Study on the Correlation of Synovial Fluid Uric Acid, Interleukin-1<i>β</i>, Interleukin-6 and Tumor Necrosis Factor-<i>α</i> with Knee Osteoarthritis_West China Medical Journal

Authors：

 WUXiao-hui ¹ , TANGLiu-gang ¹ , WANGBiao ¹ , LIUTai ¹ , ZHAOChen ¹ , YUWen-jing ² ,  LIMin ²

1. Department of Tendon Traumatology, Sichuan Orthopedic Hospital, Chengdu, Sichuan 610041, P. R. China;
2. Department of Rheumatology;Sichuan Orthopedic Hospital, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LIMin, Email: health716@gmail.com

Keywords：

Synovial fluid; Uric acid; Interleukin-1β; Interleukin-6; Tumor necrosis factor-α; Knee oteoarthritis

DOI：

10.7507/1002-0179.20150535

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Objective To investigate the correlation of synovial fluid uric acid, the serum and synovial fluid interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α with knee osteoarthritis (KOA). Methods The clinical data of 130 patients with KOA treated between January and December 2013 and 30 patients with gouty arthritis (GA) treated at the same period were collected. The clinical symptoms, Western Ontario and McMaster Universities Osteoarthritis Index score, the serum and synovial fluid IL-1β, IL-6, and TNF-α, uric acid levels, radiographic joint stenosis score, and bone hyperplasia score of the patients were compared using t-test analysis and Spearman correlation analysis. Results In the KOA group, the synovial fluid uric acid and joint stenosis score (r=0.31, P=0.037), bone hyperplasia score (r=0.38, P=0.027) were positively correlated; serum and synovial fluid uric acid gradient and hypnalgia were positively correlated (r=0.34, P=0.031); the synovial fluid IL-6 and joint stenosis score (r=0.33, P=0.029), bone hyperplasia score (r=0.37, P=0.032) were positively correlated; the synovial fluid IL-1β and joint stenosis score (r=0.39, P=0.023), bone hyperplasia score (r=0.34, P=0.034) were positively correlated; and the synovial fluid uric acid and IL-1β (r=0.26, P=0.003), IL-6 (r=0.21, P=0.016) were positively correlated. Conclusion Synovial uric acid, IL-1β and IL-6 play a role in the inflammatory progress of knee osteoarthritis.

Citation： WUXiao-hui, TANGLiu-gang, WANGBiao, LIUTai, ZHAOChen, YUWen-jing, LIMin. Study on the Correlation of Synovial Fluid Uric Acid, Interleukin-1β, Interleukin-6 and Tumor Necrosis Factor-α with Knee Osteoarthritis. West China Medical Journal, 2015, 30(10): 1862-1865. doi: 10.7507/1002-0179.20150535 Copy

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9.	青玉鳳, 周京國. 痛風發病機制及藥物治療研究現狀及展望[J]. 中華臨床醫師雜志:電子版, 2012, 6(10):2719-2723.
10.	Lorenz H, Richter W. Osteoarthritis:cellular and molecular changes in degenerating cartilage[J]. Prog Histochem Cytochem, 2006, 40(3): 135-163.
11.	丁國良. IL-1和IL-6在絕經后骨關節炎患者滑膜上的表達及臨床分析[J]. 內蒙古醫學雜志, 2014, 46(4):399-402, 512.
12.	帥明, 林荔軍, 林昭偉, 等. IL-1β、HIF-1α和VEGF在兔膝關節骨性關節炎模型滑膜中的表達[J]. 中國老年學雜志, 2013, 33(10): 2311-2313.
13.	楊雪晴, 徐建華, 丁長海, 等. 膝骨關節炎患者髕上囊滲液量與疼痛及血清白細胞介素-6、-17、-23相關性研究[J]. 中華風濕病學雜志, 2015, 19(4):219-223.
14.	張薇, 劉昌蓮, 劉小玲, 等. 滑液尿酸與骨關節炎患者病情嚴重程度相關性研究[J]. 陜西醫學雜志, 2014, 43(11):1474-1475.
15.	Jin C, Frayssinet P, Pelker R, et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy[J]. Proc Natl Acad Sci USA, 2011, 108(36):14867-14872.

1. 中華醫學會風濕病學分會. 骨關節炎診斷及治療指南[J]. 中華風濕病學雜志, 2010, 14(6):416-419.
2. 沈海麗, 夏亞一, 王翠芳, 等. 骨關節炎的疼痛機制研究進展[J]. 中華風濕病學雜志, 2011, 14(11):769-771.
3. 李敏, 梁翼, 吳曉惠, 等. 伴骨髓水腫的膝骨關節炎患者白細胞介素-1β、IL-6、TNF-α的相關性研究[J]. 中華風濕病學雜志, 2012, 16(2):107-111.
4. Denoble AE, Huffman KM, Stabler TV, et al. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation[J]. Proc Natl Acad Sci USA, 2011, 108(5):2088-2093.
5. 伍滬生. 痛風研究正逢其時[J]. 中華風濕病學雜志, 2012, 16(4): 217-219.
6. 吳華香. 美國風濕病學會痛風治療指南解讀[J]. 浙江醫學, 2014, 25(2):92-93.
7. 李敏, 梁翼, 余文景, 等. 鹽酸氨基葡萄糖聯合雙醋瑞因在伴骨髓水腫的膝骨關節炎的療效評估[J]. 華西醫學, 2012, 27(12):1764-1767.
8. 王洪, 張青松, 楊述華, 等. IL-1RⅠ、IL-1RⅡ、IL-1RAcP在骨關節炎滑膜中的表達及其生物學意義[J]. 中華風濕病學雜志, 2006, 10(8):470-473, 513.
9. 青玉鳳, 周京國. 痛風發病機制及藥物治療研究現狀及展望[J]. 中華臨床醫師雜志:電子版, 2012, 6(10):2719-2723.
10. Lorenz H, Richter W. Osteoarthritis:cellular and molecular changes in degenerating cartilage[J]. Prog Histochem Cytochem, 2006, 40(3): 135-163.
11. 丁國良. IL-1和IL-6在絕經后骨關節炎患者滑膜上的表達及臨床分析[J]. 內蒙古醫學雜志, 2014, 46(4):399-402, 512.
12. 帥明, 林荔軍, 林昭偉, 等. IL-1β、HIF-1α和VEGF在兔膝關節骨性關節炎模型滑膜中的表達[J]. 中國老年學雜志, 2013, 33(10): 2311-2313.
13. 楊雪晴, 徐建華, 丁長海, 等. 膝骨關節炎患者髕上囊滲液量與疼痛及血清白細胞介素-6、-17、-23相關性研究[J]. 中華風濕病學雜志, 2015, 19(4):219-223.
14. 張薇, 劉昌蓮, 劉小玲, 等. 滑液尿酸與骨關節炎患者病情嚴重程度相關性研究[J]. 陜西醫學雜志, 2014, 43(11):1474-1475.
15. Jin C, Frayssinet P, Pelker R, et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy[J]. Proc Natl Acad Sci USA, 2011, 108(36):14867-14872.

West China Medical Journal

Study on the Correlation of Synovial Fluid Uric Acid, Interleukin-1β, Interleukin-6 and Tumor Necrosis Factor-α with Knee Osteoarthritis

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