Clinical Analysis on 121 Cases of Hepatic Hydatidosis_West China Medical Journal

Authors：

 YANGPing ^1,2 , LONGHai-yan ¹ , YANGJing-yu ¹ ,  FENGPing ¹ , CHENLi-yu ¹

1. Infectious Disease Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Intensive Care Unit, No.4 West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

FENGPing, Email: fengp-62@163.com

Keywords：

Hepatic hydatidosis; Hepatic dysfunction; Treatment method; Effectiveness

DOI：

10.7507/1002-0179.20150470

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Objective To describe the current situation of the prevalence of hepatic hydatidosis, analyze the clinical characteristics and treatment method of the disease, in order to provide scientific basis for personal treatment plans of hepatic hydatidosis. Method The clinical data of 121 patients with recurrent hepatic hydatidosis treated between July 2006 and December 2013 were analyzed retrospectively. The general information of hydatid disease of liver, mass of liver, clinical manifestations, laboratory test results, treatment method, effectiveness of the treatment during hospitalization, and follow-up results were collected and analyzed. Results Most of the patients were adults from Sichuan and Tibet, and the majority of them had no clear occupation or clear animal contact history and had not taken raw or fresh meat. Lesions in the right lobe occurred in 87 cases, accounting for 71.90%. Abdominal pain and distension were the main clinical manifestations. Twenty-five (20.66%) of these patients were associated with hepatic dysfunction, among whom 23 patients had mild hepatic dysfunction. Alpha-fetoprotein level was increased in one (0.83%) of these cases. A total of 119 of the 121 patients received surgical treatment (98.35%) and all the surgeries were successful. Follow-up results revealed that three of the patients had recurrence. Conclusions Hepatic hydatidosis is an epidemic mainly in the Tibetan district of the West of China. The disease mainly occurs in the right lobe of the liver, which mainly causes mile liver damage. Hepatocellular carcinoma has not been found in these cases. Surgery treatment is the main therapy for liver hydatidosis and may result in good effectiveness.

Citation： YANGPing, LONGHai-yan, YANGJing-yu, FENGPing, CHENLi-yu. Clinical Analysis on 121 Cases of Hepatic Hydatidosis. West China Medical Journal, 2015, 30(9): 1645-1649. doi: 10.7507/1002-0179.20150470 Copy

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13.	黃韜, 劉佳, 羅彪, 等. 肝包蟲病的診治體會[J]. 華西醫學, 2014, 29(9):1650-1652.
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1. Guidelines for treatment of cystic and alveolar echinococcosis in humans. WHO Informal Working Group on Echinococcosis[J]. Bull World Health Organ, 1996, 74(3):231-242.
2. 徐秉銀, 趙慰先, 陳佩惠, 等. 人體寄生蟲學[M]. 北京:人民衛生出版社, 1994:142.
3. Abboud G, Kaplowitz N. Drug-induced liver injury[J]. Drug Saf, 2007, 30(4):277-294.
4. 中華醫學會傳染病與寄生蟲病學分會, 中華醫學會肝病學分會. 病毒性肝炎防治方案[J]. 人民軍醫, 1989, 19(12):15-21, 80.
5. 李曉東, 李波, 嚴律南, 等. 肝包蟲病的外科治療和并發癥的處理[J]. 華西醫學, 2005, 20(2):229-230.
6. Moro P, Schantz PM. Echinococcosis:a review[J]. Int J Infect Dis, 2009, 13(2):125-133.
7. Siqueira NG, Siqueira CM, Rodrigues-Silva R, et al. Polycystic echinococcosis in the state of Acre, Brazil:contribution to patient diagnosis, treatment and prognosis[J]. Mem Inst Oswaldo Cruz, 2013, 108(5):533-540.
8. 彭心宇, 張示杰, 牛建華, 等. 肝包蟲病外科治療術式選擇的新觀點(附684例報道)[J]. 腹部外科, 2003, 16(1):19-21.
9. 呂海龍, 彭心宇, 張士杰, 等. 不同藥物殺滅原頭節對小鼠肝細粒棘球蚴感染的影響[J]. 中國人獸共患病學報, 2009, 25(3):295-297.
10. Halezeroglu S, Okur E, Tanyü MO. Surgical management for hydatid disease[J]. Thorac Surg Clin, 2012, 22(3):375-385.
11. Parelkar SV, Gupta RK, Shah H, et al. Experience with video-assisted thoracoscopic removal of pulmonary hydatid cysts in children[J]. J Pediatr Surg, 2009, 44(4):836-841.
12. 陳文慶, 柴福祿, 顧樹南. 肝包蟲病外科治療經驗[J]. 中華外科雜志, 1994, 32(3):166-168.
13. 黃韜, 劉佳, 羅彪, 等. 肝包蟲病的診治體會[J]. 華西醫學, 2014, 29(9):1650-1652.
14. Meyssonnier V, Makovec T, Caumes E. Cystic splenomegaly[J]. J Travel Med, 2011, 18(4):294-295.
15. Pawlowski ZS, Eckert J, Vuitton DA RW, et al. Echinococcosis in humans:clinical aspects, diagnosis and treatment[M]//Eckert J, Gemmell MA, Meslin FX, et al. WHO/OIE manual on echinococcosis in humans and animals:a public health problem of global concern. Paris:Office International des E'pizooties, 2001:20-71.
16. 陳亮, 謝增如. 包蟲病放射治療的研究進展[J]. 新疆醫科大學學報, 2014, 36(4):557-559.
17. 鮑佳春, 袁鳳來, 陸偉國. 包蟲病治療進展[J]. 中國血吸蟲病防治雜志, 2010, 22(2):197-199.

West China Medical Journal

Clinical Analysis on 121 Cases of Hepatic Hydatidosis

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