廣泛性焦慮障礙靜息態功能磁共振研究進展_West China Medical Journal

Authors：

 邱昌建 , 穆超 , 沈聃琳 , 葉應華 , 孟雅婧 ,  楊彥春

四川大學華西醫院心理衛生中心（成都 610041）;

Corresponding?author：

楊彥春, Email: yanchun_yang@hotmail.com

Keywords：

廣泛性焦慮障礙; 功能磁共振; 靜息態

DOI：

10.7507/1002-0179.20150278

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任務態功能磁共振成像研究很大程度上受制于任務本身的設計與性質，隨著靜息態功能磁共振成像技術的發展，靜息態功能磁共振成像已成為研究神經、精神疾病的熱點。現就廣泛性焦慮障礙靜息態功能磁共振研究進展進行綜述。

Citation： 邱昌建, 穆超, 沈聃琳, 葉應華, 孟雅婧, 楊彥春. 廣泛性焦慮障礙靜息態功能磁共振研究進展. West China Medical Journal, 2015, 30(5): 976-979. doi: 10.7507/1002-0179.20150278 Copy

1.	Raichle ME, Mintun MA. Brain work and brain imaging[J]. Annu Rev Neurosci, 2006, 29:449-476.
2.	Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI[J]. Magn Reson Med, 1995, 34(4):537-541.
3.	Cordes D, Haughton VM, Arfanakis K, et al. Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data[J]. AJNR Am J Neuroradiol, 2001, 22(7):1326-1333.
4.	Birn RM, Diamond JB, Smith MA, et al. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI[J]. Neuroimage, 2006, 31(4):1536-1548.
5.	Beall EB, Lowe MJ. Isolating physiologic noise sources with independently determined spatial measures[J]. Neuroimage, 2007, 37(4):1286-1300.
6.	Arfanakis K, Cordes D, Haughton VM, et al. Combining Independent component analysis and correlation analysis to probe interregional connectivity in fMRI task activation datasets[J]. Magn Reson Imaging, 2000, 18(8):921-930.
7.	Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems[J]. Proc Natl Acad Sci USA, 2006, 103(26):10046-10051.
8.	Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks[J]. Proc Natl Acad Sci USA, 2005, 102(27):9673-9678.
9.	Fransson P. How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations[J]. Neuropsychologia, 2006, 44(14):2836-2845.
10.	Greicius MD, Menon V. Default-mode activity during a passive sensory task:uncoupled from deactivation but impacting activation[J]. J Cogn Neurosci, 2004, 16(9):1484-1492.
11.	Fukunaga M, Horovitz SG, Van Gelderen P, et al. Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages[J]. Magn Reson Imaging, 2006, 24(8):979-992.
12.	Horovitz SG, Fukunaga M, De Zwart JA, et al. Low frequency BOLD fluctuations during resting wakefulness and light sleep:a simultaneous EEG-fMRI study[J]. Hum Brain Mapp, 2008, 29(6):671-682.
13.	Vincent JL, Patel GH, Fox MD, et al. Intrinsic functional architecture in the anaesthetized monkey brain[J]. Nature, 2007, 447(7140):83-86.
14.	Kim MJ, Loucks RA, Palmer AL, et al. The structural and functional connectivity of the amygdala:from normal emotion to pathological anxiety[J]. Behav Brain Res, 2011, 223(2):403-410.
15.	楊麗琴, 林富春, 雷皓. 靜息狀態下腦功能連接的磁共振成像研究[J]. 波譜學雜志, 2010, 27(3):326-340.
16.	Nitschke JB, Sarinopoulos I, Oathes DJ, et al. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response[J]. Am J Psychiatry, 2009, 166(3):302-310.
