A Meta-analysis of Glucosamine for Osteoarthritis in Asian Population_West China Medical Journal

Authors：

 CHENShi-ju , LIUYuan ,  SHIGui-xiu

Department of Rheumatology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P. R. China;

Corresponding?author：

SHIGui-xiu, Email: guixiu.shi@gmail.com

Keywords：

Osteoarthritis; Glucosamine; Asian population; Meta-analysis

DOI：

10.7507/1002-0179.20150466

Video：

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Objective To study the effectiveness and safety of glucosamine for osteoarthritis (OA) in Asian population. Method Databases of PubMed, Embase, CNKI, VIP and Wanfang were searched from the time of establishment till May 2014 and controlled trials of glucosamine compared with placebo or nonsteroidal anti-inflammatory drugs (NSAIDs) were included. Quality evaluation and Meta-analysis by using RevMan 5.1 were performed. Results A total of 17 studies including 2 251 cases were included. The efficiency rate in the glucosamine group was higher than that in the NSAIDs group[OR=3.03, 95% CI (1.78, 5.18), P<0.000 1]. The efficiency rate in the glucosamine combined NSAIDs group was higher than that in the NSAIDs group[OR=4.30,95%CI (1.84,10.06),P=0.000 8]. The safety analysis showed that the adverse event rate in the glucosamine group was lower than that in the NSAIDs group[OR=0.23,95%CI (0.14,0.37),P<0.000 01], while the difference between the glucosamine combined NSAIDs group and the NSAIDs group was not statistically significant[OR=0.84, 95%CI (0.50, 1.41), P=0.50]. Conclusions Compared with NSAIDs, glucosamine is better and safer for OA treatment in Asian population.

Citation： CHENShi-ju, LIUYuan, SHIGui-xiu. A Meta-analysis of Glucosamine for Osteoarthritis in Asian Population. West China Medical Journal, 2015, 30(9): 1627-1632. doi: 10.7507/1002-0179.20150466 Copy

