Observation on the Clinical Effect of Glucosamine in the Treatment of Patients with Knee Articular Cartilage Injury Caused by Rheumatoid Arthritis_West China Medical Journal

Authors：

 LiTianhong , SunHongbing ,  ShuaiShiquan

Department of Rheumatology and Immunology, Nanchong Central Hospital, Nanchong, Sichuan 637000, P. R. China;

Corresponding?author：

ShuaiShiquan, Email: shuaishiquan@126.com

Keywords：

Glucosamine; Rheumatoid arthritis; Knee articular cartilage injury; Clinical effect

DOI：

10.7507/1002-0179.201600228

Video：

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Objective To observe and study the clinical effect of glucosamine in the treatment of patients with knee articular cartilage injury caused by rheumatoid arthritis. Methods Forty-six patients with knee articular cartilage injury caused by rheumatoid arthritis treated from January 2013 to June 2015 were selected as the research subjects, and they were randomly divided into control group (conventional treatment group, n=23) and observation group (conventional and glucosamine treatment group, n=23) . Then the Noyes classification and serum articular cartilage injury related indexes [cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-1, MMP-3 and mouse tissue inhibitors of metalloproteinase (TIMP)-1], inflammatory indexes [tumor necrosis factor (TNF)-α, interleukin (IL)- 17 and IL-33] of the two groups before and after treatment were compared. Results In the observation group, after treatment for 4, 8 and 12 weeks, Noyes grade was better than that in the control group, but with no statistical significance (P ＞ 0.05) . In the observation group, after treatment for 4, 8 and 12 weeks, serum inflammatory markers serum COMP, MMP-1, MMP-3 and TIMP-1 and other related indicators of cartilage damage and serum TNF-α, IL-17 and IL-33 were all significantly lower than those in the control group (P ＜ 0.05) . Conclusion In the treatment of patients with knee articular cartilage injury caused by rheumatoid arthritis, glucosamine has active role for the improvement of articular cartilage injury and inflammatory stress state of patients.

Citation： LiTianhong, SunHongbing, ShuaiShiquan. Observation on the Clinical Effect of Glucosamine in the Treatment of Patients with Knee Articular Cartilage Injury Caused by Rheumatoid Arthritis. West China Medical Journal, 2016, 31(5): 835-837. doi: 10.7507/1002-0179.201600228 Copy

1.	李書良, 劉立云, 高書圖. 筋骨痛消丸合硫酸氨基葡萄糖治療髖關節骨關節炎30例臨床觀察[J]. 湖南中醫雜志, 2015, 31(6) : 64-66.
2.	許美娟, 馮獻禮, 林世磅. 玻璃酸鈉聯合氨基葡萄糖治療膝關節骨性關節炎的臨床觀察[J]. 中國藥房, 2015, 26(21) : 2941-2943.
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11.	郭坤營, 張磊, 陳順興. 痹通散對膝關節炎性積液中 IL-1和TNF-α 濃度的臨床意義[J]. 中國實驗診斷學, 2015, 19(5) : 835-836.
12.	葛鴻慶, 薄智云. 腹針療法對膝骨性關節炎實驗動物模型血清 TNF-α及IL-1水平的影響[J]. 新中醫, 2014, 46(8) : 178-179.
13.	段一娜, 趙蕾, 王晶, 等. 于NF-KB通路探討薯蕷皂苷含藥血清對 IL-1β、IL-17和TNF-α誘導大鼠滑膜細胞株RSC-364的影響[J]. 時珍國醫國藥, 2014, 25(7) : 1744-1746.
14.	王靜萱, 宋英, 趙紅, 等. 芳香化酶抑制劑對膠原性關節炎大鼠血清中IL-17和RANKL/RANK/OPG的影響[J]. 實用腫瘤學雜志, 2013, 27(5) : 396-399.
15.	史麗璞, 朱明慧, 和雅. 白芍總苷聯合來氟米特治療類風濕性關節炎及對白細胞介素-1β、白細胞介素-6及腫瘤壞死因子-α的影響[J]. 中國實用醫刊, 2011, 38(3) : 1-3.

