Analysis of Fibrinogen Level in Patients Injured in Lushan and Wenchuan Earthquake_West China Medical Journal

Authors：

 HuangXunbei , NiuQian , LiaoJuan , WangXia ,  JiangHong

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding?author：

JiangHong, Email: jianghong6656@126.com

Keywords：

Earthquake; Fibrinogen; Treatment time

DOI：

10.7507/1002-0179.20160073

Video：

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Objective To explore fibrinogen (Fbg) variety in the patients wounded in Lushan and Wenchuan earthquake. Methods As the research subjects, 276 Lushan earthquake victims (from April 20th to 24th, 2013) and 503 Wenchuan earthquake victims (from May 13th to 17th, 2008) were divided into five groups according to the admission date, and then the Fbg variety in those earthquake victims were analyzed. We carried out pairwise comparison among these groups in the Lushan earthquake and Wenchuan earthquake respectively on the Fbg variety. Ninety-one fracture patients in the Lushsan earthquake and 130 fracture patients in the Wenchuan earthquake were divided into two groups according to clinical diagnosis:multiple fracture and single fracture, and then we evaluated the Fbg values in patients with different degrees of disability. Results The whole Fbg level[(2.70±1.15) g/L] in Lushan earthquake was below the level[(4.47±1.94) g/L] in Wenchuan earthquake, and the difference was statistically significant (P<0.01). The Fbg level in the patients whose admission date was within 48 hours was significantly different with that in patients whose admission date was more than 48 hours (P<0.01). The Fbg level in Lushan earthquake was below the level in Wenchuan earthquake, not only in the multiple fracture group but also in the single fracture group[in Lushan earthquake, the former was (2.21±0.76) g/L, and the latter was (1.98±0.85) g/L; in Wenchuan earthquake, the former was (3.35±1.48) g/L, and the latter was (3.11±1.05) g/L], and the difference was statistically significant (P<0.01). Conclusion Blood coagulation, especially Fbg level, has different degrees of changes in acute stress caused by emergency and in different treatment times, and it is better to take preventive measures.

Citation： HuangXunbei, NiuQian, LiaoJuan, WangXia, JiangHong. Analysis of Fibrinogen Level in Patients Injured in Lushan and Wenchuan Earthquake. West China Medical Journal, 2016, 31(2): 270-273. doi: 10.7507/1002-0179.20160073 Copy

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10.	賴紹林, 王慶, 胥伶杰, 等. 汶川地震傷員的早期傷情評估指標與其在一線醫院住院時間的相關性分析[J]. 華西醫學, 2015, 30(6):1023-1026.
11.	曾朝蓉, 李建南, 程光麗, 等. 蘆山地震震中醫院早期醫療救護組織管理分析[J]. 臨床急診雜志, 2014, 15(2):103-105.
12.	王謙, 劉遄, 王樸, 等. 蘆山地震骨折傷員傷情特點及功能分析[J]. 四川大學學報:醫學版, 2015, 46(4):606-610.
13.	孟昭軍. 骨折患者監測纖維蛋白原、D-二聚體和血小板指標的意義[J]. 中國實驗診斷學, 2014, 18(9):1477-1478.
14.	Aissaoui N, Martins E, Mouly S, et al. A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both[J]. Int J Cardiol, 2009, 137(1):37-41.
15.	王兵, 唐錫章, 胡敏, 等. 創傷能量與大鼠肢體深靜脈血栓形成的相關性[J]. 中國臨床康復, 2005, 9(14):136-137.
16.	王剛, 李強, 徐云欽, 等. 纖維蛋白原及D-二聚體雙動態曲線變化在下肢骨折深靜脈血栓預防中的價值[J]. 中國骨與關節損傷雜志, 2014, 29(10):1015-1017.

1. van Hylckama Vlieg A, Rosendaal FR. High levels of fibrinogen are associated with the risk of deep venous thrombosis mainly in the elderly[J]. J Thromb Haemost, 2003, 1(12):2677-2678.
2. 劉曉毅, 楊林, 祁光裕, 等. 白介素、C-反應蛋白和纖維蛋白原在下肢深靜脈血栓炎癥反應中的作用[J]. 中國普外基礎與臨床雜志, 2010, 17(7):660-663.
3. Ueda S, Hanzawa K, Shibata M, et al. High prevalence of deep vein thrombosis in tsunami-flooded shelters established after the great East-Japan earthquake[J]. Tohoku J Exp Med, 2012, 227(3):199-202.
4. 陳旭, 楊俊華, 黃雨蘭, 等. 蘆山地震住院傷員應激障礙及其影響因素分析[J]. 實用醫院臨床雜志, 2015, 12(6):55-58.
5. 王艷瓊, 寧寧, 劉歡, 等. 76名蘆山地震傷員創傷后應激障礙情況調查分析[J]. 護理學報, 2014, 21(6):9-11.
6. 劉瑞安, 黃壘, 李小麟, 等. 168名蘆山地震傷員急性應激障礙發生情況及影響因素分析[J]. 護理學報, 2015, 22(19):22-26.
7. Vitorino de Almeida V, Silva-Herdade A, Calado A, et al. Fibrinogen modulates leukocyte recruitment in vivo during the acute inflammatory response[J]. Clin Hemorheol Microcirc, 2012, 59(2):97-106.
8. 張毅, 司徒明鏡, 方慧, 等. 汶川大地震災區兒童青少年的地震經歷與抑郁情緒[J]. 華西醫學, 2009, 24(1):21-24.
9. 郎學勤. 云南魯甸8. 03地震成批傷員的急診分診及救護[J]. 中外醫學研究, 2015, 13(4):154-155.
10. 賴紹林, 王慶, 胥伶杰, 等. 汶川地震傷員的早期傷情評估指標與其在一線醫院住院時間的相關性分析[J]. 華西醫學, 2015, 30(6):1023-1026.
11. 曾朝蓉, 李建南, 程光麗, 等. 蘆山地震震中醫院早期醫療救護組織管理分析[J]. 臨床急診雜志, 2014, 15(2):103-105.
12. 王謙, 劉遄, 王樸, 等. 蘆山地震骨折傷員傷情特點及功能分析[J]. 四川大學學報:醫學版, 2015, 46(4):606-610.
13. 孟昭軍. 骨折患者監測纖維蛋白原、D-二聚體和血小板指標的意義[J]. 中國實驗診斷學, 2014, 18(9):1477-1478.
14. Aissaoui N, Martins E, Mouly S, et al. A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both[J]. Int J Cardiol, 2009, 137(1):37-41.
15. 王兵, 唐錫章, 胡敏, 等. 創傷能量與大鼠肢體深靜脈血栓形成的相關性[J]. 中國臨床康復, 2005, 9(14):136-137.
16. 王剛, 李強, 徐云欽, 等. 纖維蛋白原及D-二聚體雙動態曲線變化在下肢骨折深靜脈血栓預防中的價值[J]. 中國骨與關節損傷雜志, 2014, 29(10):1015-1017.

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Analysis of Fibrinogen Level in Patients Injured in Lushan and Wenchuan Earthquake

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