Analysis of the Correlation between Insulin Resistance and Plasma Homocysteine Level in Patients with Cerebral Infarction_West China Medical Journal

Authors：

 GuChengwu , GuoWeipeng , JiangShijie , YuMing , LiLinlin , FangDengfu

Department of Neurology, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;

Corresponding?author：

Keywords：

Brain infarction; Homocysteine; Insulin resistance; Risk factors

DOI：

10.7507/1002-0179.20160002

Video：

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Objective To analyze insulin resistance in patients with cerebral infarction and its correlation with plasma homocysteine level. Methods A total of 100 cerebral infarction patients diagnosed between July 2013 and August 2014 and 100 healthy physical examination subjects were included in our research. The plasma homocysteine level was detected; the levels of fasting plasma glucose and fasting insulin were detected at the same time. Results Plasma homocysteine level (34.95±14.55) μmol/L in patients with cerebral infarction was significantly higher than that of the control group (8.84±2.27) μmol/L (P<0.05). Insulin resistance index (6.24±3.15) in patients with cerebral infarction was significantly higher than that of the control group (2.19±0.63) (P<0.05). The plasma homocysteine level in the infarction group with insulin resistance was significantly higher than that in the infarction group without insulin resistance (P<0.05). The plasma homocysteine level in the infarction group without insulin resistance was significantly higher than that of the patients with insulin resistance in the control group (P<0.05). In the cerebral infarction group, insulin resistance index was positively correlated with plasma homocysteine level (r=0.600, P<0.01). Conclusion Insulin resistance and plasma homocysteine level play important roles in clinical cerebral infarction. Improving insulin resistance and decreasing plasma homocysteine level may be effective ways to reduce the incidence of cerebral infarction.

Citation： GuChengwu, GuoWeipeng, JiangShijie, YuMing, LiLinlin, FangDengfu. Analysis of the Correlation between Insulin Resistance and Plasma Homocysteine Level in Patients with Cerebral Infarction. West China Medical Journal, 2016, 31(1): 7-9. doi: 10.7507/1002-0179.20160002 Copy

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1. 李廣燦, 張玉玲, 張敏, 等. 全國第三次死因回顧抽樣調查資料分析Ⅰ:湖北省居民主要病傷死亡原因[J]. 腫瘤防治研究, 2008, 35(增刊1):31-33.
2. 中華醫學會神經病學分會腦血管病學組缺血性腦卒中二級預防指南撰寫組. 中國缺血性腦卒中和短暫性腦缺血發作二級預防指南2010[J]. 中國醫學前沿雜志:電子版, 2011, 3(3):84-93.
3. 顧成武, 郭偉鵬, 蔣世杰, 等. 腦梗死患者血漿同型半胱氨酸水平與顱內動脈粥樣硬化的相關性[J]. 華西醫學, 2014, 29(2):207-209.
4. 鄧美珍, 潘英. 腦梗死患者胰島素抵抗與腦血流動力學的相關性分析[J]. 中華臨床醫師雜志:電子版, 2014, 8(19):3462-3465.
5. 沈燕, 黎紅華, 徐志鵬, 等. 腦梗死患者胰島素抵抗與血管內皮功能損傷機制研究[J]. 中風與神經疾病雜志, 2012, 29(9):816-818.
6. 賈偉平. 中國人群胰島素抵抗的狀況[J]. 國外醫學:內分泌學分冊, 2002, 22(4):264.
7. 許予明, 譚頌, 劉鳴, 等. 腦血管疾病診斷與治療臨床指南[J]. 內科急危重癥雜志, 2005, 11(5):243-245.
8. 顧炳權, 王多寧. 血漿同型半胱氨酸水平及臨床診斷意義[J]. 中國血液流變學雜志, 2004, 14(4):630-634, 638.
9. 張麗云, 賈頤, 劉建軍, 等. 急性腦梗死患者血漿同型半脘氨酸水平及其與改良急性卒中治療低分子肝素試驗病因分型的關系[J]. 華西醫學, 2014, 29(2):202-205.
10. 李鋼, 張玉平. 胰島素抵抗與腦梗死關系的臨床研究[J]. 華中醫學雜志, 2003, 27(5):265-266.
11. 潘英, 魏佳娜, 侯清華, 等. 2型糖尿病伴胰島素抵抗與腦梗死的關系探討[J]. 中西醫結合心腦血管病雜志, 2014, 12(3):314-316.
12. Caccamo G, Bonura F, Bonura F, et al. Insulin resistance and acute coronary syndrome[J]. Atherosclerosis, 2010, 211(2):672-675.
13. Ustundag S, Arikan E, Sen S, et al. The relationship between the levels of plasma total homocysteine and insulin resistance in uncomplicated mild-to-moderate primary hypertension[J]. J Hum Hypertens, 2006, 20(5):379-381.
14. 常向云, 尹穎, 孫侃, 等. 不同糖耐量人群血漿前列腺素E2水平及與胰島素抵抗的關系[J]. 中國糖尿病雜志, 2011, 19(3):213-215.
15. Li Y, Jiang C, Xu G, et al. Homocysteine upregulates resistin production from adipocytes in vivo and in vivo[J]. Diabetes, 2008, 57(4):817-827.
16. 王蘊慧, 吳惠華, 丁紅, 等. 妊娠期胰島素抵抗及胰島β細胞功能與體重指數、血脂水平、C反應蛋白的關系探討[J]. 中華臨床醫師雜志:電子版, 2011, 5(16):4736-4740.

West China Medical Journal

Analysis of the Correlation between Insulin Resistance and Plasma Homocysteine Level in Patients with Cerebral Infarction

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