Clinical Analysis of Cranial Venous Sinus Thrombosis_West China Medical Journal

Authors：

 TANGYu-feng , ZHANGShan-shan , ZHANGYun , DUHong-cai , LIZhao-kun , ZHANGXian-wen ,  DUANJin-feng

Department of Neurologic Medicine, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;

Corresponding?author：

DUANJin-feng, Email: duancs63@163.com

Keywords：

Cranial venous sinus thrombosis; Symptoms; Anticoagulation; rombolysis; Imaging

DOI：

10.7507/1002-0179.20150532

Video：

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Objective ?To explore the clinical and imaging features of cranial venous sinus thrombosis (CVST). Methods The clinical data of 20 patients with CVST treated between January 2008 and December 2012 were retrospectively analyzed, including the clinical manifestations, neuroimaging characters and treatment outcomes. Results Among the 20 patients, there were 10 infected cases; D-dimer was detected positively in only 2 cases; cerebrospinal fluid pressure increased in 13 patients; and red blood cell population of cerebrospinal fluid increased in 12 patients. The common clinical symptoms included headache in 16 cases, eye symptoms in 12 cases, and vomiting in 10 cases. CT showed the direct signs of CVST in 3 cases, and MRI showed the direct signs of CVST in 6 cases. The common disease regions were in left transverse sinus and sigmoid sinus in 5 cases, superior sagittal sinus in 5 cases, and multiple venous sinus in 5 cases. Eighteen patients only received anticoagulation, and 2 received anticoagulation and local thrombolytic treatment. Fourteen cases recovered fully, 6 had dysfunctions. Conclusion The clinical manifestations of CVST are nonspecific. This disorder predominantly affects childbearing women. Infection is a common cause of CVST. The occlusive venous sinus can be confirmed by enhanced magnetic resonance venography or digital subtraction angiography. Anticoagulation and local thrombolytic therapy are both proved to be safe and effective in the treatment of CVST. The early diagnosis rate of CVST remains to be improved.

Citation： TANGYu-feng, ZHANGShan-shan, ZHANGYun, DUHong-cai, LIZhao-kun, ZHANGXian-wen, DUANJin-feng. Clinical Analysis of Cranial Venous Sinus Thrombosis. West China Medical Journal, 2015, 30(10): 1849-1852. doi: 10.7507/1002-0179.20150532 Copy

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15.	康曉雨, 黃理金, 文軍, 等. 顱內靜脈竇血栓形成合并顱內血腫的治療方式的系統評價[J]. 中華神經醫學雜志, 2015, 14(6):586-590.

1. Saposnik G, Barinagarrementeria F, Brown RD, et al. Diagnosis and management of cerebral venous thrombosis:a statement for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2011, 42(4):1158-1192.
2. Borhani Haghighi A, Edgell RC, Cruz-Flores S, et al. Mortality of cerebral venous-sinus thrombosis in a large National sample[J]. Stroke, 2012, 43(1):262-264.
3. Wasay M, Kojan S, Dai AI, et al. Headache in cerebral venous thrombosis:incidence, pattern and location in 200 consecutive patients[J]. J Headache Pain, 2010, 11(2):137-139.
4. 顧曉蘇, 徐得恩, 周永. 顱內靜脈竇血栓形成的臨床與影像學特點[J]. 臨床神經病學雜志, 2012, 25(2):111-114.
5. 朱德生, 張悅, 管陽太. 腦靜脈竇血栓形成的臨床與影像學特點[J]. 臨床神經病學雜志, 2013, 26(4):268-271.
6. 唐宇鳳, 段勁峰, 吳孝蘋, 等. 顱內靜脈竇血栓形成導致中樞性視野缺損的臨床特點(附3例報告)[J]. 臨床神經病學雜志, 2013, 26(2):142-143.
7. 魏妍平, 吳立文, 盧強, 等. 自發性低顱壓并發靜脈血栓形成和出血性梗死一例臨床分析[J]. 腦與神經疾病雜志, 2009, 17(4): 312-314.
8. 李佳, 鄧暉, 吳小坤, 等. 低顱壓綜合征伴發顱內靜脈竇血栓形成1例報告及文獻復習[J]. 中風與神經疾病雜志, 2012, 29(12): 1131-1132.
9. Chiewvit P, Piyapittayanan S, Poungvarin N. Cerebral venous thrombosis:diagnosis dilemma[J]. Neurol Int, 2011, 3(3):e13.
10. 范一木, 李旭東, 王世波, 等. 顱內靜脈竇血栓形成的臨床研究[J]. 中國現代神經疾病雜志, 2013, 13(3):226-231.
11. 吳昊, 付國惠. 顱內靜脈竇血栓形成的臨床與影像學特點分析[J]. 中國實用神經疾病雜志, 2013, 16(17):43-44.
12. Bushnell C, Saposnik G. Evaluation and management of cerebral venous thrombosis[J]. Continuum (Minneap Minn), 2014, 20(2): 335-351.
13. 黃海華, 秦超, 梁志堅. 顱內靜脈竇血栓形成的臨床特點及影像學分析[J]. 腦與神經疾病雜志, 2015, 23(1):53-56.
14. 李志方, 孫彬彬, 薛偉寧, 等. 顱內靜脈竇血栓形成9例臨床與影像學分析[J]. 疑難病雜志, 2015, 14(2):121-124.
15. 康曉雨, 黃理金, 文軍, 等. 顱內靜脈竇血栓形成合并顱內血腫的治療方式的系統評價[J]. 中華神經醫學雜志, 2015, 14(6):586-590.

West China Medical Journal

Clinical Analysis of Cranial Venous Sinus Thrombosis

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