1. 李書良, 劉立云, 高書圖. 筋骨痛消丸合硫酸氨基葡萄糖治療髖關節骨關節炎30例臨床觀察[J]. 湖南中醫雜志, 2015, 31(6) : 64-66.
2. 許美娟, 馮獻禮, 林世磅. 玻璃酸鈉聯合氨基葡萄糖治療膝關節骨性關節炎的臨床觀察[J]. 中國藥房, 2015, 26(21) : 2941-2943.
3. 林進, 徐丹怡. ACR/EULAR 2009年類風濕性關節炎新分類標準解讀[J]. 浙江醫學, 2010(7) : 985-987.
4. 何忠斌, 朱海波. 鹽酸氨基葡萄糖對膝骨關節炎患者血清IL-1β、 MMP-9和TNF-α表達的影響和臨床療效[J]. 醫學理論與實踐, 2015, 28(12) : 1566-1567, 1570.
5. 羅天娥, 劉桂芬. 廣義線性混合效應模型在分類重復測量資料中的應用[J]. 中國衛生統計, 2007, 24(5) : 486-487.
6. Richter J, Capková K, H?íbalová V, et al. Collagen-induced arthritis: severity and immune response attenuation using multivalent N-acetyl glucosamine[J]. Clin Exp Immunol, 2014, 177(1) : 121-133.
7. Bowes J, Eyre S, Flynn E, et al. Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris[J]. Ann Rheum Dis, 2011, 70(6) : 1016-1019.
8. 吳大華. 仙靈骨葆膠囊聯合鹽酸氨基葡萄糖片治療膝骨性關節炎效果探究[J]. 新中醫, 2015, 47(6) : 115-116.
9. 鄧小凡, 楊玉媛, 謝乃集, 等. 鹽酸氨基葡萄糖膠囊聯合丹參注射液治療膝關節骨性關節炎療效觀察[J]. 現代中西醫結合雜志, 2015, 24(13) : 1409-1410, 1419.
10. Gómez-Puerta JA, Celis R, Hernández MV, et al. Differences in synovial fluid cytokine levels but not in synovial tissue cell infiltrate between anti-citrullinated peptide/protein antibody-positive andnegative rheumatoid arthritis patients[J]. Arthritis Res Ther, 2013, 15(6) : R182.
11. 郭坤營, 張磊, 陳順興. 痹通散對膝關節炎性積液中 IL-1和TNF-α 濃度的臨床意義[J]. 中國實驗診斷學, 2015, 19(5) : 835-836.
12. 葛鴻慶, 薄智云. 腹針療法對膝骨性關節炎實驗動物模型血清 TNF-α及IL-1水平的影響[J]. 新中醫, 2014, 46(8) : 178-179.
13. 段一娜, 趙蕾, 王晶, 等. 于NF-KB通路探討薯蕷皂苷含藥血清對 IL-1β、IL-17和TNF-α誘導大鼠滑膜細胞株RSC-364的影響[J]. 時珍國醫國藥, 2014, 25(7) : 1744-1746.
14. 王靜萱, 宋英, 趙紅, 等. 芳香化酶抑制劑對膠原性關節炎大鼠血清中IL-17和RANKL/RANK/OPG的影響[J]. 實用腫瘤學雜志, 2013, 27(5) : 396-399.
15. 史麗璞, 朱明慧, 和雅. 白芍總苷聯合來氟米特治療類風濕性關節炎及對白細胞介素-1β、白細胞介素-6及腫瘤壞死因子-α的影響[J]. 中國實用醫刊, 2011, 38(3) : 1-3.

West China Medical Journal

Observation on the Clinical Effect of Glucosamine in the Treatment of Patients with Knee Articular Cartilage Injury Caused by Rheumatoid Arthritis

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