1.	Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8):1343-1355.
2.	謝河秋. 鹽酸氨基葡萄糖在膝骨性關節炎治療中的臨床觀察[J]. 現代預防醫學, 2009, 36(11):2161-2162.
3.	Wu D, Huang Y, Gu Y, et al. Efficacies of different preparations of glucosamine for the treatment of osteoarthritis:a meta-analysis of randomised, double-blind, placebo-controlled trials[J]. Int J Clin Pract, 2013, 67(6):585-594.
4.	Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses[J]. BMJ, 2003, 327(7414):557-560.
5.	左川, 楊南萍, 陳詠濤. 硫酸氨基葡萄糖與雙氯芬酸治療膝骨關節炎的臨床對照研究[J]. 中華風濕病學雜志, 2003, 7(5):306-308.
6.	張國華, 李桃. 鹽酸氨基葡萄糖與雙氯芬酸鈉緩釋片治療骨性關節炎療效對比[J]. 廣東醫學, 2006, 27(12):1907-1908.
7.	崔紅霞, 王衛衛, 孟麗華. 鹽酸氨基葡萄糖治療骨關節炎的臨床觀察[J]. 中國實用醫藥, 2008, 3(34):163-164.
8.	趙延斌, 林伍伍. 鹽酸氨基葡萄糖膠囊治療膝骨關節炎療效觀察[J]. 中國藥師, 2011, 14(9):1314-1315.
9.	吳建榮. 氨基葡萄糖對膝關節骨性關節炎臨床療效的平行對照研究[J]. 中國現代醫生, 2011, 49(16):68-69.
10.	唐一侖, 王坤正, 黨曉謙, 等. 鹽酸氨基葡萄糖結合塞來昔布治療膝骨關節炎的療效觀察[J]. 華西醫學, 2012, 27(12):1780-1783.
11.	陳作桓. 鹽酸氨基葡萄糖與雙氯芬酸鈉治療骨性關節炎療效對比[J]. 吉林醫學, 2012, 33(6):1230.
12.	向成浩, 蔣從斌, 楊萬波, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的臨床研究[J]. 華西醫學, 2012, 27(12):1796-1799.
13.	王忠平. 鹽酸氨基葡萄糖治療骨關節炎的療效評價[J]. 華西醫學, 2013, 28(1):93-94.
14.	張紹龍. 鹽酸氨基葡萄糖治療膝骨關節炎的療效觀察[J]. 醫藥前沿, 2013(8):5.
15.	李敏, 楊南萍, 尉浩, 等. 雙醋瑞因聯合鹽酸氨基葡萄糖、雙氯芬酸鈉治療骨性關節炎療效比較[J]. 華西醫學, 2009, 24(8):2067-2069.
16.	高延軍, 安久利, 趙廣. 鹽酸氨基葡萄糖聯合洛索洛芬鈉治療膝骨性關節炎臨床觀察[J]. 中國骨腫瘤骨病, 2010, 9(3):248-251.
17.	曾偉南, 周宗科, 李海, 等. 氨基葡萄糖聯合布洛芬與單用布洛芬治療髖關節骨關節炎前瞻性隨機對照臨床研究[J]. 華西醫學, 2012, 27(12):1805-1808.
18.	王燕. 氨基葡萄糖治療骨關節炎療效觀察[J]. 基層醫學論壇, 2012, 16(11):1417-1418.
19.	黎艷東. 塞來昔布聯合鹽酸氨基葡萄糖治療膝骨性關節炎[J]. 中國醫藥導報, 2012, 9(21):87-88.
20.	閔華, 蒙珍. 雙氯芬酸鈉聯合鹽酸氨基葡萄糖治療膝骨關節炎60例[J]. 中國藥業, 2013, 22(9):31-32.
21.	丁國強. 鹽酸氨基葡萄糖與對乙酰氨基酚治療膝骨關節炎的臨床療效觀察[J]. 華西醫學, 2013, 28(12):1840-1842.
22.	James CB, Uhl TL. A review of articular cartilage pathology and the use of glucosamine sulfate[J]. J Athl Train, 2001, 36(4):413-419.
23.	Mujakperuo HR, Watson M, Morrison R, et al. Pharmacological interventions for pain in patients with temporomandibular disorders[J]. Cochrane Database Syst Rev, 2010(10):CD004715.
24.	Winickoff DE, Obasogie OK. Race-specific drugs:regulatory trends and public policy[J]. Trends Pharmacol Sci, 2008, 29(6):277-279.
25.	Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis:a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4):862-869.
26.	李春潔, 賈源源, 張綺, 等. 鹽酸氨基葡萄糖片聯合玻璃酸鈉治療顳下頜關節骨關節炎的臨床隨機對照試驗[J]. 華西口腔醫學雜志, 2011, 29(6):632-635, 639.

1. Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8):1343-1355.
2. 謝河秋. 鹽酸氨基葡萄糖在膝骨性關節炎治療中的臨床觀察[J]. 現代預防醫學, 2009, 36(11):2161-2162.
3. Wu D, Huang Y, Gu Y, et al. Efficacies of different preparations of glucosamine for the treatment of osteoarthritis:a meta-analysis of randomised, double-blind, placebo-controlled trials[J]. Int J Clin Pract, 2013, 67(6):585-594.
4. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses[J]. BMJ, 2003, 327(7414):557-560.
5. 左川, 楊南萍, 陳詠濤. 硫酸氨基葡萄糖與雙氯芬酸治療膝骨關節炎的臨床對照研究[J]. 中華風濕病學雜志, 2003, 7(5):306-308.
6. 張國華, 李桃. 鹽酸氨基葡萄糖與雙氯芬酸鈉緩釋片治療骨性關節炎療效對比[J]. 廣東醫學, 2006, 27(12):1907-1908.
7. 崔紅霞, 王衛衛, 孟麗華. 鹽酸氨基葡萄糖治療骨關節炎的臨床觀察[J]. 中國實用醫藥, 2008, 3(34):163-164.
8. 趙延斌, 林伍伍. 鹽酸氨基葡萄糖膠囊治療膝骨關節炎療效觀察[J]. 中國藥師, 2011, 14(9):1314-1315.
9. 吳建榮. 氨基葡萄糖對膝關節骨性關節炎臨床療效的平行對照研究[J]. 中國現代醫生, 2011, 49(16):68-69.
10. 唐一侖, 王坤正, 黨曉謙, 等. 鹽酸氨基葡萄糖結合塞來昔布治療膝骨關節炎的療效觀察[J]. 華西醫學, 2012, 27(12):1780-1783.
11. 陳作桓. 鹽酸氨基葡萄糖與雙氯芬酸鈉治療骨性關節炎療效對比[J]. 吉林醫學, 2012, 33(6):1230.
12. 向成浩, 蔣從斌, 楊萬波, 等. 鹽酸氨基葡萄糖治療膝骨關節炎的臨床研究[J]. 華西醫學, 2012, 27(12):1796-1799.
13. 王忠平. 鹽酸氨基葡萄糖治療骨關節炎的療效評價[J]. 華西醫學, 2013, 28(1):93-94.
14. 張紹龍. 鹽酸氨基葡萄糖治療膝骨關節炎的療效觀察[J]. 醫藥前沿, 2013(8):5.
15. 李敏, 楊南萍, 尉浩, 等. 雙醋瑞因聯合鹽酸氨基葡萄糖、雙氯芬酸鈉治療骨性關節炎療效比較[J]. 華西醫學, 2009, 24(8):2067-2069.
16. 高延軍, 安久利, 趙廣. 鹽酸氨基葡萄糖聯合洛索洛芬鈉治療膝骨性關節炎臨床觀察[J]. 中國骨腫瘤骨病, 2010, 9(3):248-251.
17. 曾偉南, 周宗科, 李海, 等. 氨基葡萄糖聯合布洛芬與單用布洛芬治療髖關節骨關節炎前瞻性隨機對照臨床研究[J]. 華西醫學, 2012, 27(12):1805-1808.
18. 王燕. 氨基葡萄糖治療骨關節炎療效觀察[J]. 基層醫學論壇, 2012, 16(11):1417-1418.
19. 黎艷東. 塞來昔布聯合鹽酸氨基葡萄糖治療膝骨性關節炎[J]. 中國醫藥導報, 2012, 9(21):87-88.
20. 閔華, 蒙珍. 雙氯芬酸鈉聯合鹽酸氨基葡萄糖治療膝骨關節炎60例[J]. 中國藥業, 2013, 22(9):31-32.
21. 丁國強. 鹽酸氨基葡萄糖與對乙酰氨基酚治療膝骨關節炎的臨床療效觀察[J]. 華西醫學, 2013, 28(12):1840-1842.
22. James CB, Uhl TL. A review of articular cartilage pathology and the use of glucosamine sulfate[J]. J Athl Train, 2001, 36(4):413-419.
23. Mujakperuo HR, Watson M, Morrison R, et al. Pharmacological interventions for pain in patients with temporomandibular disorders[J]. Cochrane Database Syst Rev, 2010(10):CD004715.
24. Winickoff DE, Obasogie OK. Race-specific drugs:regulatory trends and public policy[J]. Trends Pharmacol Sci, 2008, 29(6):277-279.
25. Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis:a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4):862-869.
26. 李春潔, 賈源源, 張綺, 等. 鹽酸氨基葡萄糖片聯合玻璃酸鈉治療顳下頜關節骨關節炎的臨床隨機對照試驗[J]. 華西口腔醫學雜志, 2011, 29(6):632-635, 639.

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A Meta-analysis of Glucosamine for Osteoarthritis in Asian Population

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