響[J]. 中國胸心血管外科臨床雜志, 2005, 12(6):396-398.
5.	Naik Sk, Knight A, Elliott MJ. A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery[J]. Circulation, 1991, 84(5 Suppl):Ⅲ422-Ⅲ431.
6.	Kirklin JK, Weshaby S, Blackstine EH, et al. Complement and the damageing effect of cardiopulmonary bypass[J]. Thorac Cardiovasc, 1983, 86(3):845-847.
7.	王為民, 劉玉貞, 崔傳玉. 改良超濾在嬰幼兒先心病體外循環中的應用[J]. 江蘇醫藥, 2003, 29(2):144-145.
8.	吳鐵軍, 湯服民, 張躍東, 等. 改良超濾對心臟瓣膜置換術患者肺功能的影響[J]. 中國醫師雜志, 2009, 11(10):1382-1383.
9.	張魯英, 張廣福, 姜冠華, 等. 改良超濾技術在體外循環中的應用[J]. 中國體外循環雜志, 2004, 2(1):14-15.
10.	王偉, 朱德明, 黃惠民, 等. 10公斤以下先天性心臟病患兒圍術期減少用血[J]. 中國胸心血管外科臨床雜志, 1999, 6(4):220-222.
11.	Elliott MJ. Ultrafitration and nodified ultrafiltration in pediatric open-heart poerations[J]. Ann Thorac Surg, 1993, 56(11):1518-1522.
12.	Cheung N, Wong MP, Yuen ST, et al. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon[J]. Hum Pathol, 1998, 29(9):910-914.
13.	Shimpo H, Shimamoto A, Sawamura Y, et al. Ultrafiltration of the priming blood before cardiopulmonary bypass attenuates inflammatory response and improves postoperative clinical course in pediatricpatients[J]. Shock, 2001, 16(Suppl 1):51-54.
14.	趙琦峰, 施霖, 趙曙光, 等. 新法改良超濾在小兒體外循環術中的應用[J]. 臨床小兒外科雜志, 2002, 1(4):264-267, 276.
15.	段大為, 楊景學. 嬰幼兒體外循環的特殊性[J]. 中華胸心血管外科雜志, 2001, 17(3):185-187.
16.	陳京南, 黃勝, 馬樂龍. 改良超濾法在嬰幼兒體外循環中的應用[J]. 中國體外循環雜志, 2004, 2(4):240-241.
17.	朱德明, 王偉, 丁文祥, 等. 平衡超濾法對小兒體外循環中炎癥因子影響[J]. 臨床兒科雜志, 2003, 21(9):561-562.
18.	Konmai H, Adatia IT, Elliot MJ, et al. Incereased plasma levels of endothelin-1 after cardiopulmonary bypass in patient with pulmonary hypertension and congenital heart disease[J]. J Thorac Cardiovase Surg, 1993, 106(3):473-478.

1. Naik SK, Knight A, Elliott MJ. A successful modification of ultrafiltration for cardiopulmonary bypass in children[J]. Perfusion, 1991, 6(5):41-50.
2. Magilligan DJ, Kam CA, Johnson DC, et al. Hematocrit and blood volume control during cardiopulmonary bypass with the use of hemofiltration[J]. Circulation, 1987, 60(7):478-480.
3. Tallman RD, Dumond M, Brown D. Inflammatory mediator removal by zero-balance ultrafiltration during cardiopulmonary bypass[J]. Perfusion, 2002, 17(2):111-115.
4. 趙舉, 龍村, 馮正義, 等. 庫血預充液零平衡超濾對嬰幼兒體外循環中炎性反應的影響[J]. 中國胸心血管外科臨床雜志, 2005, 12(6):396-398.
5. Naik Sk, Knight A, Elliott MJ. A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery[J]. Circulation, 1991, 84(5 Suppl):Ⅲ422-Ⅲ431.
6. Kirklin JK, Weshaby S, Blackstine EH, et al. Complement and the damageing effect of cardiopulmonary bypass[J]. Thorac Cardiovasc, 1983, 86(3):845-847.
7. 王為民, 劉玉貞, 崔傳玉. 改良超濾在嬰幼兒先心病體外循環中的應用[J]. 江蘇醫藥, 2003, 29(2):144-145.
8. 吳鐵軍, 湯服民, 張躍東, 等. 改良超濾對心臟瓣膜置換術患者肺功能的影響[J]. 中國醫師雜志, 2009, 11(10):1382-1383.
9. 張魯英, 張廣福, 姜冠華, 等. 改良超濾技術在體外循環中的應用[J]. 中國體外循環雜志, 2004, 2(1):14-15.
10. 王偉, 朱德明, 黃惠民, 等. 10公斤以下先天性心臟病患兒圍術期減少用血[J]. 中國胸心血管外科臨床雜志, 1999, 6(4):220-222.
11. Elliott MJ. Ultrafitration and nodified ultrafiltration in pediatric open-heart poerations[J]. Ann Thorac Surg, 1993, 56(11):1518-1522.
12. Cheung N, Wong MP, Yuen ST, et al. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon[J]. Hum Pathol, 1998, 29(9):910-914.
13. Shimpo H, Shimamoto A, Sawamura Y, et al. Ultrafiltration of the priming blood before cardiopulmonary bypass attenuates inflammatory response and improves postoperative clinical course in pediatricpatients[J]. Shock, 2001, 16(Suppl 1):51-54.
14. 趙琦峰, 施霖, 趙曙光, 等. 新法改良超濾在小兒體外循環術中的應用[J]. 臨床小兒外科雜志, 2002, 1(4):264-267, 276.
15. 段大為, 楊景學. 嬰幼兒體外循環的特殊性[J]. 中華胸心血管外科雜志, 2001, 17(3):185-187.
16. 陳京南, 黃勝, 馬樂龍. 改良超濾法在嬰幼兒體外循環中的應用[J]. 中國體外循環雜志, 2004, 2(4):240-241.
17. 朱德明, 王偉, 丁文祥, 等. 平衡超濾法對小兒體外循環中炎癥因子影響[J]. 臨床兒科雜志, 2003, 21(9):561-562.
18. Konmai H, Adatia IT, Elliot MJ, et al. Incereased plasma levels of endothelin-1 after cardiopulmonary bypass in patient with pulmonary hypertension and congenital heart disease[J]. J Thorac Cardiovase Surg, 1993, 106(3):473-478.

West China Medical Journal

Modified Ultrafiltration Used for Cardiopulmonary Bypass in Children

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