Comparison between the Effect of Lidocaine Mucilage Diluent and Simethicone Emulsion for Gastroscopy_West China Medical Journal

Authors：

 WangYu ¹ , WenYing ² , ZhangQiongying ¹

1. Endoscopy Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong 518073, P. R. China;

Corresponding?author：

Keywords：

Lidocaine hydrochloride mucilage diluent; Simethicone emulsion; Gastroscopy; Effect

DOI：

10.7507/1002-0179.201600506

Video：

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Objective To explore the clinical effect of lidocaine mucilage diluent and simethicone emulsion in gastroscopy examination, in order to provide effective drugs for gastroscopy. Methods We selected 201 outpatients and the inpatients who underwent gastroscopic examination between August and October 2014 as the research subjects. Based on the kind of drug, the patients were randomly divided into research group (n=100) and control group (n=101). Patients in the research group accepted lidocaine mucilage diluent, while those in the control group received simethicone emulsion. Then we observed and compared the definition of gastroscopy, adverse drug reactions, examination time and drug price between the two groups. Results The frequencies of high, medium, and low definition of gastroscopy were respectively 63.00%, 34.00% and 3.00% among the patients in the research group, and 69.31%, 26.73% and 3.96% among patients in the control group; there was no significant differences between the two groups (Z=-0.854, P=0.393). The adverse reaction rates, testing time, and drug prices for the two groups were 0.99% vs.1.00% (P>0.05), (6.5±2.1) minutes vs.(6.6±2.0) minutes (t=0.458, P>0.05), and RMB (9.0±1.2) yuan vs.(42.8±2.8) yuan (t=227.644, P<0.05), respectively. Conclusion Lidocaine mucilage diluent and simethicone emulsion both have good effect for gastroscopic examination, which can raise the gastroscopic definition, promote endoscopic operation and observation by doctors, shorten examination time, and reduce adverse drug reactions. Both are of great value in clinical application, and lidocaine hydrochloride mucilage diluent is cheaper, which can be widely used and promoted clinically.

Citation： WangYu, WenYing, ZhangQiongying. Comparison between the Effect of Lidocaine Mucilage Diluent and Simethicone Emulsion for Gastroscopy. West China Medical Journal, 2016, 31(11): 1846-1849. doi: 10.7507/1002-0179.201600506 Copy

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15.	王蕓, 吳飛, 曹治平. 消泡劑的研究現狀與展望[J].化學工程師2008, 11(3):26-28.
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18.	武朝霞, 武永生, 蘇心鏡, 等. 利多卡因預防芬太尼在無痛胃鏡檢查時咳嗽反射的效果[J].中國誤診學雜志, 2011, 11(22):5340.

1. 廖日斌, 蘇燕波, 唐建光, 等. 咪達唑侖單用和聯合應用丙泊酚在胃鏡檢查中的效果比較[J].中國臨床醫學, 2011, 18(3):355-357.
2. 陳黎, 劉永爵, 龔益清. 西甲硅油乳劑聯合利多卡因膠漿在胃鏡檢查中的效果觀察[J].中國現代藥物應用, 2014, 8(19):147-148.
3. 董桂祥. 噴他佐辛復合靶控丙泊酚用于老年人無痛胃鏡檢查術90例[J].中國藥業, 2014, 11(13):86-88.
4. Kao SH, Hsu LL, Hsieh SI, et al. The effects of two educational interventions on knowledge and competence of nurses with regard to conveying gastroscopy-related information to patients[J].J Adv Nurs, 2013, 69(4):793-804.
5. 陳伯利, 斯望春, 張杏琴, 等. 西甲硅油在無痛胃鏡檢查中的應用[J].中國現代醫生, 2011, 49(16):58-59.
6. 鄧紅英. 肥胖患者無痛胃鏡檢查時血氧飽和度下降分析[J].按摩與康復醫學, 2011, 2(26):26-27.
7. 舒麗娟, 魏新.聯合用藥在肥胖患者無痛胃鏡中的應用[J].實用醫學雜志, 2011, 27(22):4142-4144.
8. 李長順, 楊蓬勃, 和小祥, 等. 成年國人內鏡下食管長度的研究[J].西安交通大學學報, 2005, 26(3):239-241.
9. 吳在德, 吳肇漢. 外科學[M].北京:人民衛生出版社, 2005:441.
10. 章四杰, 徐磊, 王維紅, 等. 西甲硅油和鹽酸利多卡因膠漿在胃鏡檢查中的應用效果比較[J].中國醫師進修雜志, 2011, 34(13):64-65.
11. 賴艷新, 李良芳, 陳彥, 等. 不同濃度西甲硅油溶液在無痛胃鏡檢查中的應用觀察與護理[J].臨床護理雜志, 2014, 13(1):13-16.
12. 吳云林, 陳麗娜, 王春蘭, 等. 西甲硅油在內鏡胃體胃底觀察中的價值[J].胃腸病學和肝病學雜志, 2006, 15(3):300-302.
13. 高彥花. 利多卡因用于老年患者無痛胃鏡檢查100例[J].中國老年學雜志, 2012, 32(8):1734-1735.
14. 楊聰玲, 吳行爍, 邱奕, 等. 利多卡因聯合丙泊酚行無痛胃鏡檢查的臨床體會[J].中國藥物濫用防治雜志, 2011, 17(1):21-23.
15. 王蕓, 吳飛, 曹治平. 消泡劑的研究現狀與展望[J].化學工程師2008, 11(3):26-28.
16. 李聰. 不同劑量地佐辛聯合丙泊紛用于無痛胃鏡的臨床觀察[J].中國藥物與臨床, 2014, 14(2):267-268.
17. 李延領. 芬太尼和咪達唑侖與利多卡因膠漿在無痛胃鏡檢查中的應用[J].中國現代藥物應用, 2012, 6(6):73-74.
18. 武朝霞, 武永生, 蘇心鏡, 等. 利多卡因預防芬太尼在無痛胃鏡檢查時咳嗽反射的效果[J].中國誤診學雜志, 2011, 11(22):5340.

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West China Medical Journal

Comparison between the Effect of Lidocaine Mucilage Diluent and Simethicone Emulsion for Gastroscopy

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