17.	Etkin A, Prater KE, Hoeft F, et al. Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder[J]. Am J Psychiatry, 2010, 167(5):545-554.
18.	Thomas KM, Drevets WC, Dahl RE, et al. Amygdala response to fearful faces in anxious and depressed children[J]. Arch Gen Psychiatry, 2001, 58(11):1057-1063.
19.	Mcclure EB, Monk CS, Nelson EE, et al. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder[J]. Arch Gen Psychiatry, 2007, 64(1):97-106.
20.	Monk CS, Telzer EH, Mogg K, et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder[J]. Arch Gen Psychiatry, 2008, 65(5):568-576.
21.	Monk CS, Nelson EE, Mcclure EB, et al. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder[J]. Am J Psychiatry, 2006, 163(6):1091-1097.
22.	Blair K, Shaywitz J, Smith BW, et al. Response to emotional expressions in generalized social phobia and generalized anxiety disorder:evidence for separate disorders[J]. Am J Psychiatry, 2008, 165(9):1193-1202.
23.	Whalen PJ, Johnstone T, Somerville LH, et al. A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder[J]. Biol Psychiatry, 2008, 63(9):858-863.
24.	Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1):394-400.
25.	尤美娜, 程文紅, 門衛偉, 等. 青少年廣泛性焦慮障礙患者靜息態功能磁共振成像研究[J]. 臨床精神醫學雜志, 2012, 22(5):306-309.
26.	Schienle A, Ebner F, Sch?fer A. Localized gray matter volume abnormalities in generalized anxiety disorder[J]. Eur Arch Psychiatry Clin Neurosci, 2011, 261(4):303-307.
27.	Friston KJ, Frith CD, Liddle PF, et al. Functional connectivity:the principal-component analysis of large (PET) data sets[J]. J Cereb Blood Flow Metab, 1993, 13(1):5-14.
28.	Roy AK, Fudge JL, Kelly C, et al. Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder[J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(3):290-299.e2.
29.	Etkin A, Prater KE, Schatzberg AF, et al. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder[J]. Arch Gen Psychiatry, 2009, 66(12):1361-1372.
30.	Beekman AT, Bremmer MA, Deeg DJ, et al. Anxiety disorders in later life:a report from the Longitudinal Aging Study Amsterdam[J]. Int J Geriatr Psychiatry, 1998, 13(10):717-726.
31.	Lenze EJ, Rollman BL, Shear MK, et al. Escitalopram for older adults with generalized anxiety disorder:a randomized controlled trial[J]. JAMA, 2009, 301(3):295-303.
32.	Andreescu C, Gross JJ, Lenze E, et al. Altered cerebral blood flow patterns associated with pathologic worry in the elderly[J]. Depress Anxiety, 2011, 28(3):202-209.
33.	Andreescu C, Sheu LK, Tudorascu D, et al. The ages of anxiety:differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder[J]. Int J Geriatr Psychiatry, 2014, 29(7):704-712.
34.	Chen AC, Etkin A. Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder[J]. Neuropsychopharmacology, 2013, 38(10):1889-1898.

