不適宜的左心室質量_West China Medical Journal

Authors：

 衡越 ¹ , 黃寶濤 ² ,  陳茂 ²

1. ;
2. ;

Corresponding?author：

衡越, Email: 21837869@qq.com; 陳茂, Email: hmaochen@vip.sina.com

Keywords：

不適宜的左心室質量; 左心室肥厚; 心力衰竭

DOI：

10.7507/1002-0179.201600156

Video：

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心血管疾病是嚴重危害人類健康的疾病之一，冠狀動脈粥樣硬化性心臟病、高血壓、心肌肥厚、心力衰竭等疾病的發病率呈逐年上升趨勢，臨床上，正確地對心血管疾病進行風險分層具有重大意義。相較于正常左心室質量的人群而言，并非所有的左心室肥厚均會增加患者心血管不良事件（心肌梗死、卒中、室性心律失常、心力衰竭、心源性死亡等）的發生率。不適宜的左心室質量（iLVM），是指某一個體的左心室質量超過個人血流動力學負荷所能代償部分的一種狀態。iLVM不僅與左心室構型異常及心臟收縮及舒張功能障礙密切相關，而且預示了較高的心血管疾病風險。評估iLVM能夠提高對患者潛在心血管疾病的識別能力并及時提示醫生采取干預措施，有利于減緩及逆轉左心室肥厚的發展，一定程度上減少不良心血管事件的發生，對于降低患者的心血管疾病的發病率和病死率，改善長期預后具有重要的臨床意義。現就iLVM的研究進展進行綜述。

Citation： 衡越, 黃寶濤, 陳茂. 不適宜的左心室質量. West China Medical Journal, 2016, 31(3): 586-588. doi: 10.7507/1002-0179.201600156 Copy

