A clinical analysis of 48 cases of severe drug eruption_West China Medical Journal

Authors：

 WANG Lu , CHEN Huaquan , ZHANG Zheng

Department of Dermatology, the People’s Hospital of Deyang, Deyang, Sichuan 618000, P. R. China;

Corresponding?author：

WANG Lu, Email: wanglu19850810@126.com

Keywords：

Severe drug eruption; Clinical analysis; Pathogenesis

DOI：

10.7507/1002-0179.201510122

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the clinical features and prognosis related factors of severe drug eruption. Methods The clinical data of 48 patients with drug eruption treated between January 2010 and August 2015 were retrospectively analyzed. Results The major type of drug eruption was Stevens-Johnson syndrome (58.3%), followed by toxic epidermal necrolysis (TEN) (27.1%) and hypersensitivity syndrome (14.6%). The major allergenic drug which might cuase drug eruption was antimicrobial agent (25.0%), followed by antipyretic analgesic drug (22.9%) and antigout drug (18.8%). Carbamazepine and allopurino were the common drugs caused TEN. Conclusion It is important to give sufficient corticosteroid earlier combined with intravenous immunoglobulin for reducing mortalities of severe drug eruption.

Citation： WANG Lu, CHEN Huaquan, ZHANG Zheng. A clinical analysis of 48 cases of severe drug eruption. West China Medical Journal, 2017, 32(6): 871-874. doi: 10.7507/1002-0179.201510122 Copy

1.	Li LF, Ma C. Epidemiological study of severe cutaneous adverse drug reactions in a city district of China. Clin Exp Dermatol, 2006, 31(5): 642-647.
2.	Lee HY, Chung WH. Toxic epidermal necrolysis: the year in review. Curr Opin Allergy Clin Immunol, 2013, 13(4): 330-336.
3.	Kardaun SH, Mockenhaupt M, Roujeau JC. Comments on: DRESS syndrome. J Am Acad Dermatol, 2014, 71(5): 1000-1000. e2.
4.	Lissia M, Mulas P, Bulla A, et al. Toxic epidermal necrolysis (Lyell’S disease). Bums, 2010, 36(2): 152-163.
5.	池澤善郎. DIHS及SJS/TEN重癥藥疹的治療, 日本醫學介紹, 2004, 25(2), 74-75.
6.	Kito Y, Ito T, Tokura Y, et al. High-dose intravenous immunoglobulin monotherapy for drug-induced hypersensitivity syndrome. Acta Derm Venereol, 2012, 92(1): 100-101.
7.	鐘華, 王歡, 牛軍, 等. 547 例皮膚藥物不良反應回顧性分析. 中華醫學會 2011 年全國變態反應學術會議論文集. 2011, 79(1): 52-56.
8.	Riyaz N, Sarita S, Arunkumar G, et al. Drug-induced hypersensitivity syndrome with human herpesvirus-6 reactivation. Indian J Dermatol Venereol Leprol, 2012, 78(2): 175-177.
9.	王國恩, 張曉玲, 劉敏龍, 等. 中毒性表皮松解型藥疹 20 例療效分析. 中國皮膚性病學雜志, 2016, 30(5): 37-39.
10.	焦乾升, 黃忠華, 方衛利, 等. 2013 年第四季度我院抗菌藥物使用管理情況分析. 中國藥業, 2015, 24(2): 68-69.
11.	王莉, 趙俊英. 重癥藥疹 45 例臨床分析. 中國皮膚性病學雜志, 2012, 26(10): 904-906.
12.	孟慧敏, 李利. 別嘌醇藥疹臨床特點分析. 華西醫學, 2014, 29(1): 96-97.
13.	Karlin E, Phillips E. Genotyping for severe drug hypersensitivity. Curr Allergy Asthma Rep, 2014, 14(3): 418.
14.	Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist. Br J Dermatol, 2007, 158(3): 609-611.
15.	祝倫, 蔣法新, 胡白, 等. 重癥藥疹 74 例臨床分析. 中華臨床醫師雜志, 2012, 7(6): 4093-4095.
16.	Ardern Jones MR, Friedmann PS. Skin manifestations of drug allergy. Br J Clin Pharmacol, 2011, 71(5): 672-683.
17.	廖理超, 胡白, 趙政龍, 等. 重癥藥疹 73 例臨床分析. 中國麻風皮膚病雜志, 2016, 11(32): 661-662.

1. Li LF, Ma C. Epidemiological study of severe cutaneous adverse drug reactions in a city district of China. Clin Exp Dermatol, 2006, 31(5): 642-647.
2. Lee HY, Chung WH. Toxic epidermal necrolysis: the year in review. Curr Opin Allergy Clin Immunol, 2013, 13(4): 330-336.
3. Kardaun SH, Mockenhaupt M, Roujeau JC. Comments on: DRESS syndrome. J Am Acad Dermatol, 2014, 71(5): 1000-1000. e2.
4. Lissia M, Mulas P, Bulla A, et al. Toxic epidermal necrolysis (Lyell’S disease). Bums, 2010, 36(2): 152-163.
5. 池澤善郎. DIHS及SJS/TEN重癥藥疹的治療, 日本醫學介紹, 2004, 25(2), 74-75.
6. Kito Y, Ito T, Tokura Y, et al. High-dose intravenous immunoglobulin monotherapy for drug-induced hypersensitivity syndrome. Acta Derm Venereol, 2012, 92(1): 100-101.
7. 鐘華, 王歡, 牛軍, 等. 547 例皮膚藥物不良反應回顧性分析. 中華醫學會 2011 年全國變態反應學術會議論文集. 2011, 79(1): 52-56.
8. Riyaz N, Sarita S, Arunkumar G, et al. Drug-induced hypersensitivity syndrome with human herpesvirus-6 reactivation. Indian J Dermatol Venereol Leprol, 2012, 78(2): 175-177.
9. 王國恩, 張曉玲, 劉敏龍, 等. 中毒性表皮松解型藥疹 20 例療效分析. 中國皮膚性病學雜志, 2016, 30(5): 37-39.
10. 焦乾升, 黃忠華, 方衛利, 等. 2013 年第四季度我院抗菌藥物使用管理情況分析. 中國藥業, 2015, 24(2): 68-69.
11. 王莉, 趙俊英. 重癥藥疹 45 例臨床分析. 中國皮膚性病學雜志, 2012, 26(10): 904-906.
12. 孟慧敏, 李利. 別嘌醇藥疹臨床特點分析. 華西醫學, 2014, 29(1): 96-97.
13. Karlin E, Phillips E. Genotyping for severe drug hypersensitivity. Curr Allergy Asthma Rep, 2014, 14(3): 418.
14. Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist. Br J Dermatol, 2007, 158(3): 609-611.
15. 祝倫, 蔣法新, 胡白, 等. 重癥藥疹 74 例臨床分析. 中華臨床醫師雜志, 2012, 7(6): 4093-4095.
16. Ardern Jones MR, Friedmann PS. Skin manifestations of drug allergy. Br J Clin Pharmacol, 2011, 71(5): 672-683.
17. 廖理超, 胡白, 趙政龍, 等. 重癥藥疹 73 例臨床分析. 中國麻風皮膚病雜志, 2016, 11(32): 661-662.

West China Medical Journal

A clinical analysis of 48 cases of severe drug eruption

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content