Traditional Chinese Medicine Fumigation versus Western Medicine in the Treatment of Diabetic Peripheral Neuropathy: A Meta-analysis_West China Medical Journal

Authors：

 ZhangLei ¹ , WangGuohao ¹ , WangXinman ¹ ,  MengFanjie ²

1. Graduate College;Tianjin University of Traditional Chinese Medicine, Tianjin 300073, P. R. China;
2. Teacher Development and Evaluation Department;Tianjin University of Traditional Chinese Medicine, Tianjin 300073, P. R. China;

Corresponding?author：

MengFanjie, Email: mfj127@tjutcm.edu.cn

Keywords：

Traditional Chinese medicine fumigation; Diabetic peripheral neuropathy; Meta-analysis

DOI：

10.7507/1002-0179.201600128

Video：

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Objective To evaluate the traditional Chinese medicine fumigation curative effect for the treatment of various diabetic peripheral neuropathy. Methods Databases such as China Biology Medicine Database, VIP, China Knowledge Resource Integrated Database, WanFang Data, PubMed, Embase, and the Cochrane Library were searched by computer for controlled clinical trials consistent with the inclusive criteria from the establishment of these databases until February 2016. The literature quality evaluation method of Cochrane system evaluation manual was used to evaluate the methodological quality of the studies, and then relevant data were extracted for Meta-analysis with RevMan 5.1 software. Results A total of 15 randomized controlled trials involving 1579 patients were included. Meta-analysis showed that 15 days after intervention, the total effective rate of the traditional Chinese medicine fumigation group was higher than that of the western medicine group, and the difference between the two groups was statistically significant [RR=1.39, 95%CI (1.25, 1.55), P<0.00001]; one month after intervention, the total effective rate of the traditional Chinese medicine fumigation group was significantly higher than that of the western medicine group [RR=1.26, 95%CI (1.15, 1.38), P<0.00001]; two months after intervention, the total effective rate of the traditional Chinese medicine fumigation group was significantly higher than that of the western medicine group [RR=1.22, 95%CI (1.10, 1.36), P=0.0002]. After 1 month of treatment, motor nerve conduction velocity motion [WMD=4.42 m/s, 95%CI (3.40, 5.43) m/s, P<0.00001] and median nerve sensory nerve conduction velocity [WMD=4.02 m/s, 95%CI (2.96, 5.08) m/s, P<0.00001] increased significantly more in the traditional Chinese medicine fumigation group. Conclusion The Chinese medicine fumigation treatment of diabetic peripheral neuropathy is better than oral or intramuscular vitamin B12, vitamin B1, oral oryzanol and so on.

Citation： ZhangLei, WangGuohao, WangXinman, MengFanjie. Traditional Chinese Medicine Fumigation versus Western Medicine in the Treatment of Diabetic Peripheral Neuropathy: A Meta-analysis. West China Medical Journal, 2016, 31(3): 480-486. doi: 10.7507/1002-0179.201600128 Copy

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21.	王志興, 錢茜, 梁云武, 等. 黃芪桂枝五物湯熏蒸治療糖尿病周圍神經病變的療效研究[J]. 現代醫院, 2012, 12(11):21-24.
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24.	吳艷. 祛瘀通絡熏洗方治療糖尿病周圍神經病變患者的臨床研究[D]. 武漢:湖北中醫藥大學, 2011.
25.	高學敏. 中藥學[M]. 7版. 北京:中國中醫藥出版社, 2002:53, 337, 385, 538.

