Treatment of antibiotic associated diarrhea by Bifidobacterium tetravaccine in infants in China: a Meta-analysis_West China Medical Journal

Authors：

CHAI Jianhua ,  CHANG Hongmei , LI Lian

Department of Nosocomial Infections, Chongzhou People’s Hospital, Chongzhou, Sichuan 611230, P. R. China;

Corresponding?author：

CHANG Hongmei, Email: 2293408083@qq.com

Keywords：

Bifidobacteriumtetravaccine; Infants; Antibiotic associated diarrhea; Meta-analysis

DOI：

10.7507/1002-0179.201502139

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Objective To systematically evaluate the clinical effect and safety of Bifidobacterium tetravaccine tablets in the treatment of antibiotic associated diarrhea (ADD) in infants in China. Methods Randomized controlled trials (RCTs) of treatment of AAD by Bifidobacterium tetravaccine in infants were searched by computer from China Knowledge Resource Integrated Database, VIP and Wanfang Data from their inception to November 2016. Meta-analysis of the data was carried out by RevMan 5.3 software. Results Twelve RCTs were chosen, which included 1 761 infant patients. The Meta analysis showed that the effects of treatment of ADD were significantly superior to those of the control group [OR=5.74, 95%CI (4.14, 7.96),P<0.000 01]. Among the 12 RCTs, 8 had no adverse reactions, while the rest4 articles did not mention adverse reactions. Conclusions Based on the present clinical evidences, treatment of ADD by Bifidobacterium tetravaccine in infants is effective and safe. But due to the small number and different quality of RCTs, this conclusion still needs to be confirmed by large sample, multicenter, and high-quality clinical RCTs.

Citation： CHAI Jianhua, CHANG Hongmei, LI Lian. Treatment of antibiotic associated diarrhea by Bifidobacterium tetravaccine in infants in China: a Meta-analysis. West China Medical Journal, 2017, 32(3): 395-399. doi: 10.7507/1002-0179.201502139 Copy

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13.	陳卓. 思連康治療嬰幼兒抗生素相關性腹瀉的臨床觀察. 醫學信息, 2011, 24(6): 3422-3423.
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1. 李蘭娟. 感染微生態學. 北京: 人民衛生出版社, 2002: 314.
2. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions Version 5.1.0. (2011-03-01)[2016-10-01]. http://www.Cochrane-handbook.org.
3. 呂亞清, 宋紹雄, 夏波, 等. 雙歧桿菌四聯活菌片治療嬰幼兒抗生素相關性腹瀉的療效. 實用臨床醫學, 2014, 15(9): 78-79, 84.
4. 王妍妍, 關晶, 溫韜雪. 思連康改善抗生素相關性腹瀉患兒菌群失調隨機對照研究. 中國藥業, 2016, 25(7): 5-7.
5. 朱紅英. 思連康聯合思密達治療嬰幼兒肺炎繼發腹瀉效果觀察. 現代醫藥衛生, 2007, 23(18): 2724-2725.
6. 王安林, 王榮林, 周向陽, 等. 思連康治療嬰幼兒肺炎繼發性腹瀉55例. 醫學信息, 2009, 22(10): 2114-2115.
7. 王慧. 思連康治療嬰幼兒肺炎并發腹瀉的療效觀察. 內蒙古中醫藥, 2013(19): 62-63.
8. 曾國華, 黃艷春. 思連康治療嬰幼兒肺炎繼發性腹瀉49例療效分析. 咸寧學院學報: 醫學版, 2008, 22(5): 415.
9. 陳靜, 王立平. 思連康治療嬰幼兒肺炎繼發腹瀉療效觀察. 中國醫學文摘: 兒科學, 2008, 27(3): 206-207.
10. 周晶明. 雙歧桿菌四聯活菌片治療160例嬰幼兒抗生素相關性腹瀉的臨床觀察. 中國實用醫藥, 2009, 4(33): 100-101.
11. 戴文, 馮祖章, 楊三平. 雙歧桿菌四聯活菌片治療嬰幼兒抗生素相關性腹瀉療效分析. 中國醫藥指南, 2011, 9(8): 86-87.
12. 張茜. 雙歧桿菌四聯活菌片治療抗生素相關性腹瀉療效分析. 醫學理論與實踐, 2013, 26(12): 1628-1629.
13. 陳卓. 思連康治療嬰幼兒抗生素相關性腹瀉的臨床觀察. 醫學信息, 2011, 24(6): 3422-3423.
14. 吳雄基, 陸俏群. 雙歧桿菌四聯活菌片治療嬰幼兒抗生素相關性腹瀉的臨床研究. 中國實用醫藥, 2014, 9(26): 20-21.
15. 凌俊, 譚成林. 雙歧桿菌四聯活菌片治療小兒厭食癥療效觀察. 吉林醫學, 2011, 32(22): 4599.

West China Medical Journal

Treatment of antibiotic associated diarrhea by Bifidobacterium tetravaccine in infants in China: a Meta-analysis

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