Analysis of Flash Electroretinogram and Optical Coherence Tomography for Patients with Primary Retinitis Pigmentosa_West China Medical Journal

Authors：

 BaoLi , WangXiaoyue , DuCaifeng , MengDan ,  LiuLongqian

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

LiuLongqian, Email: b.q15651@hotmail.com

Keywords：

Primary retinitis pigmentosa; Flash electroretinogram; Optical coherence tomography; Latency; Amplitude; Retinal thickness

DOI：

10.7507/1002-0179.201600499

Video：

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Objective To use flash electroretinogram (F-ERG) and optical coherence tomography (OCT) to examine patients with primary retinitis pigmentosa (RP), and analyze the specificity of the disease on F-ERG and OCT. Methods Thirty-seven patients (74 eyes) diagnosed with primary retinitis pigmentosa in the Department of Ophthalmology, West China Hospital between September 2013 to October 2014 and 38 normal volunteers (76 eyes) were included in this study. F-ERG and OCT examinations were performed on all the patients. Then, we analyzed the differences between the two groups of subjects. Results For RP patients undergoing P-ERG examination with the dark adaptation of 0.01 ERG, the latency of b wave was (73.24±6.42) ms and the amplitude of b wave was (22.87±22.48) μV; when dark adaptation of 3.0 ERG was adopted, the latency of a wave was (24.57±6.30) ms, the amplitude of a wave was (35.45±25.54) μV, the latency of b wave was (48.19±8.18) ms, and the amplitude of b wave was (119.47±50.89) μV; with the light adaptation of 3.0 ERG, the latency of a wave was (21.01±4.86) ms, the amplitude of a wave was (12.59±13.43) μV, the latency of b wave was (38.43±5.00) ms, and the amplitude of b wave was (27.19±38.12) μV. For normal volunteers undergoing F-ERG examination with the dark adaptation of 0.01 ERG, the latency of b wave was (72.63±3.49) ms and the amplitude of b wave was (86.36±21.57) μV; when the dark adaptation was 3.0 ERG, the latency of a wave was (22.88±1.62) ms, the amplitude of a wave was (210.74±43.57) μV, the latency of b wave was (42.59±2.60) ms, and the amplitude of b wave was (398.29±62.42) μV; when the light adaptation of 3.0 ERG was adopted, the latency of a wave was (16.61±0.87) ms, the amplitude of a wave was (54.26±19.64) μV, the latency of b wave was (33.29±1.11) ms, and the amplitude of b wave was (176.98±63.44) μV. There were no significant differences between the two groups when dark adaptation ERG was 0.01 (P=0.48), but for other adaptations, there were significant differences in the latency and amplitude of a and b wave between the two groups (P<0.05). The results of OCT showed that the retinal thickness of the RP patients with a range of 1 mm diameter centered on macular center concave was (218.66±74.14) mm, 3 mm diameter was (275.03±47.85) mm, and 6 mm diameter was (247.37±46.44) mm. For normal volunteers, OCT showed that the retinal thickness with a 1 mm range centered on macular center concave was (250.38±15.79) mm, 3 mm was (323.64±17.26) mm, and 6 mm was (283.44±12.50) mm. The differences between the two groups were statistically significant for each range (P<0.01). Conclusion For patients with RP, F-ERG shows latency delay and amplitude decrease for each response, while OCT displays a thinning thickness of macular fovea. Therefore, F-ERG and OCT can not only effectively evaluate the functions of macular and the surrounding retina, but can also be used as an effective method for the diagnosis of RP.

Citation： BaoLi, WangXiaoyue, DuCaifeng, MengDan, LiuLongqian. Analysis of Flash Electroretinogram and Optical Coherence Tomography for Patients with Primary Retinitis Pigmentosa. West China Medical Journal, 2016, 31(11): 1818-1821. doi: 10.7507/1002-0179.201600499 Copy

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1. 劉妍, 魏文彬. 視網膜色素變性患者視覺電生理學指標檢測分析[J].首都醫科大學學報, 2010, 31(1):44-47.
2. 董楓, 楊順海. 視網膜色素變性患者多焦視網膜電圖特征[J].中國中醫眼科雜志, 2005, 15(3):132-134.
3. 葛堅, 趙家良. 眼科學[M].北京:人民衛生出版社, 2005:317.
4. 吳德正. 羅蘭視覺電生理儀的測試方法和臨床應用圖譜學[M].北京:北京科學技術, 2006:5-7.
5. 夏小平, 田東華, 宋國祥. 原發性視網膜色素變性早期診斷臨床探討[J].中國醫藥, 2009, 4(4):310-311.
6. Wolsley CJ, Silvestri G, O'neill J, et al. The association between multifocal electroretinograms and OCT retinal thickness in retinitis pigmentosa patients with good visual acuity[J].Eye, 2009, 23(7):1524-1531.
7. Moon CH, Park TK, Ohn YH. Association between multifocal electroretinograms, optical coherence tomography and central visual sensitivity in advanced retinitis pigmentosa[J].Documenta Ophthalmologica, 2012, 125(2):113-122.
8. Gr?nse L, Ponjavic V, Andréasson S. Full-field ERG, multifocal ERG and multifocal VEP in patients with retinitis pigmentosa and residual central visual fields[J].Acta Ophthalmol Scand, 2004, 82:701-706.
9. 底煜, 周雅麗. 視網膜色素變性的視網膜電圖與光學相干斷層掃描的觀察分析[J].國際眼科雜志, 2011, 11(8):1347-1349.
10. 唐松, 黃麗娜. 視網膜色素變性患者的多焦視網膜電圖與視網膜光學相干斷層掃描的觀察分析[J].臨床眼科雜志, 2006, 14(6):483-485.
11. Tzekov RT, Locke KG. Cone and rod ERG phototransduction parameters in retinitis pigmentosa[J].Invest Ophthalmol Vis Sci, 2003, 44(9):3993-4000.
12. 牛超, 李舒茵, 李娜. 視網膜色素變性黃斑區視網膜FD-OCT及mfERG觀察[J].眼科新進展, 2014, 34(12):1161-1163.
13. Torrón-Fernández-Blanco C, Ferrer-Novella E. Optical coherence tomography of retinal pigment epithelial tears[J].Elsevier Doyma, 2007, 82(4):245-249.
14. Hazirolan D, Demir MN. Macular OCT in patients with retinitis pigmentosa[J].J Glaucoma-Cataract, 2008, 16(3):222-225.
15. Cranse L, Ponjavic V, Andreasson S. Full-field ERG, multifocal ERG and multifocal VEP in patients with retinitis pigmentosa and residual central visual fields[J].Acta Ophthalmol Scand, 2004, 82(6):701-706.
16. 劉利莉, 郭冉陽. 原發性視網膜色素變性的頻域光學相干斷層成像特征[J].眼科新進展, 2012, 32(3):279-282.
17. 劉紅, 孫丹宇. 頻域光學相干斷層掃描在原發性視網膜色素變性中的應用[J].國際眼科雜志, 2010, 10(4):677-679.

West China Medical Journal

Analysis of Flash Electroretinogram and Optical Coherence Tomography for Patients with Primary Retinitis Pigmentosa

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