1. Dyck PJ, Kratz KM, Karnes JL, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population-based cohort:the Rochester Diabetic Neuropathy Study[J]. Neurology, 1993, 43(4):817-824.
2. Prompers L, Schaper N, Apelqvist J, et al. Prediction of outcome in individuals with diabetic foot ulcers:focus on the differences between individuals with and without peripheral arterial disease. The EURODIALE Study[J]. Diabetologia, 2008, 51(5):747-755.
3. Boulton AJ, Vinik AI, Arezzo JC, et al. Diabetic neuropathies:a statement by the American diabetes association[J]. Diabetes Care, 2005, 28(4):956-962.
4. 李金花. 溫經通絡熏洗方對糖尿病周圍神經病變的療效觀察及機理探討[D]. 廣州:廣州中醫藥大學, 2008.
5. 呂仁和. 2型糖尿病及其并發癥中西醫診治學[M]. 北京:人民衛生出版社, 1997:390-394.
6. 鄭筱萸. 中藥新藥臨床研究指導原則(試行)[M]. 北京:中國醫藥科技出版社, 2002:233-237.
7. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0[updated March2011] [M/OL]. The Cochrane Collaboration, 2011. (2011-03-21)[2014-10-20]. http://www.cochrane-handbook.org.
8. 彭寶虹. 自擬糖痛方治療糖尿病周圍神經病變的臨床研究[J]. 世界中西醫結合雜志, 2012, 7(10):874-876.
9. 劉燕平, 徐玉梅, 黃少娟, 等. 當歸活血熏洗方治療糖尿病周圍神經病變的療效觀察[J]. 中國實用護理雜志, 2007, 23(16):18.
10. 閆鏞. 糖痛外洗方治療糖尿病周圍神經病變60例[J]. 河南大學學報:醫學版, 2005, 24(2):57-58.
11. 李金花, 李惠林, 趙恒俠, 等. 溫經通絡熏洗方治療DPN療效觀察及機理探討[J]. 世界中西醫結合雜志, 2010, 5(1):51-53.
12. 管靜輝. 溫經通絡熏洗方治療糖尿病周圍神經病變的臨床護理[J]. 中國現代藥物應用, 2013, 7(7):94-95.
13. 王晶, 田強. 消渴寒痛樂熏洗治療糖尿病周圍神經病變臨床觀察[J]. 遼寧中醫藥大學學報, 2012, 14(7):18-19.
14. 肖玲, 蘇波, 周華, 等. 中藥熏洗方治療糖尿病周圍神經病變臨床觀察[J]. 廣西中醫學院學報, 2004, 7(3):31-32.
15. 孟萍, 孔德明. 中藥熏洗治療2型糖尿病周圍神經病變90例療效觀察[J]. 健康必讀:下半月, 2011, 2(2):182.
16. 劉萍, 耿田軍, 劉振清. 中藥熏洗治療糖尿病周圍神經病變31 例[J]. 中國醫學創新, 2012, 9(9):109-110.
17. 劉瑾. 中藥熏洗治療糖尿病周圍神經病變33例[J]. 浙江中西醫結合雜志, 2002, 12(3):162-163.
18. 范廣巖, 李娜, 劉圣基. 中藥熏洗治療糖尿病周圍神經病變療效觀察[J]. 光明中醫, 2012, 27(8):1550-1551.
19. 周潮, 佟杰, 單友琴, 等. 四通散熏洗治療糖尿病周圍神經病變218例臨床觀察[J]. 河北中醫, 1998, 20(4):201-202.
20. 呂孟存. 活血通絡湯治療糖尿病周圍神經病變68例[J]. 河南中醫, 2007, 27(9):43-44.
21. 王志興, 錢茜, 梁云武, 等. 黃芪桂枝五物湯熏蒸治療糖尿病周圍神經病變的療效研究[J]. 現代醫院, 2012, 12(11):21-24.
22. 杜亮亮, 顏國富. 中藥熏洗治療糖尿病周圍神經病變40例臨床研究[J]. 全科醫學, 2015(2):55-56.
23. 陸祖謙, 丁維. 糖尿病周圍神經病變診治進展[J]. 藥品評價, 2013, 10(17):35-42, 45.
24. 吳艷. 祛瘀通絡熏洗方治療糖尿病周圍神經病變患者的臨床研究[D]. 武漢:湖北中醫藥大學, 2011.
25. 高學敏. 中藥學[M]. 7版. 北京:中國中醫藥出版社, 2002:53, 337, 385, 538.

West China Medical Journal

Traditional Chinese Medicine Fumigation versus Western Medicine in the Treatment of Diabetic Peripheral Neuropathy: A Meta-analysis

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