Clinical Analysis on Neonatal Respiratory Failure_West China Medical Journal

Authors：

 ZhangDeshuang ^1,2 , WangHua ¹ ,  ChenJuan ¹

1. Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Neonatology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding?author：

ChenJuan, Email: chenjuan2000@163.com

Keywords：

Neonate; Respiratory failure; Mechanical ventilation

DOI：

10.7507/1002-0179.20160071

Video：

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Objective To explore the incidence, treatment and prognosis of neonatal respiratory failure (NRF). Methods The clinical data of 421 neonates with NRF treated between January 2011 and December 2013 were retrospectively analyzed. Results The incidence and the mortality of NRF was 4.8% and 14.5%, respectively. The main primary disease of NRF was neonatal respiratory distress syndrome (36.1%) and aspiration pneumonia (29.0%). Mechanical ventilation was the main treatment for NRF (77.2%). Premature (χ²=12.216, P<0.001), low birth weight (χ²=8.932, P=0.003) and the neonatal asphyxia (χ²=6.199, P=0.013) were closely related to the prognosis of NRF, which were the risk factors of the death of NRF. Conclusion NRF is a disease with high incidence and high mortality; make effective prevention and treatment measures are important to improve the success rate of therapy for NRF.

Citation： ZhangDeshuang, WangHua, ChenJuan. Clinical Analysis on Neonatal Respiratory Failure. West China Medical Journal, 2016, 31(2): 262-265. doi: 10.7507/1002-0179.20160071 Copy

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18.	林新祝, 賴基棟, 呂梅, 等. 高頻振蕩通氣聯合肺表面活性物質治療新生兒肺出血的療效觀察[J]. 中國當代兒科雜志, 2015, 17(4):345-349.
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1. Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999[J]. Pediatrics, 2002, 110(1 Pt 1):143-151.
2. Markestad T, Kaaresen PI, R?nnestad A, et al. Early death, morbidity, and need of treatment among extremely premature infants[J]. Pediatrics, 2005, 115(5):1289-1298.
3. Qian L, Liu C, Zhuang W, et al. Neonatal respiratory failure:a 12-month clinical epidemiologic study from 2004 to 2005 in China[J]. Pediatrics, 2008, 121(5):e1115-e1124.
4. Angus DC, Linde-Zwirble WT, Clermont G, et al. Epidemiology of neonatal respiratory failure in the United States:projections from California and New York[J]. Am J Respir Crit Care Med, 2001, 164(7):1154-1160.
5. Clark RH. The epidemiology of respiratory failure in neonates born at an estimated gestational age of 34 weeks or more[J]. J Perinatol, 2005, 25(4):251-257.
6. 賴娟, 杜立中, 熊國強, 等. 1 108例新生兒呼吸衰竭的臨床流行病學特征[J]. 中國當代兒科雜志, 2016, 18(1):10-14.
7. Wang H, Gao X, Liu C, et al. Morbidity and mortality of neonatal respiratory failure in China:surfactant treatment in very immature infants[J]. Pediatrics, 2012, 129(3):e731-e740.
8. 程銳, 韓樹萍, 周曉玉, 等. 南京兩新生兒重癥監護室新生兒呼吸衰竭臨床流行病學調查[J]. 南京醫科大學學報:自然科學版, 2009, 29(12):1750-1752.
9. 朱天聞, 張永紅, 陳妍, 等. 晚期早產兒與足月新生兒呼吸衰竭發生及預后的影響因素[J]. 上海交通大學學報:醫學版, 2013, 33(7):920-925.
10. 劉敬, 王曉風, 王華偉, 等. 足月新生兒呼吸窘迫綜合征的診斷和治療研究[J]. 中華全科醫師雜志, 2013, 12(12):993-995.
11. 潘兆軍, 丁素芳, 高子波, 等. 2010年江蘇淮安基于出生人口新生兒呼吸衰竭流行病學調查[J]. 中國當代兒科雜志, 2014, 16(11):1138-1142.
12. 王海娟, 楊梅. 外源性肺表面活性物質治療足月剖宮產兒呼吸窘迫綜合征[J]. 中國新生兒科雜志, 2007, 22(5):304-305.
13. Pawar M, Mehta Y, Khurana P, et al. Ventilator-associated pneumonia:Incidence, risk factors, outcome, and microbiology[J]. J Cardiothorac Vasc Anesth, 2003, 17(1):22-28.
14. Josephson SA, Moheet AM, Gropper MA, et al. Ventilator-associated pneumonia in a neurologic intensive care unit does not Lead to increased mortality[J]. Neurocrit Care, 2010, 12(2):155-158.
15. Deng C, Li X, Zou Y, et al. Risk factors and pathogen profile of ventilator-associated pneumonia in a neonatal intensive care unit in China[J]. Pediatr Int, 2011, 53(3):332-337.
16. Roberts CL, Badgery-Parker T, Algert CS, et al. Trends in use of neonatal CPAP:a population-based study[J]. BMC Pediatr, 2011, 11:89.
17. 林新祝, 賴基棟, 蘭朝陽, 等. 豬肺表面活性物質氣管內灌洗治療重癥新生兒胎糞吸入綜合征的臨床研究[J]. 中國當代兒科雜志, 2014, 16(7):709-713.
18. 林新祝, 賴基棟, 呂梅, 等. 高頻振蕩通氣聯合肺表面活性物質治療新生兒肺出血的療效觀察[J]. 中國當代兒科雜志, 2015, 17(4):345-349.
19. 劉金鳳, 王軍. 肺表面活性物質在新生兒重癥肺炎治療中的應用價值[J]. 東南大學學報:醫學版, 2015, 34(6):958-961.
20. Rüegger C, Hegglin M, Adams M, et al. Population based trends in mortality, morbidity and treatment for very preterm- and very low birth weight infants over 12 years[J]. BMC Pediatr, 2012, 12:17.
21. Liu J, Yang N, Liu Y. High-risk factors of respiratory distress syndrome in term neonates:a retrospective case-control study[J]. Balkan Med J, 2014, 31(1):64-68.
22. 石樹中, 虞人杰, 黃醒華, 等. 新生兒窒息復蘇[M]. 上海:上海科技教育出版社, 2005:7.

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