Etiological Analysis and Clinical Characteristics of Liver Cirrhosis in Elderly Patients_West China Medical Journal

Authors：

 XuJin

Department of Gastroenterology, Guangyuan Central Hospital, Guangyuan, Sichuan 628000, P. R. China;

Corresponding?author：

Keywords：

Elderly patients; Liver cirrhosis; Clinical characteristics; Etiology

DOI：

10.7507/1002-0179.201600330

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To discuss the clinical characteristics of liver cirrhosis in elderly patients. Methods We retrospectively analyzed the clinical data of 67 patients (elderly group) with liver cirrhosis aged ≥60 treated between January 1998 and December 2010. Then, we compared these cases with another 72 liver cirrhosis patients (non-elderly group) aged<60. Results The incidence of jaundice, ascites and albumin deficiency in the elderly patients was significantly higher than that in the non-elderly patients (P<0.05). Complications in the elderly group were relatively more, including electrolyte imbalance, infections, gastrointestinal bleeding, hepatic encephalopathy, liver cancer, liver and kidney syndrome and liver and lung syndrome, and the incidence of these complications was all significantly higher than the non-elderly group (P<0.05) except the liver and kidney syndrome (P>0.05). The causes of liver cirrhosis in both groups were similar. The most common cause was hepatitis B virus infection, followed by chronic alcoholism, but in the elderly group, chronic alcoholism, cholestasis, poisoning from medicines and poisons and liver blood circulation disorders were more common than the non-elderly group (P<0.05); hepatitis B and non-alcoholic fatty hepatitis were more common in the non-elderly group than in the elderly group (P<0.05). The elderly group had more Child-Pugh class C cases (P<0.05), while there were more class A cases in the non-elderly group (P<0.05). Twenty-six patients died in the elderly group with a mortality rate of 38.8%; while only 13 died in the non-elderly group with a mortality rate of 18.1%. The difference of mortality rate was significant between the two groups (P<0.05). Common causes of death in the elderly group were infection, hepatic encephalopathy, and electrolyte disorders and gastrointestinal bleeding, while the common causes of death in the non-elderly group were gastrointestinal bleeding and electrolyte disorders. Conclusion The etiology, clinical manifestations and prognosis of liver cirrhosis in elderly patients differ from those in younger patients. We must pay more attention on treating complications of liver cirrhosis in elderly patients.

Citation： XuJin. Etiological Analysis and Clinical Characteristics of Liver Cirrhosis in Elderly Patients. West China Medical Journal, 2016, 31(7): 1209-1212. doi: 10.7507/1002-0179.201600330 Copy

1.	陳灝珠, 林果為. 實用內科學(下冊)[M]. 13版. 北京:人民衛生出版社, 2009:2078-2082.
2.	李國軍, 洪捷敏, 鄒何慧, 等. 肝硬化住院患者合并醫院感染的臨床特征[J]. 中華醫院感染學雜志, 2011, 21(4):685-686.
3.	楊中菊, 胡乃中. 老年肝硬化患者營養狀況及其與臨床相關因素分析[J]. 安徽醫學, 2011, 32(12):1998-2000.
4.	周一鳴, 周小平, 焦建中. 65例老年肝硬化的病因及臨床特點分析[J]. 臨床內科雜志, 2010, 27(6):418-420.
5.	Hoshida Y, Ikeda K, Kobayashi M, et al. Chronic liver disease in the extremely elderly of 80 years or more:clinical characteristics, prognosis and patient survival analysis[J]. J Hepatology, 1999, 31(5):860-866.
6.	黃建鋒, 張曉瓊, 鄧德堅. 慢性肝病中血清前白蛋白檢測的臨床意義探討[J]. 臨床和實驗醫學雜志, 2011, 10(8):589-590.
7.	鄭成芳. 老年肝硬化60例臨床分析[J]. 現代預防醫學, 2012, 39(9):2368-2370.
8.	侯春陽, 李方治. 老年肝硬化患者的臨床表現及嚴重并發癥觀察指標分析[J]. 中國老年保健醫學, 2011, 9(4):59.
9.	Sandor L, Kiss L. Isolated injury of the gallbladder. A rare cause of hemorrhagic shock after blunt abdominal trauma in a patient with liver cirrhosis[J]. Chirurg, 2006, 77(8):730-736.
10.	洪海龍. 老年肝硬化患者的臨床特點分析[J]. 中外醫療, 2013(19):57-58.
11.	Liang X, Bi S, Yang W, et al. Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China[J]. J Infect Dis, 2009, 200(1):39-47.
12.	Lu FM, Zhuang H. Managemant of hepatitis B in China[J]. Chin Med J(Engl), 2009, 122(1):3-4.
13.	王曉霞, 鄒正升, 李保森, 等. 2002至2011年中國"北方"地區住院肝硬化患者病因構成及變化趨勢分析[J]. 實用肝臟病雜志, 2014, 17(2):154-158.
14.	Sorensen HT, Thulstrup AM, Mellemkjar L, et al. Long-term survival and cause-specific mortality in patients with cirrhosis of the liver:a nationwide cohort study in Denmark[J]. J Clin Epidemiol, 2003, 56(1):88-93.
15.	鄧學忠, 林強, 吳鴻. 老年肝硬化76例臨床分析[J]. 河北醫學, 2003, 9(6):204-205.
16.	王世鑫, 劉宇宏. 老年肝硬化的特征[J]. 北京醫學, 1998, 20(1):48-49.
17.	翟云, 丁惠國. 肝硬化并發細菌感染的免疫學基礎與臨床特征[J]. 北京醫學, 2010, 32(3):223-226.
18.	Saab S, Hernandez JC, Chi AC, et al. Oral antibiotic prophylaxis reduces spontaneous bacterial peritonitis occurrence and improves short-term survival in cirrhosis:a meta-analysis[J]. Am J Gastroenterol, 2009, 104(4):993-1001.
19.	高匯波, 代振英. 老年肝硬化患者生存質量影響因素[J]. 中國老年學雜志, 2013, 33(9):4608-4609.
20.	劉志榮, 劉彩峰, 孫玉秋, 等. 老年肝硬化患者生存質量狀況及相關因素[J]. 中國老年學雜志, 2011, 31(12):4653-4654.

