Ginkgo Leaf Extract and Dipyridamole Combined with Betahistine Injection for the Treatment of Vertebrobasilar Ischemia with Vertigo: A Meta-analysis_West China Medical Journal

Authors：

 DaiChengzhi , PengZhuyun , LiYuedan

Department of Neurology, Meishan People's Hospital, Meishan, Sichuan 620010, P. R. China;

Corresponding?author：

Keywords：

Ginkgo leaf extract and dipyridamole injection; Betahistine injection; Vertebrobasilar ischemia with vertigo; Meta-analysis

DOI：

10.7507/1002-0179.201600332

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Objective To evaluate the effects and safety of ginkgo leaf extract and dipyridamole combined with betahistine injection for the treatment of vertebrobasilar ischemia with vertigo. Methods The Cochrane Library, Medline, Embase, Web of Science, China National Knowledge Infrastructure, VIP Database, Wanfang Database and China Biology Medicine Databases were searched from their establishment to September 2015. We used the method recommended by the Cochrane collaboration to perform a meta-analysis on randomized controlled trails. Results Six studies were included. The results of meta-analysis demonstrated that ginkgo leaf extract and dipyridamole combined with betahistine injection for the treatment of vertebrobasilar ischemia with vertigo was superior to either ginkgo leaf extract and dipyridamole or betahistine injection in total effective rate[RR=1.21, 95%CI (1.08, 1.35), P=0.000 7; RR=1.17, 95%CI (1.05, 1.31), P=0.006]. Conclusion Ginkgo leaf extract and dipyridamole combined with betahistine injection is effective for the treatment of vertebrobasilar ischemia with vertigo. However, due to the limited quantity and quality of the included studies, the results need to be further confirmed.

Citation： DaiChengzhi, PengZhuyun, LiYuedan. Ginkgo Leaf Extract and Dipyridamole Combined with Betahistine Injection for the Treatment of Vertebrobasilar Ischemia with Vertigo: A Meta-analysis. West China Medical Journal, 2016, 31(7): 1216-1219. doi: 10.7507/1002-0179.201600332 Copy

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9.	鄒立宇, 瞿立武. 倍他司汀聯合銀杏達莫治療椎基底動脈供血不足眩暈療效觀察[J]. 現代中西醫結合雜志, 2008, 17(32):5015.
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1. 彭曉琴, 張兆輝, 何國厚. 依達拉奉聯合銀杏達莫治療急性腦梗死的Meta分析[J]. 卒中與神經疾病, 2012, 19(3):159-163.
2. 陳新謙, 金有豫, 湯光. 新編藥物學[M]. 17版. 北京:人民衛生出版社, 2011:306.
3. Higgins JPT, Altman DG. Cochrane handbook for systematic reviews of interventions Version 5.1.0 (updated March 2011)[EB/OL]. The Cochrane Collaboration, 2011[2013-04-01]. http://www.cochrane-handbook.org.
4. 毛小燕. 中西醫結合治療40例眩暈療效觀察[J]. 中國保健營養:中旬刊, 2013(2):447.
5. 張宇華. 倍他司汀聯合銀杏達莫對椎基底動脈供血不足性眩暈的治療探討[J]. 中國實用醫藥, 2012, 7(8):162-163.
6. 鄭春成, 王延祥. 銀杏達莫聯合倍他司汀治療椎基底動脈供血不足性眩暈[J]. 浙江中西醫結合雜志, 2010, 20(7):437.
7. 趙春玉. 鹽酸倍他司汀、銀杏達莫注射液聯合治療椎基底動脈供血不足眩暈療效觀察[J]. 中外健康文摘, 2009, 6(31):59.
8. 達志河, 馬維晉. 倍他司汀聯合銀杏達莫治療椎基底動脈供血不足眩暈146例療效觀察[J]. 中國醫藥導刊, 2009, 11(12):2079-2080.
9. 鄒立宇, 瞿立武. 倍他司汀聯合銀杏達莫治療椎基底動脈供血不足眩暈療效觀察[J]. 現代中西醫結合雜志, 2008, 17(32):5015.
10. 趙恩平. 銀杏達莫聯合倍他司汀治療椎-基底動脈供血不足性眩暈[J]. 中國實用醫藥, 2013, 8(8):152-153.

West China Medical Journal

Ginkgo Leaf Extract and Dipyridamole Combined with Betahistine Injection for the Treatment of Vertebrobasilar Ischemia with Vertigo: A Meta-analysis

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