1.	Bang CN, Gerdts E, Aurigemma GP, et al. Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients[J]. Circ Cardiovasc Imaging, 2014, 7(3) :422-429.
2.	Huang BT, Peng Y, Liu W, et al. Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction[J]. Coron Artery Dis, 2015, 26(2) :163-169.
3.	Masugata H, Senda S, Inukai M, et al. Differences in left ventricular diastolic dysfunction between eccentric and concentric left ventricular hypertrophy in hypertensive patients with preserved systolic function[J]. J Int Med Res, 2011, 39(3) :772-779.
4.	Palmieri V, de Simone G, Roman MJ, et al. Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass[J]. Hypertension, 1999, 34(5) :1032-1040.
5.	Libhaber CD, Norton GR, Maseko MJ, et al. Relationship between inappropriate left ventricular hypertrophy and ejection fraction Independent of absolute or indexed mass in a community sample of black African ancestry[J]. J Hypertens, 2013, 31(1) :169-176.
6.	Galderisi M, de Simone G, Cicala S, et al. Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass[J]. J Hypertens, 2003, 21(11) :2183-2188.
7.	Muiesan ML, de Simone G, Ganau A, et al. Inappropriate left ventricular mass:reliability and limitations of echocardiographic measurement for risk stratification and follow-up in single patients[J]. J Hypertens, 2006, 24(11) :2293-2298.
8.	Mureddu GF, Pasanisi F, Palmieri V, et al. Appropriate or inappropriate left ventricular mass in the presence or absence of prognostically adverse left ventricular hypertrophy[J]. J Hypertens, 2001, 19(6) :1113-1119.
9.	de Simone G, Devereux RB, Kimball TR, et al. Interaction between body size and cardiac workload:influence on left ventricular mass during body growth and adulthood[J]. Hypertension, 1998, 31(5) :1077-1082.
10.	de Simone G, Verdecchia P, Pede S, et al. Prognosis of inappropriate left ventricular mass in hypertension:the MAVI Study[J]. Hypertension, 2002, 40(4) :470-476.
11.	Palmieri V, Wachtell K, Gerdts E, et al. Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension:the LIFE study[J]. Am Heart J, 2001, 141(5) :784-791.
12.	Woodiwiss AJ, Libhaber CD, Libhaber E, et al. Relationship between on-treatment decreases in inappropriate versus absolute or indexed left ventricular mass and increases in ejection fraction in hypertension[J]. Hypertension, 2012, 60(3) :810-817.
13.	Celentano A, Palmieri V, Esposito ND, et al. Inappropriate left ventricular mass in normotensive and hypertensive patients[J]. Am J Cardiol, 2001, 87(3) :361-363, A10.
14.	de Simone G, Kitzman DW, Palmieri V, et al. Association of inappropriate left ventricular mass with systolic and diastolic dysfunction:the HyperGEN study[J]. Am J Hypertens, 2004, 17(9) :828-833.
15.	Hung CS, Ho YL, Chang YY, et al. Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism[J]. Sci World J 2013, 2013:294594.
16.	Celentano A, Pietropaolo I, Palmieri V, et al. Inappropriate left ventricular mass and angiotensin converting enzyme gene polymorphism[J]. J Hum Hypertens, 2001, 15(11) :811-813.
17.	Gregori M, Tocci G, Befani A, et al. Synergic effect of high renin and aldosterone levels on inappropriate left ventricular mass and systolic function:a tissue Doppler study[J]. Int J Cardiol, 2013, 168(5) :4934-4936.
18.	Paneni F, Gregori M, Marra A, et al. Preclinical effects of healthy obesity on inappropriate left ventricular mass and systolic function[J]. Int J Cardiol, 2013, 167(6) :3047-3049.
19.	Ratto E, Leoncini G, Viazzi F, et al. Inappropriate left ventricular mass is associated with microalbuminuria independently of left ventricular hypertrophy in primary hypertension[J]. J Hypertens, 2008, 26(2) :345-350.
20.	Su HM, Lin TH, Hsu PC, et al. Association of chronic kidney disease and peripheral artery disease with inappropriate left ventricular mass[J]. PLoS One, 2012, 7(10) :e48422.
21.	Mureddu GF, Cioffi G, Stefenelli C, et al. Compensatory or inappropriate left ventricular mass in different models of left ventricular pressure overload:comparison between patients with aortic stenosis and arterial hypertension[J]. J Hypertens, 2009, 27(3) :642-649.
22.	López B, Castellano JM, González A, et al. Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension[J]. Hypertension, 2007, 50(5) :977-983.
23.	Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass in patients with primary aldosteronism[J]. Hypertension, 2008, 52(3) :529-534.
24.	Olsen MH, Wachtell K, de Simone G, et al. Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? A LIFE substudy[J]. J Hum Hypertens, 2004, 18(6) :437-443.
25.	Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass changes during treatment adversely affects cardiovascular prognosis in hypertensive patients[J]. Hypertension, 2007, 49(5) :1077-1083.