1. 陳灝珠, 林果為. 實用內科學(下冊)[M]. 13版. 北京:人民衛生出版社, 2009:2078-2082.
2. 李國軍, 洪捷敏, 鄒何慧, 等. 肝硬化住院患者合并醫院感染的臨床特征[J]. 中華醫院感染學雜志, 2011, 21(4):685-686.
3. 楊中菊, 胡乃中. 老年肝硬化患者營養狀況及其與臨床相關因素分析[J]. 安徽醫學, 2011, 32(12):1998-2000.
4. 周一鳴, 周小平, 焦建中. 65例老年肝硬化的病因及臨床特點分析[J]. 臨床內科雜志, 2010, 27(6):418-420.
5. Hoshida Y, Ikeda K, Kobayashi M, et al. Chronic liver disease in the extremely elderly of 80 years or more:clinical characteristics, prognosis and patient survival analysis[J]. J Hepatology, 1999, 31(5):860-866.
6. 黃建鋒, 張曉瓊, 鄧德堅. 慢性肝病中血清前白蛋白檢測的臨床意義探討[J]. 臨床和實驗醫學雜志, 2011, 10(8):589-590.
7. 鄭成芳. 老年肝硬化60例臨床分析[J]. 現代預防醫學, 2012, 39(9):2368-2370.
8. 侯春陽, 李方治. 老年肝硬化患者的臨床表現及嚴重并發癥觀察指標分析[J]. 中國老年保健醫學, 2011, 9(4):59.
9. Sandor L, Kiss L. Isolated injury of the gallbladder. A rare cause of hemorrhagic shock after blunt abdominal trauma in a patient with liver cirrhosis[J]. Chirurg, 2006, 77(8):730-736.
10. 洪海龍. 老年肝硬化患者的臨床特點分析[J]. 中外醫療, 2013(19):57-58.
11. Liang X, Bi S, Yang W, et al. Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China[J]. J Infect Dis, 2009, 200(1):39-47.
12. Lu FM, Zhuang H. Managemant of hepatitis B in China[J]. Chin Med J(Engl), 2009, 122(1):3-4.
13. 王曉霞, 鄒正升, 李保森, 等. 2002至2011年中國"北方"地區住院肝硬化患者病因構成及變化趨勢分析[J]. 實用肝臟病雜志, 2014, 17(2):154-158.
14. Sorensen HT, Thulstrup AM, Mellemkjar L, et al. Long-term survival and cause-specific mortality in patients with cirrhosis of the liver:a nationwide cohort study in Denmark[J]. J Clin Epidemiol, 2003, 56(1):88-93.
15. 鄧學忠, 林強, 吳鴻. 老年肝硬化76例臨床分析[J]. 河北醫學, 2003, 9(6):204-205.
16. 王世鑫, 劉宇宏. 老年肝硬化的特征[J]. 北京醫學, 1998, 20(1):48-49.
17. 翟云, 丁惠國. 肝硬化并發細菌感染的免疫學基礎與臨床特征[J]. 北京醫學, 2010, 32(3):223-226.
18. Saab S, Hernandez JC, Chi AC, et al. Oral antibiotic prophylaxis reduces spontaneous bacterial peritonitis occurrence and improves short-term survival in cirrhosis:a meta-analysis[J]. Am J Gastroenterol, 2009, 104(4):993-1001.
19. 高匯波, 代振英. 老年肝硬化患者生存質量影響因素[J]. 中國老年學雜志, 2013, 33(9):4608-4609.
20. 劉志榮, 劉彩峰, 孫玉秋, 等. 老年肝硬化患者生存質量狀況及相關因素[J]. 中國老年學雜志, 2011, 31(12):4653-4654.

West China Medical Journal

Etiological Analysis and Clinical Characteristics of Liver Cirrhosis in Elderly Patients

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content