Chaihu Drop-pill in Treatment of Common Cold: A Multi-center and Randomized Controlled Trial_West China Medical Journal

Authors：

 CHANGJing ¹ , TANGFang ² , YANFeng-jie ³ , CAIHong-yan ⁴ , QIAOShi-ju ⁵ , XIONGXu-dong ⁶ , XUEHan-rong ⁷ , CHENZhi-bin ⁸ ,  MAOBing ¹

1. Department of Combination of Traditional Chinese Medicine and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Respiratory Diseases, Tianjin Medical University General Hospital, Tianjin 300052, P. R. China;
3. Department of Respiratory Diseases, the Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P. R. China;
4. Department of Respiratory Diseases, the Integrated Medicine Hospital of Jilin Province, Changchun, Jilin 130021, P. R. China;
5. Department of Respiratory Diseases, the Second Affiliated Hospital to Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110034, P. R. China;
6. Department of Respiratory Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P. R. China;
7. Department of Respiratory Diseases, the Affiliated Hospital to Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330006, P. R. China;
8. Department of Respiratory Diseases, Fujian Institute of Traditional Chinese Medicine, Fuzhou, Fujian 350003, P. R. China;

Corresponding?author：

MAOBing, Email: maobing@medmail.com.cn

Keywords：

Herbal preparations; Randomized controlled trial; Common cold; Wind-heat syndrome; Traditional Chinese medicine

DOI：

10.7507/1002-0179.20150185

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the safety and efficacy of Chaihu drop-pill in the treatment of common cold (wind-heat syndrome). Methods A multi-center, double blind, double dummy, randomized controlled trial was conducted. A total of 479 patients with common cold (wind-heat syndrome) diagnosed between February and August, 2011, were randomly divided into two groups:the trial group (n=359) and the control group (n=120). The trial group received Chaihu drop-pill and Yinchai granule analogue three times a day, while the control group received Yinchai granule and Chaihu drop-pill analogue. The therapeutic courses of both groups were 3 days. Clinical symptoms, syndromes, and adverse effects were observed before and after the treatment. Furthermore, blood, urine and stool test, hepatorenal function test and electrocardiogram were also carried out before and after treatment. Results After treatment, the healing rates of the trial group and the control group were 32.4%, 20.2% (for full analysis set) and 32.6%, 20.5% (for per protocol set), and the overall response rates were 96.3%, 87.4% (for full analysis set) and 96.5%, 87.2% (for per protocol set). There were significant differences between the two groups (P<0.01). No adverse effects were found in the trial. Conclusion Chaihu drop-pill is effective and safe in the treatment of common cold (wind-heat syndrome).

Citation： CHANGJing, TANGFang, YANFeng-jie, CAIHong-yan, QIAOShi-ju, XIONGXu-dong, XUEHan-rong, CHENZhi-bin, MAOBing. Chaihu Drop-pill in Treatment of Common Cold: A Multi-center and Randomized Controlled Trial. West China Medical Journal, 2015, 30(4): 635-639. doi: 10.7507/1002-0179.20150185 Copy