1. Bang CN, Gerdts E, Aurigemma GP, et al. Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients[J]. Circ Cardiovasc Imaging, 2014, 7(3) :422-429.
2. Huang BT, Peng Y, Liu W, et al. Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction[J]. Coron Artery Dis, 2015, 26(2) :163-169.
3. Masugata H, Senda S, Inukai M, et al. Differences in left ventricular diastolic dysfunction between eccentric and concentric left ventricular hypertrophy in hypertensive patients with preserved systolic function[J]. J Int Med Res, 2011, 39(3) :772-779.
4. Palmieri V, de Simone G, Roman MJ, et al. Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass[J]. Hypertension, 1999, 34(5) :1032-1040.
5. Libhaber CD, Norton GR, Maseko MJ, et al. Relationship between inappropriate left ventricular hypertrophy and ejection fraction Independent of absolute or indexed mass in a community sample of black African ancestry[J]. J Hypertens, 2013, 31(1) :169-176.
6. Galderisi M, de Simone G, Cicala S, et al. Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass[J]. J Hypertens, 2003, 21(11) :2183-2188.
7. Muiesan ML, de Simone G, Ganau A, et al. Inappropriate left ventricular mass:reliability and limitations of echocardiographic measurement for risk stratification and follow-up in single patients[J]. J Hypertens, 2006, 24(11) :2293-2298.
8. Mureddu GF, Pasanisi F, Palmieri V, et al. Appropriate or inappropriate left ventricular mass in the presence or absence of prognostically adverse left ventricular hypertrophy[J]. J Hypertens, 2001, 19(6) :1113-1119.
9. de Simone G, Devereux RB, Kimball TR, et al. Interaction between body size and cardiac workload:influence on left ventricular mass during body growth and adulthood[J]. Hypertension, 1998, 31(5) :1077-1082.
10. de Simone G, Verdecchia P, Pede S, et al. Prognosis of inappropriate left ventricular mass in hypertension:the MAVI Study[J]. Hypertension, 2002, 40(4) :470-476.
11. Palmieri V, Wachtell K, Gerdts E, et al. Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension:the LIFE study[J]. Am Heart J, 2001, 141(5) :784-791.
12. Woodiwiss AJ, Libhaber CD, Libhaber E, et al. Relationship between on-treatment decreases in inappropriate versus absolute or indexed left ventricular mass and increases in ejection fraction in hypertension[J]. Hypertension, 2012, 60(3) :810-817.
13. Celentano A, Palmieri V, Esposito ND, et al. Inappropriate left ventricular mass in normotensive and hypertensive patients[J]. Am J Cardiol, 2001, 87(3) :361-363, A10.
14. de Simone G, Kitzman DW, Palmieri V, et al. Association of inappropriate left ventricular mass with systolic and diastolic dysfunction:the HyperGEN study[J]. Am J Hypertens, 2004, 17(9) :828-833.
15. Hung CS, Ho YL, Chang YY, et al. Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism[J]. Sci World J 2013, 2013:294594.
16. Celentano A, Pietropaolo I, Palmieri V, et al. Inappropriate left ventricular mass and angiotensin converting enzyme gene polymorphism[J]. J Hum Hypertens, 2001, 15(11) :811-813.
17. Gregori M, Tocci G, Befani A, et al. Synergic effect of high renin and aldosterone levels on inappropriate left ventricular mass and systolic function:a tissue Doppler study[J]. Int J Cardiol, 2013, 168(5) :4934-4936.
18. Paneni F, Gregori M, Marra A, et al. Preclinical effects of healthy obesity on inappropriate left ventricular mass and systolic function[J]. Int J Cardiol, 2013, 167(6) :3047-3049.
19. Ratto E, Leoncini G, Viazzi F, et al. Inappropriate left ventricular mass is associated with microalbuminuria independently of left ventricular hypertrophy in primary hypertension[J]. J Hypertens, 2008, 26(2) :345-350.
20. Su HM, Lin TH, Hsu PC, et al. Association of chronic kidney disease and peripheral artery disease with inappropriate left ventricular mass[J]. PLoS One, 2012, 7(10) :e48422.
21. Mureddu GF, Cioffi G, Stefenelli C, et al. Compensatory or inappropriate left ventricular mass in different models of left ventricular pressure overload:comparison between patients with aortic stenosis and arterial hypertension[J]. J Hypertens, 2009, 27(3) :642-649.
22. López B, Castellano JM, González A, et al. Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension[J]. Hypertension, 2007, 50(5) :977-983.
23. Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass in patients with primary aldosteronism[J]. Hypertension, 2008, 52(3) :529-534.
24. Olsen MH, Wachtell K, de Simone G, et al. Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? A LIFE substudy[J]. J Hum Hypertens, 2004, 18(6) :437-443.
25. Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass changes during treatment adversely affects cardiovascular prognosis in hypertensive patients[J]. Hypertension, 2007, 49(5) :1077-1083.

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