A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease_West China Medical Journal

Authors：

 HE Suyu , LIU Yijun , CHEN Yongjun , TANG Yi , XU Jianyu , WU Yan

Department of Gastroenterology, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;

Corresponding?author：

HE Suyu, Email: hesuyu2009@163.com

Keywords：

Type 2 diabetes mellitus; Gastroesophageal reflux disease; Gastrin

DOI：

10.7507/1002-0179.201601117

Video：

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Objective To investigate the gastrin level in patients with type 2 diabetes mellitus (T2DM) with gastroesophageal reflux disease (GERD), and analyze the possible mechanism of gastrin in the pathogenesis of T2DM combined with GERD. Methods Thirty-eight patients with T2DM combined with GERD treated between January 2013 and January 2015 were designated as group A; 40 patients with T2DM only were regarded as group B; 36 patients with GERD only were regarded as group C; and another 40 healthy volunteers who underwent physical examination at the same period were regarded as group D. The fasting serum levels of gastrin were measured and compared among the above four groups. Results The fasting serum level of gastrin was significantly higher in group A [(116.53±22.02) pg/mL] than group B [(101.89±20.76) pg/mL], group C [(90.04±21.16) pg/mL], and group D [(92.48±19.69) pg/mL] (P<0.01). The fasting serum level of gastrin in group B was significantly higher than group C and D (P<0.05). There was no significant difference between group C and D in terms of fasting serum level of gastrin (P>0.05). Conclusions There is a high level of gastrin in patients with GERD combined with T2DM. Abnormal secretion of gastrin may be closely related with the occurrence and development of T2DM and GERD.

Citation： HE Suyu, LIU Yijun, CHEN Yongjun, TANG Yi, XU Jianyu, WU Yan. A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease. West China Medical Journal, 2017, 32(3): 383-386. doi: 10.7507/1002-0179.201601117 Copy

1.	?Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 2010, 87(1): 4-14.
2.	Moayyedi P, Talley NJ. Gastro-esophageal reflux disease. Lancet, 2006, 367(9528): 2086-2100.
3.	Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol, 2006, 4(4): 398-407.
4.	Wang X, Pitchumoni CS, Chandrarana K,et al. Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol, 2008, 14(5): 709-712.
5.	Hirata A, Kishida K, Nakatsuji H,et al. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutr Metab (Lond), 2012, 9(1): 4.
6.	朱瑞平, 鄧長生, 朱尤慶. 老年 2 型糖尿病患者胃液體排空與胃泌素、胃動素、生長抑素的關系. 武漢大學學報: 醫學版, 2003, 24(3): 268-270.
7.	吳祖榮, 韋玲, 陳宗存, 等. 血漿P物質和血管活性腸肽在糖尿病伴胃食管反流病中表達及意義. 世界華人消化雜志, 2015, 23(27): 4447-4451.
8.	王連芬, 鄭長青, 林連捷, 等. GERDQ 量表在胃食管反流病中的診斷價值. 世界華人消化雜志, 2011, 19(18): 1941-1945.
9.	Natalini J, Palit A, Sankineni A,et al. Diabetes mellitus is an Independent risk for gastroesophageal reflux disease among urban African Americans. Dis Esophagus, 2015, 28(5): 405-411.
10.	張宏偉, 師永芳. 胃食管反流病與代謝綜合征及其組分的相關性研究. 中國醫師雜志, 2013, 15(6): 785-788.
11.	王麗紅, 仇日火. 老年糖尿病患者食管下括約肌壓力水平測定. 中國老年學雜志, 2012, 32(19): 4299-4300.
12.	向旭. 胃腸激素與糖尿病并發胃食管反流病. 胃腸病學和肝病學雜志, 2013, 22(8): 823-825.
13.	牛奔, 蘇恒, 李超, 等. 2 型糖尿病外周感覺神經病變和心自主神經病變關系的研究. 中國糖尿病雜志, 2013, 21(2): 139-141.
14.	張紹剛, 程留芳, 白梅, 等. 2 型糖尿病胃輕癱患者胃腸激素水平的測定. 中國綜合臨床, 2002, 18(5): 433-434.
15.	Horikawa A, Ishii-Nozawa R, Ohguro M,et al. Prevalence of GERD in type 2 diabetes and a comparison of clinical profiles between diabetic patients with and without GERD. Diabet Med, 2009, 26(3): 228-233.
16.	馮桂建, 胡伏蓮, 王化虹, 等. 幽門螺桿菌和胃泌素與胃食管反流病的關系. 中華醫學雜志, 2003, 83(2): 96-99.
17.	Kwon JH, Chung IS, Son HS,et al. The relationship of gastrin, pepsinogen, and Helicobacter pylori in erosive reflux esophagitis. Korean J Gastroenterol, 2008, 51(3): 159-166.
18.	Yakut M, Kabacam G, Bekta? M,et al. The effect of endogenous hypergastrinemia on lower esophageal sphincter pressure and esophageal motility. Hepatogastroenterology, 2012, 58(112): 1989-1992.
19.	劉玉成, 李玉, 解晨昊, 等. 胃泌素對胃食管反流病患者食管壓力及 pH 的影響. 河北醫科大學學報, 2002, 23(6): 327-329.
20.	Straathof JW, Lamers CB, Masclee AA. Effect of gastrin-17 on lower esophageal sphincter characteristics in man. Dig Dis Sci, 1997, 42(12): 2547-2551.