1.	李璐易, 姚寶瑩, 劉曉慧, 等. 京滬兩地看病調查[J]. 首都醫藥, 2010, 17(5):13-18.
2.	殷凱生. 普通感冒的流行病學與疾病負擔[J]. 中華內科雜志, 2012, 51(4):259-260.
3.	中國醫師協會呼吸醫師分會, 中國醫師協會急診醫師分會. 普通感冒規范診治的專家共識[J]. 中華內科雜志, 2012, 51(4):330-333.
4.	郭汝寧, 康敏, 鄭慧貞. 2006年廣州市居民普通感冒發病及就診行為分析[J]. 華南預防醫學, 2008, 34(4):46-48, 52.
5.	劉國梁, 林江濤, 劉關鍵, 等. 門診普通感冒患者對普通感冒認知的調查[J]. 中華內科雜志, 2012, 51(4):262-265.
6.	張文斌, 蔣紅麗, 周維, 等. 中藥治療急性上呼吸道感染隨機對照試驗的系統評價[J]. 中西醫結合學報, 2009, 7(8):706-716.
7.	國家食品藥品監督管理局. 中藥品種保護指導原則[EB/OL]. (2010-07-01)[2014-11-01]. http://www.zybh.gov.cn/d?xh=140891.
8.	陸再英, 鐘南山. 內科學[M]. 7版. 北京:人民衛生出版社, 2008:11.
9.	鄭筱萸. 中藥新藥臨床研究指導原則:試行[M]. 北京:中國醫藥科技出版社, 2002:58-60.
10.	國家藥品監督管理局. 《藥物臨床試驗質量管理規范》(局令第3號)[EB/OL]. (2003-08-06)[2014-11-01]. http://www.sda.gov.cn/WS01/CL0053/24473.html.
11.	黃偉, 孫蓉. 柴胡皂苷類成分化學與藥理和毒理作用研究進展[J]. 中藥藥理與臨床, 2010, 26(3):71-74.
12.	蘇偉, 陳信義, 李冬云, 等. 柴胡滴丸治療風熱感冒臨床療效觀察[J]. 北京中醫藥大學學報, 1998, 21(4):56-57.
13.	吳迺峰, 郭治昕, 王俊顯, 等. 柴胡滴丸治療感冒的臨床研究[J]. 中國醫院導刊, 2000, 2(3):37-39.

1. 李璐易, 姚寶瑩, 劉曉慧, 等. 京滬兩地看病調查[J]. 首都醫藥, 2010, 17(5):13-18.
2. 殷凱生. 普通感冒的流行病學與疾病負擔[J]. 中華內科雜志, 2012, 51(4):259-260.
3. 中國醫師協會呼吸醫師分會, 中國醫師協會急診醫師分會. 普通感冒規范診治的專家共識[J]. 中華內科雜志, 2012, 51(4):330-333.
4. 郭汝寧, 康敏, 鄭慧貞. 2006年廣州市居民普通感冒發病及就診行為分析[J]. 華南預防醫學, 2008, 34(4):46-48, 52.
5. 劉國梁, 林江濤, 劉關鍵, 等. 門診普通感冒患者對普通感冒認知的調查[J]. 中華內科雜志, 2012, 51(4):262-265.
6. 張文斌, 蔣紅麗, 周維, 等. 中藥治療急性上呼吸道感染隨機對照試驗的系統評價[J]. 中西醫結合學報, 2009, 7(8):706-716.
7. 國家食品藥品監督管理局. 中藥品種保護指導原則[EB/OL]. (2010-07-01)[2014-11-01]. http://www.zybh.gov.cn/d?xh=140891.
8. 陸再英, 鐘南山. 內科學[M]. 7版. 北京:人民衛生出版社, 2008:11.
9. 鄭筱萸. 中藥新藥臨床研究指導原則:試行[M]. 北京:中國醫藥科技出版社, 2002:58-60.
10. 國家藥品監督管理局. 《藥物臨床試驗質量管理規范》(局令第3號)[EB/OL]. (2003-08-06)[2014-11-01]. http://www.sda.gov.cn/WS01/CL0053/24473.html.
11. 黃偉, 孫蓉. 柴胡皂苷類成分化學與藥理和毒理作用研究進展[J]. 中藥藥理與臨床, 2010, 26(3):71-74.
12. 蘇偉, 陳信義, 李冬云, 等. 柴胡滴丸治療風熱感冒臨床療效觀察[J]. 北京中醫藥大學學報, 1998, 21(4):56-57.
13. 吳迺峰, 郭治昕, 王俊顯, 等. 柴胡滴丸治療感冒的臨床研究[J]. 中國醫院導刊, 2000, 2(3):37-39.

Previous Article
心搏驟停后的溶栓治療
Next Article
Effects of Emodin on the Expression of Hypoxia Inducible Factor-1α Protein in Rats with Severe Acute Pancreatitis-associated Renal Injury

West China Medical Journal

Chaihu Drop-pill in Treatment of Common Cold: A Multi-center and Randomized Controlled Trial

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content