1. Raichle ME, Mintun MA. Brain work and brain imaging[J]. Annu Rev Neurosci, 2006, 29:449-476.
2. Biswal B, Yetkin FZ, Haughton VM, et al. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI[J]. Magn Reson Med, 1995, 34(4):537-541.
3. Cordes D, Haughton VM, Arfanakis K, et al. Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data[J]. AJNR Am J Neuroradiol, 2001, 22(7):1326-1333.
4. Birn RM, Diamond JB, Smith MA, et al. Separating respiratory-variation-related fluctuations from neuronal-activity-related fluctuations in fMRI[J]. Neuroimage, 2006, 31(4):1536-1548.
5. Beall EB, Lowe MJ. Isolating physiologic noise sources with independently determined spatial measures[J]. Neuroimage, 2007, 37(4):1286-1300.
6. Arfanakis K, Cordes D, Haughton VM, et al. Combining Independent component analysis and correlation analysis to probe interregional connectivity in fMRI task activation datasets[J]. Magn Reson Imaging, 2000, 18(8):921-930.
7. Fox MD, Corbetta M, Snyder AZ, et al. Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems[J]. Proc Natl Acad Sci USA, 2006, 103(26):10046-10051.
8. Fox MD, Snyder AZ, Vincent JL, et al. The human brain is intrinsically organized into dynamic, anticorrelated functional networks[J]. Proc Natl Acad Sci USA, 2005, 102(27):9673-9678.
9. Fransson P. How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations[J]. Neuropsychologia, 2006, 44(14):2836-2845.
10. Greicius MD, Menon V. Default-mode activity during a passive sensory task:uncoupled from deactivation but impacting activation[J]. J Cogn Neurosci, 2004, 16(9):1484-1492.
11. Fukunaga M, Horovitz SG, Van Gelderen P, et al. Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages[J]. Magn Reson Imaging, 2006, 24(8):979-992.
12. Horovitz SG, Fukunaga M, De Zwart JA, et al. Low frequency BOLD fluctuations during resting wakefulness and light sleep:a simultaneous EEG-fMRI study[J]. Hum Brain Mapp, 2008, 29(6):671-682.
13. Vincent JL, Patel GH, Fox MD, et al. Intrinsic functional architecture in the anaesthetized monkey brain[J]. Nature, 2007, 447(7140):83-86.
14. Kim MJ, Loucks RA, Palmer AL, et al. The structural and functional connectivity of the amygdala:from normal emotion to pathological anxiety[J]. Behav Brain Res, 2011, 223(2):403-410.
15. 楊麗琴, 林富春, 雷皓. 靜息狀態下腦功能連接的磁共振成像研究[J]. 波譜學雜志, 2010, 27(3):326-340.
16. Nitschke JB, Sarinopoulos I, Oathes DJ, et al. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response[J]. Am J Psychiatry, 2009, 166(3):302-310.
17. Etkin A, Prater KE, Hoeft F, et al. Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder[J]. Am J Psychiatry, 2010, 167(5):545-554.
18. Thomas KM, Drevets WC, Dahl RE, et al. Amygdala response to fearful faces in anxious and depressed children[J]. Arch Gen Psychiatry, 2001, 58(11):1057-1063.
19. Mcclure EB, Monk CS, Nelson EE, et al. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder[J]. Arch Gen Psychiatry, 2007, 64(1):97-106.
20. Monk CS, Telzer EH, Mogg K, et al. Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder[J]. Arch Gen Psychiatry, 2008, 65(5):568-576.
21. Monk CS, Nelson EE, Mcclure EB, et al. Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder[J]. Am J Psychiatry, 2006, 163(6):1091-1097.
22. Blair K, Shaywitz J, Smith BW, et al. Response to emotional expressions in generalized social phobia and generalized anxiety disorder:evidence for separate disorders[J]. Am J Psychiatry, 2008, 165(9):1193-1202.
23. Whalen PJ, Johnstone T, Somerville LH, et al. A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder[J]. Biol Psychiatry, 2008, 63(9):858-863.
24. Zang Y, Jiang T, Lu Y, et al. Regional homogeneity approach to fMRI data analysis[J]. Neuroimage, 2004, 22(1):394-400.
25. 尤美娜, 程文紅, 門衛偉, 等. 青少年廣泛性焦慮障礙患者靜息態功能磁共振成像研究[J]. 臨床精神醫學雜志, 2012, 22(5):306-309.
26. Schienle A, Ebner F, Sch?fer A. Localized gray matter volume abnormalities in generalized anxiety disorder[J]. Eur Arch Psychiatry Clin Neurosci, 2011, 261(4):303-307.
27. Friston KJ, Frith CD, Liddle PF, et al. Functional connectivity:the principal-component analysis of large (PET) data sets[J]. J Cereb Blood Flow Metab, 1993, 13(1):5-14.
28. Roy AK, Fudge JL, Kelly C, et al. Intrinsic functional connectivity of amygdala-based networks in adolescent generalized anxiety disorder[J]. J Am Acad Child Adolesc Psychiatry, 2013, 52(3):290-299.e2.
29. Etkin A, Prater KE, Schatzberg AF, et al. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder[J]. Arch Gen Psychiatry, 2009, 66(12):1361-1372.
30. Beekman AT, Bremmer MA, Deeg DJ, et al. Anxiety disorders in later life:a report from the Longitudinal Aging Study Amsterdam[J]. Int J Geriatr Psychiatry, 1998, 13(10):717-726.
31. Lenze EJ, Rollman BL, Shear MK, et al. Escitalopram for older adults with generalized anxiety disorder:a randomized controlled trial[J]. JAMA, 2009, 301(3):295-303.
32. Andreescu C, Gross JJ, Lenze E, et al. Altered cerebral blood flow patterns associated with pathologic worry in the elderly[J]. Depress Anxiety, 2011, 28(3):202-209.
33. Andreescu C, Sheu LK, Tudorascu D, et al. The ages of anxiety:differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder[J]. Int J Geriatr Psychiatry, 2014, 29(7):704-712.
34. Chen AC, Etkin A. Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder[J]. Neuropsychopharmacology, 2013, 38(10):1889-1898.

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廣泛性焦慮障礙靜息態功能磁共振研究進展

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