Controlled Clinical Trials of Traditional Chinese Medicine Syndrome Classification and Intervention in the Prophylaxis of Menstrual Migraine_West China Medical Journal

Authors：

 ZHOUCong-rong ¹ ,  SUNHong-hui ²

1. Department of Traditional Chinese Medicine, Chengdu Women & Children's Central Hospital, Chengdu, Sichuan 610072, P. R. China;
2. Department of Cerebropathy, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P. R. China;

Corresponding?author：

SUNHong-hui, Email: 396296562@qq.com

Keywords：

Traditional Chinese Medicine syndrome classification; Menstrual migraine; Vitamin B2; Quasi-randomized controlled trial

DOI：

10.7507/1002-0179.20150180

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the efficacy and safety of traditinal Chinese Medicine (TCM) syndrome classification and intervention for the prophylaxis of menstrual migraine. Methods Patients consistent with the inclusion criteria from January 2013 to June 2014 were included in the trial. Patients were randomized by their visiting order into two groups:the experimental group was treated with Chinese traditional medicine compound decoctions (two doses for three days), and the control group was treated with vitamin B2 (400 mg once daily). The patients were treated for thirty days consecutively. Efficacy was assessed using the records of the frequency, duration, and severity of migraine attacks. Laboratory tests, vital signs, and adverse events were monitored. Results Both treatments led to a significant reduction in the frequency, duration, and severity of migraine attacks (P<0.05). TCM therapy was significantly better than vitamin B₂ for reducing the frequency and the duration of migraine (P<0.05). No serious adverse drug reaction was found in both groups. Conclusion TCM syndrome classification and intervention is effective and relatively safe in the prophylaxis of menstrual migraine attacks.

Citation： ZHOUCong-rong, SUNHong-hui. Controlled Clinical Trials of Traditional Chinese Medicine Syndrome Classification and Intervention in the Prophylaxis of Menstrual Migraine. West China Medical Journal, 2015, 30(4): 618-621. doi: 10.7507/1002-0179.20150180 Copy

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12.	谷峰. 中醫"頭痛"病名考辨[J]. 吉林中醫藥, 2012, 32(9):959-960.
13.	楊佳, 沈燕, 王舒. 經期偏頭痛中醫藥臨床研究進展[J]. 中華中醫藥雜志, 2013, 28(8):2374-2377.
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1. 李舜偉, 李焰生, 劉若卓, 等. 中國偏頭痛診斷治療指南[J]. 中國疼痛醫學雜志, 2011, 17(2):65-86.
2. 偏頭痛診斷與防治專家共識組. 偏頭痛診斷與防治專家共識[J]. 中華內科雜志, 2006, 45(8):694-696.
3. 王翩, 陳寧, 郭江, 等. 門診原發性頭痛患者就診類型研究[J]. 華西醫學, 2014, 29(6):1106-1108.
4. Lantéri-Minet M, Massiou H, Romatet S, et al. An instrument to assess patient perceptions of satisfaction with acute migraine treatment (EXPERT Study)[J]. Headache, 2011, 51(4):590-601.
5. Silberstein SD, Winner PK, Chmiel JJ. Migraine preventive medication reduces resource utilization[J]. Headache, 2003, 43(3):171.
6. Evers S, Afra J, Frese A, et al. EFNS guideline on the drug treatment of migraine-revised report of an EFNS task force[J]. Eur J Neurol. 2009, 16(9):968-981.
7. Tfelt-Hansen PC. Evidence-based guideline update:pharmacologic treatment for episodic migraine prevention in adults:report of the Quality Standards subcommittee of the American Academy of Neurology and the American Headache Society[J]. Neurology, 2013, 80(9):869-870.
8. Estemalik E, Tepper S. Preventive treatment in migraine and the new US guidelines[J]. Neuropsychiatr Dis Treat, 2013, 9:709-720.
9. Tfelt-Hansen PC, Hougaard A. Migraine:new US guidelines for preventive treatment of migraine[J]. Nat Rev Neurol, 2012, 8(8):419-421.
10. Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults:the american headache society evidence assessment of migraine pharmacotherapies[J]. Headache, 2015, 55(1):3-20.
11. 劉宏偉, 鄒憶懷, 張勇, 等. 偏頭痛研究方法學的現代研究概況[J]. 吉林中醫藥, 2015, 35(1):98-102.
12. 谷峰. 中醫"頭痛"病名考辨[J]. 吉林中醫藥, 2012, 32(9):959-960.
13. 楊佳, 沈燕, 王舒. 經期偏頭痛中醫藥臨床研究進展[J]. 中華中醫藥雜志, 2013, 28(8):2374-2377.
14. 杜青, 李樂軍. 偏頭痛中醫藥治療進展[J]. 吉林中醫藥, 2014, 34(3):314-317.

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