Effect of orange peel on the improvement of gastrointestinal reactions in tumor patients undergoing chemotherapy_West China Medical Journal

Authors：

ZHANGQing ,  CHENPing

Ward 3, Department of Oncology, the Second Affiliated Hospital of the Third Military Medical University, Chongqing 400037, P. R. China;

Corresponding?author：

CHENPing, Email: xinqiaochenping@163.com

Keywords：

Orange peel; Flavor; Inhalation; Chemotherapy; Gastrointestinal reactions

DOI：

10.7507/1002-0179.201511022

Video：

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Objective To observe the effect of fresh orange peel flavor inhalation on the improvement of gastrointestinal reactions such as nausea and vomiting in tumor patients during chemotherapy. Methods Ninety-one inpatients undergoing chemotherapy with PF and TP regimens between May 2012 and September 2013 were included in this study. The patients were randomly divided into orange group (n=45) and control group (n=46). Patients in the control group received conventional care, while those in the orange group were treated with fresh orange peel flavor inhalation during chemotherapy. We observed the effect of orange peel flavor inhalation on such gastrointestinal reactions as nausea and vomiting in tumor patients during chemotherapy. Results All the patients completed each cycle of chemotherapy. At the fifth day during chemotherapy, compared with the control group, the incidence rates of grade Ⅲ-Ⅳ gastrointestinal reactions (nausea and vomiting) in the orange group were significantly lower (P=0.023). At the fourth day, when gastrointestinal reactions were the most significant, the food intake of patients in the orange group was significantly higher than that in the control group (P=0.012). During chemotherapy, the addition rate of antiemetic drugs in the orange group was significantly lower than that in the control group (P=0.038). In the orange group, 80.0% of the patients had good self-feeling after orange peel flavor inhalation. Conclusions The study results have shown that fresh orange peel flavor inhalation can effectively improve the gastrointestinal reactions (such as nausea and vomiting), appetite, and degree of comfort in tumor patients during chemotherapy, and reduce the use of antiemetic drugs. This study is of great significance to guide the future research on how to reduce the discomfort of on-chemotherapy patients and provide more comfortable care.

Citation： ZHANGQing, CHENPing. Effect of orange peel on the improvement of gastrointestinal reactions in tumor patients undergoing chemotherapy. West China Medical Journal, 2017, 32(1): 77-80. doi: 10.7507/1002-0179.201511022 Copy

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8.	劉順妹. 白血病化療致患者胃腸道反應的綜合護理干預的影響研究. 中外醫學研究, 2012, 10(16): 123-124.
9.	王玉琴, 謝稚軍. 橘皮聯合止吐藥預防化療胃腸道反應療效觀察. 江西醫藥, 2011, 46(11): 1015-1016.
10.	張曉靜, 張頻. 腫瘤化療所致惡心嘔吐的發生機制和藥物治療的研究進展. 癌癥進展雜志, 2006, 4(4): 348-357.
11.	溫善祿, 李斌和, 王麗輝, 等. 化療誘發惡心嘔吐的機制及護理. 國外醫學: 護理學分冊, 1998, 17(4): 165-167.
12.	郭曉燕, 張俊華. 預防化療所致惡心嘔吐藥物及護理支持進展. 護理研究, 2003, 17(5): 258-259.
13.	熊俊芳, 張亞群. 舒適護理在化療所致惡心嘔吐中的應用. 當代護士: 學術版, 2011(3): 65-66.
14.	陳再文. 預見性護理干預對肺癌化療病人胃腸道反應的影響效果臨床觀察. 臨床和實驗醫學雜志, 2012, 11(24): 1981-1982.
15.	鄭守曾. 中醫學. 北京: 人民衛生出版社, 2002: 172.
16.	Potter P, Eisenberg S, Cain KC, et al. Orange interventions for symptoms associated with dimethyl sulfoxide during stem cell reinfusions: a feasibility study. Cancer Nurs, 2011, 34(5): 361-368.

1. ?馬隔利, 張潔, 常紅利, 等. 改善病室氣味對化療患者惡心嘔吐的影響. 現代腫瘤醫學, 2010, 18(7): 1465-1466.
2. 黃仕文, 樊巧玲, 劉華東, 等. 中醫藥干預化療嘔吐研究思考. 陜西中醫學院學報, 2010, 33(6): 141-142.
3. 王琳磷. 護理干預對結腸癌術后患者化療胃腸道反應的影響. 中外醫療, 2011, 30(32): 153.
4. 張蕾, 陳旭東, 劉閆. 應用 FolFox4 化療方案治療腸癌患者的護理. 中國傷殘醫學, 2011, 19(8): 63-64.
5. 郭麗霞. 護理干預對化療患者胃腸道反應的影響. 中國誤診學雜志, 2011, 11(17): 4080.
6. 謝佩珠. 持續護理干預對提高乳腺癌患者化療期間生活質量的影響. 中國現代藥物應用, 2011, 5(6): 160-161.
7. 王倩琴, 陳貴花, 何玉倩, 等. 檸檬外皮氣味吸入預防手術患者術后惡心嘔吐效果觀察. 實用醫技雜志, 2007, 14(20): 2740-2741.
8. 劉順妹. 白血病化療致患者胃腸道反應的綜合護理干預的影響研究. 中外醫學研究, 2012, 10(16): 123-124.
9. 王玉琴, 謝稚軍. 橘皮聯合止吐藥預防化療胃腸道反應療效觀察. 江西醫藥, 2011, 46(11): 1015-1016.
10. 張曉靜, 張頻. 腫瘤化療所致惡心嘔吐的發生機制和藥物治療的研究進展. 癌癥進展雜志, 2006, 4(4): 348-357.
11. 溫善祿, 李斌和, 王麗輝, 等. 化療誘發惡心嘔吐的機制及護理. 國外醫學: 護理學分冊, 1998, 17(4): 165-167.
12. 郭曉燕, 張俊華. 預防化療所致惡心嘔吐藥物及護理支持進展. 護理研究, 2003, 17(5): 258-259.
13. 熊俊芳, 張亞群. 舒適護理在化療所致惡心嘔吐中的應用. 當代護士: 學術版, 2011(3): 65-66.
14. 陳再文. 預見性護理干預對肺癌化療病人胃腸道反應的影響效果臨床觀察. 臨床和實驗醫學雜志, 2012, 11(24): 1981-1982.
15. 鄭守曾. 中醫學. 北京: 人民衛生出版社, 2002: 172.
16. Potter P, Eisenberg S, Cain KC, et al. Orange interventions for symptoms associated with dimethyl sulfoxide during stem cell reinfusions: a feasibility study. Cancer Nurs, 2011, 34(5): 361-368.

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