1. ?Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 2010, 87(1): 4-14.
2. Moayyedi P, Talley NJ. Gastro-esophageal reflux disease. Lancet, 2006, 367(9528): 2086-2100.
3. Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol, 2006, 4(4): 398-407.
4. Wang X, Pitchumoni CS, Chandrarana K,et al. Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol, 2008, 14(5): 709-712.
5. Hirata A, Kishida K, Nakatsuji H,et al. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutr Metab (Lond), 2012, 9(1): 4.
6. 朱瑞平, 鄧長生, 朱尤慶. 老年 2 型糖尿病患者胃液體排空與胃泌素、胃動素、生長抑素的關系. 武漢大學學報: 醫學版, 2003, 24(3): 268-270.
7. 吳祖榮, 韋玲, 陳宗存, 等. 血漿P物質和血管活性腸肽在糖尿病伴胃食管反流病中表達及意義. 世界華人消化雜志, 2015, 23(27): 4447-4451.
8. 王連芬, 鄭長青, 林連捷, 等. GERDQ 量表在胃食管反流病中的診斷價值. 世界華人消化雜志, 2011, 19(18): 1941-1945.
9. Natalini J, Palit A, Sankineni A,et al. Diabetes mellitus is an Independent risk for gastroesophageal reflux disease among urban African Americans. Dis Esophagus, 2015, 28(5): 405-411.
10. 張宏偉, 師永芳. 胃食管反流病與代謝綜合征及其組分的相關性研究. 中國醫師雜志, 2013, 15(6): 785-788.
11. 王麗紅, 仇日火. 老年糖尿病患者食管下括約肌壓力水平測定. 中國老年學雜志, 2012, 32(19): 4299-4300.
12. 向旭. 胃腸激素與糖尿病并發胃食管反流病. 胃腸病學和肝病學雜志, 2013, 22(8): 823-825.
13. 牛奔, 蘇恒, 李超, 等. 2 型糖尿病外周感覺神經病變和心自主神經病變關系的研究. 中國糖尿病雜志, 2013, 21(2): 139-141.
14. 張紹剛, 程留芳, 白梅, 等. 2 型糖尿病胃輕癱患者胃腸激素水平的測定. 中國綜合臨床, 2002, 18(5): 433-434.
15. Horikawa A, Ishii-Nozawa R, Ohguro M,et al. Prevalence of GERD in type 2 diabetes and a comparison of clinical profiles between diabetic patients with and without GERD. Diabet Med, 2009, 26(3): 228-233.
16. 馮桂建, 胡伏蓮, 王化虹, 等. 幽門螺桿菌和胃泌素與胃食管反流病的關系. 中華醫學雜志, 2003, 83(2): 96-99.
17. Kwon JH, Chung IS, Son HS,et al. The relationship of gastrin, pepsinogen, and Helicobacter pylori in erosive reflux esophagitis. Korean J Gastroenterol, 2008, 51(3): 159-166.
18. Yakut M, Kabacam G, Bekta? M,et al. The effect of endogenous hypergastrinemia on lower esophageal sphincter pressure and esophageal motility. Hepatogastroenterology, 2012, 58(112): 1989-1992.
19. 劉玉成, 李玉, 解晨昊, 等. 胃泌素對胃食管反流病患者食管壓力及 pH 的影響. 河北醫科大學學報, 2002, 23(6): 327-329.
20. Straathof JW, Lamers CB, Masclee AA. Effect of gastrin-17 on lower esophageal sphincter characteristics in man. Dig Dis Sci, 1997, 42(12): 2547-2551.

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A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease

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